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All Journal International Journal of Public Health Science (IJPHS) Majalah Kedokteran Bandung Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Medical Journal of Indonesia Jurnal NERS Biomedika The Indonesian Journal of Public Health Buletin Farmatera Jurnal Respirasi (JR) Journal Orthopaedi and Traumatology Surabaya (JOINTS) Majalah Biomorfologi (Biomorphology Journal) AKSONA Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Folia Medica Indonesiana
Viskasari P. Kalanjati
Departemen Anatomi Dan Histologi, Fakultas Kedokteran Universitas Airlangga
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Effects of methotrexate, Moringa oleifera, and Andrographis paniculata extracts on the myocardial and aortic tissue of streptozotocin-nicotinamide-induced hyperglycemic rats Pamungkas, Dimas Bathoro Bagus; Kalanjati, Viskasari Pintoko; Abdurachman; Aditya, Dwi Martha Nur; Nasution, Muhammad Husni Fansury; Syamhadi, Maya Rahmayanti
Medical Journal of Indonesia Vol. 32 No. 3 (2023): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.236944

Abstract

BACKGROUND Methotrexate (MTX) could lower glucose levels in type 1 diabetes mellitus, while Moringa oleifera and Andrographis paniculata supplementations have similar effects on hyperglycemia. This study aimed to analyze the effects of MTX, M. oleifera, and A. paniculata leaf extracts on the myocardial interleukin (IL)-6 and the histopathology of the left ventricle and aorta. METHODS 49 rats were divided equally into 7 groups: negative control and diabetic induced by streptozotocin-nicotinamide (STZ-NA) injection consisting of positive control (STZ-NA only), M. oleifera (500 mg/kgBW/day), A. paniculata (500 mg/kgBW/day), MTX (7 mg/kgBW/week), MTX (7 mg/kgBW/week)+M. oleifera (500 mg/kgBW/day), and MTX (7 mg/kgBW/week)+A. paniculata (500 mg/kgBW/day). We analyzed oral MTX, M. oleifera, and A. paniculata leaf extracts’ effects on random blood glucose, myocardial IL-6, and cardiac histopathology of STZ-NA-induced hyperglycemic male rats. Data were analyzed using Wilcoxon and Kruskal–Wallis tests. RESULTS Myocardial IL-6 in the M. oleifera group was significantly lower compared to the positive control group (p = 0.041). Compared to the positive control group, the myocardial necrosis and aortic intima–media thickness in the MTX+A. paniculata group were significantly reduced (p = 0.005 and 0.001, respectively). CONCLUSIONS MTX, M. oleifera, and A. paniculata showed antihyperglycemic effect, both individually and in combination. A. paniculata leaf extract had a significant cardioprotective effect in STZ-NA-induced hyperglycemia.
Body Mass Index, Waist-Hip Ratio and Fasting Blood Glucose Levels amongst the University Students Oktariza, Rury Tiara; Kalanjati, Viskasari Pintoko; Tirthaningsih, Ni Wajan
Folia Medica Indonesiana Vol. 57, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Overweight and obesity have been correlated to the higher risk for developing metabolic diseases in later life, i.e. DM type 2. We study the body mass index (BMI), the waist to hip ratio (WHR) and the fasting blood glucose levels (FBG) in the seemingly healthy male and female university students to comprehend these variables amongst the youth in Indonesia in 2019. The BMI and WHR of 150 male and female students aged 18-22 years old of the IIKBW, Kediri were measured by standardised anthropometry. The FBG was measured after 8 hours-minimum of fasting from the capillary blood drop using glucometer. Data was then analysed using SPSS 17 with level of significance of p<0.05. According to Asia-Pacific BMI classification, students were 30.7% obese with males significantly higher than females (p=0.016), 18% overweight (significantly higher in females, p=0.04), 36% normal and 15.3% underweight.When compared between genders, the WHR is significantly higher in males (p<0.001); whilst no significant differences in FBG (p=0.6). Four males and 5 females with FBG ≥ 100 mg/dl, whereas others were within normal limits. There are positive significant correlations between BMI and WHR in males and females (r=0.777, p<0.001; r=0.54, p<0.001, respectively). There is a significant positive correlation between the BMI and FBG with r=0.217, p=0.008; and between the WHR and FBG with r=0.21, p=0.01 amongst all students. In this study, male students have significantly higher BMI and WHR than females. Higher FBG was well observed in students with either higher BMI or WHR.
Blood Type and Blood Pressure Correlations to Body Mass Index in Young Adults Suwito, Bambang Edi; Kalanjati, Viskasari P; Abdurachman, Abdurachman
Folia Medica Indonesiana Vol. 56, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Specific ABO blood type was reported to the higher risk of having overweight and obesity. The laters had also been suggested to correlate to blood pressure. Here we studied blood type and blood pressure amongst seemingly healthy university students of IIKBW, Kediri to understand their correlations to the body mass index (BMI). The blood typing (ABO typing, Eryclone®) and blood pressure (automated digital sphygmomanometer) of 74 male and 76 female were measured in duplicate accordingly. The BMI was analysed from the student's body weight and height using a digital balance and a microtoise staturemeter, respectively. Data were analysed using SPSS 17 with p<0.05 level of significance. There were 18.7% students have A blood type, 31.3% students were B type, 44% were O and 6.0% with AB blood type. There were 30.7% students with obesity, 18% overweight, 36% normal weight and 15.3% underweight. There were 4.7% had a hypertension, 28.7% pre-hypertension, and 66.7% were normal. No significant correlations found between BMI or the blood pressure to any specific ABO blood type, except between the blood pressure and the AB blood type (r=-0.179, p=0.03). However, there was a significant correlation between BMI and blood pressure (r=0.327, p=0.000). We observed no significant associations between any specific ABO blood type with the BMI and blood pressure. However, high blood pressures amongst students with obesity were found. Males were more common to suffer from obesity and high blood pressure than females.
Oral Health Status and The Body Mass Index in Young Adults Rahmawan, Dzanuar; Kalanjati, Viskasari P; Abdurachman, Abdurachman
Folia Medica Indonesiana Vol. 56, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Poor oral health has been reported to correlate to the body mass index (BMI) of the overweight and the obesity groups. These has yet widely studied in Indonesia. The aim of this study was to analysed the oral health, socioeconomy factors (FSE) and the BMI in the seemingly healthy university students in Kediri aged 18-21 years old. This cross-sectional study was conducted amongst male and female students of IIKBW, Kediri, Indonesia (n=150). We analysed their BMI from the body weight and height (kg/m2). Their oral health was determined by the DMFT index (decayed missing filled teeth index), the stimulated salivary flow rate (SSFR) and the gingival index (GI). FSE studied include father's highest education and monthly income, tooth brushing frequency in a day and dental floss habitual use. Data was analysed using SPSS 17 with level of significance of p<0.05. No significant differences in BMI, DMFT index, SSFR and GI respectively (p=0.411;p=0.037, p=0.880, p=0.142) between male and female groups. No significant corelation BMI with DMFT index, SSFR and GI, respectively (p=0.340, p=0.420, p=0,446). FSE are not significantly correlated to either the BMI, DMFT index, SSFR orGI (p > 0.05). There were 41.8% of males and 57.8% of females have "bad” score of DMFT and 98.6% of males and 92.1% of females have "bad” score of GI; 4.1% of males and 2.6% of females have low score of SSFR.Although we found no significant differences in the BMI and oral health parameters between genders, in the seemingly healthy young adults oral health hygiene could be compromised as found in the current study indicated by bad scores of DMFT, SSFR or GI. Here we found that either BMI or FSE was not significantly correlated to any of oral health parameters measured in the current study.
Case report: Dentigerous Cyst and Canine Impaction at the Orbital Floor Hutomo, Ferdian rizky; Pratiwi, Ellen Satya; Kalanjati, Viskasari P; Rizqiawan, Andra
Folia Medica Indonesiana Vol. 55, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Dentigerous cysts are cysts of the epithelial lining of the jaws derived from the dental follicle of unerupted teeth. These cysts are often found during routine radiographic examination along with unerupted teeth. Dentigerous cysts are usually asymptomatic unless the size becomes large, thus causing swelling. This case report describes the management of dentigerous cyst in the upper left canine region with canine impaction to the orbital floor. Dentigerous cyst was treated with cyst enucleation but the impacted canine was not taken because of the magnitude of risk that can occur which was a disruption to the eye muscle. Conclusion. Treatment of dentigerous cysts can be performed by enucleation technique and management related the impacted tooth at the orbital floor needs a further evaluation consideration.
Body Mass Index and Urinalysis Markers in the Seemingly Healthy Young Adults Pradana, Krisnawan Andy; Kalanjati, Viskasari P; Tirthaningsih, Ni Wajan
Folia Medica Indonesiana Vol. 56, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Higher prevalence of albuminuria, glycosuria, and haematuria was reported in the obese people than control. We aimed to analyze the BMI and urinalysis markers among the university students aged 18-21 years old in the IIKBW, Kediri to study any correlations and differences between these variables, which to the best of our knowledge has yet widely reported in Indonesia. This study has ethics approval from Universitas Airlangga, Surabaya. The BMI was analyzed from the body weight and height of male (n=74) and female (n=76) students with no health problems recorded. The pH, nitrites, protein, erythrocytes, glucose in the urine were measured qualitatively with a dip-stick method, blinded, using the midstream urine sample collected in the morning. Data were analyzed using SPSS 17, with a level of significance of p<0.05. Abnormal pH (n=75), positive nitrites (n=24), haematuria (n=6), and proteinuria (n=149) were recorded. About 22% of students suffered from type I obesity, and 8.7% of type II. Males were significantly suffered from the obesity whilst females from the overweight (p<0.05). No significant correlations between the BMI and each urinalysis marker (BMI and nitrites p=0.936; BMI and protein p=1; BMI and pH p=0.835; BMI and blood, p=0.486; respectively); no one were found with glycosuria. No significant differences either on the BMI or the 5 urinalysis markers between male and female groups (p>0.05). Whilst no positive glycosuria samples were identified; 18.9% of males and 13.2% of females have positive nitrites, 100% of males and 98.7% of females have positive proteinuria, 2.7% of males and 7.9% of females have positive haematuria. There were 7.33% of males and 6% of females having an increased pH; whilst 20.66% of males and 16% of females having a decreased pH. Amongst the seemingly healthy university students, we found cases of urinalysis marker impairment, although no significant correlations on the BMI to the urinalysis markers that may be representing early detection for renal diseases were observed.
Analysis of Spatial Working Memory Using the Y-Maze on Rodents Treated with High-Calorie Diet and Moderate-Intensity Exercise Melbiarta, Rezy Ramawan; Kalanjati, Viskasari P.; Herawati, Lilik; Salim, Yusuf; Othman, Zulhabri
Folia Medica Indonesiana Vol. 59, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: • This article reports the use of the Y-maze as a simple yet effective method to measure spatial working memory in mice. • The Y-maze method can be used safely without exposing the animals to additional stressors, as evidenced by the absence of mortality following the test. Abstract: Spatial working memory (SWM) in humans and animal models with impaired cognitive functions has been analyzed through a number of methods. However, this is still understudied in animal models treated with a high-calorie diet (HCD) and moderate-intensity exercise (MIE). The Y-maze was utilized as the assessment method in this study. A 40 x 9 x 9 cm3 Y-maze was employed to observe the animal models' spontaneous alternation (SA) as the representation of their SWM. This was done by calculating the total alternation percentage divided by total entry minus two. A total of 17 female Mus musculus mice aged 8 weeks were tested in the Y-maze to investigate their SWM using SA calculations. Each mouse was analyzed for eight minutes and recorded in a dark and quiet room to minimize bias due to environmental noise and lighting. Comparing the treatment group's (HCD+MIE) SA to the control group's SA revealed no statistically significant difference (p=0.451). Seven mice in the treatment group performed similarly to the mice in the control group in the Y-maze test, with no significant difference in their ability to complete the task. The mice in the treatment group exhibited no motor impairment, as indicated by complete movements of all their extremities while exploring the Y-maze within the allotted time. In conclusion, the Y-maze can be used as a reliable method to analyze SWM in overweight/obese Mus musculus animal models treated with moderate-intensity physical exercise.
Hemoglobin A1c (Hba1c) is Strongly Correlated with Mean Corpuscular Volume Among Type 2 Diabetes Mellitus (T2dm) Patients Admitted in a Tertiary Hospital in East Java, Indonesia Salim, Yusuf; Kalanjati, Viskasari P.; Prajitno, Jongky H.; Melbiarta, Rezy R.
Folia Medica Indonesiana Vol. 58, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Highlight: • Moderate negative significant correlation between HbA1c and MCV levels in T2DM was yet reported widely. • MCV levels could mirror health indicator in adult T2DM patients. Abstract: HbA1c showed the average level of blood sugar in the recent 2-3 months. This parameter can be used to help physicians to diagnose T2DM and to plan appropriate treatment. Meanwhile, the mean corpuscular volume (MCV) is established from the erythrocytes levels as one of the blood corpuscles, in which hemoglobin is bound to. We hypothesize that MCV is correlated to the HbA1c levels and could be an indicator of blood sugar levels in adult T2DM patients. A retrospective cross-sectional study based on the medical record of patients admitted to the Outpatient Section of Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Indonesia from January to December 2019 was done. Patients under 18-years old, and incomplete medical record data were excluded. Adult patients diagnosed with T2DM and have been received initial treatment in this section were included (n=1.688). Data was analyzed using correlation test in SPSS 17.0 (USA), p-value less than 0.05 was considered significant. We found a significant negative correlation between HbA1c and MCV levels in these patients (r=-0.312; p<0.001). MCV levels showed a paradoxical pattern against the blood glucose levels in T2DM and could serve as the health indicator in these patients.
Co-Authors Abdurachman Abdurachman Abdurachman Abdurachman Abdurachman Aditya, Dwi Martha Nur Akbar, Ghifar Al Muqsith Alfi Amelinda Andi Muh Rahul Alfaidin Andra Rizqiawan Anna Lewi Santoso Annette d’Arqom, Annette Anung Putri Illahika Arlia Ayu Damayanti Arsyi, Danial Habri Avida Marisa Ilmi Azlin Muhammad Mohd Yasin Balogun, Olubunmi Bambang E. Suwito Bambang E. Suwito Bambang Edi Suwito Brilianti, Natasya Nurvita Damayanti, Arlia Ayu Desy Purwidyastuti Dewi Ratna Sari Dewi Sekarsari Dewi, Arni Kusuma Dion K. Dharmawan Dion Krismashogi Dharmawan Dzanuar Rahmawan Dzanuar Rahmawan Ellen Satya Pratiwi Etha Dini Widiasi Farabi, Moh. Reza Ferdian rizky Hutomo Fidiana H. Hoediyanto Haryanto Alimsardjono HERAWATI, LILIK Hidayaturrahmi, Hidayaturrahmi Hutomo, Ferdian rizky Ida Lestari Harahap Intan Anggun Pratiwi Irmawan Farindra Irvinia Septarizka Putri Radjamin Iswan Abbas Nusi Jason Lefranda Jocelino Siswanto Jongky H. Prajitno Joni Wahyuhadi, Joni Krisnawan A. Pradana Krisnawan A. Pradana Kurniawaty, Yuni Kusuma E. Purwantari Kusuma Eko Purwantari Lucky Prasetiowati Machin, Abdulloh Made Pury Pratiwi Mahdi, Rayhan B Mahrus A Rahman, Mahrus A Mariana Wahjudi Mayang Rizki Anggraeni Melbiarta, Rezy R. Melbiarta, Rezy Ramawan Meutia Maulina Nasution, Muhammad Husni Fansury Noer Halimatus Syakdiyah Nurina Hasanatuludhhiyah Oktariza, Rury Tiara Othman, Zulhabri Ovin Nada Saputri Pamungkas, Dimas Bathoro Bagus Peppy Nawangsasi Permana, Putu Bagus Dharma Pradana, Krisnawan Andy Prajitno, Jongky H. Prastiya I. Gunawan Prastiya Indra Gunawan Pratiwi, Ellen Satya Pratiwi, Octaviana Galuh Raden Argarini Rahadian I Susilo Rahmawan, Dzanuar Reza Maulana Rezy R. Melbiarta Rezy Ramawan Melbiarta Rimbun Rimbun Risdiansyah Risdiansyah Rury T. Oktariza Sakina Sakina Salim, Yusuf Soetjipto Soetjipto Susila, I Made Dwi Yudiartana Putra Syamhadi, Maya Rahmayanti Taya Elsa Savista Tirthaningsih, Ni Wajan Visuddho Warda Elmaida Rusdi Wardhana, Teddy Heri Winnie Nirmala Santosa Yudhono, Anggit Satriyo Yusuf Salim Yusuf Salim Zulhabri Othman