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All Journal International Journal of Integrated Health Sciences The Indonesian Journal of Infectious Diseases Jurnal Respirologi Indonesia Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Respiratory Science Narra J Malang Respiratory Journal Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Ophthalmologica Indonesiana Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Erlina Burhan
Departemen Pulmonologi Dan Kedokteran Respirasi Fakultas Kedokteran Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : Malang Respiratory Journal

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Chronic Obstructive Pulmonary Disease Exacerbation Complicated with Pneumonia and Lung Cancer: An Evidence-based Case Report of Erdosteine Role in the Management of Complex COPD Ilham, Ahmad Fadhil; Rakasiwi, Muhammad Ilham Dhiya; Felim, Ris Raihan; Arfan, Ahmad; Burhan, Erlina
Malang Respiratory Journal Vol. 6 No. 2 (2024): September 2024
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2024.006.02.05

Abstract

Background: Acute exacerbations of chronic obstructive pulmonary disease (COPD) are strongly associated with poor health status and morbidity. Erdosteine is a mucolytic agent that also has anti-inflammatory, antioxidant and antibacterial effects. This case report aims to evaluate the role of erdosteine in the prevention and treatment of acute exacerbations of complex COPD case. Case: A 73-year-old male arrived at the emergency department with an increased difficulty in breathing that had deteriorated over the previous 5 days, and had a history of heavy smoking for more than 40 years. Following a thorough examination, he was diagnosed with acute exacerbation of COPD (Anthonisen criteria type 2) in clinical group E, pneumonia, along with stage IIIA right lung tumor (T4N1Mx), and received erdosteine inhalation as part of his treatment. Discussion: A comprehensive search of journal databases (PubMed, EMBASE, CENTRAL, EBSCO Medline, Scopus, and ProQuest) was conducted using specific keywords, critical appraisal based on the Oxford Center for Evidence-Based Medicine. Article selection resulted in 1 systematic review article for the prevention of acute exacerbations and 1 systematic review article for the management of acute exacerbations of COPD. In patients with stable COPD, administration of erdosteine in the standard COPD regimen significantly reduced the risk of exacerbations (RR=0.65; p=0.01), while in patients with acute exacerbations of COPD, erdosteine increased treatment success (OR=3.2; p<0.0001). Conclusion: Erdosteine may serve as a therapeutic choice for COPD patients in preventing or managing acute exacerbations.
Co-Authors - Afrizal A. M. Jayusman Adang Bachtiar Adyasiwi, Galoeh Afladhia, Hanna L. Agus Dwi Susanto Agustin, Heidi Agustin, Heidy Akbar, Fadhian Andini, Salsabila R. Aniwidyaningsih, Wahju Anna Rozaliyani Anwar Jusuf Anwar Jusuf Arfan, Ahmad Aria Kekalih Arief Riadi Arifin Arifin Nawas Arifin Nawas Arifin, Arief Riadi Aristyo, Kevin Ary Indriana Savitri Asri C. Adisasmita Aufa, Akhdan Azzumar, Farchan Bahri, Syukrini Bahtiar Husain Bambang Dwi Hasto Baskoro, Hario Budhi Antariksa Budi Haryanto Budi Prasetyo Budi Prasetyo Budiman Bintang Prakoso Dahlan, Muhammad Sopiyudin Dewi Yennita Sari Diah Handayani Diah Handayani Dwi Rendra Hadi Eddy Suratman Elisna Syahruddin Elsye Souvriyanti, Elsye Erlina, Andi Fasli Jalal Felim, Ris Raihan Ferian, Muhammad Farel Findra Setianingrum Firdawati, Firdawati Gusnanto, Arief Gustya, Gita Fajri Hario Baskoro Hasibuan, Thariq Emyl Taufik Hasto, Bambang Dwi Henie Widowati Hera Afidjati Husain, Bahtiar Ibrahim Nur Insan Putra Darmawan Ilham, Ahmad F. Ilham, Ahmad Fadhil Indra Kusuma Isbaniah, Fathiyah Jaka Pradipta Jendrius Jendrius Kartikawati, Falah Kurniawan, Gerry Mega Juliana Mega Juliana Menaldi Rasmin Mirza Purwitasari Mohamad Fahmi Alatas Muchtiar, Mulyadi Muhamad Sidik Muhammad Alkaff Muhammad Ikhsan Mokoagow MUHAMMAD TAUFIK Nalapraya , Widhy Yudistira Noorwati Sutandyo Nugraha, Darrin Ananda Pangestu, Hendri Priyanti Z. Soepandi Priyanti ZS Putra, Andika Chandra Putri Suci Ramadhany Rahardjo, Tri Apriliawan Bendarto Rahmad Gurusinga Rakasiwi, Muhammad ID. Rakasiwi, Muhammad Ilham Dhiya Rifqatussaadah, Rifqatussaadah Rika Bur Rika Yuliwulandari Rima Semiarty Ririen Razika Ramdhani Rita Rogayah Rizanda Machmud Samoedro, Erlang Saputra, Tetra Arya Sari, Adistya Sariasih Arumdati Satria Pratama Satria Pratama Satria Pratama Savitri, Ary Indriana Soehardiman, Dicky Syntia Nusanti Taufik, Feni Fitriani Tika Dwi Tama Tjandra Yoga Aditama Triya Damayanti Triya Damayanti Tugas Ratmono Tugas Ratmono, Tugas Utomo, Ahmad Rusdan H Wandawa, Azlina D Wardoyo, Muhammad Prasetio Widjanantie, Siti Chandra Yasmina Hanifah Yasmina Hanifah Yulia Suciati Zaini, Jamal