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All Journal El-Hayah : Jurnal Biologi Research Journal of Life Science JFMR (Journal of Fisheries and Marine Research) Jurnal Biologi Tropis Jurnal Kelautan Nasional Jurnal Lemuru : Jurnal Ilmu Perikanan dan Kelautan Indonesia Best Journal (Biology Education, Sains and Technology) MARLIN : Marine and Fisheries Science Technology Journal Jurnal Pari Bioinformatics and Biomedical Research Journal Nekton Jurnal Airaha Buletin SWIMP Jurnal Salamata Depik Jurnal Ilmu-Ilmu Perairan, Pesisir dan Perikanan Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan
Puspitasari, Asthervina Widyastami
Politeknik Kelautan Dan Perikanan Sorong
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health Social Sciences Veterinary

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Journal : Bioinformatics and Biomedical Research Journal

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Can Cinnamaldehyde Increased the Innate Immune System on Medaka Larvae? Puspitasari, Asthervina Widyastami; Arfiati, Diana; Hu, Shao-Yang
Bioinformatics and Biomedical Research Journal Vol. 2 No. 1 (2019): Volume 2 Issue 1
Publisher : Future Science

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Abstract

Fish larvae are the early stage of the life cycle and the key to mass production of fish. Its nature which is susceptible to invade by pathogens, especially viruses, it is an important concern in increasing the innate immune system in virus invading. IFNa and Mx are inducer genes that have the most role in enhancing the innate immune system. The study was conducted in September 2017 with the experimental method. The sample used was 1-day-old medaka larvae in amount 30 fish in each tank with triplicate in each concentration. The cytotoxicity results showed that at 72 hours cinnamaldehyde immersion was 100% of medaka larvae survival rate at a concentration of 2.5 µg mL-1 and 0 µg mL-1 (control). One-Way ANOVA results, the genes expression of IFNa and Mx on 1-day-old medaka larvae showed decreasing at 2.5 µg mL-1 concentration of cinnamaldehyde immersion for 3 days with several observation periods (12h; 24h; 48h; and 72h) compared to control. The lowest expression of IFNa genes was 12h (2.54 x 10-5 ± 6.12 x 10-6) at a 2.5 µg mL-1concentration of cinnamaldehyde, and the highest expression of IFNa gene was 48h (3.95 x 10-4 ± 7.78 x 10-5)at 0 µg mL-1 (control)concentration of cinnamaldehyde. While the lowest Mx gene expression was 72h (8.96 x 10-3 ± 4.51 x 10-4) at a 2.5 µg mL-1concentration of cinnamaldehyde. And the highest Mx gene expression was 72h (0.88 ± 0.26) at 0 µg mL-1 (control)concentration of cinnamaldehyde. The immersion of cinnamaldehyde extract at a concentration of 2.5 µg mL-1 is not able to increase the innate immune system in medaka larvae. More assay is needed to determine the mechanism for the phenomenon of decreasing IFNa and Mx gene expression on fish larvae.
Co-Authors Abadi, Agung Setia Abimanyu Bayu Saputra Adita Ramadanti Aditya Brahmana Agung Setia Abadi ahmad yani Aminin, Aminin Aminuddin Firdaus Amri, Irman Andina Chairun Nisa Annisa' Bias Cahyanurani Anwari, Zaki Asep Akmal Aonullah Asep Akmal Aonullah Asmira Rumalolas Atiqoh Zummah Badaruddin, M. Iksan Bagas Prakoso Boby W Ziliwu Brahmana, Aditya Cahyanurani, Annisa Bias Charles Nalle Charliany Hetharia Damaris Payung Diana Arfiati Diana Putri Renitasari Diana Putri Renitasari Endang Yuli Herawati Ernawati Ernawati Ernawati Ernawati Ernawati Fatiha, Siva Eka Firdaus, Aminuddin Fresty Esmi Samber Hadi Nur Rohman Hafita, Yuniar Ayu Handayan Handayani Handayani Handayani - Heri Sutanto Hetharia, Charliany Hismayasari, Intanurfemi B Hismayasari, Intanurfemi B. Hu, Shao-Yang I Komang H Permana Ilham Marasabessy Intanurfemi Bacandra Hismayasari Intanurfemi Hismayasari Irawati Mei Widiastuti Iskandar Iskandar Ismail Ismail Ivonne M. Leiwakabessy Kadarusman Karepesina, Musa Kurniati, Wenty Kusriani Kusriani Latifah Latifah Leoni Hayu Sabrina Putri Luluk Suryani Manurung, Melani Marcelinus Petrus Saptono Marwa, Marwa Moejiono Moejiono Muh Guntur Ketuut Muh Kasim Muh. Kasim Muhamad Ali Ulat Muhammad Idris Muhammad Ulat Muhfizar, Muhfizar Muhklas Shah Winarno Mukhaimin, Iman Mustamir Kamaruddin Nanik Retno Buwono Nasrul Fauzi Nisa, Andina Chairun Nur Anjelika Saputri Nur Maulida Safitri Nur Syahid, Nur Nurhasanah, Dian Permanasari, Setya W. A. Poltak, Hendra Pujianto, Andreas PURWANTI PURWANTI Ramli, Taufik Hadi Ratna Ratna Renaldo Fredly Rumaherang Renitasari, Diana Putri Rezza Ruzuqi Ristiana Dwi Cahyani Rizkiah, Riza Roger R Tabalessy Ruzuqi, Rezza Sasole, Umar Shao-Yang Hu Simon Manutilaa Sirait, Egbert Josua Siti Nurkadaria Siti Rahmadani Umngelo Siti Saina Loji Sri Wahyuni Firman Suhermanto, Achmad Sukmawati Sukmawati Syafril Sanusi Tabalessy, Roger R. Umar Sasole Valentine, Riris Yuli Violando, Wiga Alif Warlela, Welin Angely Winarno, Muhklas Shah Yani Nurita Purnawanti Yenu, Hosea Zakeus Wuarbanaran