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All Journal HAYATI Journal of Biosciences Microbiology Indonesia Health Science Journal of Indonesia Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Prosiding Seminar Biologi Jurnal Sumberdaya Hayati Indonesian Journal of Cancer The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS) Acta Biochimica Indonesiana Jurnal Ilmu Kefarmasian Indonesia The New Ropanasuri Journal of Surgery Muhammadiyah Journal of Geriatric Indonesian Journal of Cancer eJournal Kedokteran Indonesia Makara Journal of Science Nanggroe: Journal Of Scholarly Service Molekul: Jurnal Ilmiah Kimia Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Biomedika Jurnal Info Kesehatan
Mohamad Sadikin
Department Of Biochemistry And Molecular Biology, Center Of Hypoxia And Oxidative Stress Studies, Faculty Of Medicine, Universitas Indonesia, Jakarta
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Hyperbaric Oxygen Therapy for Traumatic Brain Injury: A Review Of History, Development, Current Techniques, and Future Directions Wiwoho, Yudi Yuwono; Sadikin, Abdul Halim; Jusuf, Ahmad Aulia; Mulyawan, Wawan; Mudjihartini, Ninik; Ibrahim, Nurhadi; Jusman, Sri Widia A.; Sadikin, Mohamad
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.321

Abstract

Hyperbaric oxygen therapy (HBOT) has gained increasing attention as a potential adjunctive treatment for traumatic brain injury (TBI) patients. This narrative review discusses the historical background, current preclinical and clinical studies, and explores its underlying mechanisms from biomolecular, histological, and clinical perspectives. HBOT promotes neural recovery by improving oxygenation, preserving mitochondrial integrity, enhancing neurotrophic support and synaptic connectivity, mitigating secondary injury pathways (including oxidative stress, inflammation, and apoptosis), and promoting angiogenesis and vascular stability. These mechanisms have demonstrated improvements of motor, cognitive, and memory functions both in preclinical and clinical studies, although outcomes and treatment protocols vary. However, challenges remain regarding optimal protocols, patient selection, and adverse effects. Further high-quality clinical trials are required to define the optimal HBOT regimen are required.
Co-Authors . Rusdi . RUSDI Ahmad A. Jusuf Ahmad Aulia Ahmad Aulia Jusuf Ahmad R. Utomo Aldri Frinaldi Amarila Malik Andi N.K. Syarifin, Andi N.K. ANDREW ROBERT COSSINS Angelina Stevany Regina Masengi Ani R. Prijanti Ani Retno Prijanti Ardiana Kusumaningrum Arfat Lusinanto Arief Budi Witarto Aryenti . Asri Rasad Astutiati Nurhasanah ASTUTIATI NURHASANAH Bethy S. Hernowo Caroline T. Sardjono CAROLINE TAN SARDJONO Cicia Firakania, Cicia DARYL ROBERT WILLIAMS Dewi Sukmawati Diah Iskandriati Dian R. Laksmitawati Dian Ratih Laksmitawati Dwirini Retno Gunarti Dwirini Retno Gunarti Ekawati, Maria Evy Ayu Arida Fanny Septiani Farhan Febriana C. Iswanti Febriana Catur Iswanti Franciscus D. Suyatna Frans Ferdinal Frans Ferdinal HANIFAH RAHMI Hans -Joachim Freisleben Hans Joachim Freisleben HANS-JOACHIM FREISLEBEN Heri Wibowo Hermansyah Hermansyah Ichramsyah A. Rahman Ika Superti Daruningrum Indra G. Mansur Indra Gusti Mansur Irawan Satriotomo Jeanne A. Pawitan Jeanne Adiwinata Pawitan Juniarti KURNIA NUZTIR MANTOLINI Lailan Safina Nasution Lindi G Haritsyah M, Mentari Mohamad Saekhu Muchlis Ramli Muhamad Arif Budiman Muhamad Yusup Muhammad Faris Indratmo Nani Dharmasetiawani Nani Sari Murni Ni Ken Ritchie Nina Anindyawati Nina Ninik Mudjihartini Noorwati Sutandyo Novi S. Hardiany Novi Silvia Hardiany Novianti, Titta Nurhadi Ibrahim Nurhadi Ibrahim Nurjati C. Siregar Oentoeng Soeradi Pamungkas, Joko Panjaitan, Paris Praditi, Citra Raden Rara Diah Handayani Radiana D. Antarianto Rahmawati Ridwan Rahmawati Ridwan Ranti Dwi Astriani Reni Paramita Resda Akhra Syahrani Ria Syafitri Evi Gantini Rini Puspitaningrum RONDANG ROEMIATI SOEGIANTO RONDANG ROEMIATI SOEGIANTO RONDANG ROEMIATI SOEGIANTO Rostika Flora Sadikin, Abdul Halim Saleh, Mgs. M. Irsan Samsuridjal Djauzi Sari, Dewi H. SARI, MIKE PERMATA Sarmoko Sarsanti, Pungguri Ayu Nega Sekar Arumsari Septelia I. Wanandi Siregar, Nurjati Siti Rahmawati Achyat Sitorus, Novandrik Yeriko Siufui Hendrawan Sri S. Ningsih, Sri S. Sri W.A. Jusman Sri Widia A.Jusman Subandrate Suryani, N. Lilis Syarifah Dewi Syazili Mustofa Tiara Mayang Pratiwi Lio Tiwuk Susantiningsih Tomohiko Yamazaki Trismilah Margono TRISMILAH TRISMILAH Trismilah Trismilah Trismilah, Uly A. Nikmah, Uly A. Vetnizah Juniantito Wahono Sumaryono Wardaya Wardaya Wawan Mulyawan Wawan Mulyawan Wiwoho, Yudi Yuwono Yalista Fatia Nadia Yefta Moenadjat Yudianita Kesuma, Yudianita Yuhernita . Zen Hafy