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Arsyad, Muhammad Aryadi
Fakultas Kedokteran, Universitas Hasanuddin
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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KADAR PROSTAGLANDIN DAN ENDORFIN PADA REMAJA DISMENORE PRIMER YANG DIBERI SENAM DISMENORE DAN ABDOMINAL STRETCHING EXERCISE Nur Partiwi; Arsyad Aryadi; Nilawati Andi
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 12 No 2 (2020): Jurnal Riset Kesehatan Poltekkes Depkes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.615 KB)

Abstract

This study aims to determine the levels of prostaglandins and endorphins in adolescents with primary dysmenorrhea who are given dysmenorrhea and abdominal stretching exercise. The study was a quasi-experimental study with a post-test only control group design carried out in Islamic Boarding Schools with a sample of 36 primary dysmenorrhea adolescents divided into 3 groups: 12 respondents doing gymnastics dysmenorrhea, 12 respondents doing abdominal stretching exercises and 12 respondents doing nothing (Control). Dysmenorrhea exercises and abdominal stretching exercises are carried out for 4 consecutive days in the afternoon before the first day of menstruation. Furthermore, blood is drawn on the first day of menstruation for the examination of levels of prostaglandins and endorphins using the Enzyme-linked immunosorbent assay (ELISA) Kit. After intervening, prostaglandin levels in the abdominal stretching exercise group (345 pg/ml) were lower than those not given the intervention (360 pg/ml) while the gymnastics dysmenorrhea group experienced an increase in prostaglandin (391 pg/ml) compared to the control but there was no significant difference statistically. However, endorphins in the intervention group of gymnastics dysmenorrhea (138 pg/ml) and abdominal stretching exercise (115 pg/ml) were higher than those in the intervention group (112 pg/ml) although statistically showed no significant difference. The results of this study indicate gymnastics dysmenorrhea can stimulate endorphin secretion but not accompanied by a decrease in prostaglandin levels. Different things found in abdominal stretching exercises have been shown to increase endorphins followed by decreased prostaglandin levels. This shows that abdominal stretching exercise is more effectively used as a nonpharmacological therapy type of physical exercise in primary dysmenorrhea. Keywords : Prostaglandins, Endorphins, Gymnastics Dysmenorrhea, Abdominal Stretching Exercise
Kadar Prostaglandin dan Endorfin pada Remaja dengan Dismenore Primer yang diberi Hidroterapi Hangat dan Dingin Andi Asrina; Arsyad Aryadi; Nilawati Andi
JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG, Online ISSN 2579-8103 Vol 12 No 1 (2020): Jurnal Riset Kesehatan Poltekkes DepKes Bandung
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.8 KB) | DOI: 10.34011/juriskesbdg.v12i1.841

Abstract

Penelitian ini bertujuan untuk mengetahui perbandingan kadar prostaglandin dan endorfin pada remaja dengan dismenore primer dengan dan tanpa hidroterapi hangat (37-40oC) dan dingin (18-20oC). Penelitian quasi-experimental dengan rancangan post-test only control group ini dilaksanakan di Pondok Pesantren dengan jumlah sampel 36 remaja putri yang terbagi dalam 3 kelompok yaitu 12 remaja diberi hidroterapi hangat, 12 remaja diberi hidroterapi dingin dan 12 remaja tidak diberi intervensi (kontrol). Pengambilan plasma darah dilakukan setelah intervesi diberikan pada hari pertama menstruasi. Pemeriksaan kadar prostaglandin dan endorfin menggunakan metode Enzym-linked immunosorbent assay (ELISA) kit. Setelah pemberian hidroterapi dingin rerata kadar prostaglandin pada kelompok hidroterapi dingin dua kali lipat lebih tinggi (569 pg/ml) dibandingkan kontrol (394 pg/ml). Rerata kadar prostaglandin pada kelompok yang diberi hidroterapi hangat juga menunjukkan peningkatan prostaglandin (437 pg/ml) dibandingkan dengan kontrol (394 pg/ml). Selain peningkatan kadar prostaglandin, peningkatan kadar endorfin juga terjadi pada kelompok yang diberi hidroterapi hangat (154 pg/ml) dan kelompok yang diberi hidroterapi dingin (187 pg/ml) dibanding kontrol (119 pg/ml) p=0.001. Kesimpulan dalam penelitian ini adalah hidroterapi hangat dan dingin dapat meningkatkan kadar prostaglandin dan endorfin pada remaja dengan dismenore primer. Namun, hidroterapi dingin meningkatkan kadar endorfin lebih tinggi dibandingkan hidroterapi hangat. Kata kunci: Prostaglandin, Endorfin, Hidroterapi, Dismenore.
STUDI IN SILICO POTENSI ANTI KANKER SENYAWA TURUNAN KUMARIN TERHADAP PROTEIN BCL-2 Desi Dwirosalia Suparman; Ika Yustisia; Aryadi Arsyad; Muhammad husni Cangara; Ilhamjaya Patellongi; Rosdiana Natsir
Majalah Farmasi dan Farmakologi Vol. 25 No. 2 (2021): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v25i2.13648

Abstract

Mutasi pada protein anti-apoptosis BCL-2 merupakan salah satu penyebab terjadinya kanker payudara. Beberapa studi in vitro telah menunjukkan bahwa Eupatorium triplinerve Vahl, yang mengandung flavonoid, timohidrokuinon, terpenoid, karoten, vitamin C, stigmasterol, dan kumarin memiliki efek sitotoksik terhadap sel kanker payudara. Kumarin telah dilaporkan oleh berbagai penelitian berperan dalam berbagai jalur penghambatan terjadinya kanker. Tujuan penelitian ini adalah untuk melakukan dan menilai docking dari turunan senyawa kumarin yang terdapat pada tanaman Eupatorium triplinerve Vahl, yakni ayapanin dan ayapin, terhadap protein BCL-2. Docking dilakukan dengan menggunakan program command Autodock Vina pada personal computer (PC) dengan sistem operasi Windows 10 64-bit. Struktur protein BCL-2 dengan kode PDB 6QGG diunduh dari RCSB Protein Data Bank dan struktur 3D dari ayapanin dan ayapin diambil dari situs PubChem. Proses moleculer docking dilakukan secara bertahap dari penyiapan ligan dan protein, validasi metode docking, proses docking, hingga analisis data. Energi ikatan yang diperoleh dari docking antara senyawa ayapanin dan ayapin terhadap protein BCL-2 adalah -6.3 kcal/mol dan -6.9 kcal/mol dibandingkan dengan energi ikatan ligan bawaan, yakni -10.3 pada kantung aktif yang sama. Dengan demikian, ayapanin dan ayapanin memiliki potensi sebagai senyawa inhibitor protein anti-apoptosis BCL-2.
Efektifitas Daun Kubis terhadap Intensitas Nyeri Payudara pada Wanita Early Puerperium Post Seksiosesaria Wadi Renah; Mardiana Ahmad; Andi Nilawati Usman; Andi Wardihan Sinrang; Aryadi Arsyad; Risfah Yulianti
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (560.241 KB) | DOI: 10.36418/syntax-literate.v7i6.7895

Abstract

Pendahuluan. Pembengkakan payudara dapat menimbulkan nyeri pada payudara,hal ini dapat menghambat proses laktasi. Ibu post sectio caesarea memiliki hambatan menyusui tiga kali lebih besar jika mengalami nyeri payudara. Rata-rata nyeri payudara yang dirasakan berkisar nyeri sedang hingga berat (3-8). Salah satu intervensi non farmakologi mengurangi nyeri payudara yakni kompres daun kubis. Kubis mengandung asam amino, antibiotic, heterosides belerang dan mengeluarkan gel dingin yang menyerap panas sehingga dapat mengurangi nyeri payudara. Tujuan: menganalisis efektifitas kompres daun kubis dingin terhadap intensitas nyeri payudara pada wanita early puerperium post seksiosesaria di Rumah sakit Manokwari Papua Barat Tahun 2022. Metodologi: Penelitian ini menggunakan metode quasi eksperimen dengan pretest postest design. Pengambilan sampel dengan teknik purposive sampling sesuai kriteria yang telah ditetapkan. Sampel sebanyak 60 ibu puerperium post seksiosesaria dibagi menjadi 3 kelompok yakni 2 kelompok intervensi dan 1 kelompok kontrol. Setiap kelompok berjumlah 20 responden. Kelompok intervensi (kompres daun kubis dan breast care), dan 1 kelompok kontrol (breast care +edukasi menyusui). intervensi dilakukan pada hari ke 2-hari ke 7 postpartum, lama selama 30 menit setiap hari. Analisis data menggunakan uji Wilcoxon untuk menguji perbedaan intensitas nyeri payudara pre dan post intervensi. Sedangkan untuk intensitas nyeri menggunakan Cheklist six-point engorgements scale (SPES). Hasil: diperoleh perbedaan skor intensitas nyeri payudara sebelum dan sesudah diberikan intervensi kompres daun kubis, dengan rata-rata intensitas nyeri pre dengan score 6 dan post dengan score 1, dengan menggunakan uji Wilcoxon didapatkan hasil nilai p = 0,000 dimana nilai p < 0,05. Kesimpulan : kompres daun kubis efektif mengurangi intensitas nyeri payudara pada wanita Early puerperium post seksiosesaria.
THE EFFECT OF OKETANI MASSAGE ON BREASTFEEDING MOTHERS WITH BREAST MILK DAMS: A NARRATIVE REVIEW Enny Nahumuri; Mardiana Ahmad; Aryadi Arsyad; Nur Aliya Arsyad
Nurse and Health: Jurnal Keperawatan Vol 11 No 1 (2022): Nurse and Health: Jurnal Keperawatan January-June 2022
Publisher : Institute for Research and Community Service of Health Polytechnic of Kerta Cendekia, Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36720/nhjk.v11i1.350

Abstract

At the beginning of labor, the pain experienced after childbirth often makes the mother lazy to breastfeed her baby. Factors that affect failure in the process such as swollen breasts, mastitis, nipples, breast milk have not come out, and improper breastfeeding techniques. In the postpartum period, if the baby has not suckled and the breast glands are not emptied ideally, there will be a dam of milk, heat and hard, pain when groaned, nipples can flatten so that it can take the baby to suckle. This study aimed to find out the effect of Oketani massage on nursing mothers with breast milk dam. This research design is a narrative review to find and review articles from databases and theories that are descriptive. Search articles using databased ScienceDirect by entering the keyword "Oketani message, breastfeeding, milk production" obtained nine reports based on the criteria that have been set. Literature review method by filtering on the Mendeley website based on inclusion criteria, then collected and made a summary of the journal including the name of the researcher, year of publication of the journal, research title, method, and overview of results or findings. An article search by entering keywords found 39 relevant articles; after filtering, nine articles were reviewed and met the inclusion criteria; it is reported that the Oketani message will make the breasts softer, make the areola and nipples more elastic, making it easier for the baby to suckle. Breast milk flow becomes smoother because of pressure on the alveoli. The Oketani massage technique has eight steps, seven of which are in the retro mammary and one on the right and left sides of the breast (the areola area containing the myoepithelium). An Oketani massage performed for 15-20 minutes has an effect on nursing mothers with breast milk dams.
Effects of chronic insomnia disorder to third-year dentistry students GPA: Efek gangguan insomnia kronik terhadap indeks prestasi kumulatif mahasiswa tahun ketiga fakultas kedokteran gigi Widyatma Adinda Jubhari; Aryadil Arsyad; Eri Hendra Jubhari; Edy Machmud
Makassar Dental Journal Vol. 10 No. 1 (2021): Volume 10 Issue 1 April 2021
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v10i1.392

Abstract

Introduction: Insomniadisorder suffered by many students, and may affects learning process, academic performance, and health. Besides that, learning process, memory disorder, and emotional health may influence academic performance, which is an important thing for their future. Aim: To know whether chronic insomnia disorder affect the Grade Point Average of third year students from faculty of dentistry. Method: This is an observational analytic research with cross-sectional method, was performed in Faculty of Dentistry Hasanuddin University in October 2017 by total sampling. The variables are chronic insomnia disorder, and academic performance. Insomnia is diagnosed by Insomnia Screening Questionnaire, and data pro-cessed by SPSS 24 (Saphiro-Wilk and T independent test). Result: The result shows that there is one outlier which has been excluded, while insomnia disorder prevalence is about 82.25% of 62 samples, chronic insomnia disorder is about 59.67% of 62 samples, and there is no difference between GPA of chronic insomnia group and non-insomnia group (p=0.343). Con-clusion: Chronic insomnia disorder doesn’t affect the GPA of third-year students from faculty of dentistry.
Efek Diet Tinggi Protein, Rendah Karbohidrat, Rendah Lemak pada Tikus Wistar Jantan terhadap Perubahan Berat Badan, Kadar Glukosa dan Kolesterol Nur Upik En Masrika; Aryadi Arsyad; Ika Yustisia; Yulia Yusrini Djabir
JUMANTIK (Jurnal Ilmiah Penelitian Kesehatan) Vol 6, No 1 (2021)
Publisher : Prodi Kesehatan Masyarakat Fakultas Kesehatan Masyarakat UIN Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (806.378 KB) | DOI: 10.30829/jumantik.v6i1.7891

Abstract

One of the most popular diets today recommends a high protein- low carbohydrate diet as a weight loss strategy in obese patients. Diets high in protein appear to reduce appetite, energy intake, weight gain, and fat accumulation. The application of a high-protein diet has an impact on reducing the portion of other macronutrients, namely carbohydrates and fats. The purpose of this study was to determine the effect of a high protein, low carbohydrate and low fat (TPRKRL) diet on body health. With the focus of the analysis on changes in body weight, serum glucose and cholesterol levels in 22 male Wistar rat samples who were given the standard diet and the TPRKRL diet for 8 weeks. The results showed that there were no significant differences in the variables of body weight, serum glucose and cholesterol levels between the TPRKRL diet group and the control group (standard diet). In fact, the rats in the TPRKRL group experienced a relatively constant increase in body weight and glucose and cholesterol levels were susceptible to normal.Keywords: high protein; body weight; glucose; cholesterol
Pengaruh Pemberian Dehydroepiandrosterone (DHEA) terhadap Aktivitas Peroksidasi Lipid dan Kadar Nitrit Oksida pada Aorta Tikus Wistar Jantan yang Terpapar Asap Rokok Nila Ridhayani; Aryadi Arsyad; Yulia Yusrin Djabir
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol 11, No 2 (2022): September
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/sainsmat112359002022

Abstract

The research aimed to investigate the effect of dehydroepiandrosterone (DHEA) on lipid peroxidation activity and nitric oxide concentration in the aorta of male Wistar rats due to exposure to cigarette smoke. This study was a laboratory experiment using 21 rats that were divided into 3 groups: KN-14 (negative control that is given smoke exposure within 14 days), DHEA-1 (15 mg/kgBW + smoke exposure for 14 days), and DHEA-2 (30 mg/kgBW + smoke exposure for 14 days). The exposure was carried out in 25-45 minutes with 4 cigarettes/day. Surgery was performed in the 15th days to remove the aorta to examine malondialdehyde (MDA) as a biomarker of lipid peroxidation and nitric oxide (NO) concentration using Enzyme-linked Immunosorbent Assay (ELISA). The results showed that a significant increase in MDA concentrations was found in the group administered with DHEA, particularly at a dose of 30 mg/kgBW (p<0.05). Meanwhile, the administration of DHEA at doses of 15 and 30 mg/kgBW did not have a significant effect (p>0,05) on aortic NO concentrations compared to the group KN-14. Therefore, it can be concluded that the administration of DHEA could increase lipid peroxidation activity, as indicated by a significant increase in aortic MDA concentrations, without affecting aortic NO concentrations in rats exposed to cigarette smoke for 14 days.Keyword: Dehydroepiandrosterone (DHEA), MDA, NO, lipid peroxidation, exposure of cigarettes smoke
Pengaruh Pemberian Dehydrepiandrosterone (DHEA) Terhadap Paru-Paru Tikus Wistar Jantan Yang Terpapar Asap Rokok Sri Hardiyanti Asad; Aryadi Arsyad; Yulia Yusrini Djabir
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol 11, No 2 (2022): September
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35580/sainsmat112359582022

Abstract

This study investigated the effect of dehydroepiandrosterone on the lungs of male Wistar rats exposed to cigarette smoke. A total of 21 male Wistar rats were divided into 3 groups, namely the first group (negative control exposed to cigarette smoke for 14 days), the second group (given DHEA at a dose of 15 mg/kgBW and exposure to cigarette smoke), the third group (given DHEA at a dose of 30 mg/kgBW and exposure to cigarette smoke). DHEA was administered orally through a cannula 30 minutes before exposure to cigarette smoke with an exposure duration of about 25-40 minutes, equivalent to 4 cigarettes/day. After 14 days of experimentation, the rats were euthanized. Right lungs were harvested for malondialdehyde level measurement using the thiobarbituric acid reactive substance method measured by UV-Visible spectrophotometer at a wavelength of 532 nm. The left lungs were also harvested for histopathological examination. This study showed that pulmonary malondialdehyde levels in second and third group tended to be higher than in first group. Meanwhile, histopathological examination showed that the percentage of lung tissue damage in second and third group tended to be lower than in first group. Thus, it can be concluded that DHEA at doses of 15 and 30 mg/kgBW tended to act as a pro-oxidant but might potentially improve lung histology due to cigarette smoke exposure.
Pengaruh Pemberian Dehydroepiandrosterone (DHEA) terhadap Aktivitas Peroksidasi Lipid dan Kadar Nitrit Oksida pada Aorta Tikus Wistar Jantan yang Terpapar Asap Rokok Nila Ridhayani; Aryadi Arsyad; Yulia Yusrini Djabir
Jurnal Kesehatan Vol 10 No 2 (2022): Agustus
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25047/jkes.v10i2.349

Abstract

The research aimed to investigate the effect of dehydroepiandrosterone (DHEA) on lipid peroxidation activity and nitric oxide concentration in the aorta of male Wistar rats due to exposure to cigarette smoke. This study was a laboratory experiment using 21 rats that were divided into 3 groups: KN-14 (negative control that is given smoke exposure within 14 days), DHEA-1 (15 mg/kgBW + smoke exposure for 14 days), and DHEA-2 (30 mg/kgBW + smoke exposure for 14 days). The exposure was carried out in 25-45 minutes with 4 cigarettes/day. Surgery was performed in the 15th days to remove the aorta to examine malondialdehyde (MDA) as a biomarker of lipid peroxidation and nitric oxide (NO) concentration using Enzyme-linked Immunosorbent Assay (ELISA). The results showed that a significant increase in MDA concentrations was found in the group administered with DHEA, particularly at a dose of 30 mg/kgBW (p<0.05). Meanwhile, the administration of DHEA at doses of 15 and 30 mg/kgBW did not have a significant effect (p>0,05) on aortic NO concentrations compared to the group KN-14. Therefore, it can be concluded that the administration of DHEA could increase lipid peroxidation activity, as indicated by a significant increase in aortic MDA concentrations, without affecting aortic NO concentrations in rats exposed to cigarette smoke for 14 days
Co-Authors A Asrina A. Nilawati Usman A.Wardihan Sinrang A.Wardihan Sinrang Abustani, Muthiah Agustin, Dinah Inrawati Ahmad, Mardiana Al Mukarram H. A. Amir, Muzakkir Andi Nilawati Andi Nilawati Usman Andi Wardihan Sinrang Arief, Nila Ardilla Arif Santoso Ariyandy, Andi Arwan Bin Laeto Budu - Cangara, Husni Desi Dwirosalia Suparman Dewiyana, Srigita Djabir, Yulia Yusrini Djaharuddin, Irawaty Dwi Kartika Sari Dwi P. Wulansari Edy Machmud Elizabeth Catherine Jusuf Enny Nahumuri Eri Hendra Jubhari H Anwar, St Hadijah Hafsah, Amir Mahmud Hasrimayana Hasrimayana Healthy Hidayanti Idris, Irfan Ika Yustisia Ika Yustisia Ilhamjaya Patellongi Irene E. Rieuwpassa IRFAN IDRIS Ismail, Amirah Febrianti Kasim, Hasim Luciana Heidee Christianty Mallisa, Hilda Emma Mardiana Ahmad Mardiana Ahmad Mardiana Ahmad Mardiana Ahmad Marliyati Sanaky Masrika, Nur Upik En Massi, Moh Nasrum Muh Tamar Muhammad Husni Cangara Muhammad Husni Cangara Natsir, Rosdiana Nila Ridhayani Nilawati Andi Nuni Rismayanti Nurkalbi Nur Aliya Arsyad Nur Amalia Alif Nur Hayati Saud Nur Partiwi Nurjannah Damis Nurlindah Hamrun Pratiwi, Vira Prihantono, Prihantono Rafikah Hasyim Ramadhani, Sri Risfah Yulianti Risfah Yulianty Riu, Deviana Soraya Rosdiana Natsir Rosdiana Natsir Saidah Syamsuddin Sakinah, Andi Irhamnia Seri Pasongli, Seri Siti Rafiah Sitti Rafiah Sri Hardiyanti Asad St. Raf’iah Stang Stang Veni Hadju Wadi Renah Werna Nontji Widyatma Adinda Jubhari Yadul Ulya Yudi Yanto Yulia Y Djabir Yulia Yusrin Djabir Yulia Yusrini Djabir