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All Journal JBIO: jurnal biosains (the journal of biosciences) JPKMI (Jurnal Publikasi Kesehatan Masyarakat Indonesia) JOPS (Journal Of Pharmacy and Science) Hearty : Jurnal Kesehatan Masyarakat JURNAL FARMASIMED (JFM) Jurnal Kesehatan Ilmiah Indonesia / Indonesian Health Scientific Journal Contagion: Scientific Periodical Journal of Public Health and Coastal Health Jurnal 'Aisyiyah Medika Jurnal Penelitian Farmasi dan Herbal Jurnal Kesehatan Tambusai Jurnal EduHealth Ahmar Metastasis Health Journal (AMHJ) Jurnal Kolaboratif Sains Ahmar Metakarya: Jurnal Pengabdian Masyarakat Jurnal Pengabdian Masyarakat Putri Hijau JRKN Sehat Rakyat: Jurnal Kesehatan Masyarakat QISTINA: Jurnal Multidisiplin Indonesia Journal of Health Sciences and Medical Development Promotor: Jurnal Mahasiswa Kesehatan Masyarakat JUKEJ: Jurnal Kesehatan Jompa
Wahyudi Wahyudi
Universitas Islam Negeri Sumatera Utara
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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Journal : Jurnal EduHealth

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Pharmacological Potential Of Vernonia Amygdalina With Various Bioactive Compounds: A Review Wahyudi, Wahyudi; Alya Alfianti Balqis; Delfi Yunita Lubis; Laila Sari; Risca Muril Khairani; Syifana Nadia Raisya
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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Abstract

Indonesia, as a megadiverse country has a wealth of tropical plants which are used in traditional medicine, including Vernonia amygdalina Del. or African leaves, which are known to have various pharmacological properties. This plant contains bioactive compounds such as flavonoids, alkaloids, and saponins, which have the potential to be used as an effective alternative herbal treatment. The aim of this literature study is to explore the pharmacological potential of Vernonia amygdalina Del. (African leaves) as a medicinal plant rich in bioactive compounds. This research method was carried out using a Systematic Literature Review (SLR). The result of researchs related to Vernonia amygdalina pharmacological potential and its bioactive compound was extracted from research article that published in Indonesia on 2018-2024. Based on research on previous studies, it was found that the pharmacological effects of African leaves (Vernonia amygdalina) include antioxidants which show moderate antioxidant activity with an IC50 value of 107,839 ppm, antibacterial containing flavonoids, tannins, saponins, and alkaloids which have antibacterial activity, antihyperlipidemia which has been proven to be effective in increases HDL levels in mice and reduces free cholesterol, especially at high doses comparable to simvastatin, anticancer which has anticancer potential with strong cytotoxic activity against WiDr cells, and anti-diabetic which can increase pancreatic cell regeneration and reduce blood glucose levels. Based on a literature review, it can be concluded that African Leaf extract (Vernonia amygdalina) contains various bioactive compounds that have potential as antioxidant, antibacterial, anti-cholesterol, anticancer, and anti-diabetic agents.
Co-Authors Ade Risma Adelia, Nelsih Aguansyah Maulana Siregar Aisa Maharani Hasibuan Alya Alfianti Balqis Alya Najwa Amalia Rahmi Nasution Amelia Putri Amanda Nasution Aminuyati Ana Firda A'Qila Andhani, Intan Angkat, Chairunissa T. D. E. Asghoriah, Azinatul Aulia, Dinda R. Azizah, Najwa Azzahro, Rahmi Damayanti Azzura, Sabrina Febri Barus, Nency Utami Br Billa, Nurna BM, Bima Fadhilah Cantika, Shafira Putri Dalimunte, Syelsa Yustrina Damanik, Nazwa Ayudhia Ghani Dawamah, Nurazizah Delfi Yunita Lubis Delisma Simorangkir Simorangkir Dewi Safitri Ginting Dhea Rizky Fitri Saragi Dian Ika Perbina Meliala Faiza Adinda Fathur Rifqy, Iqbal Fatila, Nabila Fatima Fatima Feby A Putri Firdaus Fahdi Fransisca, Cintya Hasanatun Laili Hasibuan, Ade Degisqi Maharani Herviani Sari Herviani Sari Husnan Tengku, Najwa Azizah Jihan Nabila Ritonga Karfita Adha Kayla Mazril, Zahra Kemala Sari Damanaik Khairunnisa Khairunnisa Laila Sari Manurung, Jahrani Manurung, Revina Aulia Mawaddah Sri Rezeki Dalimunthe Mawandri, Dwi Medina Elly Vanda Mega Rahmadani Siregar Muhammad Jidan Al-Khoir Muhammad Ridwan Muhammad Sahputra Nabila, Nazua Nasution, Aldi Syahputra Nasution, Mutiara Natasya Putri Lika Nelva Nelva Nur Ashilah S Rkt Nurly Fadhila Nurmaulia Nurmaulia Nurul Fauziah Ode, Anggun Nabila Panggabean, Hikmah Tin Pivit Rahayu Pohan, Dhea Afriza Prahasti, Hanum Purba, Rizki Yani Puti Miratil Hayati Efri Putri, Dwi A. Rapotan Hasibuan Regita Cahyani Rini Handayani Risca Muril Khairani Riski Andriani Ritonga, Fani Rulianda Ritonga, Sela Rizqa Auliyah Shifah Sagala Sahilla, Rizka Salsabilla, Anggina Zahra Sembiring, Andini Sembiring, Andini Br Septiani Rizka Shelly Febrina Simatupang , Ahmad Shiddiq Sinaga, Haryanti Sirait, Salshabila Azzahra Siti Nurhaliza Sitio, Sri Sudewi Pratiwi Situmorang, Irsyad Baihaqi Sri Rezky Gantina Sri Wahdina Tanjung Syaira Alfauza Syifana Nadia Raisya Tanjung, Hazira Yulistia Tanjung, Putri Keza Hidayah Tanjung, Sri Wahdina Tengku Armita Chairiyah Tia Munika Vera Estefania Kaban Wahyuni , Raduwi Windi Zahrani Yasmin, Wan Yara