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All Journal Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Sumatera Medical Journal AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Respiratory Science Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED)
Noni Novisari Soeroso
Department Of Pulmonolgy And Respiratory Medicine, Faculty Of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Respiratory Science

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Programmed Death Ligand 1 (PD-L1) Expression in Lung Adenocarcinoma Patients Rahmat Hidayat; Noni Novisari Soeroso; Elisna Syahruddin; Dian Cahyadi; Setiaputra Setiaputra
Respiratory Science Vol. 1 No. 3 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i3.16

Abstract

Background: Programmed Death Ligand 1 (PD-L1) is a protein found in tumor cells that could inactivate T-cells. This research was done to identify the characteristics of lung adenocarcinoma patients to PD-L1 expression in Medan.  Method: Descriptive research with a cross-sectional design was used and the study was done for 12 months (January – December 2018). Sample’s collection was done at RSUP (Central Public Hospital) H. Adam Malik and the samples diagnosed with lung adenocarcinoma based on histopathological subtyping were sent to the laboratory of Dharmais Jakarta Hospital where the Ventana 22C3 Immunohistochemistry Staining was done. Results: Staining was done in 52 samples at Dharmais Jakarta Hospital and only 35 samples were deemed acceptable. In this study, participants’ ages ranged from 40 to 60 years, where the majority were male patients, 31 (88.6%) and 33 patients (82.5%) were at an advanced stage (III and IV). Conclusion: The study found that the PD-L1 expression was mostly observed in male at the age range of 40 – 60 years and stage IV lung adenocarcinoma patients with Tumour Proportion Score (TPS) of 1 – 49%.
The Association of Acquired Resistance EGFR Exon 20 T790M Mutation and Treatment Response in Lung Adenocarcinoma Patients Receiving EGFR-TKI: Relationship between Acquired Resistance T790M Mutation and RECIST 1.1 Muhammad Harbi Praditya; Noni Novisari Soeroso; Setia Putra Tarigan; Taufik Ashar
Respiratory Science Vol. 2 No. 2 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i2.32

Abstract

Background: Lung adenocarcinoma patients receiving EGFR-TKI may develop acquired resistance within 7-16 months of treatment initiation, which is characterized by the presence of exon 20 T790M mutations in treatment response patients and can be assessed objectively by CECT and then evaluated by RECIST 1.1. The purpose of this study is to look into the association between acquired resistance EGFR Exon 20 T790M mutation and treatment response in lung adenocarcinoma patients receiving EGFR-TKI. Method: This research is an analytic study with a retrospective cohort design carried out at the Oncology Polyclinic at Haji Adam Malik Hospital from October 2020 to January 2021 in all patients with adenocarcinoma lung cancer who were treated with EGFR-TKI for more than 6 months. After that, an evaluation was carried out based on RECIST 1.1 and then examined for EGFR mutations from liquid biopsy specimens in the form of circulating tumor plasma DNA (ct-DNA) with the droplet digital Polymerase Chain Reaction (ddPCR) method to detect EGFR exon 20 T790M mutations as a marker of acquired resistance. Results: It was found that the majority of subjects were female (64.5%), aged 20-69 years (58%), and non-smokers (67.7%). The most common EGFR mutation was exon 19 deletion (58.1%). The incidence of acquired resistance was found in 10 subjects (32.3%). The distribution of RECIST 1.1 results on positive acquired resistance includes progressive diseases of 35.2%; stable disease of 11.1%; partial response of 33.4%; and 100% complete response. Negative acquired resistance includes 64.8% progressive disease, 88.9% stable disease, 66.6% partial response, and 0% complete response (P=0.93). Conclusion: There is no significant association between the incidence of acquired resistance mutations EGFR exon 20 T790M and treatment response in patients with lung adenocarcinoma who received EGFR-TKI therapy.
Co-Authors Afiani, Dina Ana Rima Ana Rima Setijadi Ananda, Fannie Rizki Andarini, Sita Andreas Infianto Arfiansyah, Mochammad Aris Ariantika, Ariantika Arieta, Lydia Arif Santoso Arif Santoso Asfriyati ,MKes Bihar, Syamsul Bintang Yinke Magdalena Sinaga Buana, Indra Chen, Jery Dian Cahyadi Dian Chayadi Dumasari Siagian Duyen, Natalie Elisna Syahruddin Elisna Syahruddin Ermayanti, Sabrina Ermayanti, Sabrina Erna Mutiara Erna Mutiara Evlin Suzanna EVLINA SUZANNA, EVLINA Febiyanti, Mica Ferry Dwi Kurniawan Fotarisman Zalukhu Gema Nazri Yanni Hanif, Muhammad Alfin Harahap, Putri Wulandari Haryati Haryati Haryati Haryati Hendra Taufik Hidayat Hidayat Hidayat, Moulid Ida Ayu Jasminarti Ida Ayu Jasminarti Dwi Kusumawardani Infianto, Andreas Jasminarti, Ida Ayu Kurniawan, Ferry Dwi Laksmi Wulandari Lambok Siahaan Lim, Darren Wan-Teck Lucia Aktalina Lucia Aktalina Muhammad Harbi Praditya Nathaniel Aditya Neny Pristiwati Harahap Novita Andayani, Novita Novita Margaretta Ambarita Nurmaini Nurmaini Nurul Ramadhani Ozar Sanuddin Pratama, Avissena Dutha Pratiwi, Suryanti Dwi Putra, Andika Chandra Putra, Muhammad Yusuf Adira Putri C Eyanoer Putri Chairani Eyanoer, Putri Chairani R Lia Kusumawati R.A Henny Anggriani Rahayu Lubis Rahmat Hidayat Rahmat Hidayat Ritonga, Adewita Rosidah Hanum Hasibuan Santi Syafril Santoso, Andintia Aisyah Setiaputra Setiaputra Setyawan, Ungky Agus Siagian, Novi Andriani Siregar, Kamal Basri Sita Andarini Soliha, Chaliza Sri Melati Munir Sri Melati Munir Syamsul Bihar Tarigan, Amira Permatasari Tarigan, Setia Putra Taufik Ashar Yahwardiah Siregar Yahwardiah Siregar Zain-Hamid, Rozaimah Zaini, Jamal