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Djoko Agus Purwanto
Departemen Ilmu Kefarmasian, Fakultas Farmasi Universitas Airlangga, Indonesia
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Aktivitas Antioksidan Teh Hijau dan Teh Hitam Purwanto, Djoko Agus; Wibowo, Nadya Khadijah; Rudyanto, Marcellino
Camellia : Clinical, Pharmaceutical, Analytical and Pharmacy Community Journal Vol 1 No 2 (2022): Camellia (Clinical, Pharmaceutical, Analytical, and Pharmacy Community Journal)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/cam.v1i2.16722

Abstract

Teh adalah minuman terpopuler kedua setelah air putih di dunia. Konsumsi teh hitam di Indonesia lebih banyak dibandingkan teh hijau. Daun teh mengandung antioksidan yang dapat mencegah penyakit degeneratif seperti kanker. Teh hijau memiliki senyawa antioksidan total lebih banyak dibandingkan jenis teh lainnya. Antioksidan dalam teh terutama diperoleh dari senyawa katekin, sehingga semakin tinggi nilai total katekin maka aktivitas antioksidannya semakin besar. Berbeda dengan teh hitam yang mengalami proses fermentasi sebelum dikemas menjadi olahan teh, teh hijau tidak difermentasi. Ulasan ini menegaskan kembali aktivitas antioksidan teh hijau dibandingkan teh hitam berdasarkan total katekin dan nilai IC50 DPPH. Aktivitas antioksidan teh hijau lebih besar dibandingkan teh hitam. Nilai total katekin pada teh hijau lebih besar dibandingkan teh hitam, sedangkan nilai IC50 DPPH pada teh hijau lebih kecil dibandingkan teh hitam. Hasil tinjauan literatur ini merekomendasikan bahwa penelitian lebih lanjut dapat dikembangkan berdasarkan potensi aktivitas teh hijau dan teh hitam
Aktivitas Anti-Mycobacterium tuberculosis Kombinasi (-)-Epigallocatechin-Gallate (EGCG) dan Obat Antituberkulosis Lini Pertama Mirzautika, Anggita; Isnaeni, Isnaeni; Purwanto, Djoko Agus
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 1, FEBRUARI 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i1.1726

Abstract

Tuberculosis is a global health problem, and there is even an increase in cases of multidrug-resistant tuberculosis in the world. Therefore, research is needed that can find new anti-tuberculosis drugs (OAT) that are more effective for tuberculosis treatment. In this study, the effect of (-)-epigallocatechin-gallate (EGCG) of tea leaves (Camellia sinensis) combined with the first-line OAT will be observed, in order to find out whether EGCG has anti-tuberculosis activity and can increase the potential of first-line OAT in-vitro. The anti-tuberculosis activity of EGCG was determined by broth dilution method using Middlebrook 7H9 media at concentration of 50, 100, 150, dan 200 ppm, then the potential of first-line OAT before and after combined with the EGCG was observed. The results showed that the activity of EGCG at concentration 50 ppm and 100 ppm could inhibit the Mycobacterium tuberculosis growth by 80%, at concentration 150 ppm by 90%, and at concentration 200 ppm by 100%. First-line OAT activity before combined with EGCG was ≥ 90% at 5 ppm rifampicin, 0.5 ppm isoniazid, 50 ppm pyrazinamide, and 5 ppm ethambutol. Whereas after combined with EGCG, the potential of each drug increased, marked by anti-tuberculosis activity achieved ≥ 90% at lower concentrations, i.e. rifampicin 0.5 ppm, isoniazid 0.25 ppm, pyrazinamide 20 ppm, and ethambutol 2 ppm. These results indicated that the potential of each first-line OAT increases after being combined with EGCG, and EGCG has potentiation effect when combined with those drugs. In conclusion, EGCG can increase the first-line OAT activity
Pemanfaatan Teh dan Rempah-rempah Khas Indonesia dalam Pemeliharaan Kesehatan Warga di Sumba Timur Menghadapi Pandemi Covid-19: Tea and Indonesian Spices for Improving Health for People in East Sumba for Facing Pandemic COVID-19 Sulistyowaty, Melanny Ika; Purwanto, Djoko Agus; Agil, Mangestuti; Ekowati, Juni; Isadiartuti, Dewi; Hendradi, Esti; Purwitasari, Neny; Yusniasari, Putri Antika
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 4 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i4.7043

Abstract

The coronavirus (SARS-CoV-2) has infected nearly 4 million people worldwide. This virus was first identified in Wuhan, China, in December 2019. Every day positive cases of Covid-19 are increasing in the world. Experts are still trying to find a vaccine to prevent this virus, one of which is by increasing the body's resistance (immunity). The use of family medicinal plants (TOGA) or tea, a drink that we usually drink every day is believed to increase one's body immunity. The content of natural chemicals in tea such as EGCG and curcumin found in the rhizomes have antioxidant activity and is clinically proven to increase a person's immunity.
Drug and cosmetic safety training for cadres of family welfare program Tristiana Erawati; Dewi Melani Hariyadi; Noorma Rosita; Widji Soeratri; Tutiek Purwanti; Hadi Poerwono; Marcellino Rudyanto; Helmy Yusuf; Djoko Agus Purwanto; I Nyoman Wijaya
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol. 9 No. 2 (2024): May 2024
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v9i2.11161

Abstract

In order to increase public understanding and awareness regarding the safety use of drugs and cosmetics, the Community Service Team of the Faculty of Pharmacy, Airlangga University has held community service in Jonggrangan Village, Klaten, Central Java. The community service was carried out on July 31, 2023, with approximately 60 family welfare programs or PKK cadres and health cadres participating through training, presentations, and discussions. The activity began with a pre-test, continued with training, a presentation of the material by three experts, and a discussion, then ended with giving a post-test to the participants. The results of the pre and post-test analysis showed that participants' understanding increased. The results of the analysis of the answers to the 15 questions given showed that the increase in participants' understanding ranged from  2.13-46.02 percent. The impact of these activities on society. The increase in participants' understanding of each topic is not the same depending on the initial understanding. However, the problem is that the level of public understanding after receiving training is still below 50 percent namely on topics about the stages of using cosmetic products and about drug classification. So it is necessary to deepen the material using other strategies (appropriate methods and media).
Uji Iritabilitas Sediaan Kombinasi NLC Ekstrak Teh Hijau dan Asam Alfa-Lipoat: Irritability Test of Combination Preparations of NLC Green Tea Extract and Alpha-Lipoic Acid Afra, Fairuz Yaumil; Soeratri, Widji; Purwanto, Djoko Agus
Jurnal Sains dan Kesehatan Vol. 7 No. 1 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i1.2425

Abstract

Alpha-lipoic acid as a co-antioxidant can increase the effectiveness of green tea extract as antiaging in the NLC system by increasing stability. This research aims to prove that the preparation of NLC green tea extract with alpha-lipoic acid do not irritate the skin. The method used is making an NLC system using High Shear Homogenization with F1 (without alpha-lipoic acid), F2 (1% alpha-lipoic acid) and F3 (1.5% alpha-lipoic acid) which were tested for irritation in vivo using the back skin of mice. Then observations were made to count the number of inflammatory cells and scoring was carried out. The results obtained were that all formulas had a scoring value of 1 (average number of inflammatory cells 8-15) and were categorized as diffuse inflammatory cells with low density because they were below 50 and the sig value. > 0.05 which means the preparation group is the same as normal. In conclusion, all formulas, both F1, F2 and F3, do not cause irritation. Keywords:          NLC, alpha-lipoic acid, green tea extract, antiaging, irritate   Abstrak Asam alfa-lipoat sebagai ko-antioksidan dapat menambah efektivitas ekstrak teh hijau sebagai antiaging dalam sistem NLC dengan meningkatkan stabilitas. Penelitian ini bertujuan membuktikan sediaan NLC ekstrak teh hijau dengan asam alfa-lipoat tidak iritasi pada kulit. Metode yang digunakan yaitu pembuatan sistem NLC menggunakan High Shear Homogenization dengan F1 (tanpa asam alfa-lipoat) , F2 (1% asam alfa -ipoat) dan F3 ( 1,5% asam alfa-lipoat ) yang diuji iritasi secara in vivo dengan menggunakan kulit punggung mencit. Kemudian dilakukan pengamatan menghitung jumlah sel radang dan dilakukan skoring. Hasil yang didapatkan yaitu pada semua formula memiliki nilai skoring 1 (rata-rata jumlah sel radang 8-15) dan masuk kategori sel radang menyebar dengan kepadatan rendah karena dibawah 50 serta nilai sig. > 0,05 yang berarti kelompok sediaan sama dengan normal. Kesimpulan semua formula baik F1 , F2 dan F3 tidak menimbulkan iritasi. Kata Kunci:         NLC, asam alfa lipoat, ekstrak teh hijau, antiaging, iritasi
Pembentukan pojok herbal dan produk herbal (teh dan sirup) untuk meningkatkan kualitas kesehatan masyarakat di Desa Bengkaung, Kecamatan Batulayar, NTB Widyawaruyanti, Aty; Suciati, Suciati; Widiandani, Tri; Hidayati, Agriana Rosmalina; Hafid, Achmad Fuad; Purwanto, Djoko Agus; Purwitasari, Neny; Primaharinastiti, Riesta; Sukardiman, Sukardiman; Widyowati, Retno; Lahardo, Devanus; Ilmi, Hilkatul; Corry, Maylisa Natalia; Wicaksana, Firman; Edhi, Narendrani Sasmitaning; Hasan, Muhammad Amir
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 3 (2025): May
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v9i3.30199

Abstract

Abstrak Desa Bengkaung adalah desa yang terletak di kecamatan Batu Layar, Lombok Barat, Nusa Tenggara Barat.  Banyak potensi pada desa Bengkaung yang masih bisa dikembangkan diantaranya adalah sumber daya alam yang berlimpah. Namun, pemanfaatan sumber daya alam ini belum maksimal, yang disebabkan oleh kurangnya pengetahuan masyarakat mengenai manfaat dan  pengolahannya. Maka dilakukan pengabdian masyarakat yang berlangsung 2 tahap yaitu seminar terkait pojok herbal dan pelatihan pembuatan teh dan sirup dengan bahan kayu manis, kunyit, temu lawak, asam jawa, kapulaga untuk sediaan sirup serta bangle pada sediaan teh herbal yang berfungsi untuk meningkatkan kesehatan masyarakat. Kegiatan tersebut dilaksanakan  pada 25 Oktober 2024 dengan mitra terdiri dari  anggota IAI  kota Mataram dan kader PKK desa Bengkaung. Adapun materi pelatihan diberikan dengan metode ceramah dan metode praktik. Evaluasi dilakukan dengan cara pemberian pre-test dan post-test, kemudian dianalisis secara kuantitatif. Berdasarkan hasil pre-test dan post-test, diperoleh nilai rata-rata sebesar 60,94 dan 79.37, yang menunjukkan adanya peningkatan pengetahuan mitra terhadap materi penyuluhan yang diberikan. Teh daun salam dan JKP-Bangle dievaluasi dengan pengukuran kadar antioksidan dengan DPPH dan FRAP assay. Hasil analisis menunjukkan bahwa kadar antioksidan the daun salam dan JKP-Bangle dengan FRAP assay memperoleh kadar tertinggi tertinggi nilai masing-masing sebesar 1359.84±13.47 mg GAE/g berat kering dan 396.73±16.79 mg GAE/g berat kering. Aktivitas antioksidan yang tinggi ini mengindikasikan potensi manfaat kesehatan dalam menangkal stres oksidatif yang berhubungan dengan penyakit neurodegeneratif, kardiovaskular, dan diabetes. Kata kunci: Desa Bengkaung; pojok herbal; tanaman obat; antioksidan. Abstract Bengkaung Village is a village located in Batu Layar sub-district, West Lombok, West Nusa Tenggara.  There is a lot of potential in Bengkaung Village that can still be developed, including abundant natural resources. However, the utilization of these natural resources has not been maximized, this is caused by a lack of public knowledge regarding their benefits and processing. So community service was carried out which took place in 2 stages, namely seminars related to the herbal corner and training in making tea and syrup using cinnamon, turmeric, ginger, tamarind, cardamom for syrup and bangle preparations, as well as bangles for herbal tea preparations which function to improve health. public. This activity was carried out on 24-26 October 2024 with partners consisting of IAI members from Mataram city and PKK cadres from Bengkaung village. The training material is provided using the lecture method and the Experimental Learning method (direct implementation learning). Evaluation is carried out by giving a pre-test and post-test, then analyzed quantitatively. Based on the results of the pre-test and post-test, an average score of 60.94 and 79.37 was obtained, which indicates an increase in partners' knowledge of the extension material providedrn how to make innovative products from mangosteen fruit so that they can be produced commercially. Thus, in the long term it is expected to increase the income of the Songgon Village residents. Antioxidant levels of bay leaf tea and JKP-Bangle were evaluated using DPPH and FRAP assays. Analysis results showed that the highest antioxidant levels measured by the FRAP assay were 1359.84±13.47 mg GAE/g dry weight for bay leaf tea and 396.73±16.79 mg GAE/g dry weight for JKP-Bangle. This high antioxidant activity indicates potential health benefits in combating oxidative stress associated with neurodegenerative, cardiovascular, and diabetes-related diseases. Keywords: Songgon Village; herbal corner; medicinal plants; antioxidants.
Truck Triangulation as a Strategic Response to Delivery Inefficiencies in Export-Import Operations: A Case Study of a Global Logistics Company in Jakarta Agustina, Indri; Purwanto, Agustinus Hariadi Djoko
International Journal of Social and Management Studies Vol. 6 No. 3 (2025): June 2025
Publisher : IJOSMAS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5555/ijosmas.v6i3.514

Abstract

Logistics inefficiencies, particularly in export-import operations, remain a persistent issue in emerging markets such as Indonesia, where infrastructure constraints and high port congestion exacerbate delivery delays and empty truck returns. Existing strategies often fail to address the combined challenges of route inefficiency, asset underutilization, and lead time variability. This study investigates the effectiveness of Truck Triangulation as a strategic logistics intervention to reduce delivery inefficiencies by optimizing truck routes and fleet utilization in the context of export-import operations at global logistics company in Jakarta. A mixed-methods approach was employed, combining qualitative insights from focus group discussions with logistics managers and operational staff, and quantitative performance data analyzed. The study compared key performance indicators before and after the implementation of truck triangulation, including lead time, fleet turnover, and operational cost. The findings validate Truck Triangulation as an effective, scalable logistics model for export-import operations in infrastructure-constrained markets. This research contributes to practice by demonstrating how lean routing strategies and digital coordination can drive logistics performance and sustainability in emerging economies.
Assessing Project Management Maturity to Enhance the Sustainability and Effectiveness of Digital Transformation Initiatives Yudianingtyas, Deanur; Purwanto, Agustinus Hariadi Djoko
International Journal of Social and Management Studies Vol. 6 No. 5 (2025): October 2025
Publisher : IJOSMAS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5555/ijosmas.v6i5.532

Abstract

Digital transformation has become a strategic agenda for organizations to enhance competitiveness, operational efficiency, and long-term sustainability. However, the success of digital transformation projects largely depends on the effectiveness of project management and the organization’s project management maturity level. This study aims to analyze the maturity level of project management and its role in improving the effectiveness and sustainability of digital transformation projects in PT XYZ, a company in the Indonesian telecommunication sector. A mixed-method approach was applied: qualitative data were obtained through Focus Group Discussions (FGDs) with key stakeholders and analyzed using NVivo software, while quantitative analysis utilized secondary company data related to project performance. Project maturity was assessed using the Project Management Maturity Model (PMMM), supported by CMMI and COBIT 2019 frameworks. The results show that PT XYZ’s maturity level is at 2.4 (repeatable–defined), indicating partially defined but insufficiently standardized processes. Key issues include undocumented baseline scope, reactive cost control, unrealistic schedules, and inconsistent quality assurance practices. The findings highlight that maturity level mediates the relationship between project effectiveness and digital transformation success. The study contributes theoretically by integrating maturity level and sustainable project effectiveness within the digital transformation context, and practically by offering strategic recommendations on process standardization, human resource development, digital tool optimization, cost control, governance, and quality assurance.
Strategic Prioritization of IT Projects to Enhance Banking Operations Efficiency Saribatiara, Saribatiara; Purwanto, Agustinus Hariadi Djoko
International Journal of Indonesian Business Review Vol. 4 No. 2 (2025)
Publisher : Asosiasi Dosen Peneliti Ilmu Ekonomi dan Bisnis Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54099/ijibr.v4i2.1523

Abstract

Purpose – This study aims to develop a strategy for prioritizing information technology (IT) development projects that align with the operational objectives and resource limitations of Bank BRI. Methodology/approach – The research adopts a mixed-methods approach. The Analytical Hierarchy Process (AHP) is employed to determine the priority weight of each IT project based on five key criteria: customer acquisition, service quality, regulatory compliance, product innovation, and operational efficiency. Focus Group Discussions (FGDs) are conducted with key stakeholders to validate findings and identify implementation barriers. Root cause analysis using Why-Why and Fishbone Diagrams is performed to uncover underlying issues in project delays and prioritization gaps. Findings – It was found that projects contributing to increased transactions and customer base receive the highest priority. However, FGD findings reveal that implementation often diverges from analytical priority due to resource constraints, unclear scope, and lack of filtering mechanisms. A set of strategies is proposed to improve project filtering, resource allocation, and inter-unit coordination. Novelty/value – This research introduces an integrated prioritization framework combining AHP with stakeholder validation and root cause analysis, offering a practical approach to IT project governance in banking institutions. The model enhances decision-making beyond weight-based ranking by incorporating real-world constraints and institutional readiness.
SERVICE QUALITY ANALYSIS IN A FREIGHT FORWARDING SERVICE IN JAKARTA USING SERVQUAL AND IMPORTANCE PERFORMANCE METHOD Innisa, Deana Rohali; Purwanto, Agustinus Hariadi Djoko
International Humanities and Applied Science Journal VOLUME 8, ISSUE 1, 2025
Publisher : Universitas Mercu Buana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstract – This study was motivated by sales’ volume decline of imported cargo and customers number of a shipping company in Jakarta (PT.BX) in the last two years. This contradicted with the Ministry of Trade data showing imports increases in that period. Countermeasures have been taken through priced reduction, nevertheless, complaints persist and the decline continues. This quantitative research applied statistical descriptive technique using ServQual and Importance Performance Analysis (IPA) tools. Questionnaire was prepared based on five ServQual dimensions (tangible, reliability, responsiveness, assurance, empathy) detailed to be 25 indicators from which 31 respondents (customers) provided their feedbacks. The reliability test shows that each dimension has a Cronbach alpha above 0.6, indicating that the instrument produces consistent and stable results, making the data reliable. The results of this research showed negative gaps in all ServQual dimensions, with the Reliability dimension having the highest gap (-1.54) and the lowest Empathy dimension (-0.58). The IPA provides results in which seven indicators were identified as priorities for improvement in quadrant I, including adequate parking, sufficient number of staff, simple service procedures, staff ability to provide explanations, staff ability to handle problems, responsiveness in processing complaints, and providing correct answers to customers. In summary, this research confirms operational problems required corrective actions on the prioritized attributes.
Co-Authors A Fahmy Arif Tsani A. Toto Purnomo Abby Rahmat Kamaruzzaman Achmad Fuad Hafid Achmad Toto Poernomo Achmad Toto Purnomo Adecha Ekalipta Primazafira Adi Utarini Afra, Fairuz Yaumil Agustina, Indri Alief Putriana Rahman Anggita Mirzautika Anita Natalia Suryawijaya Asri Darmawati Asri Darmawati Aty Widyawaruyanti Audrey Gracelia Riwu Augustien, Nora Budi Suharjo Budi Wikeko Christina Destri Corry, Maylisa Natalia Devi Eka Juniarti Dewi Isadiartuti Dewi Melani Hariyadi Edhi, Narendrani Sasmitaning Erwin Astha Triyono Esti Hendradi Fairuz Yaumil Afra Fauziyah, Riska Salfa Febri Annuryanti Guniarti Guniarti Guniarti Hadi Poerwono Hadi Suhardjono Hanifah Ridha Rabbani Hasan, Muhammad Amir Heny K Daryanto Herin Mawarti Hidayati, Agriana Rosmalina I Nyoman Wijaya Ilmi, Hilkatul Innisa, Deana Rohali Ira Widjiastuti Isnaeni Isnaeni Isnaeni Iswajuni, Iswajuni Joewono Soeroso Juni Ekowati Jusak Nugraha Jusak Nugraha Kun Ismiyatin Lahardo, Devanus M. Rasjad Indra Mangestuti Agil Marcellino Rudyanto Masruratos Zahroh Melanny Ika Sulistyowaty Mirzautika, Anggita Muhammad Amin Muslihatin, Wirda Noorma Rosita Nora Augustien Pribadi, Didik Huswo Purwaningsih - Purwitasari, Neny Retno Pudji Rahayu Retno Widyowati Riesta Primaharinastiti Riesta Primaharinastiti, Riesta Rufaidah Azzahrah Saribatiara, Saribatiara Setyabudi Setyabudi Soraya Aulia Sri Iswati Suciati Suciati Sukardiman Susetyowati Susilowati Susilowati Sutini Tiara Sukmawati Toto Sudargo Tri Widiandani Tristiana Erawati Tutiek Purwanti Ujang Sumarwan Wibowo, Nadya Khadijah Wicaksana, Firman Widiwurjani Widji Soeratri Widji Soeratri Yayuk Hartriyanti Yudianingtyas, Deanur Yusniasari, Putri Antika Yusuf, Helmy