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All Journal Jurnal Penelitian Saintek EKSAKTA: Journal of Sciences and Data Analysis POSITRON Jurnal Kimia Khatulistiwa Sainstek BERKALA SAINSTEK Jurnal Sains dan Teknologi Biomedika Pharmacon Jurnal Kimia Mulawarman Jurnal Fitofarmaka Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) ALCHEMY Jurnal Penelitian Kimia Buletin Farmatera Indonesian Journal of Chemistry Indonesian Journal of Pure and Applied Chemistry Dinamisia: Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi Jambura Journal of Chemistry Jurnal Ilmu dan Teknologi Kayu Tropis ISM (Intisari Sains Medis) : Jurnal Kedokteran Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Cahaya Mandalika Jurnal Teknologi Kimia Unimal Jurnal Akademika Kimia Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Journal of Comprehensive Science Gema Lingkungan Kesehatan Jurnal Laboratorium Khatulistiwa Journal of The Indonesian Society of Integrated Chemistry al Kimiya : Jurnal Ilmu Kimia dan Terapan
Ari Widiyantoro
Program Studi Kimia, Fakultas MIPA, Universitas Tanjungpura, Pontianak 78124
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Biomedika

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EFEKTIVITAS EKSTRAK AKAR PANDAN WANGI (PANDANUS AMARYLLIFOLUS ROXB.) SEBAGAI ANTIMALARIA TERHADAP JUMLAH MONOSIT DALAM DARAH MENCIT (MUS MUSCULUS) YANG DIINFEKSI PLASMODIUM BERGHEI Dila, Gata; Kahtan, Muhammad Ibnu; Widiyantoro, Ari
Biomedika Vol 12, No 1 (2020): Biomedika Februari 2020
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v12i1.9237

Abstract

ABSTRAKMalaria merupakan salah satu penyakit infeksi yang memberikan morbiditas yang cukup tinggi di dunia dan merupakan infeksi yang ketiga teratas dalam jumlah kematian. Di Indonesia, pemberantasan penyakit malaria kurang maksimal karena adanya resistensi parasit terhadap obat antimalaria dan gangguan sistem imun. Monosit merupakan sel efektor imun yang penting dalam perlindungan terhadap patogenesis malaria yang bersifat sitostatik dan sitotoksik. Tanaman pandan wangi (Pandanus amaryllifolius Roxb.) memiliki senyawa yang dapat bekerja sebagai antimalaria dan imunomodulator. Tujuan penelitian ini yaitu mengetahui efektivitas ekstrak metanol akar pandan wangi sebagai antimalaria terhadap jumlah parasitemia dan monosit dalam darah mencit (Mus musculus) yang diinfeksi Plasmodium berghei. Penelitian yang dilakukan merupakan penelitian eksperimen murni (true experiment design) in vivo dengan desain rancangan acak lengkap (completely randomized design). Uji efektivitas ekstrak metanol akar pandan wangi sebagai antimalaria dilakukan dengan konsentrasi 6,5%, 13% dan 26%. Kontrol positif diberi 3,74 mg/mL Dihydroartemisinin-Piperaquin (DHP), kontrol negatif diberikan akuades dan kontrol normal tidak diintervensi Hasil penelitian menunjukkan konsentrasi 6,5%, 13% dan 26% memiliki aktivitas antimalaria dengan menurunkan persentase parasitemia dan meningkatkan jumlah monosit. Kesimpulan dalam penelitian ini ekstrak akar pandan wangi memiliki aktivitas malaria dengan konsentrasi yang paling baik yaitu 26% untuk menurunkan jumlah parasitemia dan meningkatkan monosit.Kata Kunci: Pandanus amaryllifolius Roxb. Antimalaria, Monosit, Plasmodium bergheiABSTRACTMalaria is one of the most common infectious diseases in the world and is the third highest infection in mortality. In Indonesia, eradication of malaria is not maximal because of parasitic resistance to antimalarial drugs and immune system disorders. Monocytes are important effector immune cells in the protection of the cytostatic and cytotoxic pathogenesis of malaria. Pandanus amaryllifolius Roxb. root plant have compounds that can work as antimalarials and immunomodulators. This research aim to determine the effectiveness of the methanol extract of Pandanus amoryllifolius Roxb. as antimalarial to parasitemia and monocytes count of blood mice (Mus musculus) with Plasmodium berghei infection. This study is a true experiment design in vivo with complete randomized design. Methanol extract of Pandanus amaryllifolius Roxb. with concentration 6.5%, 13% and 26% used as antimalarial. Dihydroartemisinin-Piperaquine (DHP) 3.74 mg/mL used as positive control, aquades used as negative control groups and the control group was not intervened. The result of this research show effectiveness as antimalarial in methanol extract of Pandanus amaryllifolius Roxb. with concentration 6,5%, 13% and 26% have antimalarial activity by decreasing percentage of parasitemia and increasing monocyte count. The conclusion of this research is the high antimalarial activity in methanol extract of Pandanus amaryllifolius Roxb. in 26% concreation which could decreased parasitemia precentage and increased monocytes count.Keywords: Pandanus amaryllifolius Roxb, Antimalarial, Monocyte, Plasmodium berghei
Co-Authors Ade Mariadi Agus Malik Ibrahim Ahmad Yani Nelly Wahyuni Lia Destiarti Ajuk Sapar Andi Hairil Alimuddin Anis Shofiyani Anis Shofiyani Annisa Dyah Astari Putri Annisa Firdaus, Navisa Arif Sulaiman Aritonang, Anthoni B. Banu Prasetya Boima Ramses Situmeang Danang Mustofa Diana Natalia Diana Natalia Dila, Gata Diva Feraldy Elvi Rusmiyanto Pancaning Wardoyo, Suci Lestari, Mukarlina, Endah Sayekti Gusrizal Gusrizal Haris, Muhammad Faisal Harlia Harlia Harlia Harlia Harlia Harlia Harlia Harlia Harlia Harlia Herlinda Djohan Ihsan, Bagus Muhammad Ikhwan, Darul Imelda Hotmarisi Silalahi Indrawati, Ratih Indri Kusharyanti Jayuska, Afghani Julinton Sianturi Kahtan, Muhammad Ibnu Kamarullah Kristina Damiyanti Kustiati Kustiati M. Irfani Hendri Mardhia, Mardhia Maryati Maryati Maulidiyah Salim Millenia, Millenia Mistika Zakiah Mohamad Adam Mustapa Muhammad Akib Yuswar Muhammad Akib Yuswar Muhammad Faisal Haris Muhammad Ibnu Kahtan Muhammad Ibnu Kahtan Nafsiatun Nelly Wahyuni Nurhayati Bialangi Nurlina, Nurlina Nurul Asikin Puji Ardiningsih Putri, Annisa Dyah Astari Putri, Rinka Carolina Rachmadi, Octavian Rahayu, Warsi Kurnia Ratna Wardani Ratnawaty, Gervacia Jenny Ratu Safitri Risa Nofiani Rr. Erni Kusuma Putri Rudiyansyah Rudiyansyah Rudiyansyah Rudiyansyah Sadenta, Deby Pascalia Sari Damayanti Sari, Emilda Septian Triadi Syahputra Sharon Angelia Shofiyani, Anis Siti Khotimah Sulistyo, Luthfi Imam Susanto, Dhessy Thamrin Usman Thamrin Usman Titin Anita Titin Anita Zahara, Titin Anita Unang Supratman Uray Ristian Wahyuningsih, Aprilia Tri Warsidah, Warsidah Weny Musa Wibowo, M. Agus Wibowo, Muhamad Agus Winda Rahmalia Yuswar, Muhammad Akib Yuszda K Salimi Zaharah, Titin Anita