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All Journal International Journal of Public Health Science (IJPHS) Majalah Kedokteran Bandung Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Medical Journal of Indonesia Folia Medica Indonesiana Jurnal NERS Biomedika The Indonesian Journal of Public Health Buletin Farmatera Jurnal Respirasi (JR) Journal Orthopaedi and Traumatology Surabaya (JOINTS) Majalah Biomorfologi (Biomorphology Journal) AKSONA Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing)

Viskasari P. Kalanjati

Departemen Anatomi Dan Histologi, Fakultas Kedokteran Universitas Airlangga

Author-ID : 3484462

Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Other

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MODULATION OF BONE TISSUE HISTOMORPHOMETRY AND MALONDIALDEHYDE EXPRESSION LEVELS BY VITAMIN C IN RODENTS AFTER PRENATAL NOISE EXPOSURE Taya Elsa Savista; Viskasari Pintoko Kalanjati; Abdurachman Abdurachman
Buletin Farmatera Vol 4, No 2 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Abstract: Vitamin C is proposed as an antioxidant to combat the oxidative stress of prenatal noise exposure in bone tissue of newborn Wistar rats. Thirty-two Wistar mothers were administered oral vitamin C 150 mg/kg BW/day from D1 of pregnancy until delivery; white noise exposure of 95 dB, 4 hr/day was given from D15 of pregnancy until delivery. Newborn rats were divided into 4 groups equally (n=24): K1 (distilled water), K2 (vitamin C), P1 (distilled water + WN), P2 (vitamin C + WN). The osteoblast and osteoclast mean cell numbers, the osteoid volume, and an oxidative stress expression level marker of malondialdehyde (MDA) were calculated from two adjacent longitudinal slices of newborn rats’ tibiae using Cell Sense and ImageJ softwares (4 μ; 400x of light microscope magnification). Data were analyze using either ANOVA and LSD post-test or Brown-Forsythe and Games Howell post- test; significance level if p<0.05. In P2, the mean number of the osteoblast was significantly higher than in P1 (p<0.001); whilst the osteoclast mean number was significantly lower compared to other groups (p=0.03). In P2, the osteoid volume was significantly higher than in P1 (p=0.021); with lower MDA levels than P1 (p=0.074). From this study, vitamin C could protect the newborn rat bones exposed by prenatal noise as an oxidative stressor.Keywords: vitamin C, prenatal noise, osteogenesis, malondialdehyde

VITAMIN C PREVENTS STRESS INDUCED CARDIOMYOPATHY IN PRENATAL NOISE EXPOSED RODENTS Winnie Nirmala Santosa; Viskasari P. Kalajanti; Ni Wajan Tirthaningsih
Buletin Farmatera Vol 4, No 2 (2019)
Publisher : Universitas Muhammadiyah Sumatera Utara

Potency of oral vitamin C to prevent cardiomyopathy in prenatal noise exposed newborn Wistar rats was studied by comparing the cardiomyocyte numbers and the extracellular matrix expressions (ECM) to controls. Twenty-four newborns (NR) of 32 pregnant mothers were divided equally into 4 groups: K1 (distilled water [DW]), K2 (150 mg/kg of BW oral vitamin C once daily [VC]), P1 (4 hours daily of white noise at 95 dB [WN]+DW), and P2 (WN+VC). VC and WN were given from D1 till birth and from D15 till birth, respectively. The hearts of NR were harvested, and processed for histology slides (2 midsagittal 4 μ cut slides/ animal) stained with hematoxyllin-eosin and Masson trichrome for the cardiomyocytes and ECM quantification at the ventricles using Image Raster 3.0 and ImageJ, respectively. Pictures from 8 visual fields/ slide were taken and analyzed in duplicate (400x magnifications under a light microscope). Data were analyzed using SPSS 17; significance level of p<0.05. In P1, the cardiomyocite cell numbers was significantly lowest (p<0.001); whilst the ECM was significantly highest than K1, K2, P2 (p<0.001 and p<0.005, respectively). Here, vitamin C could prevent the adverse effect of prenatal noise exposures in the ventricle myocardium of newborn rats.Keywords: cardiomyopathy, hypertrophy, prenatal noise, vitamin C

Korelasi Usia dan Jenis Kelamin dengan Angka Kejadian Meningioma Arlia Ayu Damayanti; Viskasari Pintoko Kalanjati; Joni Wahyuhadi
AKSONA Vol. 1 No. 1 (2021): JANUARY 2021
Publisher : Universitas Airlangga

Pendahuluan: Meningioma merupakan tumor otak primer yang berasal dari jaringan arakhnoid. Angka kejadian meningioma di Indonesia menunjukkan peningkatan dari tahun ke tahun. Selain mutasi gen supresor tumor, meningioma dapat dipengaruhi oleh faktor eksternal diantaranya usia dan jenis kelamin. Tujuan: Mengetahui hubungan antara usia dan jenis kelamin dengan angka kejadian meningioma pada pasien di RSUD Dr. Soetomo, Surabaya, Indonesia tahun 2018 berdasarkan derajat keganasannya. Metode: Penelitian ini merupakan studi observasional analitik cross-sectional retrospektif dari data sekunder lembar hasil pemeriksaan patologi anatomi pasien yang dirawat inap melalui SMF. Ilmu Bedah Saraf, RSUD Dr. Soetomo tahun 2018; data yang tidak lengkap akan dieksklusi. Analisis data dilakukan menggunakan uji Chi squre (SPSS 25) dengan tingkat signifikansi p <0,05. Hasil: Didapatkan 45 pasien meningioma yang sesuai dengan kriteria inklusi, dengan mayoritas perempuan (71%) pada kelompok usia 45 – 49 tahun (22,2%), WHO grade I (82%) dengan tipe histopatologi transisional (49%). Terdapat hubungan yang signifikan antara angka kejadian meningioma dengan kelompok usia tertentu (r = 0,718, p = 0,025), dan dengan jenis kelamin (r = 0,441, p = 0,002). Rasio perempuan dibanding laki- laki sebesar 1:2,36. Kesimpulan: Usia dan jenis kelamin berkorelasi erat dengan angka kejadianmeningioma.

PENGARUH SEKAT ALUMINIUM FOIL TERHADAP RASIO NEURON DAN NEUROGLIA JARINGAN SEREBRI TIKUS WISTAR JANTAN YANG DIBERI PAPARAN RADIASI ELEKTROMAGNETIK Irmawan Farindra; Warda Elmaida Rusdi; Viskasari P Kalanjati; Ni Wajan Tirthaningsih
Biomedika Vol 14, No 2 (2022): Biomedika Agustus 2022
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v14i2.18725

ABSTRAK Telepon selular merupakan salah satu sumber radiasi elektromagnetik (EMR). Peningkatan penggunaan telepon selular dapat meningkatkan efek negatif EMR sebagai salah satu penyebab stres oksidatif pada tubuh manusia diantaranya jaringan serebri. Aluminium foil (AF) adalah salah satu bahan yang direkomendasikan untuk melindungi otak dari efek negatif EMR karena memiliki potensi absorption loss and reflective loss. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian sekat AF terhadap EMR dari telepon selular terhadap rasio neuron dan neuroglia pada jaringan serebri tikus Wistar jantan dewasa. Sebanyak 32 ekor tikus jantan dewasa dibagi menjadi 4 kelompok (n=8). Kelompok KI EMR (-) dan AF (-); Kelompok K2 EMR (-) dan AF (+); Kelompok P1 EMR (+) dan AF (-); Kelompok P2 EMR (+) dan AF (+). Telepon selular (GSM 2100 MHz; SAR 0,84-1,86 W/kg) diletakkan di dasar wadah kotak plastik , kemudian dipaparkan 4 jam/ hari selama 30 hari. Data jumlah neuron dan neuroglia tiap kelompok dianalisis dengan tingkat signifikansi p0,05 (uji one way ANOVA, SPSS 17). Dari hasil rasio neuron dan neuroglia didapatkan penurunan rasio pada kelompok perlakuan dibandingkan kontrol, serta peningkatan rasio pada kelompok perlakuan P2 dibandingkan kelompok P1. Hal tersebut membuktikan AF dapat melindungi dari efek negatif EMR dengan meningkatkan jumlah neuroglia sebagai respon proteksi terhadap kerusakan neuron pada jaringan serebri.Kata Kunci: Aluminium Foil, Radiasi Elektromagnetik, Telepon Seluler; Serebri, Neuron, Neuroglia ABSTRACT Cellular phones are a source of electromagnetic radiation (EMR). Increased use of cellular phones, can increase the negative effects of EMR as one of the causes of oxidative stress in the human body, including cerebral tissue. Aluminum foil (AF) is one of the recommended materials as protection against the negative effects of EMR because it has the potential for absorption loss and reflective loss. This study aims to determine the effect of AF blocking on EMR from cellular phones, where the variables studied were the number of neurons and neuroglia, as well as the ratio of neurons and neuroglia in the cerebral tissue of adult male Wistar rats. This study used 32 adult male rats which were divided into 4 groups (n=8). Each mouse was placed in a plastic box container measuring 20x16x9 cm with a wire cover. A cellular phone (GSM 2100 MHz; SAR 0.84-1.86 W/kg) was placed at the bottom of the plastic case and exposed 4 hours/day for 30 days. Data were analyzed with a significance level of p0.05 (Kruskal-Wallis test or ANOVA, SPSS 17). From these results, it is evident that AF can protect against the negative effects of EMR by reducing the effects of oxidative stress by reducing neuronal damage in cerebral tissue.Keywords: Aluminium Foil, Electromagnetic Radiation, Mobile Phone, Brain, Neuron, Neuroglia

Hemoglobin A1c (Hba1c) is Strongly Correlated with Mean Corpuscular Volume Among Type 2 Diabetes Mellitus (T2dm) Patients Admitted in a Tertiary Hospital in East Java, Indonesia Yusuf Salim; Viskasari P. Kalanjati; Jongky H. Prajitno; Rezy R. Melbiarta
Folia Medica Indonesiana Vol. 58 No. 1 (2022): March
Publisher : Universitas Airlangga

Highlight:Moderate negative significant correlation between HbA1c and MCV levels in T2DM was yet reported widely.MCV levels could mirror health indicator in adult T2DM patients.Abstract:HbA1c showed the average level of blood sugar in the recent 2-3 months. This parameter can be used to help physicians to diagnose T2DM and to plan appropriate treatment. Meanwhile, the mean corpuscular volume (MCV) is established from the erythrocytes levels as one of the blood corpuscles, in which hemoglobin is bound to. We hypothesize that MCV is correlated to the HbA1c levels and could be an indicator of blood sugar levels in adult T2DM patients. A retrospective cross-sectional study based on the medical record of patients admitted to the Outpatient Section of Department of Internal Medicine, Dr. Soetomo General Academic Hospital, Indonesia from January to December 2019 was done. Patients under 18-years old, and incomplete medical record data were excluded. Adult patients diagnosed with T2DM and have been received initial treatment in this section were included (n=1.688). Data was analyzed using correlation test in SPSS 17.0 (USA), p-value less than 0.05 was considered significant. We found a significant negative correlation between HbA1c and MCV levels in these patients (r=-0.312; p<0.001). MCV levels showed a paradoxical pattern against the blood glucose levels in T2DM and could serve as the health indicator in these patients.

Analysis of Spatial Working Memory Using the Y-Maze on Rodents Treated with High-Calorie Diet and Moderate-Intensity Exercise Rezy Ramawan Melbiarta; Viskasari P. Kalanjati; Lilik Herawati; Yusuf Salim; Zulhabri Othman
Folia Medica Indonesiana Vol. 59 No. 1 (2023): March
Publisher : Universitas Airlangga

Highlights: This article reports the use of the Y-maze as a simple yet effective method to measure spatial working memory in mice. The Y-maze method can be used safely without exposing the animals to additional stressors, as evidenced by the absence of mortality following the test. Abstract: Spatial working memory (SWM) in humans and animal models with impaired cognitive functions has been analyzed through a number of methods. However, this is still understudied in animal models treated with a high-calorie diet (HCD) and moderate-intensity exercise (MIE). The Y-maze was utilized as the assessment method in this study. A 40 x 9 x 9 cm3 Y-maze was employed to observe the animal models’ spontaneous alternation (SA) as the representation of their SWM. This was done by calculating the total alternation percentage divided by total entry minus two. A total of 17 female Mus musculus mice aged 8 weeks were tested in the Y-maze to investigate their SWM using SA calculations. Each mouse was analyzed for eight minutes and recorded in a dark and quiet room to minimize bias due to environmental noise and lighting. Comparing the treatment group’s (HCD+MIE) SA to the control group’s SA revealed no statistically significant difference (p=0.451). Seven mice in the treatment group performed similarly to the mice in the control group in the Y-maze test, with no significant difference in their ability to complete the task. The mice in the treatment group exhibited no motor impairment, as indicated by complete movements of all their extremities while exploring the Y-maze within the allotted time. In conclusion, the Y-maze can be used as a reliable method to analyze SWM in overweight/obese Mus musculus animal models treated with moderate-intensity physical exercise.

Anosmia, Dysgeusia, and Comorbidity in COVID-19 Patients with Respiratory Tract Manifestations Jason Lefranda Jocelino Siswanto; Viskasari Pintoko Kalanjati; Soetjipto Soetjipto; Azlin Muhammad Mohd Yasin
Jurnal Respirasi Vol. 9 No. 3 (2023): September 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.3.2023.188-193

Introduction: Olfactory and special sensory disturbances such as anosmia and dysgeusia have been found among COVID-19 patients. These manifestations may cause post-covid sequelae, disturbing patients' quality of life who have recovered from COVID-19. This study aimed to analyze the association between anosmia and dysgeusia with the comorbidities in adult COVID-19 patients admitted to Dr. Soetomo General Hospital, Surabaya, from 1 January 2020 to 30 September 2021. Methods: This was a cross-sectional retrospective analysis study based on the medical records of all patients who met the criteria (n = 158). The minimal age inclusion was 18 years old, and the patient must be positively diagnosed with COVID-19 (reverse transcription polymerase chain reaction/RT-PCR). Results: Out of 158 patients, all had a fever, and approximately 93% of patients showed respiratory signs and symptoms. There were 128 patients (81%) who suffered from anosmia, and 15 patients (9.5%) had dysgeusia. Significant associations were found between anosmia with dysgeusia (p = 0.049) and between anosmia with cough (p = 0.003) and dyspnea (p = 0.000). The predominant comorbidities reported were overweight (60%), hypertension (42%), and type-2 diabetes mellitus (37%). Conclusion: There were significant associations between anosmia with dysgeusia and the respiratory tract signs and symptoms instead of the comorbidities reported.

A Rare Case of Dural Tail Sign in the Patient with Glioblastoma Multiforme: A Case Report Risdiansyah Risdiansyah; Kusuma Eko Purwantari; Viskasari P Kalanjati; Rahadian I Susilo
AKSONA Vol. 3 No. 2 (2023): JULY 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v3i2.46639

Highlight: A dural tail sign was found in T1W1-MR-images with contrast of a patient with glioblastoma multiforme. Glioblastoma multiforme as a grade IV malignancy of the astrocytes' glioma, the dura mater can be infiltrated and shown as DTS, although rarely reported. ABSTRACT Introduction: The dural tail sign (DTS), which is rarely seen in patients with glioblastoma multiforme (GBM), is reported here. This sign is generally found as a manifestation of meningioma due to the reactive changes of the tumor’s invasion. Case: A 61-year-old Javanese man presented with a gradually worsening headache two months prior to hospital admission. He also suffered from paralysis of his right extremities. His complete blood tests and clinical chemistry were within normal limits. A head CT scan showed a large mass near the convexity of the brain in the left parietal lobe, along with edema and a shift of the midline structures to the right. This was confirmed on the T1W1 MR images with contrast, where DTS was clearly shown. Following surgical resection and tumor excision, histopathology analysis revealed GBM with malignant cell infiltration to the dura in the vicinity of the neoplasm. Conclusion: Here we showed a DTS in GBM as a malignant infiltration marker into the dura

Pengaruh Shielding Aluminium Foil terhadap Perubahan Ketebalan Lapisan Epitel Kornea Akibat Paparan Radiasi Gelombang Elektromagnetik pada Tikus Wistar Jantan Dion K. Dharmawan; Viskasari P. Kalanjati; Abdurachman
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 7 No. 2 (2020): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universi
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v7i2.144

Ponsel telah diketahui memancarkan radiasi gelombang elektromagnetik (RGEM) yang digunakan sebagai media dalam telekomunikasi. Dampak buruk akibat paparan RGEM dapat terjadi pada lapisan epitel kornea mata yang secara anatomis terletak pada bagian anterior. Kami melakukan penelitian potensi aluminium foil (AF) sebagai perisai terhadap RGEM yang diukur dengan membandingkan ketebalan lapisan epitel kornea mata tikus kelompok kontrol dan perlakuan. Masing-masing tikus dimasukkan ke masing-masing kandang paparan secara terpisah. Sumber paparan RGEM berupa ponsel GSM 2100 (Taiwan) dengan SAR 0,84 – 1,86 W/kg yang tersambung wifi yang diletakkan di bagian bawah setiap kandang paparan tikus dengan paparan 4 jam /hari. Sejumlah 32 tikus dengan usia 2-3 bulan diacak dan dibagi menjadi 4 kelompok. Kelompok kontrol tanpa paparan RGEM terbagi menjadi K1 (tanpa pemberian AF) dan K2 (dengan pemberian AF). Sedangkan kelompok perlakuan yang diberi paparan RGEM terbagi menjadi P1 (tanpa pemberian AF) dan P2 (dengan pemberian AF). Hasil yang didapatkan bahwa kelompok P1 memiliki ketebalan lapisan epitel kornea paling tipis dibandingkan kelompok lainnya, namun secara statistik tidak signifikan (uji Kruskal Wallis; p value 0,147). Dari penelitian ini dapat disimpulkan bahwa, AF kemungkinan dapat menurunkan stres oksidatif yang memicu apoptosis pada lapisan epitel kornea mata dengan proses shielding sumber paparan RGEM.

The use of a Scorecard to Evaluate the Public’s Comprehension of COVID-19: A Pilot Study Kalanjati, Viskasari Pintoko; Hasanatuludhhiyah, Nurina; d'Arqom, Annette; Arsyi, Danial Habri; Permana, Putu Bagus Dharma; Pratiwi, Octaviana Galuh; Farabi, Moh. Reza; Susila, I Made Dwi Yudiartana Putra; Yudhono, Anggit Satriyo; Brilianti, Natasya Nurvita
Jurnal Keperawatan Soedirman Vol 17 No 3 (2022): Jurnal Keperawatan Soedirman (JKS)
Publisher : Fakultas Ilmu-ilmu Kesehatan

The rapid spread of information and infodemic might result in public confusion and hinder the handling of the COVID-19 pandemic. Public comprehension of COVID-19 as part of health literacy is an important determinant to filter hoaxes from facts. Therefore, a scoring card called the Karlivid (the COVID-19 literacy and public vaccination scorecard) was developed to evaluate the individual’s comprehension level of COVID-19. A pilot study was conducted with this scoring card. The participants were recruited via consecutive random sampling by using emails from the researcher’s contact list (n=92). A total of 78.3% of the respondents were considered to have an adequate comprehension level. Approximately 77% of all respondents agreed that this card could help them know their comprehension level, 81.5% agreed that this card could improve their comprehension, 81.5% agreed that the items in this card could help them screen facts from hoaxes, and 81.5% agreed that the language used was easily understood by the laypersons. Therefore, the Karlivid is a valid and reliable scorecard that can be used to evaluate public comprehension of COVID-19. Most of the respondents also had a good level of comprehension of this assigned topic

Co-Authors Abdurachman Abdurachman Abdurachman Abdurachman Abdurachman Aditya, Dwi Martha Nur Akbar, Ghifar Al Muqsith Alfi Amelinda Andi Muh Rahul Alfaidin Andra Rizqiawan Anna Lewi Santoso Annette dÃ¢Â€Â™Arqom, Annette Anung Putri Illahika Arlia Ayu Damayanti Arsyi, Danial Habri Avida Marisa Ilmi Azlin Muhammad Mohd Yasin Balogun, Olubunmi Bambang E. Suwito Bambang E. Suwito Bambang Edi Suwito Brilianti, Natasya Nurvita Damayanti, Arlia Ayu Desy Purwidyastuti Dewi Ratna Sari Dewi Sekarsari Dewi, Arni Kusuma Dion K. Dharmawan Dion Krismashogi Dharmawan Dzanuar Rahmawan Dzanuar Rahmawan Ellen Satya Pratiwi Etha Dini Widiasi Farabi, Moh. Reza Ferdian rizky Hutomo Fidiana H. Hoediyanto Haryanto Alimsardjono HERAWATI, LILIK Hidayaturrahmi, Hidayaturrahmi Ida Lestari Harahap Intan Anggun Pratiwi Irmawan Farindra Irvinia Septarizka Putri Radjamin Iswan Abbas Nusi Jason Lefranda Jocelino Siswanto Jongky H. Prajitno Joni Wahyuhadi, Joni Krisnawan A. Pradana Krisnawan A. Pradana Kurniawaty, Yuni Kusuma E. Purwantari Kusuma Eko Purwantari Lucky Prasetiowati Machin, Abdulloh Made Pury Pratiwi Mahdi, Rayhan B Mahrus A Rahman, Mahrus A Mariana Wahjudi Mayang Rizki Anggraeni Meutia Maulina Nasution, Muhammad Husni Fansury Noer Halimatus Syakdiyah Nurina Hasanatuludhhiyah Oktariza, Rury Tiara Ovin Nada Saputri Pamungkas, Dimas Bathoro Bagus Peppy Nawangsasi Permana, Putu Bagus Dharma Pradana, Krisnawan Andy Prastiya I. Gunawan Prastiya Indra Gunawan Pratiwi, Octaviana Galuh Raden Argarini Rahadian I Susilo Rahmawan, Dzanuar Reza Maulana Rezy R. Melbiarta Rezy Ramawan Melbiarta Rimbun Rimbun Risdiansyah Risdiansyah Rury T. Oktariza Sakina Sakina Soetjipto Soetjipto Susila, I Made Dwi Yudiartana Putra Syamhadi, Maya Rahmayanti Taya Elsa Savista Tirthaningsih, Ni Wajan Visuddho Warda Elmaida Rusdi Wardhana, Teddy Heri Winnie Nirmala Santosa Yudhono, Anggit Satriyo Yusuf Salim Yusuf Salim Zulhabri Othman

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