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All Journal BIOEDUKASI JURNAL PENDIDIKAN TAMBUSAI Journal on Education EDUKATIF : JURNAL ILMU PENDIDIKAN Jurnal Review Pendidikan dan Pengajaran (JRPP) Biopendix: Jurnal Biologi, Pendidikan dan Terapan Majalah Ilmiah Warta Dharmawangsa Best Journal (Biology Education, Sains and Technology) JURNAL ILMIAH SIMANTEK JURNAL PENDIDIKAN, SAINS DAN TEKNOLOGI Pedagogika : Jurnal Pedagogik dan Dinamika Pendidikan Jurnal Penelitian, Pendidikan dan Pengajaran: JPPP INTELEKTIUM SECONDARY : Jurnal Inovasi Pendidikan Menengah (JIPM) LEARNING : Jurnal Inovasi Penelitian Pendidikan dan Pembelajaran EDUTECH : Jurnal Inovasi Pendidikan Berbantuan Teknologi Jurnal Minda Indo-MathEdu Intellectuals Journal J-KIP (Jurnal Keguruan dan Ilmu Pendidikan) International Journal of Humanities Education and Social Sciences Emasains : Jurnal Edukasi Matematika dan Sains Indonesian Research Journal on Education Educativo: Jurnal Pendidikan Madani: Multidisciplinary Scientific Journal Journal of Community Service (JCOS) Tuhenori: Jurnal Ilmiah Multidisiplin EDUCATIONAL: Jurnal Inovasi Pendidikan dan Pengajaran Edumaspul: Jurnal Pendidikan
Novelina Andriani Zega
Universitas Nias
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Indo-MathEdu Intellectuals Journal

 1 
Potensi Mikroba Asal Tanah Hutan dan Limbah Organik sebagai Produsen Amilase, Lipase, dan Selulase untuk Aplikasi Industri Telaumbanua, Jun Mardin; Bate’e, Riston Iman; Hulu, Adil Hati; Waruwu, Linda Fatmawati; Zega, Novelina Andriani
Indo-MathEdu Intellectuals Journal Vol. 7 No. 1 (2026): Indo-MathEdu Intellectuals Journal (In-Press)
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v7i1.4882

Abstract

Hydrolytic enzymes such as amylase, lipase, and cellulase play a strategic role in various modern industrial sectors. Microorganisms isolated from forest soil and organic waste exhibit high enzyme production capabilities due to their ecological adaptation to complex substrates. This literature review examines the potential of local Indonesian microbes as a source of industrial enzymes through a systematic analysis of national research conducted during the 2015–2024 period. This study applies data analysis techniques including data reduction, data presentation, and conclusion drawing to synthesize the findings. Indonesian tropical forest soils harbor a diversity of enzyme-producing microbes with varying specific activities. Organic waste such as bagasse and fruit peels provide habitats for microbes capable of producing extracellular enzymes. The results of the literature synthesis indicate that bacterial and fungal isolates from both sources have commercial prospects for applications in the food, textile, bioenergy, and bioremediation industries. Optimizing culture conditions and large-scale production strategies are key to the successful utilization of local microbes. This study provides recommendations for further research leading to the industrialization of Indonesian microbe-based enzymes.
Identifikasi Pola Miskonsepsi Siswa pada Konsep Bioteknologi Modern dan Konvensional serta Strategi Remediasinya: Sebuah Tinjauan Literatur Gea, Sehati; Halawa, Desheriasti; Zai, Masleni; Nazara, Sudieli; Zega, Novelina Andriani
Indo-MathEdu Intellectuals Journal Vol. 7 No. 1 (2026): Indo-MathEdu Intellectuals Journal (In-Press)
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v7i1.5022

Abstract

Biotechnology education in secondary schools and universities still faces challenges in the form of high levels of student misconceptions, mainly due to the abstract nature of the material and the rapid development of technology. This study aims to identify common misconceptions in conventional and modern biotechnology material and analyse effective remediation strategies based on previous research findings. The research method used is a systematic literature review, through searching and analysing nationally and internationally accredited journal articles published between 2015 and 2025. The articles analysed were selected based on topic relevance, methodological quality, and relevance of findings. The results of the study show that the most dominant misconceptions arise in the understanding of the concept of anaerobic fermentation, the difference between cloning and IVF, and the impact of genetically modified organisms (GMOs). Remediation strategies that have proven effective include the use of Conceptual Change Text, the application of the Socio-Scientific Issues (SSI) approach, and the use of virtual laboratory simulations to help students reconstruct their understanding of concepts more accurately.
Pemanfaatan Bioteknologi dalam Peningkatan Produktivitas, Kualitas, dan Ketahanan Tanaman Pangan untuk Mendukung Pertanian Berkelanjutan Lase, Nofeberius; Lahagu, Albertus; Harefa, Lindawati; Lase, Cindri; Zalukhu, Agneris; Zega, Novelina Andriani
Indo-MathEdu Intellectuals Journal Vol. 7 No. 1 (2026): Indo-MathEdu Intellectuals Journal (In-Press)
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v7i1.5026

Abstract

This study aims to examine the role of agricultural biotechnology in improving the productivity, quality, and resilience of food crops as an effort to support sustainable agriculture. The method used is a systematic literature review of relevant national and international journal articles published between 2014 and 2025. The literature was analysed descriptively by grouping the findings based on aspects of increased productivity, crop quality, and crop resistance to biotic and abiotic stresses. The results of the analysis show that the application of biotechnology, such as genetic engineering through CRISPR-Cas9 and Agrobacterium transformation, tissue culture, and the use of functional microorganisms such as PGPR and mycorrhiza, has been proven to increase crop yields, improve nutritional content through biofortification, and increase crop resistance to pests, diseases, and environmental stress. These findings confirm that biotechnology has a significant contribution in producing superior plant varieties that are more adaptive and environmentally friendly. Thus, the integration of biotechnology into agricultural systems has the potential to become an important strategy in supporting food security and sustainable agricultural development.
Peran Kecerdasan Buatan dalam Percepatan Penemuan Obat: Analisis Integrasi AI pada Pengembangan Terapi Target untuk Penyakit Degeneratif Gea, Yusmori Isra; Gulo, Joycellin Gabriela; Telaumbanua, Angeli Valentina; Harefa, Jenni Putri; Gulo, Fantasi Iman; Zega, Novelina Andriani
Indo-MathEdu Intellectuals Journal Vol. 7 No. 1 (2026): Indo-MathEdu Intellectuals Journal (In-Press)
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v7i1.5030

Abstract

Degenerative diseases, such as Alzheimer's, Parkinson's, diabetes, and cardiovascular disease, are global health problems with increasing prevalence and economic burden. This study aims to analyse the role of Artificial Intelligence (AI) in accelerating the drug discovery process, particularly in the development of targeted therapies for degenerative diseases. The research method used is a systematic literature review of national and international journal articles published between 2019 and 2024. The data were analysed qualitatively by examining the contribution of AI at various stages of drug discovery. The results of the study show that AI plays a significant role in molecular target identification, virtual screening, drug repurposing, and drug candidate optimisation, with a prediction accuracy rate ranging from 70–85%. The application of AI is reported to reduce drug discovery time by approximately 50% and development costs by up to 40%. The conclusions of this study confirm that AI is a strategic tool in modern pharmaceutical biotechnology development, although its implementation still requires further experimental validation, standardisation, and adequate data availability, particularly in the context of drug development in Indonesia
Optimasi Produksi Bioetanol dari Limbah Kulit Pisang Melalui Variasi Waktu Fermentasi Menggunakan Saccharomyces Cerevisiae Lahagu, Analisi; Zai, Mitra Semestriani; Lawolo, Riniat; Gulo, Piderman; Waruwu, Yuri; Zega, Novelina Andriani
Indo-MathEdu Intellectuals Journal Vol. 7 No. 1 (2026): Indo-MathEdu Intellectuals Journal (In-Press)
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v7i1.5037

Abstract

This study aims to determine the effect of fermentation duration on the bioethanol yield and to determine the optimal fermentation time using Saccharomyces cerevisiae yeast. The research method involved several main stages: preparation of banana peel samples, acid hydrolysis (using H₂SO₄) to convert polysaccharides into glucose, and anaerobic fermentation. The fermentation times used in this study were 3, 5, 7, and 9 days with a constant concentration of Saccharomyces cerevisiae inoculum. The bioethanol content was measured using a distillation method followed by alcohol content measurement using an alcohol meter or gas chromatography (GC). The results showed that fermentation time had a significant effect on the bioethanol yield. The bioethanol content increased until it reached an optimal point on the 5th day (or adjust according to your data) with a content of ...%, and tended to decrease at longer fermentation times due to the depletion of nutrients in the medium and the accumulation of by-products that inhibited yeast growth. Based on these results, it can be concluded that banana peel waste is effective for use as a bioethanol substrate with an optimal fermentation time of 5 days.
Peran Enzim Amilase pada Tahapan Produksi Sirup Glukosa: Studi Literatur Waruwu, Sela Marselina; Halawa, Kadini Kurniawati; Gulo, Desta Mawati; Lase, Setiawan; Zega, Novelina Andriani
Indo-MathEdu Intellectuals Journal Vol. 7 No. 1 (2026): Indo-MathEdu Intellectuals Journal (In-Press)
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v7i1.5038

Abstract

Glucose syrup is a product of starch hydrolysis that is widely used in the food industry and other industrial sectors. Currently, the production of glucose syrup is predominantly carried out through enzymatic processes due to their higher efficiency and environmental friendliness. Amylase enzymes play a crucial role in converting starch into simple sugars. This study aims to describe the role of amylase enzymes at each stage of glucose syrup production based on a literature review. The research method employed is descriptive research using a literature study approach, involving data collection from scientific journals, books, and other relevant literature sources. The data were qualitatively analyzed by examining the function of amylase enzymes during the liquefaction and saccharification stages. The results of the review indicate that α-amylase plays a role in the liquefaction stage by breaking down starch into dextrins, while glucoamylase functions in the saccharification stage by converting dextrins into glucose. The use of amylase enzymes can enhance process efficiency and produce glucose syrup with a higher glucose content. Therefore, amylase enzymes play an essential role in determining the success of enzymatic glucose syrup production.  
Pemanfaatan Bioteknologi Konvensional dalam Pengolahan Limbah Organik Rumah Tangga Halawa, Tektonius; Halawa, Meiman; Baeha, Anggun Marfirah; Daeli, Dirikan Hati; Waruwu, Antorius; Zega, Novelina Andriani
Indo-MathEdu Intellectuals Journal Vol. 7 No. 1 (2026): Indo-MathEdu Intellectuals Journal (In-Press)
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v7i1.5039

Abstract

The largest contributor to waste generation in Indonesia comes from household organic waste, which has the potential to pollute the environment if not managed properly. Conventional biotechnology utilises the activity of natural microorganisms to process organic waste into useful products, making it a relatively simple and easy-to-implement alternative for household waste management. This article aims to review various methods of domestic organic waste treatment based on conventional biotechnology. The method used is a literature study of relevant research results and scientific publications. The results of the study show that composting, liquid organic fertiliser production, and eco-enzyme production are effective methods in reducing the volume of household organic waste. Microorganisms such as Lactobacillus sp. and decomposing fungi play an important role in converting organic waste into nutrients for plants and natural cleaning fluids. Based on these results, it can be concluded that the application of conventional biotechnology has the potential to support sustainable household organic waste management while reducing the impact of environmental pollution.
Analisis Efisiensi Fermentasi Tempeh Antara Metode Tradisional dan Modern Nazara, Agustiaman; Zebua, Putri Berlian; Lase, Suci Hati; Zega, Listen Arahan; Lase, Lilis Febrika Putri; Zega, Novelina Andriani
Indo-MathEdu Intellectuals Journal Vol. 7 No. 1 (2026): Indo-MathEdu Intellectuals Journal (In-Press)
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v7i1.5044

Abstract

This study aims to analyse the comparison of tempeh fermentation efficiency between traditional methods and modern methods based on fermentation parameter control. The research method used was a systematic literature review of 23 accredited national journal articles indexed by SINTA and published between 2013 and 2024. Articles were selected based on inclusion criteria covering discussions on fermentation parameters, tempeh product quality, and fermentation method comparisons. Data were analysed descriptively and comparatively by examining aspects of fermentation time, quality consistency, product yield, and microbial contamination levels. The results of the study show that modern fermentation methods that apply temperature control and the use of standardised starters can shorten fermentation time by 18–24% compared to traditional methods. In addition, modern methods produce better quality consistency, as indicated by lower protein content and texture variation. Product yield also increased by 12–15%, accompanied by lower levels of pathogenic microbial contamination. These findings indicate that the application of modern fermentation methods has the potential to improve the efficiency and quality of tempeh production and can be a relevant alternative for the development of small and medium-scale tempeh industries without eliminating local food characteristics.  
Perspektif Bioetika Terhadap Penggunaan Data Genomik dalam Riset Personalized Medicine Telaumbanua, Titi Krisnawati; Zega, Perlindungan; Waruwu, Jernih Puspita Sari; Zega, Novelina Andriani
Indo-MathEdu Intellectuals Journal Vol. 7 No. 1 (2026): Indo-MathEdu Intellectuals Journal (In-Press)
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/imeij.v7i1.5046

Abstract

Advances in genome sequencing technology have opened significant opportunities for the development of personalized medicine, but have also given rise to ethical complexities that require in-depth study. This study aims to identify and analyze key bioethical issues arising from the use of genomic data for personalized medicine research through a critical-normative literature review. A thematic analysis of the selected literature identified four key bioethical domains: autonomy and informed consent in the context of complex genomic data, privacy and data security facing the risks of leaks and misuse, fairness in access to genomic services, and the potential for genetic discrimination. Findings indicate that implementing the principle of autonomy faces technical challenges in conveying comprehensible information, while privacy issues require inadequate regulatory frameworks in many countries. Genetic discrimination in the context of insurance and employment poses a real threat that requires explicit legal protection. This study recommends the development of an integrative bioethical framework that connects classical ethical principles with the realities of genomic technology, strengthening genomic data protection regulations, and adapting informed consent mechanisms. Policy implications include the urgency of harmonizing regulations across countries and strengthening the capacity of research ethics committees to evaluate genomic research protocols
Co-Authors Asni Junita Zega Baeha, Anggun Marfirah Bate’e, Riston Iman Daeli, Dirikan Hati Dalifati Ziliwu Dedi Susanti Mendrofa Desman Telaumbanua Desman Telaumbanua Dohona, Siska Tri Sintia Elsaria Zendrato EMANUEL ZEBUA Gea, Deswan Gea, Juwita Kristiani Gea, Kristin Mintaria Gea, Sehati GEA, SEPI FITA SARI Gea, Yusmori Isra Gulo, Denika Gulo, Desta Mawati Gulo, Fantasi Iman Gulo, Jovial Vince Hasrat Gulo, Joycellin Gabriela Gulo, Margaret Mesra Wati GULO, NESTIN WANTALENTA Gulo, Piderman GULO, REMILIANTI Halawa, Desheriasti Halawa, Erik Arisman Halawa, Kadini Kurniawati Halawa, Meiman Halawa, Tektonius Halawa, Wa’adil Hardikupatu Gulo Hardikupatu Gulo HAREFA , AGNES RENOSTINI Harefa, Agnes Renostini Harefa, Alirwan Forniat Harefa, Angel Renostini Harefa, Enjel Otniat Putri Harefa, Gita Claresta Evelyn Harefa, Jenni Putri Harefa, Kasih Putri Harefa, Lindawati Harefa, Winndy Adian Sari Hartanilah Zalukhu Hia, Efori Hia, Jun Mestika Fati Hulu, Adil Hati Hulu, Debi Rebeka Hulu, Kharisman Hulu, Lisna Dewita HULU, TRIS DESNIAT NATALIA Hulu, Yoren Oktariani Ibefati Zai Kharisman Alfandi Laoli Lahagu, Albertus Lahagu, Analisi Lahagu, Aperius Lahagu, Jelinus Lahagu, Kensi Agnes Sofyanti LAIA, AGUSTINA MARNATA Laoly , Li Isatri Lase, Cindri Lase, Destalena Libertini Lase, Lilis Febrika Putri Lase, Nofeberius Lase, Setiawan Lase, Suci Hati Lawolo, Riniat Maruhawa, Ismi Andani Masalena Harefa Mei Putra Telaumbanua Mendrofa, Desinurani Miseri Cordias Zega Moriani Tafonao Natalia Kristiani Lase Natalia Kristiani Lase, Natalia Kristiani Nathanael Sitanggang Nazara, Agustiaman Nazara, Melvan Nastuti Nazara, Sudieli Ndraha, Fita Kritiani Ndruru, Trisnawati Nikolas Folfin Daeli Noperiusman Gea Orderzil Orderzil ROHMAT POLINUS ZILIWU Sokhizaro Hulu SUDARMAN ZEBUA Sudiria Harefa Telaumbanua, Angeli Valentina Telaumbanua, Faustus Telaumbanua, Jun Mardin Telaumbanua, Titi Krisnawati Telaumbanua, Yovita Florentina Waruwu, Antorius Waruwu, Astri Purna Wati Waruwu, Jernih Puspita Sari Waruwu, Linda Fatmawati Waruwu, Sela Marselina Waruwu, Toroziduhu Waruwu, Yaredi Waruwu, Yuri Yaredi Waruwu Yertamina Waruwu Zai, Masleni Zai, Mitra Semestriani Zalukhu, Agneris Zebua, Abertina Zebua, Fitri Arni Zebua, Putri Berlian ZEGA, BOY RICARDO Zega, Listen Arahan Zega, Otanius Zega, Perlindungan