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Effectiveness of Guided Imagery to %FEV1, Absolut Neutrophil, Anxiety, and Quality of Life in Stable Chronic Obstructive Pulmonary Disease (COPD) Patient Herlina, Liana; Sutanto, Yusup Subagio; Nugroho, I.G.B Indro; Harsini, Harsini; Prasetya, Windu
Jurnal Respirologi Indonesia Vol 44 No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.387

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a leading factor in morbidity and mortality worldwide associated with excessive chronic inflammatory response. Guided imagery is a relaxation technique to achieve the desired positive outcome. This study analyzed the effectiveness of guided imagery in stable COPD patients on the value of % FEV1, absolute neutrophils, anxiety, and the standard of living in those with steady COPD.Methods: Experimental analytic research with quasi-experimental, pretest and post-test design. Subjects were outpatient stable COPD patients at the pulmonary polyclinic of UNS Surakarta Hospital in January-June 2022. Subjects were divided into guided imagery intervention groups for 4 weeks and controls. Subjects were then examined for %FEV1 by spirometry, absolute neutrophils, Taylor Minnesota Anxiety Scale (TMAS) questionnaire, and St. George Respiratory Questionnaire (SGRQ) quality of life questionnaire, and re-evaluated after four weeks.Results: There were 32 research subjects. The findings demonstrated that the therapy group did not endure a significant increase in the mean value of %FEV1 (P=0.617). Meanwhile, the mean value of %FEV1 significantly decreased in the control group (P=0.025), given that the control group's value of % FEV1 fell. In contrast, the treatment group's increased, even if the difference was not statistically significant, the use of guided imagery could effectively halt the decline in %FEV1 value. Compared to the control group (P=0.014), the TMAS anxiety score was lower in the treatment group (P≤0.001). The overall SGRQ score (quality of life) considerably decreased in the treatment group (P≤0.001) while significantly increasing in the control group (P=0.014). Absolute neutrophils were found in both the treatment group and the control group (P=0.642; P=0.224, respectively). Absolute neutrophil blood levels in the treatment and control groups did not differ significantly.Conclusion: Guided imagery is effective on %FEV1 values, anxiety, and quality of life in stable COPD patients but not against absolute neutrophils.
Differences in Interleukin-6 Levels, Neutrophil Levels, and Length of Hospitalization in Pneumonia Patients with and without Garlic Supplementation (Allium sativum) Irawan, Yogie; Harsini, Harsini; Sutanto, Yusup Subagio
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.396

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bacteria, viruses, fungi, or parasites, with high mortality and morbidity rates. The examination of IL-6 and neutrophils helps in diagnosis as a marker of inflammation, a predictor of mortality and morbidity, and is useful in evaluating the outcome of treatment. Garlic and its organosulfur content possess anti-inflammatory activity that has the potential to be used as additional therapy in pneumonia patients.Methods: A clinical study with a pretest-posttest quasi-experimental design was conducted on pneumonia patients who were hospitalized at Dr. Moewardi General Hospital, Surakarta from August to October 2022 by consecutive sampling. The treatment group (n=20) received standard therapy plus 3.5 mg of garlic capsules per day for 6 days, while the control group (n=20) received standard therapy. Levels of IL-6 and neutrophil were calculated on the first and sixth days, while the length of hospitalization was calculated from when the patient was admitted until discharge.Results: There was a significant IL-6 difference in the treatment group (P=0.027) and a neutrophil difference in the treatment group (P=0.025) compared to the control group, but there was no significant difference (P=0.876) in the length of stay in the treatment group compared to the control group.Conclusion: Giving garlic as a supplemental therapy to pneumonia patients could significantly reduce IL-6 and neutrophil levels.
Serum Matrix Metalloproteinase 9 Level, Blood Absolute Neutrophil Count in Correlation with Diffusion Capacity and Exercise Capacity of Stable Chronic Obstructive Pulmonary Disease Patients at Universitas Sebelas Maret Hospital Lestari, Anggraini Dwi; Apriningsih, Hendrastutik; Reviono, Reviono; Sutanto, Yusup Subagio; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.400

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Background: Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide. Exposure to cigarette smoke activates alveolar macrophages producing neutrophils and proteases such as MMP-9 and NE that damage the extracellular matrix triggering emphysema as well as spill over into the systemic circulation. This study aimed to determine the correlation of serum MMP-9 level and blood absolute neutrophil count with diffusion capacity and exercise capacity of stable COPD patients.Methods: A cross-sectional observational study was conducted in stable COPD patients visiting the pulmonary outpatient clinic of Universitas Sebelas Maret (UNS) Hospital in October 2022. Consecutive sampling was applied for sample collection. We assessed diffusion capacity and exercise capacity with the DLCO method and 6MWT, respectively. We examined serum MMP-9 level and blood absolute neutrophil count. All data were statistically analyzed with SPSS 22.0 and P<0.05 was considered significant.Results: Thirty stable COPD patients were included in the study comprising 19 males (63.3%), and 11 females (36.7%). With a mean age of 61.90±9.99. Serum MMP-9 level did not correlate with either diffusion capacity and blood absolute neutrophil count (P=0.898 and P=0.589, respectively). However, serum MMP-9 level had a significant correlation with exercise capacity (P=0.014). There was no correlation between blood absolute neutrophil count with diffusion capacity and exercise capacity (P=0.0281 and P=0.592, respectively). Diffusion capacity related to exercise capacity (P=0.001).Conclusion: Serum MMP-9 level is not related to diffusion capacity, but it is related to exercise capacity. Blood absolute neutrophil count is not related to diffusion capacity or exercise capacity. Serum MMP-9 level is not associated with blood absolute neutrophil count. Diffusion capacity is related to exercise capacity. 
Effects of Aerobic Exercise on The Six Minutes Walking Test and Quality of Life in EGFR Mutation Non-Small Cell Lung Cancer Patients Sibarani, Lia Priscilia; Setijadi, Ana Rima; Apriningsih, Hendrastutik; Harsini , Harsini; Raharjo, A. Farih; Sutanto, Yusup Subagio
Jurnal Respirologi Indonesia Vol 45 No 2 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i2.613

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Background: Lung cancer reduces lung function, muscle mass, and psychological well-being, which lowers exercise capacity and quality of life. Pulmonary rehabilitation, such as aerobic exercise, can improve exercise capacity and the quality of life (QoL) in lung cancer patients. This study aimed to investigate the influence of aerobic exercise on the six-minute walking test (6MWT) and the quality of life of lung cancer patients. Methods: A clinical trial with a quasi-experimental, pretest, and post-test design was conducted on stage ≥IVa adenocarcinoma lung cancer patients who were receiving outpatient targeted therapy at the pulmonary clinic of Dr. Moewardi General Hospital for ≥1 month starting from May 2023, until the required sample size was met. The 6MWT and Functional Assessment of Cancer Therapy-Lung (FACT-L) were measured at the baseline and eight weeks ±2 weeks after aerobic exercise by walking about 15-20 minutes and breathing exercises. Results: The study included fourteen patients in the control group and fifteen patients in the aerobic group. The mean difference of 6MWT between the control and the aerobic group was 38.33 m. Functional, lung cancer subscale (LCS), total, and TOI in FACT-L showed significant differences in the increment pre-test and post-test between the control and aerobic group (P<0.05), with significant differences in pre-test and post-test of most categories in both groups, except for social. Conclusion: Aerobic exercise, psychological support, and nutrition have significantly improved the 6MWT and quality of life in lung cancer patients.
Differences in White Blood Cells, Neutrophil-to-Lymphocyte Ratio, Tumor Necrosis Factor-α based on Procalcitonin Level in Community-Acquired Pneumonia Patients Sutanto, Yusup Subagio; Apriningsih, Hendrastutik; Syaikhu, Akhmad; Siregar, Sihsusetyaningtyas Tiominar
Jurnal Respirologi Indonesia Vol 44 No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.632

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Background: Community-acquired pneumonia (CAP) is a respiratory infectious disease caused by bacteria, viruses, or fungi. Procalcitonin (PCT) levels will rise, especially in bacterial infection. PCT examination in CAP can help to confirm the diagnosis and anticipate complications. CAP is diagnosed by symptoms, vital signs, laboratory tests, and radiographic investigations. Inflammatory biomarkers are required for predicting causative microorganisms, guiding antibiotic therapy, and determining severity. The purpose of this study is to compare NLR, WBC, and TNF-α levels in CAP patients dependent on PCT level.Methods: This was an analytical cross-sectional study involving 43 CAP patients admitted to Universitas Sebelas Maret (UNS) Hospital and Moewardi Regional General Hospital Surakarta between February and March 2023. Patients were separated into two groups based on PCT levels: those with levels ≤0.12 ng/mL and >0.12 ng/mL. All patients provided a blood sample for NLR, WBC, TNF-α, and PCT testing. The independent t-test and Mann-Whitney tests were performed for statistical analysis of two unpaired groups, and the Chi-square or Fisher exact test was utilized for ordinal categorical data. If the value of P<0.05, the result is statistically significant.Results: NLR and TNF-α levels were higher in the PCT group >0.12 ng/mL and statistically significant with a value of P=0.001. WBC levels in the PCT group >0.12 ng/mL were higher, but the difference was not statistically significant (P=0.096).Conclusion: The NLR value, WBC, and TNF-α levels were found to be higher in the group with PCT >0.12 ng/mL. 
The Dissemination of Synbiotic Tempe Extract Krenova Soygurt Products as Functional Drinks for Stunting Prevention through Community Partnership Programs Agnes Sri Harti; Mellia Silvy Irdianty; Nurul Devi Ardiani; Bambang Abdul Syukur; Yusup Subagio Sutanto
Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan (Abdigermas) Vol. 2 No. 3 (2024): Jurnal Ilmiah Pengabdian Kepada Masyarakat Bidang Kesehatan (Abdigermas)
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/abdigermas.v2i3.309

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This activity aimed to educate the public about Synbiotic Tempe Extract Krenova Soygurt Products as Functional Drinks for Stunting Prevention. The implementation of activities as community service in the form of health education and counseling on stunting prevention involved 10 lecturers, 12 students along with 9 cadres and 30 people from the Cempaka Integrated Health Post, Wonorejo Village, Gondangrejo, Karanganyar Regency. The social community activity was carried out on August 26, 2024, and the community received a response and enthusiasm through active participation and involvement in the discussion and question and answer sessions. The essence of the implementation and dissemination of the benefits of synbiotic soygurt tempeh can function as a functional drink based on science and technology, halal and economical through a community partnership program carried out sustainably, completely, and meaningfully at the Cempaka Integrated Health Post, Wonorejo Village, Gondangrejo District, Karanganyar Regency to achieve the target of down streaming Kreova health products that are beneficial to the community and support the success of the Government's program in overcoming and reducing the incidence of stunting in Indonesia.
Peningkatan Pengetahuan mengenai Upaya Berhenti Merokok pada Kader dan Tenaga Kesehatan Anindita Hapsari, Brigitta Devi; Adhiputri, Artrien; Suryawati, Betty; Reviono, Reviono; Sutanto, Yusup Subagio; Harsini, Harsini; Marwoto, Marwoto
Smart Society Empowerment Journal Vol 3, No 3 (2023): November
Publisher : Faculty of Medicine, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ssej.v3i3.79224

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Pendahuluan: Perokok adalah seseorang yang menghisap rokok ≥ 100 batang selama hidupnya dan saat ini masih merokok atau sudah berhenti merokok kurang dari 1 tahun. Asap rokok memiliki efek negatif terhadap kesehatan karena mengandung lebih dari 4.000 senyawa kimia, 400 zat berbahaya, dan 43 zat karsinogenik. Rokok mengandung nikotin yang bersifat adiksi menyebabkan ketergantungan sehingga diperlukan upaya lebih lanjut agar dapat berhenti merokok. Upaya berhenti merokok berlangsung baik apabila didukung kemampuan tenaga kesahatan yang memadai. Penelitian ini bertujuan meningkatkan kemampuan tenaga kesehatan dalam program berhenti merokok serta meningkatkan pengetahuan masyarakat mengenai bahaya rokok.Metode: Kegiatan pengabdian kepada masyarakat ini bekerjasama dengan Puskesmas Purwodiningratan Kota Surakarta. Metode yang digunakan adalah memberikan penyuluhan kepada kader juga kepada tenaga kesehatan di wilayah Puskesmas tersebut tentang upaya berhenti merokok. Evaluasi kegiatan dilakukan penilaian pre dan post test yang bertujuan mengetahui tingkat pengetahuan kader dan tenaga kesehatan mengenai upaya berhenti merokok.Hasil dan Pembahasan: Jumlah peserta kegiatan adalah sebanyak 26 kader dan 16 tenaga kesehatan. Hasil evaluasi menunjukkan bahwa kader dan tenaga kesehatan sudah mempunyai pengetahuan yang cukup tentang upaya berhenti merokok, tetapi dalam beberapa hal masih perlu ditingkatkan, terutama mengenai metode dan pendampingan perokok dalam melakukan upaya berhenti merokok. Didapatkan peningkatan nilai post-test menunjukkan peningkatan pengetahuan dari kader dan tenaga kesehatan setelah diberikan paparan tentang materi tersebut. Peningkatan tingkat pemahaman kader kesehatan sebesar 22% dan tenaga kesehatan sebesar 53%.Kesimpulan: Terjadi peningkatan pengetahuan tentang upaya berhenti merokok pada kader dan tenaga kesehatan Puskesmas Purwodiningratan.
Edukasi Kesehatan dan Implementasi Produk Krenova Krim Galenik Untuk Perawatan Luka Melalui Optimalisasi Pemberdayaan Kemitraan Masyarakat Agnes Sri Harti; Bambang Abdul Syukur; Yusup Subagio Sutanto; Hermiana Ernastin Tobi; Nony Puspawati
Jurnal Masyarakat Madani Indonesia Vol. 4 No. 3 (2025): Agustus
Publisher : Alesha Media Digital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59025/5m5ga075

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Penerapan hasil riset civitas akademika Universitas Kusuma Husada Surakarta terkait eksplorasi potensi bahan alam dan pengembangn teknologi formulasi sediaan galenik berbasis bahan alam perlu dioptimalkan untuk menunjang efektivitas terapi perawatan luka. Produk krenova krim galenik untuk perawatan luka berbasi seromukoid bekicot 1%, ekstrak kulit durian 1% dan kitosan 1%, telah terdaftar Paten Sederhana No. S00202214385 dan No. S00202010479. Tingginya kasus luka kronis disebabkan paradigma yang masih ada di masyarakat khususnya di Posyandu RW 16 Ceplukan, Desa Wonorejo, memberikan gambaran perlunya dilakukan edukasi kesehatan bagi masyarakat terkait permasalahan perawatan luka. Tujuan kegiatan melakukan edukasi kesehatan dan implementasi produk krenova untuk perawatan luka berbasis knowledge based economy, healthy and safety product melalui optimalisasi pemberdayaan kemitraan masyarakat. Metode pelaksanaan berupa edukasi kesehatan menggunakan leaflet, diskusi dan tanya jawab serta evaluasi kegiatan melalui pre dan post kuisioner tentang perawatan luka terhadap 30 peserta. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan terhadap materi manajemen perawatan luka yaitu peserta memiliki pengetahuan baik pre test 5 peserta (16,7%) dan post test 21 peserta (70). Implementasi esensi dan kebermanfaatan hasil riset yaitu terjalinnya kolaborasi kemitraan link and match dengan stake holder, DUDI dan masyarakat guna mendukung suksesnya program Pemerintah untuk menunjang efektivitas terapi perawatan luka kronis.
The Agreement Level of Colorimetric Indicator Paper and pH Meter Examination Compared to Urine Analyzer in Measuring Exudative Pleural Effusion Fluid pH Muttaqin Huda; Yusup Subagio Sutanto; Jatu Aphridasari
Jurnal Respirologi Indonesia Vol 46 No 2 (2026)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v46i2.1086

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Background: Pleural effusion is an abnormal accumulation of fluid in the pleural space, commonly associated with pulmonary infections and malignancies. Measurement of pleural fluid pH is necessary for diagnosis, therapeutic decision-making, and prognostic evaluation. Multiple methods are used, including pH meters, indicator papers, and urine analyzers, but their concordance has not been widely studied in Indonesia. This study aimed to assess the agreement of pleural fluid pH results measured using pH meters, indicator papers, and urine analyzers to support the appropriate selection of diagnostic methods. Methods: This observational analytic study with a cross-sectional design was conducted at dr. Moewardi General Hospital, Surakarta, from February to June 2025. The sample consisted of 55 patients with exudative pleural effusion who met the inclusion criteria. Pleural fluid pH was measured using three methods: colorimetric indicator paper, a pH meter, and a urine analyzer. Data were analyzed using the Kappa coefficient and the Intraclass Correlation Coefficient (ICC) to assess the agreement between methods. Results: The mean pH values of pleural fluid measured by the urine analyzer, pH meter, and colorimetric indicator paper were 8.18±0.47, 8.13±0.46, and 8.15±0.59, respectively. Agreement analysis showed a very strong and statistically significant correlation between the pH meter and urine analyzer (ICC=0.948; P<0.001), between the pH strip and urine analyzer (ICC=0.855; P<0.001), and between the pH meter and pH strip (ICC=0.916; P<0.001). A significant positive correlation was also observed between glucose levels and pH measured by both the urine analyzer and the pH meter. Conclusion: There is good agreement among pH measurements obtained using colorimetric indicator paper, urine analyzer, and pH meter in exudative pleural effusion fluid.
Analysis of Risk Factors for Antimicrobial Resistance in Nosocomial Pneumonia Larissa Amanda; Jatu Aphridasari; Yusup Subagio Sutanto
Respiratory Science Vol. 6 No. 2 (2026): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v6i2.179

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Background: Antibiotic resistance is often linked to nosocomial pneumonia, one of the most prevalent hospital-acquired illnesses. Determining risk factors is crucial for management and preventative plans. To develop preventative and control measures, this research was conductedto identify the variables linked to antibiotic resistance in nosocomial pneumonia patients. Method: In this retrospective cohort analysis, 237 individuals with nosocomial pneumonia were included. Odds Ratios (OR) were computed for relevant factors after data were evaluated using the chi-square or Fisher’s exact test to find significant relationships between patient characteristics and antibiotic resistance. Results: Of the 237 patients, 58.2% exhibited antibiotic resistance. Several variables were found to be significantly associated with antibiotic resistance: age >59 years (OR=1.68; P=0.049), intensive care unit (ICU) admission (OR=2.65; P=0.002), high care unit (HCU) admission (OR=2.16; P=0.028), history of prior antibiotic use (OR=2.42; P=0.004), and endotracheal tube (ETT) use (OR=2.04; P=0.024). Patients older than 59 years had a 1.68-fold higher risk. Those admitted to the ICU and HCU had 2.65-fold and 2.16-fold higher risks, respectively. Patients with a history of prior antibiotic use had a 2.42-fold increased risk, and those with ETT use had a 2.04-fold increased risk. Conclusion: Older age, admission to intensive care units (ICU/HCU), previous antibiotic use, and endotracheal tube use are significant factors associated with antibiotic resistance in nosocomial pneumonia. These findings highlight key areas for targeted interventions to mitigate resistance.
Co-Authors -, Harsini -, Reviono . Reviono Adam Prabata Adhiputri, Artrien Agnes Sri Harti Agnes Sri Harti Agnes Sri Harti Agnes Sri Harti Akhmad Syaikhu Ana Rima Ana Rima Setijadi Ana Rima Setijadi Ana Rima Setijadi Anindita Hapsari, Brigitta Devi Aphridasari, Jatu Apridasari, Jatu Apriningsih, Hendrastutik Ari Julian Saputra Ari Natalia Probandari Artrien Adhiputri Arwin Muhlishoh Atmojo, Anang Purwoko Avamira Rosita Pranoto Bambang Abdul Syukur Bambang Abdul Syukur Bhisma Murti Brian Wasita Brian Wasita Caesaria Sarah Selleca Debree Septiawan Debree Septiawan Dhani Redhono, Dhani Diana Kurniasari Sagita Fahlevie Fahlevie Farih Raharjo Fitrotin Aziza Hari Wujoso Harsini Harsini , Harsini Harsini Harsini Hendra - Kurniawan Hendra Kurniawan Hendra Kurniawan Hendrastutik Apriningsih Hendrastutik Apriningsih Hermiana Ernastin Tobi Heru Sigit Pramono Ita Haryatie Jatu Aphridasari Jatu Apridasari Jatu Apridasari Jatu Aviani Jerry Indra Setiawan Kiki Widyastuti Kurniawan, Yoseph Dwi Larissa Amanda Leli Saptawati Lestari, Anggraini Dwi Liana Herlina Linda Soebroto Luths Maharina Magdalena - Sutanto Magdalena Sutanto Maria Dewi Caetline Maria Dewi Caetline marwoto marwoto Mellia Silvy Irdianty Mia Herdiyani Achmad Mochammad Imron Awalludin Muhammad Addinul Huda Murti, Paulus Wisnu Kuncoro Muttaqin Huda Nony Puspawati Nony Puspawati Nugroho, I.G.B Indro Nur Amalia Santang Nurul Devi Ardiani Nurul Devi Ardiani, Nurul Devi Paulus Arka Triyoga Putranto, Wachid R, Sari Apriliana Rahajeng Putriningrum Raharjo, A. Farih Ratna Adhika Reviono Reviono - Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Reviono Roman Diaz Rullyano Hardian Saelan, Saelan Safina Mutmainnah Samuel Samuel - Samuel - Samuel Samuel Santi, Nur Satria Maulana EH Sebayang, Pribadi M Septiawan, Debree Sibarani, Lia Priscilia Sigit, Indarto Siregar, Sihsusetyaningtyas Tiominar Soetejo, FX Sri Haryati Subandrio, Subandrio Sulistyani Kusumaningrum Suradi Suradi Suradi Suradi Suradi Suradi SURYAWATI, BETTY Sutanto, Magdalena Sutanto, Magdalena Sutanto Teguh Budi Santosa Vita Ovaria Wahyu Rima Agustin Wahyuningsih Safitri, Wahyuningsih Wati, Martha Ratna Widiastuti Widiastuti Widyasanti, Diana Windu Prasetya Windu Prasetya Windu Prasetyo Yanny Octavia Sally Ride Yogie Irawan Yundari, Yundari