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All Journal HAYATI Journal of Biosciences ACTA VETERINARIA INDONESIANA Jurnal Sain Veteriner Jurnal Teknosains Media Kedokteran Hewan ARSHI Veterinary Letters Pharmacoscript Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Community Development Journal: Jurnal Pengabdian Masyarakat Indonesian Journal of Applied Research (IJAR) Jurnal Buana Farma Eduvest - Journal of Universal Studies Jurnal Veteriner dan Biomedis Current Biomedicine Indonesian Journal of Chemical Science
Madyastuti, Rini
Divisi Farmakologi Dan Toksikologi, Sekolah Kedokteran Hewan Dan Biomedis, IPB University, Bogor, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary

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Frekuensi Penggunaan Obat Antifungal di Salah Satu Klinik Hewan di Kabupaten Bogor pada Tahun 2020 - 2022 Prasetyo, Bayu Febram; Purwono, Rini Madyastuti; Wulandari, Nenis Rahma; Hikmarizky, Firda
Jurnal Sain Veteriner Vol 42, No 2 (2024): Agustus
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.90442

Abstract

Dermatofitosis adalah penyakit kulit yang disebabkan oleh kapang dermatofita dan umum terjadi pada hewan peliharaan seperti anjing dan kucing. Penyakit ini bersifat zoonosis dan mudah terjadi di lingkungan dengan kelembaban yang tinggi. Penanganan dermatofitosis salah satunya dengan pemberian obat antifungal. Penelitian ini bertujuan mengetahui frekuensi jumlah penggunaan obat antifungal terbanyak untuk kasus dermatofitosis di klinik hewan objek penelitian. Penelitian dilakukan secara deskriptif dengan menggunakan 71 data rekam medis pasien yang terinfeksi dermatofita. Hasil penelitian menunjukkan obat antifungal yang digunakan untuk kasus dermatofitosis sebanyak 19 kali penggunaan ketoconazole, 40 kali penggunaan itraconazole, 6 kali penggunaan griseofulvin, dan 6 kali penggunaan salep racikan. Berdasarkan hasil penelitian, itraconazole adalah obat antifungal yang paling banyak digunakan untuk penanganan kasus dermatofitosis di klinik hewan tersebut.
In Silico Study of Antioxidant Compounds in Ipomoea aquatica Forsk as Acetylcholinesterase (AChE) Enzyme Inhibitor in Alzheimer’s Disease Nugraha, Salma E.P; Rini Madyastuti Purwono
Indonesian Journal of Chemical Science Vol. 14 No. 3 (2025): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v14i3.18022

Abstract

Alzheimer’s Disease is a form of dementia characterized by a progressive decline in cognitive function, encompassing various aspects of intellectual abilities. Acetylcholinesterase (AChE) is an enzyme that degrades the neurotransmitter acetylcholine and plays an important role in regulating neurotransmission at synapses across the nervous system. Disruption of this cholinergic transmission significantly impacts the development of Alzheimer's disease. Compounds with AChE inhibitory activity are known to be promising drug candidates for treating this disease. In this study, an in-silico analysis was conducted on antioxidant compounds, specifically carotenoid compounds from Ipomoea aquatica Forsk, to determine whether these compounds could be potential drug candidates for Alzheimer's treatment using molecular docking methods. The 3D structure of the Acetylcholinesterase (AChE) receptor was obtained from the Protein Data Bank, while the structure of the carotenoid compounds was obtained from the PubChem database. The software used for the molecular docking simulation was AutoDock Vina, with additional supporting software such as AutoDockTools 1.5.6, PyMOL, and LigPlot. The analysis results showed that β-carotene is the best antioxidant, with binding energy and inhibition constant values of -10.2 kcal/mol and 20.06 μM, respectively, with hydrogen bonding occurring at the amino acid residue PHE 295.
The In Silico Toxicity of Serai Wangi (Cymbopogon nardus) and Mimba (Azadirachta indica anggraeni, Henny endah; Purwono, Rini Madyastuti; Sutardi, Lina Noviyanti; Mustika, Aulia Andi; Manalu, Wasmen; Andriyanto, Andriyanto
Acta VETERINARIA Indonesiana Vol. 13 No. 3 (2025): November 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.3.278-285

Abstract

Natural active-ingredient-based shampoos offer an effective and eco-friendly solution for maintaining the skin and hair health of companion animals. This study aimed to predict the toxicity of phytochemical compounds from citronella oil (Cymbopogon nardus) and neem oil (Azadirachta indica) using an in silico approach with the ProTox-II platform. The analyzed compounds included limonene, farnesene, eucalyptol, menthol, oleic acid, p-cymene, indole, (9Z)-9- octadecenamide, amylbenzene, p-cresol, camphor, and dieugenol, selected based on LC-MS/MS analysis. The evaluated toxicological parameters comprised oral acute toxicity (LD50), hepatotoxicity, immunotoxicity, genotoxicity (cytotoxicity, mutagenicity, carcinogenicity), as well as nuclear receptor signaling and stress response pathways. The results revealed that p-cymene exhibited the highest toxicity (LD50 = 3 mg/kg, class I), followed by oleic acid (LD50 = 48 mg/kg, class II), whereas amylbenzene was classified as non-toxic (LD50 = 6430 mg/kg, class VI). All compounds were predicted to be non-hepatotoxic and non-immunotoxic; however, p-cymene, indole, and amylbenzene showed potential carcinogenicity. Limonene was predicted to be active against AhR, ER, MMP, and ATAD5 receptors, while dieugenol was active against nrf2/ARE, HSE, and MMP. These predictions suggest that most compounds are safe for shampoo applications, except for p-cymene, which requires further evaluation. This study provides preliminary insights for the development of safe and effective natural-based shampoos.
ANTIHIPERPIGMENTASI Hylocereus costaricensis MELALUI INHIBISI TIROSINASE: STUDI NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING Prasetyo, Bayu Febram; Alauddin, Daffa Rizal Dzulfaqaar; Purwono, Rini Madyastuti
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1570

Abstract

Hyperpigmentation was driven by increased melanogenesis and oxidative stress, creating a need for effective and safe depigmenting candidates. This study aimed to identify bioactive compounds from Hylocereus costaricensis, to map hyperpigmentation-related targets and pathways using network pharmacology, and to evaluate the binding potential of selected compounds to a melanogenesis target using molecular docking. The workflow included compound screening and drug-likeness/ADMET evaluation, prediction of compound targets and hyperpigmentation-associated genes, construction of compound–target–disease and protein–protein interaction networks, topological and GO/KEGG enrichment analyses, and docking to TYRP1 (PDB: 5M8O). Five main candidates, namely 2,2-dimethyl-3-phenylpropanoic acid, ferulic acid, o-coumaric acid, p-coumaric acid, and vanillic acid, have met the initial criteria. Network pharmacology highlighted a multi-target mechanism by prioritizing key nodes including AKT1, EGFR, PIK3CA, TYR, and CDK4 and by indicating enriched signaling pathways relevant to pigmentation regulation and oxidative-stress responses. Docking results showed moderate affinities, with binding energies of approximately −6.551 to −6.184 kcal/mol and estimated inhibition constants of 15.779 to 29.315 µM, and 2,2-dimethyl-3-phenylpropanoic acid yielded the best score among the tested ligands. Overall, the integrated network pharmacology–docking strategy provided a rational prioritization of compounds and targets for developing anti-hyperpigmentation agents derived from H. costaricensis; however, the evidence remained preliminary and required further experimental validation and mechanistic confirmation.
PELATIHAN PEMBUATAN JAMU TERNAK UNTUK DOMBA DI AL-BAROQAH FARM KECAMATAN DRAMAGA, KABUPATEN BOGOR: Jamu Ternak Bayu Febram Prasetyo; Rini Madyastuti Purwono; Lina Noviyanti Sutardi; Anisa Rahma; Baharun Rasyid
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 6 No. 4 (2025): Volume 6 No 4 Tahun 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v6i4.48460

Abstract

Kesehatan ternak merupakan aspek krusial dalam mendukung keberhasilan usaha peternakan, khususnya pada sektor peternakan domba. Namun ketergantungan peternak terhadap obat-obatan sintetis masih tinggi, yang berdampak pada biaya produksi dan risiko resistensi antimikroba. Untuk mengatasi permasalahan ini, dilakukan kegiatan pengabdian kepada masyarakat berupa pelatihan pembuatan jamu ternak berbahan herbal lokal sebagai alternatif pengobatan alami. Kegiatan dilaksanakan secara partisipatif bersama peternak mitra Al-Baroqah Farm di Kecamatan Dramaga, Bogor. Materi pelatihan meliputi pengenalan bahan herbal (kunyit, kayu manis, lada, sambiloto, dan indigofera), teknik formulasi jamu fermentasi, serta praktik aplikasi pada domba. Hasil kegiatan menunjukkan bahwa peternak sangat antusias dan mampu mengikuti seluruh tahapan pelatihan dengan baik. Jamu yang diformulasikan terbukti dapat meningkatkan nafsu makan, imunitas, serta produktivitas domba, sekaligus mengurangi ketergantungan terhadap obat sintetis. Pelatihan ini berhasil memperkenalkan model pemeliharaan peternakan yang sehat, ekonomis, dan berkelanjutan berbasis kearifan lokal.
Computational screening of boswellic acid for its antibacterial activity against acne-causing bacteria via molecular docking Dedi Damhuri; Ietje Wientarsih; Rini Madyastuti Purwono; Agustin Indrawati; Asri Rizky; Jessica Anggun Safitri; Ahmad Syarifuddin
Jurnal Teknosains Vol 15, No 1 (2025): December
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/teknosains.106278

Abstract

Acne vulgaris (AV) is a common inflammatory-skin disorder associated with bacterial infections, particularly Cutibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. The rising resistance to conventional antibiotics has prompted the exploration of natural compounds such as boswellic acid, which is known for its antibacterial potential. This study aimed to evaluate the antibacterial activity of boswellic acid using an in-silico approach through molecular docking against several essential bacterial target proteins implicated in acne pathogenesis. The boswellic acid ligand was obtained from the PubChem database, while the three-dimensional structures of the target proteins were retrieved from the RCSB Protein Data Bank. Blind docking was performed using AutoDock Tools version 1.5.7 and AutoDock Vina, followed by interaction analysis using Discovery Studio Visualizer and Visual Molecular Dynamics (VMD). Nine bacterial proteins involved in vital cellular processes such as metabolism, protein synthesis, biofilm formation, and DNA replication were selected, including transcriptional regulator TcaR, penicillin-binding proteins (PBPs), tyrosyl-tRNA synthetase (TyrRS), 3-ketoacyl-ACP synthase III (KAS III), CRISPR-associated protein, DNA gyrase, transcriptional regulator MarR, methylmalonyl-CoA epimerase, and accumulation-associated protein (Aap). The docking results demonstrated that all target proteins exhibited negative binding energy values (< 0), indicating thermodynamically stable and spontaneous interactions. Among these, TcaR displayed the highest binding affinity with a binding energy of −10.2 kcal/mol and formed nine conventional hydrogen bonds, reflecting a particular and stable interaction. Key interacting residues included Gln: B61, HisA:42, AsnA:20, AsnB:17, and Arg1:110. In contrast, the Aap protein formed only one covalent bond, indicating the weakest interaction. These findings suggest that boswellic acid effectively inhibits key bacterial proteins, particularly those involved in transcriptional regulation and biofilm development. Therefore, boswellic acid holds significant potential as a safe and effective topical antibacterial agent for further growth in biomedical engineering-based formulations.
Co-Authors A.S. Satyaningtijas Agustin Indrawati ahmad syarifuddin Alauddin, Daffa Rizal Dzulfaqaar Andriyanto Andriyanto ANGGARA ALDOBRATA Anggraeni, Henny Endah Anisa Rahma Anisa, Rahma Anita Esfandiari Aritonang, Erfan Andrianto Asri Rizky Aulia Andi Mustika Bachmid, Salma Safitri Baharun Rasyid Baharun, Rasyid Bambang Pontjo Priosoeryanto Bayu Febram Prasetyo Bayu Febran Prasetyo Budiono, Novericko Ginger Damhuri, Dedi Daniel Happy Putra Dea Khalissa Anidya Dian Firnanda Diaz, Fariz Arrachman DIMAS ANDRIANTO Erni H Purwaningsih Eva Harlina Fadiela Salima Putri Farhamzah Fitri, Arni Diana Gunanti Hadiyanti, Cresensia Rara Hikmarizky, Firda Ietje Wientarsih IETJE WIENTARSIH Ikrar Trisnaning Hardi Utami Indah Kurnia Klara Jessica Anggun Safitri Joko Pamungkas Khoirun Nisa Kusumawati, Nina Tri LAKSMI AMBARSARI Lina Novianti Sutardi Lina Novianti Sutardi, Lina Novianti Lina Noviyanti Sutardi Maharani, Alya Rizqi May, Ng U Mega Safithri Mufida, Anis Arifatu Muhammad Agung Nulhakim Nabila Nur Nafiati Nina Kusumawati Nina Tri Kusumawati Nisa, Nunik Nida Choerun Nugraha, Salma E.P Nugroho, Radhitya Aryo Nurdiansyah, Rio Dwi Haryadi Nurhidayat Nurhidayat Nurkarimah, Dona Astari Pudji Achmadi Putri, Fadiela Salima Riki Siswandi Rizal Arifin Akbari Saragih, Adrian Sa’diah, Siti Setyo Widodo Setyo Widodo Sugeng Santoso SUPRIYONO Supriyono, Supri Tarigan, Ronald TATI NURHAYATI Trioso Purnawarman Vetnizah Juniantito Wasmen Manalu Wilujeng, Retno Wulandari, Nenis Rahma