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All Journal Nexus Kedokteran Komunitas Berkala Ilmu Kesehatan Kulit dan Kelamin Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ners JOURNAL LA MEDIHEALTICO Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Journal of Social Research MEDICINUS Indonesian Basic and Experimental Health Sciences

Nurrachmat Mulianto

Unknown Affiliation

Author-ID : 324340

Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

Published : 37 Documents Claim Missing Document

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Hubungan Riwayat Atopik dan Masa Kerja dengan Kejadian Dermatitis Kontak Iritan pada Pekerja Cuci Motor di Kecamatan Jebres Surakarta Nur Ismi Mustika Febriani; Nurrachmat Mulianto; . Hardjono
Nexus Kedokteran Komunitas Vol 2, No 1 (2013): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Irritant contact dermatitis is the most common form of occupational skin disease, accounting for up to 80% of all occupational skin disorders. Atopic history and work period are risk factors for irritant contact dermatitis. This study aimed to analyze the relation of atopic history and work period with the incidence of irritant contact dermatitis on motorcycle wash workers at District of Jebres in Surakarta. Method: This study was observational analytics with cross sectional approach. Subjects were male who worked in motorcycle wash at District of Jebres in Surakarta. Samples were 60 workers. This samples were taken by fixed disease purposive sampling. Data were collected by questionaire and digital autograph, then analyzed by multiple logistic regression analysis using SPSS 17.0 for windows. Result: The results of atopic history analysis showed that there was a positive relationship between atopic history and the incidence of irritant contact dermatitis. Motorcycle wash workers who had atopic history would increase the risk to get irritant contact dermatitis 8.44 times than workers who hadnt atopic history (OR = 8.44; CI 95% 2.203 s/d 32.341). The results from analysis variable of work period showed significant relationship between work period and the incidence of irritant contact dermatitis. The worker who had worked ? 3 years had a greater risk 4.91 times than workers who had worked < 3 years (OR = 4.91; CI 95% 1.365 s/d 17.675). Conclusion : There was a positive relationship between atopic history and work period with the incidence of irritant contact dermatitis on motorcycle wash workers at District of Jebres in Surakarta. The motorcycle wash workers who had atopic history and had worked ? 3 years would increase the risk of irritant contact dermatitis. Keywords : irritant contact dermatitis, atopic history, work period, motorcycle wash workers

The Relationship between Healthy Life Behavior (Knowledge, Attitude, and Practice) with the Occurrence of Scabies in Daarul Quran Islamic Boarding School Surakarta Astrid Astari Aulia; Nurrachmat Mulianto; Suci Widhiati
Nexus Kedokteran Komunitas Vol 6, No 1 (2017): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Introduction: Healthy life behavior is knowledge, attitudes, and practice to maintain healthy condition and prevent disease, as well as an active role in public health movement. The high prevalence of scabies in boarding school in Indonesia is influenced by lack of knowledge about scabies. Data from Daarul Quran Islamic Boarding Schools health center during the period of February-August 2015 show that there were 40 students from total of 162 (24.6%) students who at least once been infected by scabies. Based on the explanation above, researchers interested in conducting a study to determine the relationship between healthy behavior which consist of knowledge, attitudes, and practices with the occurance of scabies in Daarul Quran Islamic Boarding School Surakarta. Methods: This study was an observational analytic with cross-sectional approach. A total of 155 students of Daarul Quran Islamic Boarding School Surakarta involved as research subjects. The dependent variable in this study was the occurance of scabies while the independent variables consist of knowledge, attitudes, personal hygiene and habits. Independent variables were measured using a questionnaire. The variables were analyzed by bivariate analysis using chi-square test. Result: There were 59 (38,1%) from 155 students of Daarul Qur'an Surakarta Islamic Boarding School infected by scabies. A number of 31 (52.5%) of the total 59 infected students aged 13 years. Most of the students exposed to scabies still in 7th grade (55.9%). Bivariate analysis showed that there was a significant relationship between knowledge (p = 0.021), attitude (p = 0.029), action (personal hygiene (p = 0.024) and habits (p = 0.024)) with occurence of scabies in Pondok Pesantren Daarul Qur 'an Surakarta. Conclusions: There is a relationship between healthy life behavior (knowledge, attitudes, and practices) and scabies occurrence in Daarul Qur'an Islamic Boarding School Surakarta, therefore more effective promotion and health education is needed to lower scabies incidence. Keywords: Scabies, Healthy Life Behavior, Knowledge, Attitude, Practices

Korelasi Kadar Serum Nitric Oxide (NO) dengan Tipe dan Derajat Keparahan Psoriasis Fiska Rosita; Bobby Febrianto; Ambar Aliwardani; Putti Fatiharani; Wibisono Nugraha; Muhammad Eko Irawanto; Nurrachmat Mulianto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Psoriasis is a chronic, immune-mediated disorder that results from a polygenic predisposition. Nitric oxide (NO) has been considered as important factors in the pathogenesis of psoriasis. This study aims to determine the correlation of serum NO levels with the type and severity of psoriasis. This cross-sectional study was conducted from May to September 2018. Difference in the average of serum NO levels in psoriasis patients with control groups is analyzed using t-test. The Spearman correlation test was used to see the correlation of serum NO levels with type and severity of psoriasis measured by Psoriasis Area and Severity Index (PASI) score. There was significant difference between serum NO level in the control group compared to the group of psoriasis patients (p=0.037). Patient with generalized pustular psoriasis has the highest mean of NO level (59.07 µmol/L). There was no significant correlation between serum NO level with type (r=0.008, p=0.9710 and severity (r=0.157, p=0.486) of psoriasis. Nitric oxide levels are elevated in psoriasis patients, which indicate that oxidative stress plays an important role in the etiopathogenesis of psoriasis.

Ulkus Marjolin yang Berkembang dari Ulkus Trofik Kronis pada Pasien Kusta Adniana Nareswari; Harijono Kariosentono; Nugrohoaji Dharmawan; Muhammad Eko Irawanto; Nurrachmat Mulianto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Marjolin’s ulcer is a malignant complication of chronic ulcer. Changes in ulcer lesions to malignancy can be caused by chronic irritation, infection, decreased vascular variation, and increased expression of proto-oncogene. The most common histopathological form of Marjolin's ulcer is squamous cell carcinoma. A 55-year-old man, complaining of a protruding wound on his left hand that has not healed since three years ago. The patient was diagnosed with leprosy 30 years ago with a history of incomplete treatment. On physical examination, the left palmar region showed solitary ulcer, ±10x8x1.5 cm in size, nodular surface, reddish, hard consistency, with bulging and irregular edge. Slit-skin smear (SSS) examination with Ziehl-Neelsen staining found abundant acid-fast bacilli. Histopathological examination of the ulcer edge shows appearance of epithelial tumor, with differentiated epidermal cells invading the dermis, tumor cells arranged focally and concentrically with a mass of keratin appeared as horn pearl cells. Fite-Faraco staining found abundant M. leprae acid-fast bacilli. Based on the patient’s medical history and clinical examination, patient was diagnosed with Marjolin's ulcer in multibacillary (MB) leprosy. Patient was treated with MB multidrug therapy for 12 months and below-wrist amputation.

Laporan Kasus Terapi Kombinasi Kuretase dan Cimetidine Oral pada Pasien Moluskum Kontangiosium Annisa Fildza Hashfi; Nurrachmat Mulianto; Winda Wijayanti; Niluh Wijayanti
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Background: Molluscum contagiosum is an infectious disease of the skin caused by poxvirus. The virus may be transmitted through direct skin and mucous membrane contact, including sexual contact, and through contaminated fomites. The prevalence of sexually transmitted molluscum contagiosum has increased in recent years. This disease causes anxiety and discomfort for the patients. Diagnosis of molluscum contagiosum is made based on history taking, physical examination, dermoscopic examination, and histopathological examination. Proper diagnosis and management can help to reduce risk of recurrence. Case: A 26-year-old woman with main complaint of developing shiny white rashes on her thighs and buttocks since 3 months ago. The nodules felt itchy yet painless. At first, only 4 papules appeared on the buttocks. In the last month, the nodules multiplied and spread to the thighs. The patient had tried to squeeze the nodule and rice-like white mass came out. The patient had history of unprotected sexual intercourse. Dermatological examination on the right and left femoral regions and the gluteus, found that there were discrete, multiple shiny white pearl-like papules of 0.1-0.5 cm in size, smooth surface, well-defined, dome-shaped, umbilicated with caseous plug. Dermoscopic examination showed a white to yellow polylobular appearance with crown vessel. Histopathological examination showed an appearance of intracytoplasmic eosinophil inclusion bodies (molluscum bodies). Discussion: Clinical findings such as discrete multiple, pearl-colored, umbilicated dome-shaped papules, are characteristic features of molluscum contagiosum. Dermoscopic examination results and histopathological images also support the diagnosis of molluscum contagiosum. Treatment was carried out using curettage on the lesions and prescription of oral cimetidine 2x800 mg for 2 months. No recurrence was found after 5 months of follow-up

Profile of Candidiasis Patients in RSUD Dr. Moewardi Surakarta January 2016−December 2019 Nurrachmat Mulianto; Siti Efrida Fiqnasyani
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Background: Candidiasis is caused by Candida sp. infection, mainly Candida albicans. The skin, mucous membranes, nails, and digestive tract are organs that can be affected by this infection. The risk of infection is higher in immunocompromised individuals. Objective: To determine the profile of candidiasis patients in Dr. Moewardi Hospital Surakarta between January 2016-December 2019. Method: This is a retrospective, descriptive study that evaluate the distribution of sex, age, primary diagnosis, comorbidities, and candidiasis type among candidiasis patients in RSUD Dr. Moewardi. Results: During study period, there were 177 candidiasis patients (147 outpatients and 30 inpatients). Pseudohyphae was seen in all inpatients’ KOH test. Majority of the patients are women (77,97%), age distribution varies between outpatients and inpatients. Cutaneous candidiasis was found in 53,74% outpatients and 66,67% inpatients. Type 2 diabetes mellitus was the most frequent (20%) comorbidity among those patients. Topical miconazole 2% and systemic fluconazole 150 mg were given to 42,37% and 33,90% patients, respectively.

Kromoblastomikosis Penyakit Jamur yang Terabaikan Danu Yuliarto; Achmad Satya Negara; Harijono Kariosentono; Nugrohoaji Dharmawan; Nurrachmat Mulianto
MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i1.116

Chromoblastomycosis is a deep fungal infection of the skin and subcutaneous tissue caused by pigmented or dematiaceous fungi. This disease is endemic in tropical and subtropical regions such as Asia, Africa, and Latin America. Chromoblastomycosis is more common in adult men who work in agricultural areas, work as gardeners, or as carpenters. The diagnosis of chromoblastomycosis is confirmed by the finding of muriform cells or medlar bodies obtained from skin scrapings, microscopic culture, or tissue histopathological examination. The clinical feature varies, the initial lesion is a papule that spreads slowly over several months or years, and then this lesion will form a plaque with atrophic center. Many patients go undiagnosed at the early stage of the disease because this stage is rarely seen. Treatment of chromoblastomycosis includes surgery for the initial lesion and pharmacological therapy using antifungal agent such as itraconazole, the most commonly used drug for the treatment of chromoblastomycosis. The prognosis for chromoblastomycosis is poor, except on new lesions.

Profile of Generalized Pustular Psoriasis Inpatient Installation at Dr. Moewardi General Hospital Surakarta from January 2018-December 2022 Hidayati, Nurul; Mulianto, Nurrachmat; Noviani, Laura; Lidjaja, Lifesia Natali
Journal La Medihealtico Vol. 5 No. 4 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i4.1584

Generalized pustular psoriasis (GPP) is a form of psoriasis characterised by the presence of sterile pustules. Its prevalence is between 2 and 3.5% of the population worldwide and in Indonesia it is 2.5% of the population. It can cause severe physical and psychosocial distress affecting the patient's quality of life. Objective: To describe the profile of GPP patients treated in the inpatient installation of Dr. Moewardi Hospital, Surakarta in the period of January 2018-December 2022. A retrospective descriptive study was conducted using the secondary data of medical records of GPP patients treated in the inpatient installation of Dr. Moewardi Hospital from January 2018 to December 2022. Results: In the 5-year period, there were 23 GPP inpatients, predominated by female (78.26%) with the age ranged from 5 to 74 years old. Generalised pustular psoriasis mostly affected the age group of 41- 50 years old (26.04%). Most patients were hospitalized for 6–10 days (39.13%). The most common therapy was immunosuppressant (65.2%) followed by oral corticosteroids (26.1%) and zinc (17.4%). Most patients also received moisturizer therapy (56.5%). Generalised pustular psoriasis mostly affects people aged between 41 and 50 years old. Females are more prone to GPP. The therapy given are oral immunosuppressive regimens, oral corticosteroids, zinc, topical corticosteroids and moisturizers.

Modalitas Terapi Veruka Vulgaris Dita Eka Novriana; Nurrachmat Mulianto
MEDICINUS Vol. 38 No. 1 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/26szjs56

Veruka vulgaris adalah lesi jinak akibat infeksi human papillomavirus (HPV) dengan lesi berupa papul verukosa dengan permukaan keratotik. Beberapa modalitas terapi dapat diberikan pada veruka vulgaris, antara lain berupa terapi destruktif, terapi antivirus, imunoterapi, dan pembedahan, dengan hasil yang bervariasi. Veruka vulgaris memiliki risiko kekambuhan yang cukup tinggi karena terdapat kemungkinan adanya sisa partikel HPV pascaterapi.

An Unusual Case of Pemphigus Foliaceus Arising in a Patient with Psoriasis Vulgaris Nurrachmat Mulianto; Osdatilla Esa Putri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 2 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i2.1190

Background: Pemphigus foliaceus (PF) is a rare autoimmune blistering disease characterized by superficial, fragile blisters. Psoriasis vulgaris, a chronic inflammatory skin condition, has been rarely associated with PF. This case report presents an unusual instance of PF developing in a patient with a history of psoriasis vulgaris. Case presentation: A 54-year-old Indonesian woman presented with a one-year history of scaly skin and reddish spots across her body, worsening over the past week. She had a prior diagnosis of psoriasis vulgaris and was undergoing methotrexate therapy (15 mg/week) without significant improvement. Three months prior, she developed loose blisters on her back that spread to her hands, rupturing easily and leaving painful sores. The patient denied any mucosal involvement. One week before her presentation, her symptoms worsened following relocation-related stress. Dermatological examination revealed generalized multiple erythematous patches with scales, some with ruptured blisters leaving erosions, and a positive Nikolsky sign. Histopathological examination confirmed PF. The patient was treated with intravenous methylprednisolone, oral erythromycin and paracetamol, topical mupirocin, and clobetasol. After one month, due to a lack of improvement, azathioprine was added, leading to lesion improvement without side effects. Conclusion: This case highlights the rare but potential development of PF in patients with psoriasis vulgaris. The complex interplay between these two conditions warrants further investigation. Early diagnosis and appropriate treatment are crucial for managing PF and improving patient outcomes.

Co-Authors . Hardjono Achmad Satya Negara Adniana Nareswari Ahmad Fiqri, Ahmad Ambar Aliwardani Annisa Fildza Hashfi Arie Kusumawardani Arrochman, Ferry Astrid Astari Aulia Aulia Rahman Ayu Kusuma Dewi Azhar Arrosyid Benedikta Lauda Betaubun, Ance Imelda Bobby Febrianto Damayanti, Willa Danu Yuliarto Dhamayanti, Marsita Endy Dharmawan, Nugrohoaji Diana, Rina Dita Eka Novriana Dwi Hidayah Endra Yustin Ellistasari Endraputra, Pristiawan Farida Mustifah, Etty Fatiharani Dewi, Putty Fiska Rosita Harijono Kariosentono Indah Julianto Indah Julianto, Indah Irawanto, Muhammad Eko Ivani Kariosentono, Harijono Kusumawardani, Arie Lidjaja, Lifesia Natali Mardiana - Mochtar, Moerbono Muhammad Eko Irawanto Murasmita, Alamanda Murastami, Ammarilis Niluh Wijayanti Novan Adi Setyawan Noviani, Laura Nugraha, Wibisono Nur Ismi Mustika Febriani Nurul Hidayati Oktriana, Putri Osdatilla Esa Putri Paramita Sari, Anggana Rafika Prasetyadi Mawardi Primisawitri, Pratiwi Prasetya Putri, Osdatilla Esa Putti Fatiharani Rafika Paramitasari, Anggana Rieka Sulaikha, Khalida Rinandari, Ummi Rini Hastuti Risman, Muhammad Rosmarwati, Ervina Satya Negara, Achmad Sesia Pradestine Shelly Lavenia Sambodo Siti Efrida Fiqnasyani Suci Widhiati Toha, Synthia Sari Tri Ifanti, Rakhma Tri Irfanti, Rakhma TUTIK RAHAYU Utama, Rahmat Firdaus Dwi Wibisono Nugraha Widhiati, Suci Winda Wijayanti Wirawan, Eka Putra

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