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All Journal Nexus Kedokteran Komunitas Berkala Ilmu Kesehatan Kulit dan Kelamin Bioscientia Medicina : Journal of Biomedicine and Translational Research Health and Medical Journal Jurnal Ners JOURNAL LA MEDIHEALTICO Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Journal of Social Research MEDICINUS Indonesian Basic and Experimental Health Sciences

Nurrachmat Mulianto

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Author-ID : 324340

Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Korelasi Kadar Serum Nitric Oxide (NO) dengan Tipe dan Derajat Keparahan Psoriasis Fiska Rosita; Bobby Febrianto; Ambar Aliwardani; Putti Fatiharani; Wibisono Nugraha; Muhammad Eko Irawanto; Nurrachmat Mulianto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Psoriasis is a chronic, immune-mediated disorder that results from a polygenic predisposition. Nitric oxide (NO) has been considered as important factors in the pathogenesis of psoriasis. This study aims to determine the correlation of serum NO levels with the type and severity of psoriasis. This cross-sectional study was conducted from May to September 2018. Difference in the average of serum NO levels in psoriasis patients with control groups is analyzed using t-test. The Spearman correlation test was used to see the correlation of serum NO levels with type and severity of psoriasis measured by Psoriasis Area and Severity Index (PASI) score. There was significant difference between serum NO level in the control group compared to the group of psoriasis patients (p=0.037). Patient with generalized pustular psoriasis has the highest mean of NO level (59.07 µmol/L). There was no significant correlation between serum NO level with type (r=0.008, p=0.9710 and severity (r=0.157, p=0.486) of psoriasis. Nitric oxide levels are elevated in psoriasis patients, which indicate that oxidative stress plays an important role in the etiopathogenesis of psoriasis.

Ulkus Marjolin yang Berkembang dari Ulkus Trofik Kronis pada Pasien Kusta Adniana Nareswari; Harijono Kariosentono; Nugrohoaji Dharmawan; Muhammad Eko Irawanto; Nurrachmat Mulianto
MEDICINUS Vol. 34 No. 2 (2021): MEDICINUS
Publisher : PT Dexa Medica

Marjolin’s ulcer is a malignant complication of chronic ulcer. Changes in ulcer lesions to malignancy can be caused by chronic irritation, infection, decreased vascular variation, and increased expression of proto-oncogene. The most common histopathological form of Marjolin's ulcer is squamous cell carcinoma. A 55-year-old man, complaining of a protruding wound on his left hand that has not healed since three years ago. The patient was diagnosed with leprosy 30 years ago with a history of incomplete treatment. On physical examination, the left palmar region showed solitary ulcer, ±10x8x1.5 cm in size, nodular surface, reddish, hard consistency, with bulging and irregular edge. Slit-skin smear (SSS) examination with Ziehl-Neelsen staining found abundant acid-fast bacilli. Histopathological examination of the ulcer edge shows appearance of epithelial tumor, with differentiated epidermal cells invading the dermis, tumor cells arranged focally and concentrically with a mass of keratin appeared as horn pearl cells. Fite-Faraco staining found abundant M. leprae acid-fast bacilli. Based on the patient’s medical history and clinical examination, patient was diagnosed with Marjolin's ulcer in multibacillary (MB) leprosy. Patient was treated with MB multidrug therapy for 12 months and below-wrist amputation.

Laporan Kasus Terapi Kombinasi Kuretase dan Cimetidine Oral pada Pasien Moluskum Kontangiosium Annisa Fildza Hashfi; Nurrachmat Mulianto; Winda Wijayanti; Niluh Wijayanti
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Background: Molluscum contagiosum is an infectious disease of the skin caused by poxvirus. The virus may be transmitted through direct skin and mucous membrane contact, including sexual contact, and through contaminated fomites. The prevalence of sexually transmitted molluscum contagiosum has increased in recent years. This disease causes anxiety and discomfort for the patients. Diagnosis of molluscum contagiosum is made based on history taking, physical examination, dermoscopic examination, and histopathological examination. Proper diagnosis and management can help to reduce risk of recurrence. Case: A 26-year-old woman with main complaint of developing shiny white rashes on her thighs and buttocks since 3 months ago. The nodules felt itchy yet painless. At first, only 4 papules appeared on the buttocks. In the last month, the nodules multiplied and spread to the thighs. The patient had tried to squeeze the nodule and rice-like white mass came out. The patient had history of unprotected sexual intercourse. Dermatological examination on the right and left femoral regions and the gluteus, found that there were discrete, multiple shiny white pearl-like papules of 0.1-0.5 cm in size, smooth surface, well-defined, dome-shaped, umbilicated with caseous plug. Dermoscopic examination showed a white to yellow polylobular appearance with crown vessel. Histopathological examination showed an appearance of intracytoplasmic eosinophil inclusion bodies (molluscum bodies). Discussion: Clinical findings such as discrete multiple, pearl-colored, umbilicated dome-shaped papules, are characteristic features of molluscum contagiosum. Dermoscopic examination results and histopathological images also support the diagnosis of molluscum contagiosum. Treatment was carried out using curettage on the lesions and prescription of oral cimetidine 2x800 mg for 2 months. No recurrence was found after 5 months of follow-up

Profile of Candidiasis Patients in RSUD Dr. Moewardi Surakarta January 2016−December 2019 Nurrachmat Mulianto; Siti Efrida Fiqnasyani
MEDICINUS Vol. 35 No. 2 (2022): MEDICINUS
Publisher : PT Dexa Medica

Background: Candidiasis is caused by Candida sp. infection, mainly Candida albicans. The skin, mucous membranes, nails, and digestive tract are organs that can be affected by this infection. The risk of infection is higher in immunocompromised individuals. Objective: To determine the profile of candidiasis patients in Dr. Moewardi Hospital Surakarta between January 2016-December 2019. Method: This is a retrospective, descriptive study that evaluate the distribution of sex, age, primary diagnosis, comorbidities, and candidiasis type among candidiasis patients in RSUD Dr. Moewardi. Results: During study period, there were 177 candidiasis patients (147 outpatients and 30 inpatients). Pseudohyphae was seen in all inpatients’ KOH test. Majority of the patients are women (77,97%), age distribution varies between outpatients and inpatients. Cutaneous candidiasis was found in 53,74% outpatients and 66,67% inpatients. Type 2 diabetes mellitus was the most frequent (20%) comorbidity among those patients. Topical miconazole 2% and systemic fluconazole 150 mg were given to 42,37% and 33,90% patients, respectively.

Kromoblastomikosis Penyakit Jamur yang Terabaikan Danu Yuliarto; Achmad Satya Negara; Harijono Kariosentono; Nugrohoaji Dharmawan; Nurrachmat Mulianto
MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i1.116

Chromoblastomycosis is a deep fungal infection of the skin and subcutaneous tissue caused by pigmented or dematiaceous fungi. This disease is endemic in tropical and subtropical regions such as Asia, Africa, and Latin America. Chromoblastomycosis is more common in adult men who work in agricultural areas, work as gardeners, or as carpenters. The diagnosis of chromoblastomycosis is confirmed by the finding of muriform cells or medlar bodies obtained from skin scrapings, microscopic culture, or tissue histopathological examination. The clinical feature varies, the initial lesion is a papule that spreads slowly over several months or years, and then this lesion will form a plaque with atrophic center. Many patients go undiagnosed at the early stage of the disease because this stage is rarely seen. Treatment of chromoblastomycosis includes surgery for the initial lesion and pharmacological therapy using antifungal agent such as itraconazole, the most commonly used drug for the treatment of chromoblastomycosis. The prognosis for chromoblastomycosis is poor, except on new lesions.

Modalitas Terapi Veruka Vulgaris Dita Eka Novriana; Nurrachmat Mulianto
MEDICINUS Vol. 38 No. 1 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/26szjs56

Veruka vulgaris adalah lesi jinak akibat infeksi human papillomavirus (HPV) dengan lesi berupa papul verukosa dengan permukaan keratotik. Beberapa modalitas terapi dapat diberikan pada veruka vulgaris, antara lain berupa terapi destruktif, terapi antivirus, imunoterapi, dan pembedahan, dengan hasil yang bervariasi. Veruka vulgaris memiliki risiko kekambuhan yang cukup tinggi karena terdapat kemungkinan adanya sisa partikel HPV pascaterapi.

Co-Authors . Hardjono Achmad Satya Negara Adniana Nareswari Ahmad Fiqri, Ahmad Ambar Aliwardani Annisa Fildza Hashfi Arie Kusumawardani Arrochman, Ferry Arrosyid, Azhar Astrid Astari Aulia Aulia Rahman Ayu Kusuma Dewi Azhar Arrosyid Benedikta Lauda Betaubun, Ance Imelda Bobby Febrianto Damayanti, Willa Danu Yuliarto Dhamayanti, Marsita Endy Dharmawan, Nugrohoaji Diana, Rina Dita Eka Novriana Dwi Hidayah Endra Yustin Ellistasari Endraputra, Pristiawan Farida Mustifah, Etty Fatiharani Dewi, Putty Fiska Rosita Harijono Kariosentono Indah Julianto Indah Julianto, Indah Irawanto, Muhammad Eko Ivani Kamilah, Lian Kariosentono, Harijono Kusumawardani, Arie Lidjaja, Lifesia Natali Mardiana - Mochtar, Moerbono Muhammad Eko Irawanto Murasmita, Alamanda Murastami, Ammarilis Niluh Wijayanti Novan Adi Setyawan Noviani, Laura Nugraha, Wibisono Nur Ismi Mustika Febriani Nurul Hidayati Oktaviani, Trya Oktriana, Putri Osdatilla Esa Putri Paramita Sari, Anggana Rafika Prasetyadi Mawardi Primisawitri, Pratiwi Prasetya Putri, Osdatilla Esa Putti Fatiharani Rafika Paramitasari, Anggana Rieka Sulaikha, Khalida Rinandari, Ummi Rini Hastuti Risman, Muhammad Rosmarwati, Ervina Satya Negara, Achmad Sesia Pradestine Shelly Lavenia Sambodo Siti Efrida Fiqnasyani Suci Widhiati Toha, Synthia Sari Tri Ifanti, Rakhma Tri Irfanti, Rakhma TUTIK RAHAYU Utama, Rahmat Firdaus Dwi Wibisono Nugraha Widhiati, Suci Winda Wijayanti Wirawan, Eka Putra

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