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All Journal International Journal of Public Health Science (IJPHS) Majalah Kedokteran Bandung Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Medical Journal of Indonesia Folia Medica Indonesiana Jurnal NERS Biomedika The Indonesian Journal of Public Health Buletin Farmatera Jurnal Respirasi (JR) Journal Orthopaedi and Traumatology Surabaya (JOINTS) Majalah Biomorfologi (Biomorphology Journal) AKSONA Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing)
Viskasari P. Kalanjati
Departemen Anatomi Dan Histologi, Fakultas Kedokteran Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Body Mass Index and Urinalysis Markers in the Seemingly Healthy Young Adults Pradana, Krisnawan Andy; Kalanjati, Viskasari P; Tirthaningsih, Ni Wajan
Folia Medica Indonesiana Vol. 56 No. 2 (2020): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.486 KB) | DOI: 10.20473/fmi.v56i2.21233

Abstract

Higher prevalence of albuminuria, glycosuria, and haematuria was reported in the obese people than control. We aimed to analyze the BMI and urinalysis markers among the university students aged 18-21 years old in the IIKBW, Kediri to study any correlations and differences between these variables, which to the best of our knowledge has yet widely reported in Indonesia. This study has ethics approval from Universitas Airlangga, Surabaya. The BMI was analyzed from the body weight and height of male (n=74) and female (n=76) students with no health problems recorded. The pH, nitrites, protein, erythrocytes, glucose in the urine were measured qualitatively with a dip-stick method, blinded, using the midstream urine sample collected in the morning. Data were analyzed using SPSS 17, with a level of significance of p<0.05. Abnormal pH (n=75), positive nitrites (n=24), haematuria (n=6), and proteinuria (n=149) were recorded. About 22% of students suffered from type I obesity, and 8.7% of type II. Males were significantly suffered from the obesity whilst females from the overweight (p<0.05). No significant correlations between the BMI and each urinalysis marker (BMI and nitrites p=0.936; BMI and protein p=1; BMI and pH p=0.835; BMI and blood, p=0.486; respectively); no one were found with glycosuria. No significant differences either on the BMI or the 5 urinalysis markers between male and female groups (p>0.05). Whilst no positive glycosuria samples were identified; 18.9% of males and 13.2% of females have positive nitrites, 100% of males and 98.7% of females have positive proteinuria, 2.7% of males and 7.9% of females have positive haematuria. There were 7.33% of males and 6% of females having an increased pH; whilst 20.66% of males and 16% of females having a decreased pH. Amongst the seemingly healthy university students, we found cases of urinalysis marker impairment, although no significant correlations on the BMI to the urinalysis markers that may be representing early detection for renal diseases were observed.
Blood Type and Blood Pressure Correlations to Body Mass Index in Young Adults Suwito, Bambang Edi; Kalanjati, Viskasari P; Abdurachman, Abdurachman
Folia Medica Indonesiana Vol. 56 No. 3 (2020): September
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.363 KB) | DOI: 10.20473/fmi.v56i3.24557

Abstract

Specific ABO blood type was reported to the higher risk of having overweight and obesity. The laters had also been suggested to correlate to blood pressure. Here we studied blood type and blood pressure amongst seemingly healthy university students of IIKBW, Kediri to understand their correlations to the body mass index (BMI). The blood typing (ABO typing, Eryclone®) and blood pressure (automated digital sphygmomanometer) of 74 male and 76 female were measured in duplicate accordingly. The BMI was analysed from the student's body weight and height using a digital balance and a microtoise staturemeter, respectively. Data were analysed using SPSS 17 with p<0.05 level of significance. There were 18.7% students have A blood type, 31.3% students were B type, 44% were O and 6.0% with AB blood type. There were 30.7% students with obesity, 18% overweight, 36% normal weight and 15.3% underweight. There were 4.7% had a hypertension, 28.7% pre-hypertension, and 66.7% were normal. No significant correlations found between BMI or the blood pressure to any specific ABO blood type, except between the blood pressure and the AB blood type (r=-0.179, p=0.03). However, there was a significant correlation between BMI and blood pressure (r=0.327, p=0.000). We observed no significant associations between any specific ABO blood type with the BMI and blood pressure. However, high blood pressures amongst students with obesity were found. Males were more common to suffer from obesity and high blood pressure than females.
Oral Health Status and The Body Mass Index in Young Adults Rahmawan, Dzanuar; Kalanjati, Viskasari P; Abdurachman, Abdurachman
Folia Medica Indonesiana Vol. 56 No. 4 (2020): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (361.03 KB) | DOI: 10.20473/fmi.v56i4.24611

Abstract

Poor oral health has been reported to correlate to the body mass index (BMI) of the overweight and the obesity groups. These has yet widely studied in Indonesia. The aim of this study was to analysed the oral health, socioeconomy factors (FSE) and the BMI in the seemingly healthy university students in Kediri aged 18-21 years old. This cross-sectional study was conducted amongst male and female students of IIKBW, Kediri, Indonesia (n=150). We analysed their BMI from the body weight and height (kg/m2). Their oral health was determined by the DMFT index (decayed missing filled teeth index), the stimulated salivary flow rate (SSFR) and the gingival index (GI). FSE studied include father's highest education and monthly income, tooth brushing frequency in a day and dental floss habitual use. Data was analysed using SPSS 17 with level of significance of p<0.05. No significant differences in BMI, DMFT index, SSFR and GI respectively (p=0.411;p=0.037, p=0.880, p=0.142) between male and female groups. No significant corelation BMI with DMFT index, SSFR and GI, respectively (p=0.340, p=0.420, p=0,446). FSE are not significantly correlated to either the BMI, DMFT index, SSFR orGI (p > 0.05). There were 41.8% of males and 57.8% of females have "bad” score of DMFT and 98.6% of males and 92.1% of females have "bad” score of GI; 4.1% of males and 2.6% of females have low score of SSFR.Although we found no significant differences in the BMI and oral health parameters between genders, in the seemingly healthy young adults oral health hygiene could be compromised as found in the current study indicated by bad scores of DMFT, SSFR or GI. Here we found that either BMI or FSE was not significantly correlated to any of oral health parameters measured in the current study.
SPATIAL MEMORY AND HISTOMORPHOLOGICAL CHANGES INDUCED BY SUBCHRONIC NITROCELLULOSE INHALATION IN MICE: ROLE OF DEXAMETHASONE IN THE CEREBRUM Balogun, Olubunmi; Kalanjati, Viskasari P
The Indonesian Journal of Public Health Vol. 20 No. 1 (2025): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijph.v20i1.2025.29-43

Abstract

Introduction: Thinners are toxic substances used as organic solvents. Adolescents (11%) use thinners as inhalants regularly, which is linked to brain damage and learning deficits. This study looked at the effects of thinner inhalation in adult male mice and dexamethasone's anti-inflammatory effects on pyramidal neurons and glia. Aim: To investigate dexamethasone's anti-inflammatory effects on nitrocellulose inhalation. Methods: Forty mice were used; group one served as a control; group two was exposed to 1200ppm nitrocellulose in a whole-body inhalation chamber for 42 days; group three was injected with 2.5mg/kg dexamethasone twice weekly; and group four received nitrocellulose inhalation daily and dexamethasone twice weekly. Neurobehavioral study for learning and memory was conducted before sacrifice. Brains were harvested and processed for histology and biochemical activities of MDA and IL-6. Analysis of data was done using Graphpad Prism 8.4.3 with level of significance at P<0.05. Results: Indices of learning and memory in the nitrocellulose group were reduced escape latency and duration spent in the quadrant but not in the control or dexamethasone group (P=0.009). The MDA and IL-6 levels were higher in the nitrocellulose group compared to control and dexamethasone groups (P=0.02; P=0.03, respectively). Density of pyramidal neurons in layer 5 and 6 was significantly lower in the nitrocellulose treated groups compared to control and dexamethasone (P<0.0001). Conclusion: Dexamethasone reduced neuronal and glial cell damages in the pre-frontal cortex, accompanied with spatial learning and memory improvement.
Cerebellar Purkinje Cells and GABA Neurotransmission in the Diabetic Rodent Models: A Systematic Review Kalanjati, Viskasari P; Mahdi, Rayhan B; Aditya, Dwi Martha Nur
AKSONA Vol. 5 No. 2 (2025): JULY 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v5i2.70359

Abstract

Highlight: Reduced cerebellar Purkinje cell numbers and altered dendritic trees due to cell deaths were reported in hyperglycemia.  In hyperglycemia, altered GABAergic neurotransmissions are due to lower GABA synthesis and its receptors expression levels in cerebellum. Impaired motor and cognitive functions were observed related to cerebellar Purkinje cell damage in a diabetic rat model.   ABSTRACT Introduction: Hyperglycemia-induced neurotoxicity has been linked to the cerebellum, specifically the impairment of Purkinje cells; its relation to GABA neurotransmission has yet to be cleared. Objective: We conducted an updated review on the mechanism of hyperglycemia-induced impairment of cerebellar Purkinje cells in a rodent diabetic model. Methods: A modified ScR-PRISMA flow diagram was applied as the screening tool. All English-language research articles published between 2014 and 2024 that containing the purposed topics and were indexed in PubMed and Medline were included. These articles were then critically appraised using the JBI checklist to minimize  potential bias. The final inclusion of 8 articles was included for analysis and discussion, together with additional retrieved articles. Results: Hyperglycemic-induced subjects demonstrated a marked reduction in Purkinje and granular cell populations, accompanied by several morphological impairments. Alterations were observed in GABAergic inhibitory neurotransmission, including receptors and GABA synthesis, compared to controls. These findings are consistent with observed deficits in motor coordination and cerebellar function. Conclusion: Hyperglycemia produces adverse effects on the function and survival of Purkinje cells in the cerebellum. Impaired GABAergic neurotransmission might result as parts of oxidative stress and inflammation induced by hyperglycemia in the cerebellar cells. Taken altogether, these results in motor impairment and cognitive dysfunction.
GABRA6 and SLC6A4 genotypes are correlated with the fasting blood glucose and physical fitness in the seemingly healthy young adults Viskasari P Kalanjati; Mariana Wahjudi; Kusuma E. Purwantari; Visuddho; Peppy Nawangsasi; Rury T. Oktariza; Krisnawan A. Pradana; Dzanuar Rahmawan; Bambang E. Suwito
Jurnal Ners Vol. 18 No. 1 (2023): MARCH 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jn.v18i1.43770

Abstract

Introduction: We examined environmental and genetic factors potentially correlated with the blood glucose and physical fitness in Kediri, East Java, Indonesia to elucidate the predominant cardiovascular disease risk. Methods: This was a cross-sectional study on 68 adults aged 18-22 years. Direct interview was conducted to get socio-economy,  daily diets (rice/ R, snacks and sweets/ SS, veggies and fruits/ VF), daily activity (locomotors and non-locomotors) data. Peripheral blood-GABRA6 and SLC6A4 polymorphisms, fasting blood glucose (FBG), blood pressure, 3 fitness parameters (1 min push-up, 3 minutes step up, pulse rate after 3 minutes step-up) were measured by 2 independent and pre-trained medical doctors. Kruskal-Wallis, Chi-Square, and eta-coefficient tests were used to seek differences between genotypes and correlation strength between variables, respectively (significant if p<0.05). Results: Both gene's genotypes showed significant correlations with the FBG (p=0.042, p=0.013, respectively); GABRA6 polymorphism significantly correlated with SU (p=0.033). There was a significant difference in the FBG between 2 VF subgroups (p=0.02). Strongest association was found between FBG and SLC6A4 (η=0.3); PR and GABRA6 (η=0.168), PU and SLC6A4 (η=0.38); SU and Locomotors (η=0.237). Conclusions: In these seemingly healthy young adults, daily diets and the genotypes of both genes have a good association with the FBG and physical fitness levels.
Thumb Arthrodesis in The Arthritis Cases: A Scoping Review Akbar, Ghifar; Kalanjati, Viskasari Pintoko; Wardhana, Teddy Heri
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 13 No. 1 (2024): April 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v13i1.2024.35-40

Abstract

Backgrounds: Osteoarthritis in the thumb is a common condition affecting men and women, especially postmenopausal women, causing pain, swelling, and reduced hand function. Arthrodesis is a treatment option for thumb arthritis, increasingly accessible in medical practice, though coverage remains limited. This article aims to review recent case reports on thumb arthrodesis in older people over the last three years, depicting the method's use and outcomes. Methods: After filtering per PRISMA-Sc guidelines on PubMed and the Journal of Hand Surgery (2020-2023), with additional manual filtering, four articles were found and analyzed using the JBI Critical Appraisal Checklist for Case Reports before inclusion. Result: Four case reports related to pollex arthrodesis in the last three years were published in PubMed. These include rare cases of bilateral thumb psoriatic arthritis, a novel surgical approach for nonunion after arthrodesis, and successful fusion using a vascularized bone graft. The limited number of articles may be attributed to the research cycle, shifting focus, and alternative treatments. With increased healthcare access and osteoarthritis prevalence, more people will seek treatment, potentially leading to increased arthrodesis procedures. Opportunities for new research include evaluating surgical techniques, biomaterials, and growth factors to enhance bone healing. Long-term follow-up studies remain crucial for identifying risk factors and improving patient outcomes in thumb arthrodesis. Conclusion: Despite limited research published in the last three years, arthrodesis remains a relevant treatment option for pollex conditions, with rising demand due to increasing osteoarthritis prevalence and healthcare access. Further research on surgical innovations and long-term outcomes is crucial.
Effects of methotrexate, Moringa oleifera, and Andrographis paniculata extracts on the myocardial and aortic tissue of streptozotocin-nicotinamide-induced hyperglycemic rats Pamungkas, Dimas Bathoro Bagus; Kalanjati, Viskasari Pintoko; Abdurachman; Aditya, Dwi Martha Nur; Nasution, Muhammad Husni Fansury; Syamhadi, Maya Rahmayanti
Medical Journal of Indonesia Vol. 32 No. 3 (2023): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.236944

Abstract

BACKGROUND Methotrexate (MTX) could lower glucose levels in type 1 diabetes mellitus, while Moringa oleifera and Andrographis paniculata supplementations have similar effects on hyperglycemia. This study aimed to analyze the effects of MTX, M. oleifera, and A. paniculata leaf extracts on the myocardial interleukin (IL)-6 and the histopathology of the left ventricle and aorta. METHODS 49 rats were divided equally into 7 groups: negative control and diabetic induced by streptozotocin-nicotinamide (STZ-NA) injection consisting of positive control (STZ-NA only), M. oleifera (500 mg/kgBW/day), A. paniculata (500 mg/kgBW/day), MTX (7 mg/kgBW/week), MTX (7 mg/kgBW/week)+M. oleifera (500 mg/kgBW/day), and MTX (7 mg/kgBW/week)+A. paniculata (500 mg/kgBW/day). We analyzed oral MTX, M. oleifera, and A. paniculata leaf extracts’ effects on random blood glucose, myocardial IL-6, and cardiac histopathology of STZ-NA-induced hyperglycemic male rats. Data were analyzed using Wilcoxon and Kruskal–Wallis tests. RESULTS Myocardial IL-6 in the M. oleifera group was significantly lower compared to the positive control group (p = 0.041). Compared to the positive control group, the myocardial necrosis and aortic intima–media thickness in the MTX+A. paniculata group were significantly reduced (p = 0.005 and 0.001, respectively). CONCLUSIONS MTX, M. oleifera, and A. paniculata showed antihyperglycemic effect, both individually and in combination. A. paniculata leaf extract had a significant cardioprotective effect in STZ-NA-induced hyperglycemia.
Co-Authors Abdurachman Abdurachman Abdurachman Abdurachman Abdurachman Aditya, Dwi Martha Nur Akbar, Ghifar Al Muqsith Alfi Amelinda Andi Muh Rahul Alfaidin Andra Rizqiawan Anna Lewi Santoso Annette d’Arqom, Annette Anung Putri Illahika Arlia Ayu Damayanti Arsyi, Danial Habri Avida Marisa Ilmi Azlin Muhammad Mohd Yasin Balogun, Olubunmi Bambang E. Suwito Bambang E. Suwito Bambang Edi Suwito Brilianti, Natasya Nurvita Damayanti, Arlia Ayu Desy Purwidyastuti Dewi Ratna Sari Dewi Sekarsari Dewi, Arni Kusuma Dion K. Dharmawan Dion Krismashogi Dharmawan Dzanuar Rahmawan Dzanuar Rahmawan Ellen Satya Pratiwi Etha Dini Widiasi Farabi, Moh. Reza Ferdian rizky Hutomo Fidiana H. Hoediyanto Haryanto Alimsardjono HERAWATI, LILIK Hidayaturrahmi, Hidayaturrahmi Ida Lestari Harahap Intan Anggun Pratiwi Irmawan Farindra Irvinia Septarizka Putri Radjamin Iswan Abbas Nusi Jason Lefranda Jocelino Siswanto Jongky H. Prajitno Joni Wahyuhadi, Joni Krisnawan A. Pradana Krisnawan A. Pradana Kurniawaty, Yuni Kusuma E. Purwantari Kusuma Eko Purwantari Lucky Prasetiowati Machin, Abdulloh Made Pury Pratiwi Mahdi, Rayhan B Mahrus A Rahman, Mahrus A Mariana Wahjudi Mayang Rizki Anggraeni Meutia Maulina Nasution, Muhammad Husni Fansury Noer Halimatus Syakdiyah Nurina Hasanatuludhhiyah Oktariza, Rury Tiara Ovin Nada Saputri Pamungkas, Dimas Bathoro Bagus Peppy Nawangsasi Permana, Putu Bagus Dharma Pradana, Krisnawan Andy Prastiya I. Gunawan Prastiya Indra Gunawan Pratiwi, Octaviana Galuh Raden Argarini Rahadian I Susilo Rahmawan, Dzanuar Reza Maulana Rezy R. Melbiarta Rezy Ramawan Melbiarta Rimbun Rimbun Risdiansyah Risdiansyah Rury T. Oktariza Sakina Sakina Soetjipto Soetjipto Susila, I Made Dwi Yudiartana Putra Syamhadi, Maya Rahmayanti Taya Elsa Savista Tirthaningsih, Ni Wajan Visuddho Warda Elmaida Rusdi Wardhana, Teddy Heri Winnie Nirmala Santosa Yudhono, Anggit Satriyo Yusuf Salim Yusuf Salim Zulhabri Othman