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All Journal Jurnal Kajian Akuntansi Li Falah: Jurnal Studi Ekonomi dan Bisnis Islam Jurnal Medik Veteriner Ovozoa: Journal of Animal Reproduction journal of Basic Medical Veterinary Bima Abdi: Jurnal Pengabdian Masyarakat Journal of Islamic and Law Studies (JILS) Al-Tijary : Jurnal Ekonomi dan Bisnis Islam Jurnal Kedokteran Hewan Jurnal Tatsqif Jurnal Ekonomi Pembangunan dan Pariwisata Analysis : Journal of Education Jurnal Agro Veteriner Smart Dedication: Jurnal Pengabdian Masyarakat
Rimayanti Rimayanti
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Journal : journal of Basic Medical Veterinary

 1 
POTENSI KANDUNGAN ANTIOKSIDAN RUMPUT KEBAR (Biophytum Petersianum Klotzsch) TERHADAP APOPTOSIS DAN GAMBARAN HISTOPATOLOGIS TESTIS PADA MENCIT (MUS MUSCULUS) YANG DIPAPAR 2,3,7,8-Tetrachlorodibenzo-p-dioxin Dewita, Dewita; Widjiati, Widjiati; Rimayanti, Rimayanti; Suprayogi, Tri Wahyu; Hariadi, Mas'ud; Plumeriastuti, Hani
Journal of Basic Medical Veterinary Vol. 8 No. 1 (2019): Journal of Basic Medical Veterinary, June 2019
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/.v8i1.19986

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is the most toxic compound in the dioxin group. This compound is a pollutant for the environment and very harmful to human health and enter the body through the mucous membranes in the mouth and the respiratory tract and can be transmitted through the placenta and lactation. The aim of this study was to know the antioxidantpotency of to resolve reproduction disturbance caused by TCDD exposure.Thirty Balb/C male mice were divided into five different groups, the negative control group, a positive control group exposed to TCDD at a dose of 7 μg/kg BW, P1 group of groups exposed to TCDD doses of 7 μg / kg BW and given Biophytum petersianum extract 0.05mg/gBB/day, group P2 group exposed to TCDD doses of 7μg/kgBW and given 0.080mg/gBB/day, and group P3 were exposed to TCDD dose of 7μg/kgBB and given the extract of Biophytum petersianum 0.135mg/gBB/day during day 2 to day 55. On the 56th day the mice were sacrificed and apoptotic examination and spermatogenic cell histopathological features were performed on the testis. The results showed that: P2 (0,433 ± 0,497; p<0,05) and P3 (0,200 ± 0,000 p<0,05) groups were the most effective group in decreasing spermatogenic cell apoptosis compared to positive control group (2,933 ± 1,5832 p<0,05). The Johnsen score result showed that P2 (9,400 ± 0,420) and P3 (9,800 ± 0,253) groups improving the histopathologic picture of spermatogenic cells in seminiferous tubules compared to positive control group (7,20 ± 0,400) p<0,05. Conclusion of this study were Biophytum petersianum is effective to solve reproduction disturbances caused by exposure of TCDD and the P3 group is the most effective group.
Co-Authors Abdullah Hasib Amrullah, Muhammad Fajar Annisa Nur Fitria Rahma Anwar Hafidzi Anwar Ma'ruf Arumugam, Aswini Asrar, Siti Iqmallisa Nurrill Budi Utomo BUDI UTOMO Dewita Dewita Eka Pramyrtha Hestianah Eka Pramyrtha Hestianah, Eka Pramyrtha Elzaanin, Amina A.A Erlangga, Made Bagus Erma Safitri Estoepangestie, A.T. Soelih Fithriana Syarqawie Gandul Atik Yuliani Ginta Riady Hana Eliyani Hani Plumeriastuti Hardaningtyas, Enggar Hariadi, Mas'ud Hermin Ratnani Herry Agoes Hermadi Hidajati, Nove Hidayatik, Nanik Ikhsan, Dilla Amalia Bilqis Ilham Akbar Ilmi, Laily 'Ulya Nurul IMAM MUSTOFA Ismudiono Ismudiono Johansyah, Fadilla Anita Kinksky Kadek Rachmawati Khairullah, Aswin Rafif Listyorini, Linda Mafruchati, Maslichah Malia, Malia Mayola, Dilla Aranda Mirni Lamid Muhaimin Muhaimin Muhammad Noval Muhammad Syahid Muhammad Yunus Nisa, Ainul Hayatin Nove Hidajati Novianti, Arindita Niatazya Nurwijayanti Pasang, Gabriel Sampe Pratama, Hanif Sabekti Pudji Srianto Purnawan, Ahmad Budi Putri, Natalie Lovena Pramono Qodri, Winda Nurul Lailatil Raharjo, Dadik Rahmahani, Jola Rahmawati, Mitha Ardila Rezady, Ganeswara Muharam Hazmi Ristiani, Widya Aulia Rochmah Kurnijasanti Rosyta, Pegy Safitri, Erma - Santoso, Kuncoro Puguh Sayi Datur Rohmah Shabira, Zahra Sherina Lashita Candrakirana Sri Hidanah Sri Mulyati Sri Mulyati Sri Pantja Madyawati Sri Pantja Madyawati, Sri Pantja Suherni Susilowati Supriyadi Supriyadi Suzanita Utama Syuhuud Arumbinang Wajdi, Syuhuud Arumbinang Tatik Hernawati Tita Damayanti Lestari Tjuk Imam Restiadi Tri Wahyu Suprayogi Tsaniya Atikahani Shabirah Tyasmingsih, Wiwiek Ummaisyah, Winadya Reika Viski Fitri Hendrawan Wahjuni, Retno Sri Warsito, Sunaryo Hadi Widjaja, Made Ngakan Rai Widjiati Widjiati, Widjiati Widya Paramita Lokapirnasari Wiwik Misaco Yuniarti Wurlina, W Yulianna Puspitasari