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All Journal Medicina Buletin Udayana Mengabdi E-Jurnal Medika Udayana Majalah Ilmiah Fisioterapi Indonesia JURNAL BIOMEDIK E-Jurnal Udayana Medica Jurnal Kesehatan Andalas MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Bali Anatomy Journal Oryza : Jurnal Pendidikan Biologi Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan

I Wayan Sugiritama

Departemen Histologi Fakultas Kedokteran Universitas Udayana

Author-ID : 388906

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Other

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Prevalence of risk factors associated with hypertension at Sanglah General Hospital, Bali Mahen Isaac Pannir Chelvam; I Wayan Sugiritama; I Gusti Nyoman Kamasan Arijana
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: High blood pressure, also called "hypertension," is a serious medical condition. It happens when the force of the blood pumping through the arteries is too strong. The World Health Organization rates hypertension as one of the most important causes of premature death worldwide, and the problem is growing. This study aimed to determine the risk factors affecting Hypertension at Sanglah general hospital.Methods: This study was a descriptive study with a cross-sectional approach. The data used in this study is a secondary data collected from medical record of the patients with Hypertension at Sanglah general hospital, Denpasar, Bali in the year of 2015 until 2016. The data was categorized based on Body Mass Index (BMI), gender, age, alcohol consumption, and history of cardiovascular diseases.Results: There are 73(60.83%) males and 47(39.17%) females, the majority of patients were in the age group of 18 â€“ 70 years of age with the age group of 40 - 50 carrying a rather large quantity of 45.8% among the male gender and for the female gender the age group of 51 â€“ 60 showed the highest percentage of 38.2%, the sample consists of 60.83% of males and 39.17 of females from the total 120 samples taken from Sanglah general hospital. As for Body Mass Index (BMI), 25 â€“ 29.9 has the most significant value of 49 (40.83%) when compared to the other nutritional statuses present. The patients with the cardiovascular disease showed a very substantial amount of 69 (57.5%) among males and 41 (34.17%) among females. Patients with a history of alcohol consumption for the male gender had a value of 34 (28.30%), and for the female gender group, it carried an amount of 2 (1.70%).Conclusions: This study succeeded in identifying 120 samples of patients with hypertension and their contributing risk factors. The majority of the Samples were with body mass index (BMI) 25 â€“ 29.9 (40.83%). The samples with a history of cardiovascular disease showed a value of 69 (57.5%) among males and 41 (34.17%) among females. Patients with a history of alcohol consumption for the male gender had a value of 34 (28.30%), and for the female gender group, it carried an amount of 2 (1.70%)

Pemberian ekstrak kulit buah anggur (Vitis vinifera L.) mampu menurunkan kadar malondialdehid (MDA) plasma pada tikus dengan diet tinggi kolesterol Etik Nurhidayati; Ni Made Linawati; I Wayan Sugiritama
Intisari Sains Medis Vol. 11 No. 2 (2020): (Available online: 1 August 2020)
Publisher : DiscoverSys Inc.

Introduction: High cholesterol levels will cause disease, one of which is cardiovascular disorders or diseases. Based on WHO data in 2012 there were 17.5 million deaths in the world due to cardiovascular disease. Coronary heart occupies the highest position at 42% where one of the most common risk factors is dyslipidemia. This research aimed to evaluate the effect of grape skin extract on plasma MDA level.Methods: This study is an experimental study with a post-test only control group research design. Thirty male Wistar rats aged 2-3 months with a body weight of around 200 grams and healthy, classified into 4 treatment groups and a control group with a high cholesterol diet and administration of different dosages of grape skin extract, dose of 100 mg/175 gbw (gram body weight), 250 mg/175 gbw, and 500 mg/175 gbw. All blood samples were taken on day 30 and an MDA test was performed. Kruskal Wallis test was performed to analyze the correlation.Results: The test results obtained with p<0.05 in the group of rats given grape skin extract at a dose of 100 mg/175 gbw, 250 mg/175 gbw, and 500 mg/175 gbw, thus showing significantly lower MDA levels compared with control group.Conclusion: Administration of grape skin extract to rats given a high cholesterol diet may reduce plasma MDA levels.Â Latar belakang: Kolesterol yang tinggi di dalam darah akan mengakibatkan berbagai masalah kesehatan, salah satunya adalah gangguan atau penyakit kardiovaskular. Data tahun 2012 terdapat 17,5 juta kematian di dunia karena masalah kardiovaskular. Jantung koroner menduduki posisi tertinggi yaitu 42% dimana salah satu faktor risiko terseringnya adalah dislipidemia. Mengetahui dampak pemberian kulit buah anggur terhadap MDA plasma tikus adalah sasaran penelitian ini.Metode: Sebuah penelitian eksperimental menggunakan metode post-test only diterapkan pada penelitian ini. Tiga puluh tikus wistar jantan, umur 2-3 bulan, berat rerata 200 gram, dan sehat, dikelompokkan ke dalam 1 kelompok kontrol serta 4 kelompok perlakuan dengan diet tinggi kolesterol dan pemberian dosis ekstrak kulit anggur yang berbeda-beda, yaitu dosis 100 mg/175 gbb, 250 mg/175 gbb dan 500 mg/175 gbb. Pada akhir penelitian, yaitu hari ke- 30, semua sampel diambil darahnya kemudian dilakukan uji MDA.Hasil: Uji penelitian dengan Kruskal Wallis memperoleh hasil p=0,035 (p<0,05) pada kelompok tikus yang diberikan ekstrak kulit anggur dengan dosis 100 mg/175 gbb, 250 mg/175 gbb dan 500 mg/175 gbb, sehingga menunjukkan kadar MDA lebih rendah signifikan dibanding dengan kontrol.Simpulan: Pemberian ekstrak kulit buah anggur memiliki dampak penurunan MDA plasma pada tikus dengan diet tinggi kolesterol.

Efek Pemberian Kulit Buah Naga merah (Hylocereus polyrhizus) terhadap Tebal Endometrium dan Miometrium Tikus Model Menopause Wong, Ferdinand; Sugiritama, I Wayan; Ratnayanti, I Gusti Ayu Dewi; Wahyuniari, Ida Ayu Ika; Wiryawan, I Gusti Nyoman Sri
E-Jurnal Medika Udayana Vol 12 No 6 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i06.P15

ABSTRACT Effects of Giving Red Dragon Fruit Skin (Hylocereus polyrhizus) as Phytoestrogens on Endometriak Thickness and Myometrium of Menopausal Model Rats Background: Menopause is a condition in which the body experiences a lack of estrogen due to decreased ovarian function. Decreased estrogen levels result in particular changes in the thickness and shape of the uterus. Phytoestrogens are herbal compounds that have several similarities to the functions and structures of estrogen. Phytoestrogens also can be an alternative as a therapeutic option when they need a substitute for estrogen. Among several types of phytoestrogens, anthocyanin is one of the potential. Anthocyanins are mostly found in the red dragon fruit, Hylocereus polyrhizus. Red dragon fruit skin contains anthocyanins. Anthocyanins compounds have the potential to overcome the symptoms caused by menopause through their phytoestrogens and antioxidant activity.Objective: The main purpose of this study is to determine the effect of red dragon fruit skin extract (Hylocereus polyrhizus) on the thickness of the endometrium ad myometrium in menopausal model rats. Methods: This study applied a randomized post-test only control group design using a sample of 30 female wistar rats that met the inclusion and exclusion criteria. The sample was divided into 3 (three) treatment groups where a group was consisted of 10 female wistar rats. The treatment group 1 was the control group, while the treatment group 2 was the group given the ethanol extract of red dragon fruit skin at a dose of 60 mg/200 grBW/day for 30 days, and the treatment group 3 was the group given the ethanol extract of red dragon fruit skin at a dose of 90 mg/200 grBW/day for 30 days. Results: The study signified an increase in the endometrial thickness after being given red dragon fruit extract (Hylocereus polyrhizus) at a dose of 60 mg/200 grBW and 90 mg/200 grBW in menopausal model rats. In the single-lane ANOVA test, the thickness of the endometrium found a significance value of 0.038 (p<0.05), while the thickness of the myometrium found a significance value of 0.000 (p<0.05).

Pengaruh Ekstrak Etanol Kulit Buah Naga Merah (Hylocereus polyrhizus) terhadap Deposisi Kolagen pada Hepar Tikus Model Menopause Kenjiro, Eduardo; Arijana, I Gusti Kamasan Nyoman; Sugiritama, I Wayan; Ratnayanti, I Gusti Ayu Dewi
E-Jurnal Medika Udayana Vol 12 No 6 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i06.P18

Background : Estrogen is a steroid hormone that is not only the primary sexual hormone in women, but also functions to protect the body from many damaging conditions, especially in the liver. Red dragon fruit (Hylocereus polyrhizus) rind is known to have a higher antioxidant potential than the fruit flesh and has the potential to be an alternative solution for this condition. Objective : To determine the effect of giving Hylocerus polyrhizus rind extract on collagen deposition in the livers of menopausal wistar rats. Methods : This randomized post-test only control group design study was conducted on in vivo experimental animals in the form of rats that had undergone the ovariectomy procedure and were randomly divided into three groups. Group P0 served as the control without intervention, P1 with the intervention of ethanol extract of red dragon fruit rind at a dose of 60 body weight/200gr/day, while P2 with the intervention at a dose of 90 body weight/200grBB/day. Results : Of the 30 mice divided into three groups, the mean area of collagen deposition was obtained in the P0 (24,130 ± 7,205), P1 (18,325 ± 4,221) and P2 groups (12,576 ± 3,739). The test results with One Way ANOVA found a significant difference with a value of p = 0.000189. The results of the LSD Post Hoc test found a significant difference in mean between the P0 and P2 groups (p = 0.00017). Conclusion : Administration of Hylocereus polyrhizus ethanol extract inhibited the expansion of collagen deposition in the treatment group's livers when compared to the control group's livers.

PENGARUH PEMBERIAN EKSTRAK ETANOL KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) TERHADAP EKSPRESI KOLAGEN DINDING VAGINA PADA TIKUS MODEL MENOPAUSE Rahcmanita, Dhila Cahya; Sugiritama, I Wayan; Ratnayanti, I Gusti Ayu Dewi; Wahyuniari, Ida Ayu Ika
E-Jurnal Medika Udayana Vol 12 No 6 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i06.P16

The skin of red dragon fruit (Hylocereus polyrhizus) contains polyphenols, in particular anthocyanins, which may act as phytoestrogens and antioxidants. Phytoestrogens can help synthesize collagen through their bonds with estrogen receptors and antioxidants prevent the accumulation of free radicals that can damage collagen, so the skin of red dragon fruit has the potential to prevent vaginal organ disorders due to the reduced amount of collagen in the vaginal wall during menopause. This study aims to prove the effectiveness of the ethanol extract of Hylocereus polyrhizus rind in preventing decreased collagen in the vaginal wall of menopausal rats. This study was structured using a randomized post-test only control group design on 30 female Wistar rats, which were divided into three groups, namely the control group (P0) was given normal saline, the treatment group (P1) was given ethanol extract 60mg/200grBW and (P2) was given ethanol extract 90mg/200grBB. Dosing rats orally for 30 days, then vaginal wall samples were taken to examine vaginal collagen levels with Sirius red staining. The amount of collagen is calculated by the percentage area of ??the collagen pixels compared to the pixels of the entire vaginal tissue. The results show that the mean amount of collagen at P0, P1 and P2 is 55.53 ± 8.12 respectively; 67.50±3.89; 78.14±5.87. The One-way ANOVA test shows statistically significant differences among the groups (p = 0.000). The post hoc analysis using the LSD test finds that the mean amount of vaginal collagen in P2 is the highest than P0 (p=0.000) and P1 (p=0.001) and P1 is higher than P0 (p=0.000). It is concluded that giving of ethanol extract of Hylocereus polyrhizus rind is able to prevent the decrease in vaginal wall collagen in menopausal rats.

PENGARUH KRIM TOPIKAL EKSTRAK DAUN KELOR TERHADAP KELEMBABAN KULIT YANG TERPAPAR SINAR ULTRAVIOLET B Gabrielle, Gabrielle; Arijana, I G Kamasan Nyoman; Sugiritama, I Wayan; Ratnayanti, I Gusti Ayu Dewi
E-Jurnal Medika Udayana Vol 12 No 11 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i11.P17

Exposure to UV light as an inducer of ROS will damage lipid macromolecules, proteins, and DNA. Lipids as a layer that prevents evaporation of the skin will lose the ability to hold water evaporation due to excessive UV exposure for a long time so that the impact on the skin will look dry due to an increase in transepidermal water loss (TEWL) so that the water content in the stratum corneum (SC) decreases. Adverse effects on the skin caused by free radicals such as dry skin can be overcome with several active ingredients contained in Moringa leaf extract (Moringa oleifera) which contain flavonoids and other active ingredients. This study aims to analyze the effect of Moringa (Moringa oleifera) leaf extract cream with concentrations of 5%, 10%, and 20% on moisture in rat skin exposed to UV light. This study used a randomized pre-test and post-test pattern on 30 male Wistar rats which were split up randomly into 5 groups. The moisture value of the rat skin was measured to find the moisture value before treatment (pre-test) using a skin analyzer 24 hours after shaving. The group will be divided into control, base cream, Moringa leaf extract cream with a concentration of 5%, 10%, and 20%. The cream will be applied 20 minutes before and 4 hours after exposure to UVB rays. Response to therapy was measured using a skin analyzer 24 hours after 2 weeks of irradiation in the 5 groups. Data analysis used the Wilcoxon, Kruskal-Wallis, and Mann-Whitney tests. Based on data analysis of the mean skin moisture value, no significant difference was found between the pretest and posttest, but the post-test data between concentration groups showed significant results as measured using the Kruskal Wallis test and the Mann-Whitney test.

PENGARUH PEMBERIAN EKSTRAK KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) SEBAGAI FITOESTROGEN TERHADAP STEATOSIS HEPAR TIKUS MODEL MENOPAUSE Hernowo, Elliana Freya; Arijana, IGK Nyoman; Sugiritama, I Wayan; Ratnayanti, IGA Dewi
E-Jurnal Medika Udayana Vol 12 No 6 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i06.P17

Latar belakang: Wanita menopause akan mengalami penurunan hormon estrogen. Hormon estrogen diketahui memiliki sifat hepatoprotektif yang mampu mencegah terjadinya perlemakan pada hepar. Penurunan kadar estrogen bisa digantikan dengan senyawa fitoestrogen. Kulit buah naga merah (Hylocereus polyrhizus) diketahui memiliki banyak kandungan antosianin yang terbukti memiliki aktivitas sebagai fitoestrogen. Tujuan: Mengetahui adakah perubahan steatosis hepar tikus model menopause dengan pemberian ekstrak etanol kulit buah Hylocereus Polyrhizus. Metode: Penelitian ini merupakan penelitian randomized post-test control group design dengan menggunakan tiga kelompok sampel yang sudah melalui prosedur ovariektomi. Ketiga kelompok adalah kelompok P0 sebagai kontrol tanpa intervensi, P1 dengan intervensi ekstrak etanol kulit buah naga merah dosis 60mg/200grBB, dan P2 dengan intervensi ekstrak etanol kulit buah naga merah dosis 90mg/200grBB. Hasil: Didapatkan rerata jumlah sel steatosis per 100 sel hepar tikus model menopause pada kelompok P0, P1, dan P2 adalah 59,1259 ± 10,0087; 53,0435 ± 14,0674; 41,5001 ± 10,5814. Hasil One Way ANOVA menemukan adanya perbedaan yang bermakna dengan nilai p = 0,013. Hasil uji Post Hoc LSD menemukan perbedaan rerata antara kelompok P2 dengan P0 ditemukan bermakna (p = 0,004) dan P2 dengan P1 juga bermakna (p = 0,047). Sedangkan P0 dan P1 tidak bermakna (p = 0,247). Simpulan: Ekstrak etanol kulit buah Hylocereus Polyrhizus memiliki pengaruh terhadap steatosis hepar tikus model menopause. Didapatkan steatosis hepar terendah pada kelompok intervensi 90mg/200grBB. Kata kunci : Hylocereus polyrhizus, steatosis, menopause, fitoestrogen

EFEK PEMBERIAN TEH KOMBINASI EUPHORBIA MILII DAN PROPOLIS TERHADAP GAMBARAN HISTOPATOLOGI HEPAR TIKUS WISTAR JANTAN Rastika, I Gede Agus; Linawati, Ni Made; Ratnayanti, I Gusti Ayu Dewi; Sugiritama, I Wayan
E-Jurnal Medika Udayana Vol 11 No 5 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i05.P09

ABSTRAK Pendahuluan: Indonesia mempunyai sumber daya melimpah yang dapat digunakan sebagai pengobatan tradisional. Dua diantaranya yaitu tanaman Euphorbia milii dan propolis. Euphorbia milii dan propolis mempunyai beragam manfaat seperti antioksidan, antibakteri, dan imunomodulator. Efek toksik dari teh kombinasi Euphorbia milii dan propolisx terhadap hepar belum dilaksanakan penelitian sebelumnya. Tujuan dari dilaksanakannya penelitian ini yaitu untuk mengetahui efek pemberian teh kombinasi dari bunga Euphorbia milii dan propolis terhadap gambaran histopatologi hepar tikus wistar jantan. Metode: Penelitian ini merupakan penelitian analitik eksperimental dengan rancangan penelitian berupa randomized post-test only control group design. Dua puluh empat tikus wistar jantan berusia 8 sampai 12 minggu dengan berat badan ± 0.2 kg dibagi menjadi 4 kelompok, yaitu; kelompok kontrol (pakan standar + aquabidest), P1 (teh kombinasi Euphorbia milii dan propolis 40mg/100grbb selama 2 minggu), P2 (teh kombinasi Euphorbia milii dan propolis 40mg/100grbb selama 4 minggu), dan P3 (teh kombinasi Euphorbia milii dan propolis 40mg/100grbb selama 6 minggu). Hasil: Berdasarkan analisis data dari rerata skoring degenerasi dan nekrosis sel hepatosit, tidak ditemukan perbedaan rerata yang signifikan diantara kelompok kontrol dan kelompok perlakuan P1, P2, dan P3 (p>0,05). Simpulan: Berdasarkan hasil yang diperoleh, dapat disimpulkan bahwa pemberian teh kombinasi Euphorbia milii dan propolis dengan dosis 40mg/100grbb tidak menimbulkan kerusakan yang bermakna terhadap hepar tikus wistar jantan. Kata kunci : Teh kombinasi, Euphorbia milii dan propolis, Histopatologi hepar

Tinjauan Literatur: PATOGENESIS DAN TERAPI ATROFI VAGINA Sugiritama, I Wayan; Linawati, Ni Made; Wiryawan, I Gusti Nyoman Sri; Wahyuniari, Ida Ayu Ika; Ratnayanti, Gusti Ayu Dewi; Arijana, I Gusti Kamasan Nyoman
Majalah Kesehatan Vol. 11 No. 2 (2024): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2024.011.02.8

Atrofi vagina adalah masalah kesehatan yang paling banyak dialami oleh wanita menopause. Patogenesisnya berkorelasi dengan penurunan kadar hormon estrogen, yang mengakibatkan epitel vagina lebih tipis dengan proporsi sel-sel superfisial yang menurun. Pada dinding vagina terjadi penurunan jumlah serabut kolagen, penurunan massa otot polos dan penurunan vaskularisasi. Konsekuensi dari perubahan tersebut adalah dinding vagina mengalami penurunan dalam ukuran, elastis, lubrikasi, dan integritas lapisan mukosa. Gejala yang paling sering dialami adalah rasa nyeri pada vagina, yang akhirnya menyebabkan ketakutan untuk melakukan aktivitas seksual.Penanganan gejala atrofi vagina menjadi penting karena populasi wanita menopause yang besar dan akan terus meningkat. Tujuan penulisan tinjauan literatur adalah mengulas patogenesis atrofi vagina dan berbagai macam pilihan terapinya. Literatur didapatkan melalui pencarian pada Google Scholar dan PubMed database selama tahun 2022 dan dipilih terbitan 10 tahun terakhir, baik dalam Bahasa Indonesia maupun Bahasa Inggris. Kata kunci yang digunakan adalah menopause, atrofi vagina, patogenesis atrofi vagina, terapi atrofi vagina, fitoestrogen, Selective Estrogen Estrogen Receptors (SERM), dan terapi sulih hormon. Hasil menemukan bahwa sebagian besar kasus tidak terdiagnosis dan hanya sedikit yang mendapat terapi yang tepat. Sebagian besar wanita menopause mengobati sendiri gejala atrofi vagina yang dialami dengan obat-obat yang dijual bebas dan ada banyak kasus yang tidak diobati. Terapi utama atrofi vagina adalah hormon yang diberikan secara sistemik atau topikal. Salah satu terapi sistemik adalah SERM. Terapi topikal pilihannya sangat banyak yaitu fitoestrogen, asam hialuronat, pelembab, pelumas, kolostrum, vitamin, herbal, terapi laser dan radio frekuensi. Berbagai jenis metode terapi memiliki mekanisme kerja yang berbeda, sebagian besar terbukti efektif mampu memperbaiki struktur dan fisiologi vagina serta mampu mengurangi gejala atrofi vagina dan juga memperbaiki fungsi seksual.

Ekstrak Etanol Ubi Jalar Ungu untuk Mencegah Peningkatan pH Vagina setelah Ovariektomi Bilateral pada Tikus Wistar Sugiritama, I Wayan; Sri Wiryawan, I Gusti Nyoman; Linawati, Ni Made; Wahyuniari, Ida Ayu Ika; Ratnayanthi, I Gusti Ayu Dewi; Arijana, I Gusti Nyoman Kamasan
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5641

AVaginal atrophy is one of the most common health problems in postmenopausal women. The disease is characterized by decreasing layers and maturation index of the vaginal epithelium and an increase in vaginal pH. A decrease in vaginal acidity will increase the susceptibility to infections since acidic pH protects the vagina from pathogens infection. The previous study has proven that phytoestrogens were effective to improve the microstructures of the vaginal, reduce urogenital complaints, and improve vaginal pH. The purple sweet potato (Ipomea batatas L.) which is cultivated in Bali was recognized for its high anthocyanin content and was reported to have phytoestrogen activity. The aim of the present study is to evaluate the effect of purple sweet potato on vaginal pH in an animal model of menopause. The randomized pre-test post-test control group design study was conducted using 36 bilateral ovariectomized female Wistar rats as an animal model of menopause. The animals were divided randomly into a control group (T0) which was given saline and a treatment group (T1) given an ethanolic extract of purple sweet potato 400 mg/day for 30 days. Vaginal pH was measured before treatment, every week during treatment, and after treatment. The result of the study showed that there was an increase in vaginal pH of the T0 on the 2nd and 3rd week, and after treatment (P

Co-Authors Agus Eka Darwinata Alifia Dwi Lestari Anak Agung Gede Eka Septian Utama Arcana N Ari Wibawa Ari Wibawa Aria Wibawa Arijana, I G Kamasan Nyoman Arijana, I Gusti Nyoman Kamasan Arijana, IGK Nyoman Bella Aulya Safitri Desak Putu Citra Udiyani Dewa Ayu Agus Sri Laksmi Dewi, Anak Ayu Nyoman Trisna Narta Dyta Putri Aryo Eswariy Chandramogan Etik Nurhidayati Eugenia Meidy Fedik Abdul Ratam Ferbian M. Siswanto, Ferbian M. Fitrotul Imaniyah Gabrielle, Gabrielle Gayathiri Mohana Krishnan Gede Parta Kinandana Gede Wirata Gusti Ngurah Mayun Hernowo, Elliana Freya I Dewa Ayu Eka Widiari Putri I Dewa Ayu Inten Primayanti I Dewa Gede Angga Triadi Nata I Gde Haryo Ganesha I Gusti Ayu Dewi Ratnayanthi I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Dewi Ratnayanti I Gusti Ayu Dwita Wahyu Laksmi I Gusti Kamasan I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Gusti Nyoman Sri Wiryawan I Made Jawi I Made Krisna Dinata I MADE MULIARTA . I Made Niko Winaya I Made Sudarmaja I Nyoman Adi Putra I Nyoman Wande I Putu Adi Merta I Putu Adiartha Griadhi I Putu Dema Prasetya I Wayan Juli Sumadi I. G. A. D. Ratnayanthi Ida Ayu Dewi Wiryanthini Ida Ayu Ika Wahyuniari IGN Iswarabhuwana WP Indira Vidiari Juhanna Intan Syahirah Bt Abdul Rauap Jessica Yuwono Joshua Ezra Ronaldo Bayak Kadek Ady Antara Kenjiro, Eduardo Komang Dhyanayuda P. Komang Jegek Triangga Apsari Linawati N.M Linawati, Ni M. Linawati, NM Luh Putu Ratna Sundari M Widnyana Made Dwi Indah Permatahati Gita Made Hendra Satria Nugraha Made Tami Budirejeki Mahen Isaac Pannir Chelvam Masnathasari, NM Ayu Maulidya, Maulidya Mayun G.N Melita Soares Cristovao N. M. Linawati Negara, Anak Agung Gede Angga Puspa Ni Kadek Mira Wirayani Ni Komang Tristiana Dewi Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Ni Luh Nopi Andayani Ni Luh Nopi Andayani, Ni Luh Nopi Ni Made Deni Purnama Ni Made Linawati Ni Made Mertaniasih Ni Made Rininta Adi Putri Ni Nyoman Mekar Sari Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Ni Putu Junika Putri Ni Putu Sriwidyani Nila Wahyuni Norshazreen Nazri Nuril Hidayah Pangkahila, Elionardo Putra, I Putu Yudi Pramana Putri Miucin Raditya Pradipta Rahcmanita, Dhila Cahya Rastika, I Gede Agus Ratnayanthi, I Gusti Ayu Dewi Ratnayanti, Gusti Ayu Dewi Regina, Ni Kadek Pramesti Ruthirar Kalaichelvam Santoso, Natania Faustine Saraswati, Ni Luh Putu Gita Karunia Saraswati, Putu Ayu Sita Susilo, Yunike Trisna Damayanti Vania Lannisa Haestidyatami Widianti, IGA Wona, Yohana Virani Wong, Ferdinand Yogarani V.C Rajappan Zahra, Fahdia Fitrianti

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