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All Journal Jurnal Ilmiah Farmasi VA Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Riset Keuangan dan Akuntansi (JRKA) Media Ilmu Kesehatan JURNAL PENDIDIKAN TAMBUSAI Jurnal Mandala Pharmacon Indonesia JITEKGI Jurnal Ilmiah dan Teknologi Kedokteran Gigi Health Information : Jurnal Penelitian Indonesian Journal of Global Health research Jurnal Ecogen Jurnal Kesmas Asclepius Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kesehatan Tambusai Educoretax Jurnal Multidisiplin Madani (MUDIMA) Jurnal Farmasi Komunitas Jurnal Indonesia Sehat (JURINSE) International Journal of Integrative Sciences Riset Informasi Kesehatan Jurnal Kesehatan Tropis Indonesia Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Journal of Health Management and Pharmacy Exploration (JOHMPE) Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan Edutechnium Journal of Educational Technology ASPIRATOR - Journal of Vector-Borne Diseases Studies Jurnal Mitra Pengabdian Farmasi Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Tri Wijayanti
Staf Loka Litbang P2B2 Banjarnegara
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL DAUN SAMPARE (Glochidion philippicum (Cav.) C.B.Rob.) PADA MENCIT PUTIH JANTAN (Mus musculus) YANG DIINDUKSI PEPTON Amala, Ima Choirul; Sarimanah, Jamilah; Wijayanti, Tri
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art10

Abstract

Background: Sampare leaves (Glochidion philippicum (Cav.) C.B. Rob.) contain secondary metabolites, including flavonoids, tannins, steroids, alkaloids, and saponins, which exhibit antipyretic potential.Objective: This study aimed to evaluate the antipyretic efficacy of the ethanolic extract of sampare leaves in a peptone-induced fever mouse model.Method: The ethanolic extract of sampare leaves was prepared via maceration, and its secondary metabolites were qualitatively identified using standard test-tube reagents. For the in vivo study, twenty-five male Swiss mice (Mus musculus) were randomly divided into five groups. Group I (negative control) received a 0.5% CMC-Na suspension, and Group II (positive control) received paracetamol at a dose of 65 mg/kg body weight (BW). Groups III, IV, and V were administered the ethanolic extract at doses of 200, 400, and 800 mg/kg BW, respectively. Pyrexia was induced via subcutaneous injection of peptone (0.5 mL/g BW). Rectal temperatures were measured using a digital thermometer every 15 minutes for a duration of 180 minutes. Data were analyzed using the Shapiro-Wilk test, followed by repeated measures ANOVA and an appropriate post-hoc test.Results: The maceration process yielded 20.05% (w/w) of ethanolic extract. Phytochemical screening confirmed the presence of tannins, flavonoids, steroids, alkaloids, and saponins. Furthermore, the in vivo evaluation showed that the extract exhibited significant antipyretic activity. The 800 mg/kg BW dose demonstrated the highest antipyretic activity, which was significantly different from the negative control (p < 0.05) and comparable to the positive control (paracetamol). Conclusion: Sampare leaf ethanol extract had antipyretic activity, with an effective dose of 800 mg/kg body weight in mice.
Co-Authors 'Aini, Zakiyyah Qurrotul Afandi, Mukhamad Aini, Zakiyyah Qurrotu Almauiza, Monica Ihksan Amala, Ima Choirul Andintias, Mohammad Febry Andito, Didik Anwar, Alifia Auriel Aulia, Intan Sofia Irsa Azizah, Deva Yolanda Dwi Nur Azizah, Tri Nur Baroya, Ni’mal Bina Ikawati Boedirahardja, Partana Cholilah, Cholilah Dahlifah, Dahlifah Dewi Ekowati Dewi, Lucia VIta Inandha Dwi Laksana, Sigit Fida’ Husain Firdaus, Muhammad Aisy Akbar Gunawan Pamudji Widodo Hamdi Hamdi Hananto, Laura Angelica Harsono, Samuel Budi Ika Purwidyaningrum Iqbal Arraniri Ismi Rahmawati Iswandi Jason Merari Peranginangin Jawahir, Irvan Juniartini KATNI KATNI, KATNI Kurnilia, Reza Dea Lies Zulfiati Lukito Mindi Cahyo M. Yogi Riyantama Isjoni Mamik Ponco Rahayu Mardika, Dayatri Nur Muchromin, Muchromin Muhammad Farid Muslihatin, Muslihatin Nuraini Harmastuti Octavia, Selly Dilla Octavia Oetari Oetari, RA. Opstaria saptarini Puspitasari, Aldita Cahyani Rahman, Bayu Kurnia Risny Oklyan S, Armida Safitri, Delvia Sakaria, Hamra Sakinah Sarnia Iriani Lihawa Santi Dwi Astuti Saputri, Chynthia Iga Sarimanah, Jamilah Satibi Satibi Sofya, Rani Sunaryo Syahputra, Rizka Wahyu Tristiyanti, Rahayu Wahyuningtiyas, Triya Wiwin Herdwiani Yasir Maulana, Yasir Yennike Tri Herawati Yulhendri Yulhendri Yustyananingrum, Nora Zakiyyah Qurrotul ‘Aini