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All Journal Smart Medical Journal Jurnal Respirologi Indonesia Majalah Kedokteran Andalas Jurnal Respirasi (JR) Health and Medical Journal Indian Journal of Forensic Medicine & Toxicology Respiratory Science Cermin Dunia Kedokteran Jurnal Epidemiologi Kesehatan Indonesia
Putra, Andika Chandra
Departemen Pulmonologi Dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Indonesia-RSUP Persahabatan, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Evaluation of Mortality Risk Factors of COVID-19 in Jakarta Tertiary Hospital During Peak of Second Wave and Predictive Utility of Community RT-PCR Low CT Values Putra, Andika Chandra; Burhan, Erlina; Aufa, Akhdan; Bur, Rika; Pangestu, Hendri; Bahri, Syukrini; Souvriyanti, Elsye; Muchtiar, Mulyadi; Erlina, Andi; Aditama, Tjandra Yoga; Yuliwulandari, Rika; Kusuma, Indra; Suciati, Yulia; Rifqatussaadah, Rifqatussaadah; Jalal, Fasli; Gusnanto, Arief; Utomo, Ahmad Rusdan H
Respiratory Science Vol. 4 No. 2 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i2.133

Abstract

Background: The Delta variant of SARS-CoV-2 led to a surge in COVID-19 cases in Indonesia. This study aimed to assess the demographic profile and mortality rates of hospitalized COVID-19 patients in YARSI referral hospital, Jakarta, comparing pre-Delta and Delta wave periods. The study also investigated whether low CT values in RT-PCR tests indicated heightened viral transmission before the Delta wave surge. Method: A retrospective analysis was conducted on 1,457 COVID-19 patients hospitalized at YARSI (January-August 2021) and 25,279 RT-PCR test results from walk-in patients (April-August 17, 2021). Differences were evaluated using Chi-square or Fisher’s Exact Tests while binary logistic regression was used to assess mortality risk factors. Results: There were increased proportions of pregnant women, patients aged 20-29 and those with coronary artery disease during the Delta wave. This period also showed a significant increase in mortality rates, with the highest seen in patients >60 years old or those with multiple comorbidities. Notably, most of the deceased patients (131 of 139) were unvaccinated. Analysis of RT-PCR data showed rising percentages of positive results with low CT values (below 21 or 15) from April to June. Conclusion: The Delta wave saw a higher risk of hospitalization among young individuals and pregnant women, despite their low mortality risk. The unvaccinated and those with multiple comorbidities faced higher mortality risks. Increases in RT-PCR positivity with low CT values preceded the July COVID-19 case surge.
Pulmonary Hypertension: Understanding the Underlying Anatomy and Physiology of Pulmonary Circulation Amien, Bagus Radityo; Putra, Andika Chandra
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.779

Abstract

The circulatory system has a vital role in fulfilling oxygen demand in tissues and maintaining homeostasis. There are two types of circulatory systems in our body, the systemic and pulmonary circulation. Pulmonary circulation, the critical pathway of blood oxygenation through heart-lung-pulmonary vascular interaction, remains poorly understood despite its central role in the various pulmonary vascular diseases. One of the most prevalent pulmonary vascular diseases is pulmonary hypertension (PH), which is characterized by high mortality and disease progression. A thorough understanding of the physiologic structure and function of pulmonary circulation is essential for diagnosing and treating patients with PH.  Pulmonary blood flow is determined by pulmonary vascular pressure (PVP) and pulmonary vascular resistance (PVR). Lung volume, neural factors (sympathetic and parasympathetic nervous systems), humoral factors (vasoconstrictor and vasodilator), and alveolar hypoxia play an important role in regulating PVR. Alveolar hypoxia triggers hypoxic pulmonary vasoconstriction to maintain the ventilation-perfusion ratio balance. High PVR increases pulmonary arterial pressure (Pa), which is the main pathophysiology of PH. In addition, endothelial dysfunction and vasoactive imbalance also contribute significantly to the pathogenesis of the disease.
Indonesian Society of Respirology Position Paper on Lung Cancer Control in Indonesia Andarini, Sita; Santoso, Andintia Aisyah; Arfiansyah, Mochammad Aris; Syahruddin, Elisna; Zaini, Jamal; Putra, Andika Chandra; Kurniawan, Ferry Dwi; Ermayanti, Sabrina; Soeroso, Noni Novisari; Munir, Sri Melati; Infianto, Andreas; Setijadi, Ana Rima; Setyawan, Ungky Agus; Wulandari, Laksmi; Haryati, Haryati; Jasminarti, Ida Ayu; Hidayat, Moulid; Santoso, Arif
Jurnal Respirologi Indonesia Vol 44 No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.884

Abstract

Lung cancer is a major health concern in Indonesia due to its increasing prevalence, late-stage diagnosis, younger population, and high mortality. Addressing this issue requires nationwide implementation of comprehensive lung cancer control, which includes risk reduction and prevention strategies, focusing on tobacco control and air pollution mitigation. Screening with low-dose computed tomography (LDCT) and early detection in symptomatic patients, along with TB screening programs and all non-communicable diseases, is strongly recommended to enhance early case findings, treatment effectiveness, and overall patient outcomes. A multidisciplinary team (MDT) approach is important to ensure accurate diagnosis and comprehensive care. Moreover, the integration of palliative care at the early stages of advanced lung cancer is vital, focusing on symptom management and enhancing the quality of life for patients. While national guidelines are available for the diagnosis and treatment of lung cancer, significant disparities in healthcare access remain across Indonesia. Thus, it is essential to improve universal health coverage and referral systems to guarantee equal access to lung cancer care for patients at all levels through advocacy and ease of access.
The Impact of Smoking Degree on One Year Survival of Non-Small Cell Lung Cancer (NSCLC) at Persahabatan Hospital Wicaksono, Arief; Adisasmita, Asri C.; Putra, Andika Chandra
Jurnal Epidemiologi Kesehatan Indonesia Vol. 8, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Lung cancer is a major global mortality problem with the worst prognosis compared to other types of cancer. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and smoking is one of the main factors causing lung cancer. This study aims to determine the one-year survival of NSCLC patients with smoking levels and to determine what factors affect survival. This study is an observational study with a retrospective method, looking at medical record data of NSCLC patients both inpatients and outpatients at Persahabatan Hospital between January 2023 and December 2023 and then followed up until September 2024. Survival analysis using the Kaplan Meier method and the Log-Rank test was used to find the differences between variables. Based on 248 NSCLC patients, 105 patients had low-moderate degree of smoking, and 145 patients had severe degree of smoking. The average age are 57 years old. The highest level of education are high school/equivalent (178 patients). Employment status are workers (211 patients). Marital status are married (216 patients). Performance status are ECOG-PS >2 (137 patients). Clinical stage are stage IV (194 patients). The one-year survival probability was 28.13% in the low-moderate degree of smoking group and 39.82% in the severe degree of smoking group with a median 122 days and 234 days respectively. There was a statistically significant difference in survival probability between degree of smoking, employment status, marital status, performance status and clinical stage with p<0.05.
Co-Authors Agus Dwi Susanto Agustiyanti, Dian Fitria Ahmad Hudoyo Amien, Bagus Radityo Ana Rima Setijadi Andarini, Sita Anky Zannati Anwar Jusuf Arfiansyah, Mochammad Aris Arief Wicaksono, Arief Arif Santoso Asri C. Adisasmita Aufa, Akhdan Aulya Fairuz Azika, Wira Norman Bahri, Syukrini Bettia Bermawi Budhi Antariksa Budi Haryanto C. Krismini Dwi Irianti Dewi Yennita Sari Elisna Syahruddin Elsye Souvriyanti, Elsye Erdayani, Eva Erlina Burhan Erlina, Andi Ermayanti, Sabrina Fariz, Nurwidya Fasli Jalal Fransiska Fransiska Ginindha Izzati Sabila Gusnanto, Arief Haryati Haryati Hendra Koncoro Hera Afidjati Herjuno Ari Nugroho, Herjuno Ari Hidayat, Moulid Ibrahim Nur Insan Putra Darmawan Idris Idris Ifan Aulia Candra Indra Kusuma Indriawati, Indriawati Infianto, Andreas Isbaniah, Fathiyah Jamsari Jamsari Jasminarti, Ida Ayu JB Endrotomo Sumargono Kurniawan, Ferry Dwi Laksmi Wulandari Laurentius Aswin Pramono Maria Edith Sulistio Mohamad Fahmi Alatas Mohammad Fahmi Alatas Muammar Emir Ananta Muchtiar, Mulyadi Muhamad Rizqy Fadhillah Muhammad Alkaff Noni Novisari Soeroso Pangestu, Hendri Popi Hadi Wisnuwardhani, Popi Hadi Rachmat Hamonangan Ramzi Ramzi RATIH ASMANA NINGRUM Ratna Moniqa Retno Ariza Soeprihatini Soemarwoto Ridwanuloh, Asep Muhammad Rifqatussaadah, Rifqatussaadah Rika Bur Rika Yuliwulandari, Rika Rita Rogayah Robert Sinto Samoedro, Erlang Saniyyah, Zahrah Santoso, Andintia Aisyah Setiawan, Ruby Setyawan, Ryan Haryo Setyawan, Ungky Agus Soehardiman, Dicky Sri Melati Munir Steven Jonathan Sushadi, Pangda Sopha Syazili Mustofa Taufik, Feni Fitriani Tjandra Yoga Aditama Utomo, Ahmad Rusdan H Utomo, Ahmad Rusdan Handoyo wahyuni wahyuni Wawan Abdullah Setiawan Wira Winardi Wiwien Heru Wiyono Wulandari, Ari Sulistyo Yanwirasti Yulia Suciati Zaini, Jamal