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Anas Fadli Wijaya
Universitas Dr. Soebandi
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Telang Flower Infusion Reduces Inflammation and Increases Goblet Cells in Infection Salmonella typhimurium Models Destiawan, Rian Anggia; Delvia Asista Indarusanti; Ahdiah Imroatul Muflihah; Anas Fadli Wijaya
Jurnal Kesehatan dr. Soebandi Vol 13 No 2 (2025): Vol. 13 No. 2 (2025): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v13i2.1015

Abstract

Typhoid fever is an infectious disease caused by Salmonella Sp. This infection leads to a rise in inflammatory cells and a reduction in goblet cells, which are essential for protecting the intestinal lining. An alternative treatment option is the use of telang flower infusion, as its antioxidant content and active compounds show potential as anti-inflammatory agents. The purpose of this study was determining the effect of telang flower infusa on reducing inflammatory cells and increasing goblet cells in mice infected with S. typhimurium. This research design used the complete Randomized Design Method (RAL). The population of this study used mice (Mus musculus) which were divided into 6 groups: negative (without treatment), positive (only infected), stimuno (given a dose of 0.25 ml/20 g BB), treatment 1 (given telang flower infusa dose 0.25 ml/20 g BB), treatment 2 (given telang flower infusa dose 0.5 ml/20 g BB), and treatment 3 (given telang flower infusa dose 1 ml/20 g BB). Then, followed by necropsy, tissue processing, histology observation, and data analysis using Kruskal Wallis. Based on data analysis using normality and homogeneity test, the sig value was <0.05. So, the data is non-normal and not homogeneous. Meanwhile, in the Kruskal Wallis test, the sig value was 0.288 > 0.05, which means that there is no effect of swallowed flower infusion. There is no effect of telang flower infusa on reducing inflammatory cells and increasing goblet cells. Biologically, telang flower infusion can reduce inflammatory cells and increase goblet cells in mice infected with Salmonella typhimurium infection
Co-Authors Ade Sucipto Aggustin, Ayu Tri Agustin, Ayu Tri AHDIAH IMROATUL MUFLIHAH Ahdiah Imroatul Muflihah Alisa Alfiya Makki Arif Santoso Azizah, Laila Camelia Nur Delvia Asista Indarusanti Destiawan, Rian Anggia Dwi Susanto, Fajar Elnaja, Dinar Anisa Fuzianingsih, Eka Novia Hanifiyah, Fitroh Hartalina Mufidah Hayati, Farhatul Hidayati, Larantika Hidayati, Sholihatil Holifah, Siti Nur Humairoh, Riska Tsamarah Ikhsan, Ahmad Mufti Imroatul Muflihah, Ahdiah Kamaliyah, Indy Kumalasari, Nurul Chamidah Laila Camelia Laila Camelia Nur Azizah Laksono, Eko Budi Lenny Yulia Widia Sari Leny Yulia Widia M Syaifuddin M. Elyas Arif Budiman Makki, Alisa Alfiya Maruni Wiwin Diarti Meri, Meri Mufidah, Hartalina Muflihah, Ahdiah Imroatul Muhammad Wildanun Ulum Mutia Hariani Nurjanah Mutiurrohman, Achmad Ni Ketut Yuliana Sari Nosa Ika Cahyariza Nosa Ika Cahyariza Nurjanah, Mutia Hariani Pratikah Verdianti Purwanti, Ananda Kamila Nurcahya Putri Aprilia, Diah Putri, Diva Amalia Queen Nurul Sufi Rahma Diyan Martha Rahmawati, Ayu Sintya Citra Rahmawati, Septyana Eka RIAN ANGGIA DESTIAWAN Rian Anggia Destiawan Romaidha, Iqlila Rossa, Handita Emilia Safitri, Yunita Diyah Sholihatil Hidayati Sigit Purwanto Siswidiani, Maya Diva Siti Maimunah Sofia Soleha, Nurmaidatus sufi, Queen Nurul Sulastri Sulastri Tilarso, Dara Pranidya Urip Urip Wafa, Muhammad Ali Widayanti, Sindi Dwi Widia, Leny Yulia Yulia Widia Sari, Leny Yunan Jiwintarum