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All Journal journal of internal medicine Microbiology Indonesia Folia Medica Indonesiana Jurnal NERS Indonesian Journal of Tropical and Infectious Disease Indonesian Journal of Chemistry Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) ANIMA Indonesian Psychological Journal Indian Journal of Forensic Medicine & Toxicology Narra J Jurnal Natural
Nasronudin Nasronudin
Faculty Of Medicine, Universitas Airlangga, Surabaya. Indonesian-Japan Collaborative Research Center For Emerging And Re-emerging Infectious Diseases, Institute Of Tropical Disease, Universitas Airlangga, Surabaya.
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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The Prevalence of Human Immunodefiency Virus-1 (HIV-1) Subtypes and Transmission Method among HIV/AIDS Infection Patient in Tulungagung, East Java Indonesia Ardianto, Achmad; Khairunisa, Siti Qamariyah; Kotaki, Tomohiro; Witaningrum, Adiana Mutamsari; Qushay, M.; Juniastuti, Juniastuti; Rahayu, Retno Pudji; Widiyanti, Prihartini; Utomo, Budi; Lusida, Maria Inge; Nasronudin, Nasronudin
Indonesian Journal of Tropical and Infectious Disease Vol 5, No 5 (2015)
Publisher : Institute of Topical Disease

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Abstract

The rapid epidemic growth of HIV is continuing in Indonesia. There are some factors which have influenced the spreading of this epidemic in Indonesia, such as the poor awareness to avoid unsafe free sex attitude and the sharing of needles and syringes among intravenous drug users (IDUs). The sexual transmission of HIV has also apparently increased in Tulungagung. Commercial sex workers play a significant role in the spread of HIV in Tulungagung. People in Tulungagung have worked at other countries as Indonesian migrants. This condition can cause the increase number of HIV-1 case and the possibility of genetic variation (subtype) HIV-1 in Tulungagung. This research is aimed to analyze the subtype and to determine estimation of transmission mode on infected patient of HIV-1 and AIDS who came to Seruni clinic Dr. Iskak hospital in Tulungagung. 40 HIV?AIDSpatients were interviewed to determine the subtype and the transmission mode. The results showed that 14 of 40 plasma samples (35%) were successfully to amplified and sequenced. OverallCRF01-AE wereidentified as predominant subtype among HIV/AIDS patients in Tulungagung. Based on individual information, 31 of 40 subjects (77%) were heterosexual transmission.
EVALUATION ON THE EFFECT OF ANTIRETROVIRAL DRUGS ON CD4 T-CELL AND THE INCREMENT OF BODY WEIGHT AMONG HIV-AIDS PATIENTS IN SURABAYA Frederika, Edith; Normalina, Irine; Nasronudin, Nasronudin; Mega, Rury
Indonesian Journal of Tropical and Infectious Disease Vol 3, No 2 (2012)
Publisher : Institute of Topical Disease

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Abstract

Antiretroviral drug discovery has encouraged a revolution in the care of people living with HIV, although it has not been able to cure diseases and to increase the challenge in terms of drug side effects. Side effects of antiretroviral drugs are fairly common occurrences in HIV patients and generally occurr within the first three months after initiation of antiretroviral therapy, although long-term side effects are also often found afterwards. This study aims to evaluate the number of CD4 T-cells in patients with AIDS before and after getting on ARV therapy, the side effects arising during the taking of ARVs are related to the increment of body weight among the HIVAIDS patients. Subjects were then narrowed down from 25 to 12 due to the incomplete data. The results showed that the top three most side effects which often occur in people with AIDS are appetite loss (20.0%), nausea (17.8%), and diarrhoea (15.6%). Meanwhile, about 58% of the subjects experienced increment of their body weight, and 42% were losing weight due to the side effects of the ARV therapy. Among those who lost their body weight, 50% were in the productive ages between 21–30 years old. The present study shows that combination antiretroviral therapy gives good results to the increased number of CD4 T-cells in patients living with HIV, as shown by the tendency of an increment in the number of CD4 T-cells in patients who received antiretroviral therapy. However, around 42% of those patients were losing weight because of the side effects of the therapy. Therefore, the importance of giving specific nutrient to overcome with the weight loss is needed to be given to the patients HIV instead of only giving the ARV treatment.
A PATIENT DENGUE HEMORRHAGIC FEVER WITH SPASMS Kholili, Ulfa; Nasronudin, Nasronudin
Indonesian Journal of Tropical and Infectious Disease Vol 5, No 3 (2014)
Publisher : Institute of Topical Disease

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Abstract

Indonesia is one of the countries with the high endemic of Dengue viral infection followed by Thailand, Myanmar, India and Srilanka. For more 10-15 years, Dengue Viral Infection/DHF has become a cause of patient who should be hospitalized and was the first cause of death children in south easthern Asia.1,2 Batavia was the first city of Indonesia found Dengue Viral infection which had been written in journal by David Bylon in the 1779. Encephalopathy of dengue (ED) is one unusually complication of dengue viral infection which had been characterized by aberration the arrangement of nerves central (CNS). This paper want to describe of a young teenage with suffer from DHF and seizure. Beside it, pleural effusion and cerebral edema had been found. Seizure most likely due to dengue encephalopathy associated with cerebral edema and was supported by positive IgG and IgM anti dengue. Corticosteroid was given toimprove cerebral edema. By good management as long as admission, she was discharged from hospital with a good condition.
Management Patient of Swine Influenza Gunawan, Endra; Nasronudin, Nasronudin
Indonesian Journal of Tropical and Infectious Disease Vol 5, No 5 (2015)
Publisher : Institute of Topical Disease

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Abstract

Influenza is an acute respiratory diseases caused by various influenza virus which infect the upper and lower respiratory tract and often accompanied by systemic symptoms such as fever, headache and muscle pain. Influenza spreads through the air. Swine influenza comes from swine and can cause an outbreaks in pig flocks. Even this is a kind of a rare case but the swine influenza could betransmitted to human by direct contact with infected swine or through environment that already being contaminated by swine influenza virus. There are 3 types of swine influenza virus namely H1N1, H3N2 and H1N2. Type H1N1 swine-virus had been known since 1918. Avian influenza virus infection is transmitted from one person to another through secret containing virus. Virus is binded into the mucous cells of respiratory tract before it is finally infecting the cells itself. Management patients with H1N1 influenza is based on the complications and the risk. Besides, it is also need to consider the clinical criteria of the patient. Therapy medicamentosa is applied to the patients by giving an antiviral, antibiotics and symptomatic therapy. Prevention can be done by avoid contact with infected animal or environment, having antiviral prophylaxis and vaccination.
HIV and Malaria Parwitasari, Ririek; Nasronudin, Nasronudin
Indonesian Journal of Tropical and Infectious Disease Vol 5, No 1 (2014)
Publisher : Institute of Topical Disease

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Abstract

HIV/AIDS is a global problem involving industrialized and developing country including Indonesia. Malaria has killed millions of human beings almost 3 million people each year, whereas since 1999, nearly 36 million people in the world infected with HIV and 3 million more have died (Kakilaya, 2006). HIV infection increases the risk and aggravate malaria. In Africa in the area of malaria transmission intensities high and low, HIV aggravate malaria and improve case fatality at any age (Eline 2006). HIV is an RNA viruses whose hallmark is the reverse transcriptation of its genomic. Malaria is a protozoan disease transmitted by the bite of infected anopheles mosquito. Infection malaria can stimulate HIV replication and may cause faster progression of HIV disease.
PROFIL PENDERITA SEPSIS AKIBAT BAKTERI PENGHASIL ESBL Irawan, Danny; -, Hamidah; -, Purwati; EA, Triyono; -, Bramantono; V, Arfianto; U, Hadi; -, Nasronudin; -, Suharto; E, Soewandojo
journal of internal medicine Vol. 13, No. 1 Januari 2012
Publisher : journal of internal medicine

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Abstract

Extended Spectrum !-Lactamases (ESBL) is plasmid enzyme which catalyzing hydrolysis and inactivation !-lactamantibiotic, including third generation of Cephaloporin, penicillin and aztreonam. This enzyme is mutation of !-lactamaseTEM-1, TEM-2, and SHV-1 which commonly found in Enterobacteriaceae and normally have resistance to penisillin andrst generation celaphorin. The incidence of infection cause by ESBL bacterial is increasing worldwide. AntimicrobialResistance in Indonesia: prevalence and prevention (AMRIN study) is showed incidence of infection ESBL bacterial 29%E. coli, and 36% K. pneumonia. This study is descriptive and restrospectively learn about prole of DMK with septicemiapatient caused by ESBL bacterial in Internal Medicine Ward RSUD Dr Soetomo within 1st January 2010 until 30th June2011. Sixty four patient were recruited and 48 patients with ESBL bacterial positive. Mortality rate is 16.7%, severe septiccondition 27.08%, septic shock 14.58%. The result of positive ESBL bacterial was found from urine culture (37.5%).Sensitivity of antibiotics results are meropenem (98.07%), amikacin (88.46%).
Physical Exercise in Clinical Stage IIhuman Immunodeficiency Virus Infection Patients’ Increasesskeletal Muscle MAss Through the Increasing of Myogenic Regulatory Factors Expression Sri Mardjiati Mei Wulan; Hening Laswati; Usman Hadi; Nasronudin Nasronudin
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17091

Abstract

Background: Human Immunodeficiency Virus infection is a chronic diseasethat threatensthe health ofmillionsof people inthe worldand causing disability. One of the factors that causedisabilityis HIVmusclewasting,causing a decrease inthe quality of lifethat interferethe daily activitiesand evenincreased mortality. Properphysical exercise is needed to prevent and treat muscle wasting.Methods: This studyusinghuman subjectswithclinicalstageII HIVinfection. Subjectswere groupedinto two:Intervention (n =9) that subjects whogetmoderate-intensity physicalexercise (HIVA) for 8weeks andControl (n=9) as subjects wereobservedfor 8 weeks. Muscles samples were taken fromthe vastuslateralismusclebiopsiesthat performed24 hoursafterthe lastphysical exercise,immunohistochemicalexaminationwithmonoclonalantibodyanti-Pax7, anti-MyoD1 andanti-myogenin and measurement of thigh circumference.Results: Therewere significant increase in regeneration of skeletal muscle in the intervention group(increasing of Pax7, MyoD1 and myogenin) than the control groupand significant increase in quadricepsmuscles mass as measured by thigh circumference (p < 0.001).Conclusion: HIVA physical exerciseof moderate intensityincreasesskeletal muscleregenerationinclinicalstageII HIVinfectionthroughthe increasingPax7, MyoD1, myogeninexpression and followed by an increaseof quadriceps muscles mass.
Predictor of Mortality COVID-19 in Two Referral Hospital in Surabaya, Indonesia Usman Hadi; Bramanton; Tri Pudy Asmarawati; Musofa Rusli; Nasronudin; Brian Eka Rachman; M. Vitanata Arfijanto
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17659

Abstract

Introduction: World Health Organization had identified COVID-19 in January 2019. This disease is caused by SARS-CoV-2, which spread throughout the world and became a pandemic on March 20, 2020. COVID-19 is still a health problem because it has not clear whether the patients will be cured and survive from the disease or not. This study aims to determine the predictors of mortality from COVID-19 at Dr. Soetomo General Academic Hospital and Universitas Airlangga Hospital in Surabaya, Indonesia.Method: This study was conducted in Dr. Soetomo General Academic Hospital (referral hospital for COVID-19, 1500 beds) and Universitas Airlangga Hospital (Referal Hospital for COVID-19, 600 beds). The study used data on patients with confirmed COVID-19 who were hospitalized at these two referral hospitals. Predictors of mortality were analyzed using logistic regressions.Result: There were 247 COVID-19 patients enrolled in this study, all patients were tested positive PCR SARS-CoV-2. The main complaints were cough, nasal congestion, dyspnea, and fever. Significant predictor mortality in this study were age >60 years old (OR: 3.24, 95% CI, 1.36 - 7.70), chronic kidney disease (OR: 5.71, 95% CI, 2.05 - 15.89), obesity (OR: 8.22, 95% CI,1.5 - 54.17), malignancy (OR: 6.025, 95% CI, 1.1- 33.00), coronary heart disease (OR: 5.31, 95% CI, 1.28 - 21.98) , and C-reactive protein >10 mg/L (OR 4.603, 95% CI, 2.03 - 10.44).Conclusions: Obesity and the presence of malignancy, chronic kidney disease, heart disease and age >60 yearsold are the strongest predictors of mortality in people with COVID-19, despite high CRP results.
The Relation Between Levels of TNF Alpha, IL-1B, PGE2 and PLA with the Severity Degree of Dengue Hemorrhagic . PURWATI; . NASRONUDIN; ENDANG RETNOWATI KUSUMOWIDAGDO; FEDIK ABDUL RANTAM
Microbiology Indonesia Vol. 5 No. 2 (2011): June 2011
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (73.223 KB) | DOI: 10.5454/mi.5.2.1

Abstract

The pathogenesis of dengue virus infection is still being debated.  Based on the existing data, there is a strong evidence that the immunopathological mechanism plays a role in dengue virus infection with various complications.  Some unknown immune responses play a role in the pathogenesis of dengue virus infection. Researchers are trying to establish the role of several inflammatory mediators such as PLA2, IL-1, TNF-, PGE2, PGI2, Thromboxane A2, Leucotrien and MPTP, in relation to the severity degree of the dengue virus infection.  The aim of this study is to recognize the relation between the severity degrees of DHF (Dengue Hemorrhagic Fever) patients and the immunological profile in the sub-cellular level, such as PLA2, IL-1, TNF-, PGE2 and PLA 2.  The collected data was processed and presented analytically. The relation between each parameter (TNFα, SPLA2, PGE2,IL-1β) and the degree of DHF was analyzes, using Spearman's correlation analysis, ordinal regression, and using ANOVA.  It was shown that there was no relation between the levels of TNF-ά, PGE2, IL-1β, and SPLA2  in patients with various degrees of DHF, but there were significant differences between DHF grade 1 and 3, and also 2 and 3, on IL-1β.  There were increased levels of the four parameters in dengue grade 1 to 2, but decreased levels in grade 3. This can be caused by inflammatory processes, but the severity degree of DHF can also be influenced by complement, thromboxane, and leukotrien.
Decrease Risk Behavior HIV Infected on Construction Laborers with Behavior Change Communication (BCC) Approach Purwaningsih Purwaningsih; Nasronudin Nasronudin; Nuzul Qur’aniati; Ferry Effendi
Jurnal Ners Vol. 9 No. 2 (2014): Oktober 2014
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (764.953 KB) | DOI: 10.20473/jn.v9i2.2565

Abstract

Introduction: Percentage of HIV-AIDS cases based on the types of work in East Java in 2011 shows that construction workers occupied ranks the top five ranked groups with 249 people (31%) after a group of commercial sex workers (CSWs) group. The purpose of this study was to determine the effectiveness of BCC approach to the reduction of contracting HIV risk behavior in the construction laborers. Method: This study used operational research design. In this study measures the effectiveness of behavior change of construction workers on the prevention of HIV transmission by comparing the behavior of the construction workers before and after the intervention. The subjects of this study were 150 people risk group of construction workers who work and are spread throughout the city of Surabaya. This research was carried out into three phases, namely, phase preintervention research, intervention research, and post-intervention phase of the study. Implemented in the first year and second year praintervensi stage implemented intervention and post-intervention phases.Result: The results of this study showed that 72% of construction workers is productive (18–35 years) and visit his family more than once a month (38%). There is 20% of construction workers had sex with commercial sex workers and no one was using drugs. By 50% of construction workers never get information about HIV/AIDS and as many as 48% never use the services of HIV/AIDS.Discussion: External motivation construction workers associated with the utilization of behavioral HIV/AIDS services with sufficient correlation. Strong external motivation is influenced by risk behaviors of HIV/AIDS were conducted and the desire to get help. Weak external motivation is influenced by a lack of exposure to information related to HIV/AIDS services. The results of the FGD stakeholders have the perception is the same if a construction worker is a high risk group of contracting HIV. Most of the construction workers not have enough knowledge for the prevention of HIV transmission because they do not have access to HIV care and behavior are at risk of contracting HIV by construction workers.
Co-Authors . PURWATI Achmad Ardianto, Achmad Adiana Mutamsari Witaningrum Adiana Mutamsari, Adiana Agung Prasetiyo Aksono HP., Eduardus Bimo Aldise Mareta Nastri, Aldise Mareta Arfianti Arfianti Arfianto V Arief Suseno, Arief Artaria Tjempakasari, Artaria Asmarawati, Tri Pudy Atika Atika Badi'ah, Hanim Istatik Bambang Prajogo Bimo Aksono Bimo Dwi Lukito, Bimo Dwi Bramanton Bramantono Bramantono, Bramantono Budi Utomo Danny Irawan Djojosugito, Fauzia A. Dwi Wahyu Indriati, Dwi Wahyu Eddy Bagus Wasito Eddy Wasito, Eddy Edith Frederika, Edith Endah Dewati, Endah Endang Retnowati ENDANG RETNOWATI KUSUMOWIDAGDO Endra Gunawan Fedik Abdul Rantam Ferdiansyah Ferdiansyah Ferry Effendi Ganden Supriyanto Hadi U Hamidah - Hening Laswati Putra Indrati, Agnes R. Irine Normalina, Irine Irma Yuliawati, Irma Johana E. Prawitasari Juniastuti Juniastuti Khairunisa, Siti Khairunisa, Siti Q. Lilis Mundri Jannah, Lilis Mundri M. Qushay, M. Maria Inge Lusida Masanori Kameoka, Masanori Maskoep, Wiwiek Indriyani Mei Wulan, Sri Mardjiati Meilani Meilani, Meilani Muhammad Qushai Y. Matondang, Muhammad Qushai Y. Muhammad Qushai Yunifiar M, Muhammad Qushai Muhammad Vitanata Arfijanto, Muhammad Vitanata Musofa Rusli Ni Kadek Mulyantari Ni Nyoman Tri Puspaningsih Nur Syamsiatul Fajar, Nur Syamsiatul Nurlaila Effendy Nuzul Qur'aniati Prihartini Widiyanti Purwaningsih - Purwati - Purwati Purwati Rachman, Brian E. Rachman, Brian Eka Rahayu Anggraini Rahmat Zainuddin, Rahmat Retno Indrawati Roestamadji Retno Pudji Rahayu Ririek Parwitasari, Ririek Rudi Wisaksana Rury Mega, Rury Shuhei Ueda, Shuhei Siregar, Fajri M. Siti Qamariyah Khairunisa, Siti Qamariyah Siti Qomariyah Khairunisa, Siti Qomariyah SOETJIPTO . Soewandojo E Suharto - Suryono Suryono Thomas Dicky Hastjarjo, Thomas Dicky Tigor Yeheskiel, Tigor Tjahjono, Ganis Tomohiro Kotaki, Tomohiro Triyono EA Ulfa Kholili Usman Hadi Yayuk Susilawati, Yayuk Yulia Ismail Yulia Sari Ismail