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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN MEDIA MEDIKA INDONESIANA JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Nutrition College Jurnal Biotek Medisiana Indonesia Medical Journal of Indonesia Jurnal Kesehatan The Indonesian Biomedical Journal Media Medika Muda Medica Hospitalia Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) World Nutrition Journal Medica Arteriana (Med-Art) Indonesian Journal of Applied Research (IJAR) Diponegoro International Medical Journal (DIMJ) Jurnal Kesehatan dr. Soebandi
Banundari Rachmawati
Department Of Clinical Pathology, Faculty Of Medicine, Universitas Diponegoro, Semarang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Environmental Science Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Jurnal Kesehatan

 1 
PENGARUH PEMBERIAN Zn TERHADAP KADAR GLUKOSA DARAH DAN KADAR SUPEROKSIDA DISMUTASE PADA TIKUS WISTAR YANG DIINDUKSI STREPTOZOTOCIN Kartika, Nadini; Rachmawati, Banundari; Johan, Andrew
Jurnal Kesehatan Vol 9, No 1 (2016): Jurnal Kesehatan
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jurkes.v9i1.3410

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Giving Zn could reduce the reactivity of ROS due to hyperglycemia by increasing SOD status. Zinc ability as an antioxidant also can improve blood glucose level in diabetes mellitus patients. To prove the effect of Zn with the doses of 3 mg/kg BW and 5 mg/kg BW for 30 days onblood glucose and SOD levels in Wistar rats induced by STZ. Twenty-eight rats were divided into 4 groups includes K1 as a negative control group, K2 as a positive control group that is induced by STZ 40 mg/kg BW, K3 as? group that is induced by STZ 40 mg/kg BW and Zn were given at a dose of 3 mg/kg BW for 30 days orally and K4 as aa group that is induced by STZ 40 mg/kg BW and Zn were given at a dose of 5 mg/kg BW for 30 days orally. Examination of blood glucose levels used GODPAP methods and SOD levels checked with a colorimeter method. Data were analyzed using Paired T-Testsand Wilcoxon tests. There was a significant decrease in blood glucose levels after administration of 3 mg/kg BW Zn (p = 0,003) and 5 mg/kg BW (p = 0.018) for 30 days in Wistar rats induced by STZ. There was no significant increase in SOD levels after administration of 3 mg/kg BW Zn (p = 0,120) but a significant increase in SOD levels after administration of 5 mg/kg BW Zn (p = 0,038) for 30 days in Wistar rats induced by STZ. Administration of 5 mg/kg BW Zn for 30 days showed a better effect on blood glucose and SOD levels in Wistar rats induced by STZ when compared with administration of 3 mg/kg BW Zn.
PENGARUH PEMBERIAN Zn TERHADAP KADAR GLUKOSA DARAH DAN KADAR SUPEROKSIDA DISMUTASE PADA TIKUS WISTAR YANG DIINDUKSI STREPTOZOTOCIN Nadini Kartika; Banundari Rachmawati; Andrew Johan
Jurnal Kesehatan Vol 9, No 1 (2016): Jurnal Kesehatan
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jk.v9i1.3410

Abstract

Co-Authors Agung Aji Prasetyo, Agung Aji Ahmad Reza Ajoekesoema, Tanti Andreas Arie Setiawan Andrew Johan Aryu Candra Asri Ragil Kemuning Asti, Herniah Basti Andriyoko Budi Mulyono Corrie Abednego Crisdayani, Carissa Putri Cynthia Citra Darmono SS Devi Ermawati Dian Widyaningrum Dian Widyaningrum Djuara P Lubis Driyah, Srilaning Dwi Retnoningrum Dwi Retnoningrum Edi Dharmana Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Edwin Basyar Elida Soviana Febe Christianto Fifin Luthfia Rahmi Hardhono Susanto Herniah Asti Wulanjani Hertanto Wahyu Subagio Ida Parwati Ignatius Riwanto, Ignatius Indranila Kustarini Samsuria Indriani Silvia Innawati Jusup Kartika, Nadini Kurniawati, Dewi M Lestari, Sarah Syifa Lisyani Budipardigdo Suromo Luciana Sutanto Lusiana Batubara Mabruratussania Maherdika Mahmudah Hidayati Meita Hendrianingtyas Meita Hendrianingtyas Melkior Krisna Arondaya MI Diah P Mila Niqi Itami Muchlis Ahsan Udji Sofro Muh Agus Barliyan Muji Rahayu Nadini Kartika Niken Puruhita Novita Indayanie Novitasari, Sherly Nyoman Suci Widyastiti Permatasari, Narulita Dyah Prihartiwi Purnamasari Probosuseno Probosuseno, Probosuseno Purnama, Yugi Hari Chandra Purwanto AP Putri Theresia LA Bancin Resty Ryadinency Retnaningsih - Ria Triwardhani Riansari, Anugrah Riwanto Samsuria, Indranila K Sanjaya Santoso Santoso Jaeri Santoso Jaeri Setiawan L, Edward Kurnia Soeharyo Hadisaputro Sofyan Harahap Subandhini Arika Pradati Suhartono, Suhartono Suharyo Hadisaputro Sukartini, Ninik Sulistiana Jhon Desel Surohadi, Natra D. Syaravina, Elita Theresia Ilyan Tjokorda Gde Dalem Pemayun Tri Indah Winarni Tri N. Kristina, Tri N. Triwardhani, Ria Tulaar, Angela B. M. Wardhani, Avriana Pety Wibisono, Agoes Wicaksono, Maulana Akbar Wicaksono, Muhammad Agung Wibowo Yenny Yulianti Yoanita Pratiwi Budiwiyono Yuswo Supatmo