Claim Missing Document
Check
Articles

Found 37 Documents
Search

ACE2 EXPRESSION OF HYPERTENSIVE RAT LUNGS GIVEN ACE-I, CCB, AND SWITCHING ACEI TO CCB Abustani, Muthiah; Arsyad, Aryadi; Idris, Irfan; Djabir, Yulia Yusrini; Djaharuddin, Irawaty; Kasim, Hasim; Ismail, Amirah Febrianti
Jurnal Kesehatan Vol 17 No 2 (2024): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v17i2.38444

Abstract

Latar belakang : Hipertensi merupakan komorbid terbanyak pada COVID-19 dan ACE2 sebagai reseptor yang akan berikatan dengan virus SARS-COV-2, juga berperan dalam regulasi tekanan darah. Penggunaan obat antihipertensi seperti ACE-I atau CCB dapat mempengaruhi ekspresi ACE2. Penggunaan ACE-I selama pandemi menuai pro dan kontra yang memunculkan saran penggantian golongan obat antihipertensi seperti CCB. Tujuan : Mengetahui ekspresi ACE2 jaringan paru tikus setelah induksi hipertensi dan dilanjutkan dengan pemberian ACE-I (kaptopril) atau CCB (amlodipine), dan switching ACE-I menjadi CCB. Metode : Post control group design menggunakan 30 sampel tikus Sprague dawley yang dibagi menjadi 5 kelompok yaitu non-hipertensi, hipertensi, hipertensi + ACE-I, hipertensi + CCB, dan hipertensi + ACE-I switching CCB. Induksi hipertensi menggunakan L-NAME selama 6 minggu dan pengukuran tekanan darah menggunakan metode non-invasif. Pemberian obat antihipertensi diberikan selama 1 minggu. Ekspresi ACE2 diukur menggunakan ELISA kit Elabscience®. Hasil : Ekspresi ACE2 pada kelompok non hipertensi vs hipertensi tidak ditemukan perbedaan bermakna. Ekspresi ACE2 pada kelompok hipertensi dengan pengobatan ACE-I vs CCB ditemukan lebih tinggi pada kelompok CCB (p = 0.042). Ekspresi ACE2 pada kelompok hipertensi dengan pengobatan lebih tinggi dibanding kelompok hipertensi tanpa pengobatan (p = 0.001). Diskusi : Ekspresi ACE2 lebih tinggi pada kelompok dengan pengobatan ACE-I dengan cara menghambat efek Angiotensin II, sehingga kadar ACE2 meningkat sebagai mekanisme kompensasi. Sedangkan CCB akan meningkatkan kadar Angiotensin I dan menurunkan rasio Angiotensin (1-7)/ Angiotensin I dan menurunkan rasio ACE2/ACE Kesimpulan : Ekspresi ACE2 meningkat pada jaringan paru hipertensi dengan pengobatan ACE-I, CCB, dan switching ACE-I menjadi CCB.
Effect Of Serum Ferritin Levels On The Event Of Preeclampsia In Pregnant Women In First Trimester Agustin, Dinah Inrawati; Massi, Moh Nasrum; Usman, Andi Nilawati; Hadju, Veni; Prihantono, Prihantono; Arsyad, Aryadi
JKM (Jurnal Kebidanan Malahayati) Vol 9, No 4 (2023): Volume 9 No. 4 Oktober 2023
Publisher : Program Studi Kebidanan Fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkm.v9i4.12699

Abstract

Latar Belakang Preeklamsia merupakan penyakit multisistem yang etiologinya belum diketahui, dengan manifestasi klinis yang beragam. Laporan terbaru dari WHO memperkirakan bahwa preeklampsia menyebabkan 70.000 kematian ibu setiap tahunnya di dunia. Society for the Study of Hypertension in Pregnant (ISSHP) mendefinisikan preeklamsia sebagai hipertensi de-novo dengan tekanan darah sistolik lebih tinggi dari 140 mmHg atau tekanan darah diastolik lebih tinggi dari 90 mmHg pada dua pengukuran terpisah (antara 4-6 jam). terjadi setelah usia kehamilan 20 minggu. Pemeriksaan kadar feritin serum untuk menyaring kejadian preeklamsia pada awal kehamilan sangat diperlukan karena tingginya jumlah penderita preeklamsia di Indonesia dan dampak negatif preeklamsia terhadap kehamilan.Tujuan dari tinjauan literatur ini adalah untuk mengetahui pengaruh pemeriksaan kadar feritin serum terhadap kejadian preeklamsia pada ibu hamil trimester pertama.Metode Beberapa database elektronik dicari untuk mengidentifikasi studi yang relevan dengan Juli 2021: Scopus, Pubmed, Google Scholar Scholar, dan PubMed. Kata kunci yang dipilih dalam pencarian mencakup 'Serum Ferritin' (dan variasinya, misalnya Ferritin dalam serum, Ferritin), dikombinasikan dengan istilah-istilah yang terkait dengan Preeklamsia termasuk 'Preeklampsia dan Kehamilan', 'Preeklamsia ibu', dan 'preeklamsia hipertensi.' Kriteria inklusi yang digunakan adalah artikel full text, menggunakan rancangan randomized controlled trial, eksperimental dan quasi eksperimen, menggunakan bahasa Indonesia dan Inggris, sampel ibu hamil dengan preeklamsia dan fokus literatur intervensi kadar feritin serum. Sebanyak 103 artikel teridentifikasi (Scopus=39; Google Scholar=23; PubMed=41).Hasil diperoleh 19 jurnal internasional dan 11 jurnal nasional relevan. Hasil analisis menunjukkan adanya perubahan kadar feritin serum pada ibu hamil dengan preeklampsia.Kesimpulan Kadar feritin serum yang lebih tinggi berhubungan dengan kejadian preeklamsia. Tinjauan menyeluruh ini mengkaji literatur untuk lebih memahami elemen-elemen ini, dan menggabungkan 30 artikel relevan untuk menjelaskan efektivitas pengujian serum feritin terhadap kejadian preeklamsia, serta beberapa rekomendasi untuk mengatasi masalah serius ini. Secara total, 30 artikel terkait serum feritin dan preeklampsia diidentifikasi.Saran Perlu dikembangkan studi literatur lebih lanjut mengenai kadar feritin serum terhadap kejadian preeklampsia pada ibu hamil. Hal ini didasarkan pada beberapa temuan baru biomarker lain untuk mendeteksi kejadian preeklamsia pada ibu hamil  Kata Kunci Kadar Ferritin Serum, Preeklampsia, Ibu Hamil Trimester Pertama ABSTRACT Background Preeclampsia is a multisystem disease of unknown etiology, with diverse clinical manifestations. The latest report from WHO estimates that preeclampsia accounts for 70,000 maternal deaths annually in the world. The Society for the Study of Hypertension in Pregnancy (ISSHP) defines preeclampsia as de-novo hypertension with a systolic blood pressure higher than 140 mmHg or a diastolic blood pressure higher than 90 mmHg on two separate measurements (between 4-6 hours). occurs after 20 weeks of gestation. Examination of serum ferritin levels to screen for the incidence of pre-eclampsia in early pregnancy is very necessary because of the high number of patients with preeclampsia in Indonesia and the negative impact of preeclampsia on pregnancy.The purpose of this literature review is to determine the effect of examination of serum ferritin levels on the incidence of preeclampsia in first trimester pregnant women.Methods Several electronic databases were searched to identify studies relevant to July 2021: Scopus, Pubmed, Google Scholar Scholar, and PubMed. Keywords selected in the search included 'Serum Ferritin' (and its variations, eg Ferritin in serum, Ferritin), in combination with terms related to Preeclampsia including 'Preeclampsia and Pregnancy', 'Maternal preeclampsia,' and 'hypertension preeclampsia.' The inclusion criteria used were full text articles, using a randomized controlled trial design, experimental and quasi-experimental, using Indonesian and English, samples of pregnant women with preeclampsia and the focus of the intervention literature on serum ferritin levels. A total of 103 articles were identified (Scopus=39; Google Scholar=23; PubMed=41).Results  19 international journals and 11 relevant national journals were obtained. The results of the analysis showed that there was a change in serum ferritin levels in pregnant women with preeclampsia.Conclusions Higher serum ferritin levels are associated with the incidence of preeclampsia. This scoping review examines the literature to better understand these elements, and incorporates 30 relevant articles to describe the effectiveness of serum ferritin testing on the incidence of preeclampsia, as well as some recommendations to address this serious problem. In total, 30 articles related to serum ferritin and preeclampsia were identified.Suggestion There is a need to develop further literature studies on serum ferritin levels on the incidence of preeclampsia in pregnant women. This is based on several new findings of other biomarkers for detecting the incidence of preeclampsia in pregnant women Keyword : Serum Ferritin Levels, Preeclampsia, First Trimester Pregnant Women 
Moringa Leaf Extract Capsules Enriched with Royal Jelly on Cortisol and Stress Dwi Kartika Sari; Hadju, Veni; Werna Nontji; Mardiana Ahmad; Aryadi Arsyad; Andi Nilawati Usman; Yudi Yanto; Taqwin, Taqwin
Jurnal Kesehatan Masyarakat Vol. 20 No. 4 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i4.3578

Abstract

During pregnancy, physiological and psychological changes often increase stress and cortisol levels. Administering moringa leaf extract capsules fortified with royal jelly presents a viable intervention to alleviate this stress. This study investigates the specific effects of these capsules on cortisol and stress levels in pregnant women. The study was conducted as a true experimental, single-blind, randomized controlled trial involving 61 pregnant women. The intervention group (n = 31) received moringa leaf extract capsules enriched with royal jelly, while the control group (n = 30) received multi-micronutrient supplements. The findings revealed a noteworthy reduction in cortisol levels within the intervention group (p = 0.030), from 26.61 ± 8.15 to 19.98 ± 14.00, as well as in the control group (p = 0.003), from 21.13 ± 7.76 to 13.26 ± 16.09. Likewise, stress levels exhibited a significant decrease within the intervention group (p = 0.016), decreasing from 18.68 ± 3.74 to 28.75 ± 15.02, and the control group (p = 0.000), declining from 19.17 ± 3.64 to 16.20 ± 3.38. Moringa leaf extract capsules enriched with royal jelly, as a natural remedy, merit the recommendation for inclusion in initiatives to enhance maternal and infant health.
EFEK PERMEN KARET, MADU, DAN MOBILISASI DINI TERHADAP PEMULIHAN PERISTALTIK USUS DAN WAKTU FLATUS PADA PASIEN POST SEKSIO SESAREA: EFFECTS OF GUM, HONEY, AND EARLY MOBILIZATION ON RECOVERY OF INTESTINE PERISTALTIC AND FLATUS TIME IN PATIENTS POST CAESAREAN SECTION Hasrianti, Hasrianti; Aryadi Arsyad; Usman, Andi Nilawati; Ramadany, Sri; Nontji, Werna; Hafsa, Mahmud
GEMA KESEHATAN Vol. 16 No. 2 (2024): Desember 2024
Publisher : POLTEKKES KEMENKES JAYAPURA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47539/gk.v16i2.459

Abstract

Seksio sesarea menjadi salah satu operasi besar pada abdomen yang berhubungan langsung dengan perubahan post operatif dalam sistem saraf otonom yang menyebabkan penurunan pergerakan usus pada sistem pencernaan. Penelitian ini bertujuan untuk membandingkan efek mengunyah permen karet, mengonsumsi madu dan mobilisasi dini terhadap laju pemulihan fungsi peristaltik usus dan waktu kentut pada pasien post seksio sesarea. Penelitian ini menggunakan desain Quasi Experimental dengan pendekatan post-test only group design. Sebanyak 78 wanita post seksio sesarea dipilih melalui teknik purposive sampling, memenuhi kriteria inklusi serta bersedia berpartisipasi, dibagi menjadi tiga kelompok: Permen Karet (PK) + Mobilisasi Dini (MD), Madu (M) + MD, dan MD saja. Intervensi diberikan 3 jam post seksio sesarea, sedangkan pengukuran peristaltik usus dan waktu flatus dilakukan setiap 2 jam. Peristatik usus berbeda signifikan (P=0,00) di antara ketiga kelompok pada jam ke I, II dan III. Kelompok PK + MD mencatatkan rata-rata peristaltik tertinggi 28 kali, diikuti oleh kelompok M + MD 25 kali, dan MD 21 kali. Waktu flatus juga menunjukkan perbedaan signifikan antar kelompok (P= 0,041) dengan kelompok PK + MD mencatatkan rata-rata waktu flatus lebih cepat 500 menit dibandingkan kelompok M + MD 611 menit dan MD 754 menit. Mengunyah permen karet dengan mobilisasi dini terbukti lebih efektif dalam mempercepat pemulihan peristaltik usus dan waktu pertama flatus pada pasien pasca-seksio sesarea dibandingkan dengan kombinasi pemberian madu dan mobilisasi dini, maupun mobilisasi dini saja. Kata kunci: Flatus, Madu, Mobilisasi Dini, Peristaltik Usus, Permen Karet     A cesarean section is considered a major abdominal surgery that directly relates to post-operative changes in the autonomic nervous system, causing a reduction in intestinal movement within the digestive system. This study compares the effects of chewing gum, honey administration, and early mobilization on the speed of intestinal peristalsis recovery and the time to first flatus in post-cesarean section patients. This research uses a Quasi-Experimental design with a post-test-only group design approach. Seventy-eight women in the post-cesarean section were selected through purposive sampling, met the inclusion criteria, and agreed to participate. They were divided into three groups: Chewing Gum (CG) + Early Mobilization (EM), Honey (H) + EM, and EM alone. The interventions were administered 3 hours post-cesarean section, while intestinal peristalsis and flatus time were measured every 2 hours. Intestinal peristalsis showed a significant difference (P=0.00) between the three groups during the first, second, and third hours. The CG + EM groups recorded the highest average peristalsis at 28 times, followed by the H + EM groups at 25 times and the EM group at 21 times. Flatus time also showed a significant difference between groups (P=0.041), with the CG + EM groups recording a faster average flatus time of 500 minutes compared to the H + EM groups at 611 minutes and the EM group at 754 minutes. Chewing gum combined with early mobilization accelerates the recovery of intestinal peristalsis and the time to first flatus in post-cesarean section patients compared to honey administration with early mobilization or early mobilization alone. Keywords: Chewing Gum, Early Mobilization, Flatus, Honey, Intestinal Peristalsis
THE EFFECTS OF SIMVASTATIN, ROSUVASTATIN, AND FENOFIBRATE ON THE BODY WEIGHT AND LIPID PROFILES OF FEMALE RATS TREATED WITH ORAL CONTRACEPTIVES AND A HIGH-FAT DIET Putri, Dwi Anggara; Djabir, Yulia Yusrini; Bahar, Muhammad Akbar; Alam, Gemini; Rahman, Latifah; Aswad, Muhammad; Arsyad, Muhammad Aryadi
Jurnal Kedokteran Hewan Vol 16, No 3 (2022): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v16i3.22196

Abstract

This study aimed to compare the effects of simvastatin, rosuvastatin, and fenofibrate therapies on the body weight and lipid profiles of the female rats receiving a combination of oral contraceptives (COC) and a high-fat diet (HFD). Twenty female Wistar rats (130-200 g) were divided equally into four groups. The rats received a standard diet for seven days, and their baseline lipid profiles were analyzed. All rats also received COC containing 15.1 g/kg levonorgestrel/3.1 g/kg estradiol with HFD for 60 days. Starting on day 31, the rats were given the respected treatment. The control group received the vehicle, whereas the others were treated with either simvastatin (2.1 mg/kg), rosuvastatin (0.5 mg/kg), or fenofibrate (8.2 mg/kg). Blood samples were taken on days 30 and 60. The results showed that the administration of COC+HFD and vehicle for 30 days increased the rats body weight and dyslipidemia, characterized by a significant decrease in Low-Density Lipoprotein (HDL) and an increase in total cholesterol (TC) and triglycerides (TG) levels (P0.05). Among the treatments, only fenofibrate was found to be able to prevent a significant weight gain in rats. Both fenofibrate and rosuvastatin inhibited a significant rise in TG and TC levels. Meanwhile, the simvastatin administration failed to do the same. Although statistically insignificant, all treatments increased rats HDL levels. Thus, it can be concluded fenofibrate was the most effective treatment among all in reducing weight gain and improving the lipid profile of dyslipidemic rats induced by oral contraceptives and a high-fat diet.
Prenatal Covid-19 on Toddler Development Pasongli, Seri; Budu, Budu; Ahmad, Mardiana; Prihantono, Prihantono; Hidayanti, Healthy; Arsyad, M. Aryadi
JURNAL INFO KESEHATAN Vol 21 No 2 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss2.1176

Abstract

Along with the spread of the COVID-19 pandemic, there has been an increase in reports of confirmed cases of pregnant women with COVID-19. Exposure to the virus in pregnancy can affect the fetus and result in long-term vulnerability to abnormalities in the child's brain development. This study aimed to determine the impact of prenatal Covid-19 on the development of toddlers. The research method uses observational cross-sectional analysis. Secondary data on confirmed Covid-19 mothers were obtained from Prof. RD Kandou General Hospital, Wolter Monginsidi Hospital, and Manado Adventist Hospital. Primary data on toddler development using the KPSP Development Questionnaire instrument were obtained from 10 Community Health Centers in Manado City with a total of 92 respondents for two, 46 respondents were born to mothers with Covid-19 during the prenatal period and 46 toddlers were born to mothers who were not confirmed to have Covid-19 during the prenatal period. The results showed that there was no significant effect with a p-value of 0.562 for toddlers born to Covid-19 mothers on impaired gross motor, fine motor, socialization, and independence, speech, and language development. Based on the results of the study it can be concluded that both toddlers born to Covid-19 mothers and toddlers who were not born to Covid-19 mothers are at risk of experiencing growth disturbances, especially toddlers born during the Covid-19 pandemic because there could be long-term effects that could occur in infants who are exposed to the virus during the prenatal/intrauterine period.
Pengaruh Pemberian Minuman Sopi Mayang Beralkohol terhadap Jumlah Spermatozoid, Pada Tikus Putih (Rattus norvegicus) Jantan Sanaky, Marliyati; Idris, Irfan; Rafiah, Siti; Arsyad, Aryadi
MAHESA : Malahayati Health Student Journal Vol 4, No 11 (2024): Volume 4 Nomor 11 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i11.15041

Abstract

ABSTRACT The alcoholic Sopi drink comes from palm trees (Arenga pinnata MERR), a type of palm tree spread throughout almost all of Indonesia. The alcohol in the traditional Sopi drink is ethanol (CH3CH2-OH) from fermented sap. This study aimed to examine the effect of Sopi Mayang drink on the increase in cytochrome P450 mRNA expression, increase in CYP2E1 protein levels and decrease in the number of spermatozoids using male white rats. This research is laboratory experimental, using the Randomized Post-test Only Control Group Design. Giving Sopi Mayang with a dose of 2.7 ml decreased the number of spermatozoids, namely 33,815,000, compared to the control group without giving Sopi Mayang, namely 56,680,000 (p = 0.0001). Sopi Mayang, with a dose of 4.05 ml, decreased sperm count from 33,815,000 to 22,334,775 (p= 0.0001). Sopi Mayang, with a dose of 5.4 ml, decreased sperm count from 22,865,000 to 18,250,309 (p=0.0001). There was a decrease in the number of spermatozoids in mice given Sopi Mayang. Keywords: Alcohol, Sopi Mayang, Spermatozoid, white rats ABSTRAK Minuman Sopi beralkohol berasal dari  pohon Enau/Aren (Arenga pinnata MERR) termasuk salah satu jenis tanaman palma, yang tersebar hampir di seluruh wilayah Indonesia. Alkohol yang terkandung dalam minuman tradisional Sopi adalah etanol (CH2CH3-OH) dari fermentasi nira. Penelitian ini ditujukan untuk melihat pengaruh minuman Sopi Mayang terhadap jumlah peningkatan ekspresi mRNA sitokrom P450, peningkatan kadar protein CYP2E1dan penurunan jumlah spermatozoid dengan menggunakan tikus putih jantan. Penelitian ini adalah eksperimental laboratoris, dengan menggunakan rancangan The Randomized Post-test Only Control Group Design. Pemberian Sopi Mayang dengan dosis 2,7 ml terjadi penurunan jumlah spermatozoid yaitu 33.815.000  dibandingkan dengan kelompok kontrol  tanpa pemberian  Sopi Mayang yaitu 56.680.000 (p = 0,0001). Sopi Mayang dengan dosis 4,05 ml terjadi penurunan jumlah sperma dari 33.815.000 menjadi 22.334.775 (p= 0,0001).  Sopi Mayang dengan dosis 5,4 ml terjadi penurunan jumlah sperma dari 22.865.000 menjadi 18.250.309 (p=0,0001). Terjadi penurunan jumlah spermatozoid, pada tikus yang diberikan Sopi Mayang. Kata Kunci: Alkohol, Sopi Mayang, Spermatozoid, Tikus Putih
Co-Authors A Asrina A. Nilawati Usman A.Wardihan Sinrang A.Wardihan Sinrang Abustani, Muthiah Agustin, Dinah Inrawati Ahmad, Mardiana Al Mukarram H. A. Amir, Muzakkir Andi Nilawati Andi Nilawati Usman Andi Wardihan Sinrang Arief, Nila Ardilla Arif Santoso Ariyandy, Andi Arwan Bin Laeto Budu - Cangara, Husni Desi Dwirosalia Suparman Dewiyana, Srigita Djabir, Yulia Yusrini Djaharuddin, Irawaty Dwi Kartika Sari Dwi P. Wulansari Edy Machmud Elizabeth Catherine Jusuf Enny Nahumuri Eri Hendra Jubhari Gemini Alam H Anwar, St Hadijah Hafsa, Mahmud Hafsah, Amir Mahmud Hasrianti, Hasrianti Hasrimayana Hasrimayana Healthy Hidayanti Idris, Irfan Ika Yustisia Ika Yustisia Ilhamjaya Patellongi Irene E. Rieuwpassa IRFAN IDRIS Ismail, Amirah Febrianti Kasim, Hasim Latifah Rahman Luciana Heidee Christianty Mallisa, Hilda Emma Mardiana Ahmad Mardiana Ahmad Mardiana Ahmad Mardiana Ahmad Masrika, Nur Upik En Massi, Moh Nasrum Muh Tamar Muh. Akbar Bahar Muhammad Aswad Muhammad Husni Cangara Muhammad Husni Cangara Natsir, Rosdiana Nila Ridhayani Nilawati Andi Nuni Rismayanti Nurkalbi Nur Aliya Arsyad Nur Amalia Alif Nur Hayati Saud Nur Partiwi Nurjannah Damis Nurlindah Hamrun Pratiwi, Vira Prihantono, Prihantono Putri, Dwi Anggara Rafiah, Siti Rafikah Hasyim Ramadhani, Sri Risfah Yulianti Risfah Yulianty Riu, Deviana Soraya Rosdiana Natsir Rosdiana Natsir Saidah Syamsuddin Sakinah, Andi Irhamnia Sanaky, Marliyati Seri Pasongli, Seri Sitti Rafiah Sri Hardiyanti Asad Sri Ramadany, Sri St. Raf’iah Stang Stang Veni Hadju Wadi Renah Werna Nontji Werna Nontji, Werna Widyatma Adinda Jubhari Yadul Ulya Yudi Yanto Yulia Y Djabir Yulia Yusrin Djabir Yulia Yusrini Djabir