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All Journal International Journal of Public Health Science (IJPHS) Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Pharmascience Science and Technology Indonesia Ilmu Gizi Indonesia Indonesian Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Journal of halal product and research (JHPR) Community Empowerment Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Jurnal Kajian Islam Modern Journal of Halal Science and Research Open Community Service Journal Riwayat: Educational Journal of History and Humanities Journal of Food and Pharmaceutical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian
Nina Salamah
Fakultas Farmasi, Universitas Ahmad Dahlan
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary Other

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Journal : Pharmascience

 1 
Efek Imunomodulator Ekstrak Etanol Akar Pasak Bumi (Eurycoma Longifolia, Jack) terhadap Ekspresi CD57 pada Hepar Tikus yang Diberi Doksorubisin Wahyuningtyas, Nurma; Amukti, Danang Prasetyaning; Nurani, Laela Hayu; Salamah, Nina
Jurnal Pharmascience Vol 11, No 2 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i2.18499

Abstract

Agen kemoterapi yang terbukti dapat menurunkan imunitas tubuh adalah doksorubisin. Akar pasak bumi (Eurycoma longifolia, Jack) telah digunakan untuk meningkatkan imunitas serta antikanker. CD57 merupakan suatu penanda diferensiasi terminal dan  disfungsi limfosit pada sel T CD8+, CD4+, dan NK sel. Studi ini menyelidiki efek EEAPB pada ekspresi CD57 hati mencit SD (Sprague Dawley) yang diberi doksorubisin. Dalam penelitian ini, 49 tikus dibagi menjadi 7 kelompok. Kelompok I sebagai kontrol doksorubisin, kelompok II sebagai kontrol EEAPB 200 mg/kgBB, dan kelompok III, IV, dan V sebagai kelompok perlakuan doksorubisin + EEAPB 50 mg/kgBB, 100 mg/kgBB, dan 200 mg/kgBB. Kelompok VI sebagai kontrol pelarut (CMC Na 1%), dan kelompok VII sebagai kontrol sehat. Penelitian dilanjutkan dengan pewarnaan hati tikus dengan imunohistokimia untuk mengidentifikasi ekspresi CD57, dan pengujian statistik dilakukan dengan SPSS. Seluruh kelompok perlakuan mempunyai efek penurunan % ekspresi CD57 secara signifikan dibandingkan dengan kelompok kontrol doksorubisin. Oleh karena itu, EEAPB dapat meningkatkan imunitas dengan menurunkan persentase ekspresi CD57 pada hati tikus strain SD yang telah diberikan doksorubisin secara signifikan dan dosis yang dapat menurunkan persentase ekspresi CD57 maksimal, yaitu 50 mg/Kg BB. Kata Kunci: Doksorubisin, Kemoterapi, Pasak Bumi, Anti kanker, Hepatoprotektor A chemotherapy agent that has been shown to lower immunity is doxorubicin. The root of pasak bumi (Eurycoma longifolia, Jack) has been used to boost immunity and as an anticancer. CD57 is a marker of terminal differentiation and lymphocyte dysfunction in CD8+, CD4+, and NK T cells. This study investigated the effect of EEAPB on liver CD57 expression of SD (Sprague Dawley) mice treated with doxorubicin. In this study, 49 mice were divided into seven groups. Group I as doxorubicin control, group II as EEAPB 200 mg/kgBB control, and groups III, IV, and V as doxorubicin + EEAPB 50 mg/kgBB, 100 mg/kgBB, and 200 mg/kgBB treatment groups. Group VI was used as solvent control (CMC Na 1%), and group VII was used as healthy control. The study was followed by staining the liver of mice with immunohistochemistry to identify CD57 expression, and statistical testing was performed with SPSS. All treatment groups had the effect of decreasing the % expression of CD57 compared to the doxorubicin control group. Therefore, EEAPB can improve immunity by reducing the percentage of CD57 expression in the liver of SD strain rats that have been given doxorubicin at a dose that reduces the maximum rate of CD57 expression, which is 50 mg/Kg BW.
Co-Authors A Riyanto Abdul Rohman Agustin LN Aminin Ajeng Dian Pertiwi, Ajeng Dian Anggita Devi Anita Wening Sejati Anjani, Ratna Annta Kern Nugrohowati Any Guntarti Any Guntarti Any Guntarti Any Guntarti Any Guntarti Ar Rahma, Nur Aulia Banundari Rachmawati Barokati Azizah Basuki, Nazih Citra Ariani Edityaningrum, Citra Citra Dhea Cantika Danang Prasetyaning Amukti Desti Kameliani Dwi Fitriani Erlinda Widyasari Fathurohman SW, Oman Fathurrohman SW, Oman FATMAWATI, ARUM Fella Qulsum Maulida Firdaus, Rizqi Amalia Gunawan Anugra Sumule, Joshua Hari Susanti Hayati, Farida Hikmah, Nazila Nur Ikawati, Retty INNAYAH IZATI Irfan, Nawwar Jaswir, Irwandi Jufri, Sayyidah Luthfiyah Justitia Cahyani Fadli Juwitaningtyas, Titisari Kasmawati, Henny Kurniaty, Santyas Kurniawan, Muhammad Fariez Laela Hayu Nurani Liani Farahana Ma'ruf, Muhammad Mae Sri Hartati Wahyuningsih Mahendra, Muhammad Reza Miftahul Rozak Mohamed, Farahidah Muhammad Sulkhan Muhti Al Abror Mukti Utomo, Adhitya Ilham Mustofa Ahda Nanik Sulistyani Nining Sugihartini Novitasari, Putri Rachma Nurkhasanah Mahfudh Pangaribuan, Ika S Pinus Jumariyatno Pora, Yohana Laura Silfia Pradini, Ni Komang Virginia Rina Handayani Rosyida Awalia Safitri Rozak, Miftahul Saraswati, Damai Ira SATRIYAS ILYAS Sembiring, Rinawati Sihaloho, Serli Sitarina Widyarini Siti Athiyah Umaiyah Siti Fatimah Sultan Sudibyo Martono Sudibyo Martono Sugiyanto - Sugiyanto . Sugiyanto . Sugiyanto Sugiyanto Sugiyanto Sugiyanto Sultan, Siti Fatimah Sunarti Sunarti Suwidjiyo Pramono Suwidjiyo Pramono SW, Oman Fathurohman Uddin, ABM Helal Verda Farida Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wahyu Widyaningsih Wahyuningtyas, Nurma Widi Astuti, Silvia Ferry WULANDARI Yamin Yulianti, Rista Yuny Erwanto Yuny Erwanto Zahra Alya Putri