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All Journal HAYATI Journal of Biosciences Farmaka Indonesian Journal of Applied Sciences Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia MPI (Media Pharmaceutica Indonesiana) CHEMPUBLISH JOURNAL The Indonesian Biomedical Journal Jurnal Kimia Terapan Indonesia JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Jurnal Ilmiah Farmako Bahari Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Jurnal Farmasi Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian
Sri Adi Sumiwi
Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : MPI (Media Pharmaceutica Indonesiana)

 1 
Efek Antikalkuli Ekstrak Etanol Herba Seledri (Apium graveolens L.) terhadap Tikus yang Diinduksi Hidroksiprolin Taofik Rusdiana; Lutfi Sulaiman; Eli Halimah; Ami Tjitraresmi; Sri Adi Sumiwi; Yanni D. Mardhiani; Anas Subarnas
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.2052

Abstract

The investigation efforts of an alternative treatment of the kidney stone disease by utilizing Indonesian native plants have still continued both for treatment and prevention. This study aims to strengthen the scientific evidence of the activity of celery as an anticalculi by in vivo assessment using hydroxyprolineinduced rat method. The white male wistar rats used in this study were intraperitoneally induced by hydroxyproline in order to form kidney stones, the celery extract preparations were then given at a dose of 50, 100, and 200 mg/kg of body weight orally for 5 days and observed following parameters: concentration of filtrate urinary calcium, concentration of urinary sediment calcium, as well as kidney to body weight ratio. The results showed that the concentration of filtrate urinary calcium in the test group at a dose of 200 mg/ kg body weight was significantly higher than those of negative control group, whereas the other test groups were not significantly different with the negative control group. The similar result was also shown on the parameter of calcium concentration in the urine sediment, while the ratio of kidney to body weight showed significant differences between all test groups and the negative control group. It can be concluded that the ethanol extract of the herb celery has an anticalculi activity in rats at a dose of 200 mg/kg of body weight.
Co-Authors Ade Zuhrotun Ahmad Muhtadi Ai Hertati Ai Hertati, Ai Ajeng Diantini, Ajeng Aliya Nur Hasanah Ami Tjitraresmi Anas Subarnas Anna Yuliana, Anna Anni Anggraeni Anni Anggraeni, Anni Anni Aoggraeoi" Apriali, Kirka Dwi Ardiansyah, Fahriza Aryanti, Ninda Asman Sadino Azzahra, Nabila Putri Clara Sunardi Clara Sunardi Clara Sunardi Dani Sujana Darmawan, Michelle Darwati Darwati Darwati Darwati Darwati, Darwati ELI HALIMAH Ellin Febrina Ellin Febrina FAUZI, DIANE FITRI NURJANAH Gofarana Wilar Hartono, Ayu Previani Hazna Putri Salsabilla Hendrayana, Jemmy Hendrayana, Jemmy Ida Musfiroh, Ida Iis Leniawati Indah Suasani Wahyuni Irma Erika Herawati Irma Melyani Puspitasari Irma Meylani Puspitasari Izzatul Khoirunnisa Jennifer Kolina Julisiana Sanggelorang Jutti Levita KHOIRINA NUR SA'IDAH Kokom, Asep Kolina, Jennifer Kusuma, Winny Lutfi Sulaiman MANUELA GLENATALIE PAKPAHAN Mardhiani, Yanni Dhiani Marline Abdassah Bratadiredja Marline Abdassah, Marline MEGANTARA, SANDRA Mochamad Rizal Moelyono, M W Moelyono, M W Mohamad Taufik Ismullah Muchtaridi Muchtaridi Muhammad Ryan Radix Rahardhian Mutakin Mutakin Mutakin Mutakin Mutakin Mutakin Nisa Masyitah NUR RAMADHANI MAUNG MANURUNG Nurfadillah, Nisrina Nurike Susendi Nyi Mekar Saptarini Okta Nama Putra Pangestu, Lauren Putri, Chintiana Nindya Rahadianti Khofii Suwanditya Ramadaini, Tiara Ramonah, Dewi Renny Amelia Riezki Amalia Rini Hendriani Ririn Suharsanti, Ririn Rochjana, Anna Uswatun Hasanah Ronny Lesmana Saeful Amin, Saeful SAFIRA ANNISSA Sari Sumarni Shaleha, Resha Resmawati Siti Saleha Sriwidodo Sriwidodo Steffi Liem Supriyatna Supriyatna Susilawati, Elis Suwandi, Deden Winda Taofik Rusdiana TIANA MILANDA Tina Rostinawati WAHYU EKA SAPUTRI Winny Kusuma Yasmiwar Susilawati Yoga Windhu Wardhana Yohanes, David Christianto Yoppi Iskandar Yuli Andriani Yunita .