Viskasari P. Kalanjati
Departemen Anatomi Dan Histologi, Fakultas Kedokteran Universitas Airlangga

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Korelasi Usia dan Jenis Kelamin dengan Angka Kejadian Meningioma Arlia Ayu Damayanti; Viskasari Pintoko Kalanjati; Joni Wahyuhadi
AKSONA Vol. 1 No. 1 (2021): JANUARY 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.656 KB) | DOI: 10.20473/aksona.v1i1.99

Abstract

Pendahuluan: Meningioma merupakan tumor otak primer yang berasal dari jaringan arakhnoid. Angka kejadian meningioma di Indonesia menunjukkan peningkatan dari tahun ke tahun. Selain mutasi gen supresor tumor, meningioma dapat dipengaruhi oleh faktor eksternal diantaranya usia dan jenis kelamin. Tujuan: Mengetahui hubungan antara usia dan jenis kelamin dengan angka kejadian meningioma pada pasien di RSUD Dr. Soetomo, Surabaya, Indonesia tahun 2018 berdasarkan derajat keganasannya. Metode: Penelitian ini merupakan studi observasional analitik cross-sectional retrospektif dari data sekunder lembar hasil pemeriksaan patologi anatomi pasien yang dirawat inap melalui SMF. Ilmu Bedah Saraf, RSUD Dr. Soetomo tahun 2018; data yang tidak lengkap akan dieksklusi. Analisis data dilakukan menggunakan uji Chi squre (SPSS 25) dengan tingkat signifikansi p <0,05. Hasil: Didapatkan 45 pasien meningioma yang sesuai dengan kriteria inklusi, dengan mayoritas perempuan (71%) pada kelompok usia 45 – 49 tahun (22,2%), WHO grade I (82%) dengan tipe histopatologi transisional (49%). Terdapat hubungan yang signifikan antara angka kejadian meningioma dengan kelompok usia tertentu (r = 0,718, p = 0,025), dan dengan jenis kelamin (r = 0,441, p = 0,002). Rasio perempuan dibanding laki- laki sebesar 1:2,36. Kesimpulan: Usia dan jenis kelamin berkorelasi erat dengan angka kejadianmeningioma.
PENGARUH SEKAT ALUMINIUM FOIL TERHADAP RASIO NEURON DAN NEUROGLIA JARINGAN SEREBRI TIKUS WISTAR JANTAN YANG DIBERI PAPARAN RADIASI ELEKTROMAGNETIK Irmawan Farindra; Warda Elmaida Rusdi; Viskasari P Kalanjati; Ni Wajan Tirthaningsih
Biomedika Vol 14, No 2 (2022): Biomedika Agustus 2022
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v14i2.18725

Abstract

ABSTRAK Telepon selular merupakan salah satu sumber radiasi elektromagnetik (EMR). Peningkatan penggunaan telepon selular dapat meningkatkan efek negatif EMR sebagai salah satu penyebab stres oksidatif pada tubuh manusia diantaranya jaringan serebri. Aluminium foil (AF) adalah salah satu bahan yang direkomendasikan untuk melindungi otak dari efek negatif EMR karena memiliki potensi absorption loss and reflective loss. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian sekat AF terhadap EMR dari telepon selular terhadap rasio neuron dan neuroglia pada jaringan serebri tikus Wistar jantan dewasa. Sebanyak 32 ekor tikus jantan dewasa dibagi menjadi 4 kelompok (n=8). Kelompok KI EMR (-) dan AF (-); Kelompok K2 EMR (-) dan AF (+); Kelompok P1 EMR (+) dan AF (-); Kelompok P2 EMR (+) dan AF (+). Telepon selular (GSM 2100 MHz; SAR 0,84-1,86 W/kg) diletakkan di dasar wadah kotak plastik , kemudian dipaparkan 4 jam/ hari selama 30 hari. Data jumlah neuron dan neuroglia tiap kelompok dianalisis dengan tingkat signifikansi p0,05 (uji one way ANOVA, SPSS 17). Dari hasil rasio neuron dan neuroglia didapatkan penurunan rasio pada kelompok perlakuan dibandingkan kontrol, serta peningkatan rasio pada kelompok perlakuan P2 dibandingkan kelompok P1. Hal tersebut membuktikan AF dapat melindungi dari efek negatif EMR dengan meningkatkan jumlah neuroglia sebagai respon proteksi terhadap kerusakan neuron pada jaringan serebri.Kata Kunci: Aluminium Foil, Radiasi Elektromagnetik, Telepon Seluler; Serebri, Neuron, Neuroglia ABSTRACT Cellular phones are a source of electromagnetic radiation (EMR). Increased use of cellular phones, can increase the negative effects of EMR as one of the causes of oxidative stress in the human body, including cerebral tissue. Aluminum foil (AF) is one of the recommended materials as protection against the negative effects of EMR because it has the potential for absorption loss and reflective loss. This study aims to determine the effect of AF blocking on EMR from cellular phones, where the variables studied were the number of neurons and neuroglia, as well as the ratio of neurons and neuroglia in the cerebral tissue of adult male Wistar rats. This study used 32 adult male rats which were divided into 4 groups (n=8). Each mouse was placed in a plastic box container measuring 20x16x9 cm with a wire cover. A cellular phone (GSM 2100 MHz; SAR 0.84-1.86 W/kg) was placed at the bottom of the plastic case and exposed 4 hours/day for 30 days. Data were analyzed with a significance level of p0.05 (Kruskal-Wallis test or ANOVA, SPSS 17). From these results, it is evident that AF can protect against the negative effects of EMR by reducing the effects of oxidative stress by reducing neuronal damage in cerebral tissue.Keywords: Aluminium Foil, Electromagnetic Radiation, Mobile Phone, Brain, Neuron, Neuroglia
Anosmia, Dysgeusia, and Comorbidity in COVID-19 Patients with Respiratory Tract Manifestations Jason Lefranda Jocelino Siswanto; Viskasari Pintoko Kalanjati; Soetjipto Soetjipto; Azlin Muhammad Mohd Yasin
Jurnal Respirasi Vol. 9 No. 3 (2023): September 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.3.2023.188-193

Abstract

Introduction: Olfactory and special sensory disturbances such as anosmia and dysgeusia have been found among COVID-19 patients. These manifestations may cause post-covid sequelae, disturbing patients' quality of life who have recovered from COVID-19. This study aimed to analyze the association between anosmia and dysgeusia with the comorbidities in adult COVID-19 patients admitted to Dr. Soetomo General Hospital, Surabaya, from 1 January 2020 to 30 September 2021. Methods: This was a cross-sectional retrospective analysis study based on the medical records of all patients who met the criteria (n = 158). The minimal age inclusion was 18 years old, and the patient must be positively diagnosed with COVID-19 (reverse transcription polymerase chain reaction/RT-PCR). Results: Out of 158 patients, all had a fever, and approximately 93% of patients showed respiratory signs and symptoms. There were 128 patients (81%) who suffered from anosmia, and 15 patients (9.5%) had dysgeusia. Significant associations were found between anosmia with dysgeusia (p = 0.049) and between anosmia with cough (p = 0.003) and dyspnea (p = 0.000). The predominant comorbidities reported were overweight (60%), hypertension (42%), and type-2 diabetes mellitus (37%). Conclusion: There were significant associations between anosmia with dysgeusia and the respiratory tract signs and symptoms instead of the comorbidities reported.
A Rare Case of Dural Tail Sign in the Patient with Glioblastoma Multiforme: A Case Report Risdiansyah Risdiansyah; Kusuma Eko Purwantari; Viskasari P Kalanjati; Rahadian I Susilo
AKSONA Vol. 3 No. 2 (2023): JULY 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v3i2.46639

Abstract

Highlight: A dural tail sign was found in T1W1-MR-images with contrast of a patient with glioblastoma multiforme. Glioblastoma multiforme as a grade IV malignancy of the astrocytes' glioma, the dura mater can be infiltrated and shown as DTS, although rarely reported.   ABSTRACT Introduction: The dural tail sign (DTS), which is rarely seen in patients with glioblastoma multiforme (GBM), is reported here. This sign is generally found as a manifestation of meningioma due to the reactive changes of the tumor’s invasion. Case: A 61-year-old Javanese man presented with a gradually worsening headache two months prior to hospital admission. He also suffered from paralysis of his right extremities. His complete blood tests and clinical chemistry were within normal limits. A head CT scan showed a large mass near the convexity of the brain in the left parietal lobe, along with edema and a shift of the midline structures to the right. This was confirmed on the T1W1 MR images with contrast, where DTS was clearly shown. Following surgical resection and tumor excision, histopathology analysis revealed GBM with malignant cell infiltration to the dura in the vicinity of the neoplasm. Conclusion: Here we showed a DTS in GBM as a malignant infiltration marker into the dura    
Pengaruh Shielding Aluminium Foil terhadap Perubahan Ketebalan Lapisan Epitel Kornea Akibat Paparan Radiasi Gelombang Elektromagnetik pada Tikus Wistar Jantan Dion K. Dharmawan; Viskasari P. Kalanjati; Abdurachman
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 7 No. 2 (2020): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universi
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v7i2.144

Abstract

Ponsel telah diketahui memancarkan radiasi gelombang elektromagnetik (RGEM) yang digunakan sebagai media dalam telekomunikasi. Dampak buruk akibat paparan RGEM dapat terjadi pada lapisan epitel kornea mata yang secara anatomis terletak pada bagian anterior. Kami melakukan penelitian potensi aluminium foil (AF) sebagai perisai terhadap RGEM yang diukur dengan membandingkan ketebalan lapisan epitel kornea mata tikus kelompok kontrol dan perlakuan. Masing-masing tikus dimasukkan ke masing-masing kandang paparan secara terpisah. Sumber paparan RGEM berupa ponsel GSM 2100 (Taiwan) dengan SAR 0,84 – 1,86 W/kg yang tersambung wifi yang diletakkan di bagian bawah setiap kandang paparan tikus dengan paparan 4 jam /hari. Sejumlah 32 tikus dengan usia 2-3 bulan diacak dan dibagi menjadi 4 kelompok. Kelompok kontrol tanpa paparan RGEM terbagi menjadi K1 (tanpa pemberian AF) dan K2 (dengan pemberian AF). Sedangkan kelompok perlakuan yang diberi paparan RGEM terbagi menjadi P1 (tanpa pemberian AF) dan P2 (dengan pemberian AF). Hasil yang didapatkan bahwa kelompok P1 memiliki ketebalan lapisan epitel kornea paling tipis dibandingkan kelompok lainnya, namun secara statistik tidak signifikan (uji Kruskal Wallis; p value 0,147). Dari penelitian ini dapat disimpulkan bahwa, AF kemungkinan dapat menurunkan stres oksidatif yang memicu apoptosis pada lapisan epitel kornea mata dengan proses shielding sumber paparan RGEM.
The use of a Scorecard to Evaluate the Public’s Comprehension of COVID-19: A Pilot Study Kalanjati, Viskasari Pintoko; Hasanatuludhhiyah, Nurina; d'Arqom, Annette; Arsyi, Danial Habri; Permana, Putu Bagus Dharma; Pratiwi, Octaviana Galuh; Farabi, Moh. Reza; Susila, I Made Dwi Yudiartana Putra; Yudhono, Anggit Satriyo; Brilianti, Natasya Nurvita
Jurnal Keperawatan Soedirman Vol 17 No 3 (2022): Jurnal Keperawatan Soedirman (JKS)
Publisher : Fakultas Ilmu-ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.523 KB) | DOI: 10.20884/1.jks.2022.17.3.6572

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The rapid spread of information and infodemic might result in public confusion and hinder the handling of the COVID-19 pandemic. Public comprehension of COVID-19 as part of health literacy is an important determinant to filter hoaxes from facts. Therefore, a scoring card called the Karlivid (the COVID-19 literacy and public vaccination scorecard) was developed to evaluate the individual’s comprehension level of COVID-19. A pilot study was conducted with this scoring card. The participants were recruited via consecutive random sampling by using emails from the researcher’s contact list (n=92). A total of 78.3% of the respondents were considered to have an adequate comprehension level. Approximately 77% of all respondents agreed that this card could help them know their comprehension level, 81.5% agreed that this card could improve their comprehension, 81.5% agreed that the items in this card could help them screen facts from hoaxes, and 81.5% agreed that the language used was easily understood by the laypersons. Therefore, the Karlivid is a valid and reliable scorecard that can be used to evaluate public comprehension of COVID-19. Most of the respondents also had a good level of comprehension of this assigned topic
SPATIAL MEMORY AND HISTOMORPHOLOGICAL CHANGES INDUCED BY SUBCHRONIC NITROCELLULOSE INHALATION IN MICE: ROLE OF DEXAMETHASONE IN THE CEREBRUM Balogun, Olubunmi; Kalanjati, Viskasari P
The Indonesian Journal of Public Health Vol. 20 No. 1 (2025): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijph.v20i1.2025.29-43

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Introduction: Thinners are toxic substances used as organic solvents. Adolescents (11%) use thinners as inhalants regularly, which is linked to brain damage and learning deficits. This study looked at the effects of thinner inhalation in adult male mice and dexamethasone's anti-inflammatory effects on pyramidal neurons and glia. Aim: To investigate dexamethasone's anti-inflammatory effects on nitrocellulose inhalation. Methods: Forty mice were used; group one served as a control; group two was exposed to 1200ppm nitrocellulose in a whole-body inhalation chamber for 42 days; group three was injected with 2.5mg/kg dexamethasone twice weekly; and group four received nitrocellulose inhalation daily and dexamethasone twice weekly. Neurobehavioral study for learning and memory was conducted before sacrifice. Brains were harvested and processed for histology and biochemical activities of MDA and IL-6. Analysis of data was done using Graphpad Prism 8.4.3 with level of significance at P<0.05. Results: Indices of learning and memory in the nitrocellulose group were reduced escape latency and duration spent in the quadrant but not in the control or dexamethasone group (P=0.009). The MDA and IL-6 levels were higher in the nitrocellulose group compared to control and dexamethasone groups (P=0.02; P=0.03, respectively). Density of pyramidal neurons in layer 5 and 6 was significantly lower in the nitrocellulose treated groups compared to control and dexamethasone (P<0.0001). Conclusion: Dexamethasone reduced neuronal and glial cell damages in the pre-frontal cortex, accompanied with spatial learning and memory improvement.
Cerebellar Purkinje Cells and GABA Neurotransmission in the Diabetic Rodent Models: A Systematic Review Kalanjati, Viskasari P; Mahdi, Rayhan B; Aditya, Dwi Martha Nur
AKSONA Vol. 5 No. 2 (2025): JULY 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v5i2.70359

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Highlight: Reduced cerebellar Purkinje cell numbers and altered dendritic trees due to cell deaths were reported in hyperglycemia.  In hyperglycemia, altered GABAergic neurotransmissions are due to lower GABA synthesis and its receptors expression levels in cerebellum. Impaired motor and cognitive functions were observed related to cerebellar Purkinje cell damage in a diabetic rat model.   ABSTRACT Introduction: Hyperglycemia-induced neurotoxicity has been linked to the cerebellum, specifically the impairment of Purkinje cells; its relation to GABA neurotransmission has yet to be cleared. Objective: We conducted an updated review on the mechanism of hyperglycemia-induced impairment of cerebellar Purkinje cells in a rodent diabetic model. Methods: A modified ScR-PRISMA flow diagram was applied as the screening tool. All English-language research articles published between 2014 and 2024 that containing the purposed topics and were indexed in PubMed and Medline were included. These articles were then critically appraised using the JBI checklist to minimize  potential bias. The final inclusion of 8 articles was included for analysis and discussion, together with additional retrieved articles. Results: Hyperglycemic-induced subjects demonstrated a marked reduction in Purkinje and granular cell populations, accompanied by several morphological impairments. Alterations were observed in GABAergic inhibitory neurotransmission, including receptors and GABA synthesis, compared to controls. These findings are consistent with observed deficits in motor coordination and cerebellar function. Conclusion: Hyperglycemia produces adverse effects on the function and survival of Purkinje cells in the cerebellum. Impaired GABAergic neurotransmission might result as parts of oxidative stress and inflammation induced by hyperglycemia in the cerebellar cells. Taken altogether, these results in motor impairment and cognitive dysfunction.
GABRA6 and SLC6A4 genotypes are correlated with the fasting blood glucose and physical fitness in the seemingly healthy young adults Viskasari P Kalanjati; Mariana Wahjudi; Kusuma E. Purwantari; Visuddho; Peppy Nawangsasi; Rury T. Oktariza; Krisnawan A. Pradana; Dzanuar Rahmawan; Bambang E. Suwito
Jurnal Ners Vol. 18 No. 1 (2023): MARCH 2023
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jn.v18i1.43770

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Introduction: We examined environmental and genetic factors potentially correlated with the blood glucose and physical fitness in Kediri, East Java, Indonesia to elucidate the predominant cardiovascular disease risk. Methods: This was a cross-sectional study on 68 adults aged 18-22 years. Direct interview was conducted to get socio-economy,  daily diets (rice/ R, snacks and sweets/ SS, veggies and fruits/ VF), daily activity (locomotors and non-locomotors) data. Peripheral blood-GABRA6 and SLC6A4 polymorphisms, fasting blood glucose (FBG), blood pressure, 3 fitness parameters (1 min push-up, 3 minutes step up, pulse rate after 3 minutes step-up) were measured by 2 independent and pre-trained medical doctors. Kruskal-Wallis, Chi-Square, and eta-coefficient tests were used to seek differences between genotypes and correlation strength between variables, respectively (significant if p<0.05). Results: Both gene's genotypes showed significant correlations with the FBG (p=0.042, p=0.013, respectively); GABRA6 polymorphism significantly correlated with SU (p=0.033). There was a significant difference in the FBG between 2 VF subgroups (p=0.02). Strongest association was found between FBG and SLC6A4 (η=0.3); PR and GABRA6 (η=0.168), PU and SLC6A4 (η=0.38); SU and Locomotors (η=0.237). Conclusions: In these seemingly healthy young adults, daily diets and the genotypes of both genes have a good association with the FBG and physical fitness levels.
Thumb Arthrodesis in The Arthritis Cases: A Scoping Review Akbar, Ghifar; Kalanjati, Viskasari Pintoko; Wardhana, Teddy Heri
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 13 No. 1 (2024): April 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v13i1.2024.35-40

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Backgrounds: Osteoarthritis in the thumb is a common condition affecting men and women, especially postmenopausal women, causing pain, swelling, and reduced hand function. Arthrodesis is a treatment option for thumb arthritis, increasingly accessible in medical practice, though coverage remains limited. This article aims to review recent case reports on thumb arthrodesis in older people over the last three years, depicting the method's use and outcomes. Methods: After filtering per PRISMA-Sc guidelines on PubMed and the Journal of Hand Surgery (2020-2023), with additional manual filtering, four articles were found and analyzed using the JBI Critical Appraisal Checklist for Case Reports before inclusion. Result: Four case reports related to pollex arthrodesis in the last three years were published in PubMed. These include rare cases of bilateral thumb psoriatic arthritis, a novel surgical approach for nonunion after arthrodesis, and successful fusion using a vascularized bone graft. The limited number of articles may be attributed to the research cycle, shifting focus, and alternative treatments. With increased healthcare access and osteoarthritis prevalence, more people will seek treatment, potentially leading to increased arthrodesis procedures. Opportunities for new research include evaluating surgical techniques, biomaterials, and growth factors to enhance bone healing. Long-term follow-up studies remain crucial for identifying risk factors and improving patient outcomes in thumb arthrodesis. Conclusion: Despite limited research published in the last three years, arthrodesis remains a relevant treatment option for pollex conditions, with rising demand due to increasing osteoarthritis prevalence and healthcare access. Further research on surgical innovations and long-term outcomes is crucial.
Co-Authors Abdurachman Abdurachman Abdurachman Abdurachman Abdurachman Aditya, Dwi Martha Nur Akbar, Ghifar Al Muqsith Alfi Amelinda Andi Muh Rahul Alfaidin Andra Rizqiawan Anna Lewi Santoso Annette d’Arqom, Annette Anung Putri Illahika Arlia Ayu Damayanti Arsyi, Danial Habri Avida Marisa Ilmi Azlin Muhammad Mohd Yasin Balogun, Olubunmi Bambang E. Suwito Bambang E. Suwito Bambang Edi Suwito Brilianti, Natasya Nurvita Damayanti, Arlia Ayu Desy Purwidyastuti Dewi Ratna Sari Dewi Sekarsari Dewi, Arni Kusuma Dion K. Dharmawan Dion Krismashogi Dharmawan Dzanuar Rahmawan Dzanuar Rahmawan Ellen Satya Pratiwi Etha Dini Widiasi Farabi, Moh. Reza Ferdian rizky Hutomo Fidiana H. Hoediyanto Haryanto Alimsardjono HERAWATI, LILIK Hidayaturrahmi, Hidayaturrahmi Hutomo, Ferdian rizky Ida Lestari Harahap Intan Anggun Pratiwi Irmawan Farindra Irvinia Septarizka Putri Radjamin Iswan Abbas Nusi Jason Lefranda Jocelino Siswanto Jongky H. Prajitno Joni Wahyuhadi, Joni Krisnawan A. Pradana Krisnawan A. Pradana Kurniawaty, Yuni Kusuma E. Purwantari Kusuma Eko Purwantari Lucky Prasetiowati Machin, Abdulloh Made Pury Pratiwi Mahdi, Rayhan B Mahrus A Rahman, Mahrus A Mariana Wahjudi Mayang Rizki Anggraeni Melbiarta, Rezy R. Melbiarta, Rezy Ramawan Meutia Maulina Nasution, Muhammad Husni Fansury Noer Halimatus Syakdiyah Nurina Hasanatuludhhiyah Oktariza, Rury Tiara Othman, Zulhabri Ovin Nada Saputri Pamungkas, Dimas Bathoro Bagus Peppy Nawangsasi Permana, Putu Bagus Dharma Pradana, Krisnawan Andy Prajitno, Jongky H. Prastiya I. Gunawan Prastiya Indra Gunawan Pratiwi, Ellen Satya Pratiwi, Octaviana Galuh Raden Argarini Rahadian I Susilo Rahmawan, Dzanuar Reza Maulana Rezy R. Melbiarta Rezy Ramawan Melbiarta Rimbun Rimbun Risdiansyah Risdiansyah Rury T. Oktariza Sakina Sakina Salim, Yusuf Soetjipto Soetjipto Susila, I Made Dwi Yudiartana Putra Syamhadi, Maya Rahmayanti Taya Elsa Savista Tirthaningsih, Ni Wajan Visuddho Warda Elmaida Rusdi Wardhana, Teddy Heri Winnie Nirmala Santosa Yudhono, Anggit Satriyo Yusuf Salim Yusuf Salim Zulhabri Othman