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EFEK PERMEN KARET, MADU, DAN MOBILISASI DINI TERHADAP PEMULIHAN PERISTALTIK USUS DAN WAKTU FLATUS PADA PASIEN POST SEKSIO SESAREA: EFFECTS OF GUM, HONEY, AND EARLY MOBILIZATION ON RECOVERY OF INTESTINE PERISTALTIC AND FLATUS TIME IN PATIENTS POST CAESAREAN SECTION Hasrianti, Hasrianti; Aryadi Arsyad; Usman, Andi Nilawati; Ramadany, Sri; Nontji, Werna; Hafsa, Mahmud
GEMA KESEHATAN Vol. 16 No. 2 (2024): Desember 2024
Publisher : POLTEKKES KEMENKES JAYAPURA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47539/gk.v16i2.459

Abstract

Seksio sesarea menjadi salah satu operasi besar pada abdomen yang berhubungan langsung dengan perubahan post operatif dalam sistem saraf otonom yang menyebabkan penurunan pergerakan usus pada sistem pencernaan. Penelitian ini bertujuan untuk membandingkan efek mengunyah permen karet, mengonsumsi madu dan mobilisasi dini terhadap laju pemulihan fungsi peristaltik usus dan waktu kentut pada pasien post seksio sesarea. Penelitian ini menggunakan desain Quasi Experimental dengan pendekatan post-test only group design. Sebanyak 78 wanita post seksio sesarea dipilih melalui teknik purposive sampling, memenuhi kriteria inklusi serta bersedia berpartisipasi, dibagi menjadi tiga kelompok: Permen Karet (PK) + Mobilisasi Dini (MD), Madu (M) + MD, dan MD saja. Intervensi diberikan 3 jam post seksio sesarea, sedangkan pengukuran peristaltik usus dan waktu flatus dilakukan setiap 2 jam. Peristatik usus berbeda signifikan (P=0,00) di antara ketiga kelompok pada jam ke I, II dan III. Kelompok PK + MD mencatatkan rata-rata peristaltik tertinggi 28 kali, diikuti oleh kelompok M + MD 25 kali, dan MD 21 kali. Waktu flatus juga menunjukkan perbedaan signifikan antar kelompok (P= 0,041) dengan kelompok PK + MD mencatatkan rata-rata waktu flatus lebih cepat 500 menit dibandingkan kelompok M + MD 611 menit dan MD 754 menit. Mengunyah permen karet dengan mobilisasi dini terbukti lebih efektif dalam mempercepat pemulihan peristaltik usus dan waktu pertama flatus pada pasien pasca-seksio sesarea dibandingkan dengan kombinasi pemberian madu dan mobilisasi dini, maupun mobilisasi dini saja. Kata kunci: Flatus, Madu, Mobilisasi Dini, Peristaltik Usus, Permen Karet     A cesarean section is considered a major abdominal surgery that directly relates to post-operative changes in the autonomic nervous system, causing a reduction in intestinal movement within the digestive system. This study compares the effects of chewing gum, honey administration, and early mobilization on the speed of intestinal peristalsis recovery and the time to first flatus in post-cesarean section patients. This research uses a Quasi-Experimental design with a post-test-only group design approach. Seventy-eight women in the post-cesarean section were selected through purposive sampling, met the inclusion criteria, and agreed to participate. They were divided into three groups: Chewing Gum (CG) + Early Mobilization (EM), Honey (H) + EM, and EM alone. The interventions were administered 3 hours post-cesarean section, while intestinal peristalsis and flatus time were measured every 2 hours. Intestinal peristalsis showed a significant difference (P=0.00) between the three groups during the first, second, and third hours. The CG + EM groups recorded the highest average peristalsis at 28 times, followed by the H + EM groups at 25 times and the EM group at 21 times. Flatus time also showed a significant difference between groups (P=0.041), with the CG + EM groups recording a faster average flatus time of 500 minutes compared to the H + EM groups at 611 minutes and the EM group at 754 minutes. Chewing gum combined with early mobilization accelerates the recovery of intestinal peristalsis and the time to first flatus in post-cesarean section patients compared to honey administration with early mobilization or early mobilization alone. Keywords: Chewing Gum, Early Mobilization, Flatus, Honey, Intestinal Peristalsis
THE EFFECTS OF SIMVASTATIN, ROSUVASTATIN, AND FENOFIBRATE ON THE BODY WEIGHT AND LIPID PROFILES OF FEMALE RATS TREATED WITH ORAL CONTRACEPTIVES AND A HIGH-FAT DIET Putri, Dwi Anggara; Djabir, Yulia Yusrini; Bahar, Muhammad Akbar; Alam, Gemini; Rahman, Latifah; Aswad, Muhammad; Arsyad, Muhammad Aryadi
Jurnal Kedokteran Hewan Vol 16, No 3 (2022): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v16i3.22196

Abstract

This study aimed to compare the effects of simvastatin, rosuvastatin, and fenofibrate therapies on the body weight and lipid profiles of the female rats receiving a combination of oral contraceptives (COC) and a high-fat diet (HFD). Twenty female Wistar rats (130-200 g) were divided equally into four groups. The rats received a standard diet for seven days, and their baseline lipid profiles were analyzed. All rats also received COC containing 15.1 g/kg levonorgestrel/3.1 g/kg estradiol with HFD for 60 days. Starting on day 31, the rats were given the respected treatment. The control group received the vehicle, whereas the others were treated with either simvastatin (2.1 mg/kg), rosuvastatin (0.5 mg/kg), or fenofibrate (8.2 mg/kg). Blood samples were taken on days 30 and 60. The results showed that the administration of COC+HFD and vehicle for 30 days increased the rats body weight and dyslipidemia, characterized by a significant decrease in Low-Density Lipoprotein (HDL) and an increase in total cholesterol (TC) and triglycerides (TG) levels (P0.05). Among the treatments, only fenofibrate was found to be able to prevent a significant weight gain in rats. Both fenofibrate and rosuvastatin inhibited a significant rise in TG and TC levels. Meanwhile, the simvastatin administration failed to do the same. Although statistically insignificant, all treatments increased rats HDL levels. Thus, it can be concluded fenofibrate was the most effective treatment among all in reducing weight gain and improving the lipid profile of dyslipidemic rats induced by oral contraceptives and a high-fat diet.
Prenatal Covid-19 on Toddler Development Pasongli, Seri; Budu, Budu; Ahmad, Mardiana; Prihantono, Prihantono; Hidayanti, Healthy; Arsyad, M. Aryadi
JURNAL INFO KESEHATAN Vol 21 No 2 (2023): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol21.Iss2.1176

Abstract

Along with the spread of the COVID-19 pandemic, there has been an increase in reports of confirmed cases of pregnant women with COVID-19. Exposure to the virus in pregnancy can affect the fetus and result in long-term vulnerability to abnormalities in the child's brain development. This study aimed to determine the impact of prenatal Covid-19 on the development of toddlers. The research method uses observational cross-sectional analysis. Secondary data on confirmed Covid-19 mothers were obtained from Prof. RD Kandou General Hospital, Wolter Monginsidi Hospital, and Manado Adventist Hospital. Primary data on toddler development using the KPSP Development Questionnaire instrument were obtained from 10 Community Health Centers in Manado City with a total of 92 respondents for two, 46 respondents were born to mothers with Covid-19 during the prenatal period and 46 toddlers were born to mothers who were not confirmed to have Covid-19 during the prenatal period. The results showed that there was no significant effect with a p-value of 0.562 for toddlers born to Covid-19 mothers on impaired gross motor, fine motor, socialization, and independence, speech, and language development. Based on the results of the study it can be concluded that both toddlers born to Covid-19 mothers and toddlers who were not born to Covid-19 mothers are at risk of experiencing growth disturbances, especially toddlers born during the Covid-19 pandemic because there could be long-term effects that could occur in infants who are exposed to the virus during the prenatal/intrauterine period.
Pengaruh Pemberian Minuman Sopi Mayang Beralkohol terhadap Jumlah Spermatozoid, Pada Tikus Putih (Rattus norvegicus) Jantan Sanaky, Marliyati; Idris, Irfan; Rafiah, Siti; Arsyad, Aryadi
MAHESA : Malahayati Health Student Journal Vol 4, No 11 (2024): Volume 4 Nomor 11 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i11.15041

Abstract

ABSTRACT The alcoholic Sopi drink comes from palm trees (Arenga pinnata MERR), a type of palm tree spread throughout almost all of Indonesia. The alcohol in the traditional Sopi drink is ethanol (CH3CH2-OH) from fermented sap. This study aimed to examine the effect of Sopi Mayang drink on the increase in cytochrome P450 mRNA expression, increase in CYP2E1 protein levels and decrease in the number of spermatozoids using male white rats. This research is laboratory experimental, using the Randomized Post-test Only Control Group Design. Giving Sopi Mayang with a dose of 2.7 ml decreased the number of spermatozoids, namely 33,815,000, compared to the control group without giving Sopi Mayang, namely 56,680,000 (p = 0.0001). Sopi Mayang, with a dose of 4.05 ml, decreased sperm count from 33,815,000 to 22,334,775 (p= 0.0001). Sopi Mayang, with a dose of 5.4 ml, decreased sperm count from 22,865,000 to 18,250,309 (p=0.0001). There was a decrease in the number of spermatozoids in mice given Sopi Mayang. Keywords: Alcohol, Sopi Mayang, Spermatozoid, white rats ABSTRAK Minuman Sopi beralkohol berasal dari  pohon Enau/Aren (Arenga pinnata MERR) termasuk salah satu jenis tanaman palma, yang tersebar hampir di seluruh wilayah Indonesia. Alkohol yang terkandung dalam minuman tradisional Sopi adalah etanol (CH2CH3-OH) dari fermentasi nira. Penelitian ini ditujukan untuk melihat pengaruh minuman Sopi Mayang terhadap jumlah peningkatan ekspresi mRNA sitokrom P450, peningkatan kadar protein CYP2E1dan penurunan jumlah spermatozoid dengan menggunakan tikus putih jantan. Penelitian ini adalah eksperimental laboratoris, dengan menggunakan rancangan The Randomized Post-test Only Control Group Design. Pemberian Sopi Mayang dengan dosis 2,7 ml terjadi penurunan jumlah spermatozoid yaitu 33.815.000  dibandingkan dengan kelompok kontrol  tanpa pemberian  Sopi Mayang yaitu 56.680.000 (p = 0,0001). Sopi Mayang dengan dosis 4,05 ml terjadi penurunan jumlah sperma dari 33.815.000 menjadi 22.334.775 (p= 0,0001).  Sopi Mayang dengan dosis 5,4 ml terjadi penurunan jumlah sperma dari 22.865.000 menjadi 18.250.309 (p=0,0001). Terjadi penurunan jumlah spermatozoid, pada tikus yang diberikan Sopi Mayang. Kata Kunci: Alkohol, Sopi Mayang, Spermatozoid, Tikus Putih
The Effect of Edu-IFA on Knowledge and Compliance with Fe Tablet Consumption in Pregnant Women in Makassar City Zhagira, Tira; Catherine Jusuf, Elizabet; Usman, Andi Nilawati; Ahmad, Mardiana; Nontji, Werna; Arsyad, Aryadi; Intan Idiana Hassan
Window of Health : Jurnal Kesehatan Vol 8 No 2 (April 2025)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.v8i2.1533

Abstract

Anemia in pregnancy is still a serious problem in Indonesia, with a prevalence of 48.9%. Iron supplementation is widely considered an important strategy to reduce the incidence. The aim of the study is to analyze the effect of educational videos on the knowledge and compliance of pregnant women with Fe tablet consumption and to compare the impact of knowledge and compliance with the consumption of Fe tablets on pregnant women between the intervention group and the control group. The methods used in this study were quasi-experimental with a nonequivalent control group design. Sampling by the exhaustive sampling technique consisted of 64 respondents, with the intervention group of 32 people and the control group of 32 people. This study was carried out at the Dahlia Health Center and the Pertiwi Health Center in Makassar City for 5 months, with an intervention of 90 tablets or 3 months. Data were analyzed using the Chi-Square, Wilcoxon, McNemar, and Mann-Whitney tests. The result shows the intervention group showed a 100.0% increase in knowledge and 59.4% in compliance, while the control group experienced a 90.6% increase in knowledge and 56.2% in compliance. The educational video on the importance of blood supplement tablets during pregnancy effectively increases knowledge and compliance with Fe tablet consumption in pregnant women, so it is hoped that health workers can use educational video media as an alternative method in counseling.
Moringa Leaf Extract Capsules Enriched with Royal Jelly on Cortisol and Stress Dwi Kartika Sari; Veni Hadju; Werna Nontji; Mardiana Ahmad; Aryadi Arsyad; Andi Nilawati Usman; Yudi Yanto; Taqwin Taqwin
Jurnal Kesehatan Masyarakat Vol. 20 No. 4 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i4.3578

Abstract

During pregnancy, physiological and psychological changes often increase stress and cortisol levels. Administering moringa leaf extract capsules fortified with royal jelly presents a viable intervention to alleviate this stress. This study investigates the specific effects of these capsules on cortisol and stress levels in pregnant women. The study was conducted as a true experimental, single-blind, randomized controlled trial involving 61 pregnant women. The intervention group (n = 31) received moringa leaf extract capsules enriched with royal jelly, while the control group (n = 30) received multi-micronutrient supplements. The findings revealed a noteworthy reduction in cortisol levels within the intervention group (p = 0.030), from 26.61 ± 8.15 to 19.98 ± 14.00, as well as in the control group (p = 0.003), from 21.13 ± 7.76 to 13.26 ± 16.09. Likewise, stress levels exhibited a significant decrease within the intervention group (p = 0.016), decreasing from 18.68 ± 3.74 to 28.75 ± 15.02, and the control group (p = 0.000), declining from 19.17 ± 3.64 to 16.20 ± 3.38. Moringa leaf extract capsules enriched with royal jelly, as a natural remedy, merit the recommendation for inclusion in initiatives to enhance maternal and infant health.
Pengaruh Pemberian Dehydroepiandrosterone (DHEA) terhadap Aktivitas Peroksidasi Lipid dan Kadar Nitrit Oksida pada Aorta Tikus Wistar Jantan yang Terpapar Asap Rokok Nila Ridayani; Aryadi Arsyad; Yulia Yusrini Djabir
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol. 11 No. 2 (2022): Volume 11 Nomor 2 (September 2022)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The research aimed to investigate the effect of dehydroepiandrosterone (DHEA) on lipid peroxidation activity and nitric oxide concentration in the aorta of male Wistar rats due to exposure to cigarette smoke. This study was a laboratory experiment using 21 rats that were divided into 3 groups: KN-14 (negative control that is given smoke exposure within 14 days), DHEA-1 (15 mg/kgBW + smoke exposure for 14 days), and DHEA-2 (30 mg/kgBW + smoke exposure for 14 days). The exposure was carried out in 25-45 minutes with 4 cigarettes/day within 14 days. Surgery was performed in the 15th days to remove the aorta to examine malondialdehyde (MDA) as a biomarker of lipid peroxidation and nitric oxide (NO) concentration using Enzyme-linked Immunosorbent Assay (ELISA). The results showed that a significant increase in MDA concentrations was found in the group administered with DHEA, particularly at a dose of 30 mg/kgBW (p<0.05). Meanwhile, the administration of DHEA at doses of 15 and 30 mg/kgBW did not have a significant effect (p>0,05) on aortic NO concentrations compared to the group KN-14. Therefore, it can be concluded that the administration of DHEA could increase lipid peroxidation activity, as indicated by a significant increase in aortic MDA concentrations, without affecting aortic NO concentrations in rats exposed to cigarette smoke for 14 days.
Pengaruh Pemberian Dehydrepiandrosterone (DHEA) Terhadap Paru-Paru Tikus Wistar Jantan Yang Terpapar Asap Rokok Sri Hardiyanti Asad; Aryadi Arsyad; Yulia Yusrini Djabir
Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam Vol. 11 No. 2 (2022): Volume 11 Nomor 2 (September 2022)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study investigated the effect of dehydroepiandrosterone on the lungs of male Wistar rats exposed to cigarette smoke. A total of 21 male Wistar rats were divided into 3 groups, namely the first group (negative control exposed to cigarette smoke for 14 days), the second group (given DHEA at a dose of 15 mg/kgBW and exposure to cigarette smoke), the third group (given DHEA at a dose of 30 mg/kgBW and exposure to cigarette smoke). DHEA was administered orally through a cannula 30 minutes before exposure to cigarette smoke with an exposure duration of about 25-40 minutes, equivalent to 4 cigarettes/day. After 14 days of experimentation, the rats were euthanized. Right lungs were harvested for malondialdehyde level measurement using the thiobarbituric acid reactive substance method measured by UV-Visible spectrophotometer at a wavelength of 532 nm. The left lungs were also harvested for histopathological examination. This study showed that pulmonary malondialdehyde levels in second and third group tended to be higher than in first group. Meanwhile, histopathological examination showed that the percentage of lung tissue damage in second and third group tended to be lower than in first group. Thus, it can be concluded that DHEA at doses of 15 and 30 mg/kgBW tended to act as a pro-oxidant but might potentially improve lung histology due to cigarette smoke exposure.
Co-Authors A Asrina A. Nilawati Usman A.Wardihan Sinrang A.Wardihan Sinrang Abustani, Muthiah Agustin, Dinah Inrawati Ahmad, Mardiana Al Mukarram H. A. Amir, Muzakkir Andi Irhamnia Sakinah Andi Nilawati Andi Nilawati Usman Andi Wardihan Sinrang Arief, Nila Ardilla Arif Santoso Ariyandy, Andi Arwan Bin Laeto Budu - Cangara, Husni Catherine Jusuf, Elizabet Desi Dwirosalia Suparman Dewiyana, Srigita Djabir, Yulia Yusrini Djaharuddin, Irawaty Dwi Kartika Sari Dwi P. Wulansari Edy Machmud Elizabeth Catherine Jusuf Enny Nahumuri Eri Hendra Jubhari Gemini Alam H Anwar, St Hadijah Hafsa, Mahmud Hafsah, Amir Mahmud Hasrianti, Hasrianti Hasrimayana Hasrimayana Healthy Hidayanti Idris, Irfan Ika Yustisia Ika Yustisia Ilhamjaya Patellongi Intan Idiana Hassan Irene E. Rieuwpassa, Irene E. IRFAN IDRIS Ismail, Amirah Febrianti Kasim, Hasim Latifah Rahman Luciana Heidee Christianty Mallisa, Hilda Emma Mardiana Ahmad Mardiana Ahmad Mardiana Ahmad Mardiana Ahmad Masrika, Nur Upik En Massi, Moh Nasrum Muh Tamar Muh. Akbar Bahar Muhammad Aswad Muhammad Husni Cangara Muhammad Husni Cangara Natsir, Rosdiana Nila Ridayani Nila Ridhayani Nilawati Andi Nuni Rismayanti Nurkalbi Nur Aliya Arsyad Nur Amalia Alif Nur Hayati Saud Nur Partiwi Nurjannah Damis Nurlindah Hamrun Pratiwi, Vira Prihantono, Prihantono Putri, Dwi Anggara Rafiah, Siti Rafikah Hasyim Ramadhani, Sri Risfah Yulianti Risfah Yulianty Riu, Deviana Soraya Rosdiana Natsir Rosdiana Natsir Saidah Syamsuddin Sanaky, Marliyati Seri Pasongli, Seri Sitti Rafiah Sri Hardiyanti Asad Sri Ramadany, Sri St. Raf’iah Stang Stang Taqwin Taqwin Veni Hadju Veni Hadju Wadi Renah Werna Nontji Werna Nontji, Werna Widyatma Adinda Jubhari Yadul Ulya Yudi Yanto Yulia Y Djabir Yulia Yusrin Djabir Yulia Yusrini Djabir Zhagira, Tira