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All Journal Indonesian Journal of Chemistry JCRS (Journal of Community Research and Service) Jurnal Mandala Pharmacon Indonesia Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Pengabdian dan Pengembangan Masyarakat Indonesia Sevanam: Jurnal Pengabdian Masyarakat Jurnal Farmasi Klinik dan Sains SWARNA: Jurnal Pengabdian Kepada Masyarakat Journal of Pharmaceuticals and Natural Sciences Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan Jurnal Riseta Naturafarm
Almeida, Maria
Fakultas Farmasi, Universitas Mulawarman, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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Effectivity of Antihypertensive Drugs Use in Pregnant Woman with Diagnoses of Preeclampsia Hospitalized at Abdoel Wahab Sjahranie Hospital and Inche Abdoel Moeis Hospital Samarinda City: Efektivitas Penggunaan Obat Antihipertensi Pada Ibu Hamil dengan Diagnosa Preeklampsia Rawat Inap di RSUD Abdoel Wahab Sjahranie dan RSUD Inche Abdoel Moeis Kota Samarinda Difta, Rismania Shita; Mus, Nurul Muhlisa; Almeida, Maria; Herman, Herman
Jurnal Riseta Naturafarm Vol. 2 No. 2 (2025): Jurnal Riseta Naturafarm
Publisher : B-Creta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jrn.v2i2.7384

Abstract

The use of appropriate and effective antihypertensive drugs is needed so that blood pressure in preeclampsia patients can be controlled so as not to endanger the condition of the mother and fe-tus. This study aims to determine the rationality and effectiveness of the use of antihypertensive drugs at RSUD Abdoel Wahab Sjahranie and RSUD Inche Abdoel Moeis in the period January 2022 - December 2023 which was carried out through retrospective data observation of hospital-ized patients with a total of 12 samples (RSUD Abdoel Wahab Sjahranie) and 10 samples (RSUD Inche Abdoel Moeis). The results of the evaluation of the rationality of antihypertensive drugs used were assessed as appropriate patients, appropriate indications, appropriate drugs, ap-propriate doses and appropriate time intervals of administration each by 100% based on the 2016 POGI guideline, Hospital Formulary, 2023 SOMANZ guideline, 2021 ISSHP guideline, and 2019 ACOG guideline. The effectiveness of using Methyldopa monotherapy showed better blood pressure reduction results (34.81/12.37 mmHg) than Nifedipine (21.41/5.6 mmHg), while the combination of Nifedipine and Methyldopa showed greater results than monotherapy (38.5/15.2 mmHg).
Formulation of Air Freshener Gel Combination of Mint Leaf Essential Oil (Mentha piperita L.) and Lemon (Citrus limon (L) Burm F.) Hafidzah, Nurul; Putri, Novita Eka Kartab; Almeida, Maria; Rusman, Arman; Herman, Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 2 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/qds89550

Abstract

Air freshener gel is a semi-solid fragrance product that uses carrageenan and pectin as gel-forming components to overcome unpleasant odors when in a room with high temperatures. The purpose of this study was to determine the composition of carrageenan and pectin as gel-forming materials for air fresheners and the composition of the aroma comparison of mint oil (Mentha piperita L.) and lemon (Citrus limon (L) Burm F). The gel base was made with a ratio of carrageenan: pectin concentration of 1: 2; 1.8: 1.2; 2.5: 0.5 then the base was evaluated including organoleptic examination, stability test and gel hardness. The best base was then added with mint oil and lemon with a ratio of 1: 1.5; 1.25: 1.25; 1.5: 1 and the gel preparation was evaluated with organoleptic parameters, gel stability, gel hardness, liquid evaporation, fragrance resistance and hedonic test. The results of the study showed that the best base preparation after the evaluation of the base was a ratio of carrageenan: pectin concentration of 25: 0.5. Evaluation of the preparation with the addition of mint leaf oil (Mentha piperita L.) and lemon (Citrus limon (L) Burm F) to the base showed a value that was not too significant in the evaluation results. In the hedonic test, the formula with the addition of 2.5%: 2.5% mint leaf oil (Mentha piperita L.) and lemon (Citrus limon (L) Burm F) was the formula preferred by the panelists. So it can be concluded that the carrageenan and pectin combination room freshener gel with a concentration ratio of 2.5: 0.5% can be formulated as a base for room freshener gel preparations, namely producing a chewy and elastic gel base. The formulation of the most preferred combination of mint leaf essential oil and lemon oil as a gel fragrance is with a concentration of 2.5: 2.5%, because it produces a refreshing aroma
Activity Test of The Combination Papaya Leaf Extract (Carica papaya L.) and Soursop Leaf Extract (Annona muricata L.) on Decreasing Blood Glucose Levels in Rats (Rattus norvegicus) Arfiani, Putri Yuni; Almeida, Maria; Arifian, Hanggara; Arief, Maryam Jamila; Herman, Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 1 No. 3 (2024): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v1i3.101117

Abstract

Diabetes mellitus (DM) is one of the most common health disorders and its prevalence rate is increasing every year. Natural compounds can be an alternative treatment for DM. Previous re-search reports for papaya leaves (Carica papaya L.) and soursop leaves (Annona muricata L.) showed activity in lowering blood glucose levels when used alone. Therefore, in this study, the two samples were combined to lower blood glucose levels. Both leaves were extracted using the decoction method. This study aims to identify secondary metabolite compounds in papaya leaf extract (Carica papaya L.) and soursop leaf extract (Annona muricata L.), then continued with determining the activity and effectiveness of lowering blood glucose levels. The results of the identification of secondary metabolite compounds showed several groups of compounds such as flavonoids, saponins and tannins. The combination of papaya leaf extract and soursop leaf extract showed a decrease in blood glucose levels. In more detail, EDPS 1:2 and EDPS 2:1 were statistically significant against negative controls. EDPS 1:2 showed the most effective percentage reduction in blood glucose levels at 22.72%  
Alkaloid Profiling of Kadamba (Mitragyna speciosa Korth. Havil.) Leaves through Chromatographic Separation and UV-Vis Spectrophotometery Analysis Arifuddin, M.; Azmi, Fatur Rahman; Iswahyudi, Iswahyudi; Bone, Mahfuzun; Farrah, Harra Ismi; Arifian, Hanggara; Almeida, Maria; Rusman, Arman; Samsul, Erwin; Riki, Riki; Rija'i, Hifdzur Rashif; Hikmawan, Baso Didik; Junaidin, Junaidin; Febrina, Lizma; Rusli, Rolan; Ibrahim, Arsyik; Ahmad, Islamudin; Herman, Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.44

Abstract

Mitragyna speciosa Korth. berasal dari famili Rubiaceae yang banyak tumbuh di daratan negara-negara Asia Tenggara. Tumbuhan ini selain disebut Kratom, khususnya di daerah Kalimantan Timur dikenal juga dengan nama "Kadamba". Mitragyna speciosa Korth. belongs to the Rubiaceae family and is widely found in the mainland of Southeast Asian countries. This plant, known as Kratom, is also referred to as "Kadamba" in East Kalimantan. Kadamba has been used for generations as a traditional medicine and contains predominantly alkaloid compounds, which generally function as analgesics, antitussives, antidiarrheals, adrenergic agents, antimalarials, antibacterials, and antinociceptives. The aim of this research is to determine the isolation and identification methods for alkaloid compounds in Kadamba leaves. In this study, extraction was performed using methanol solvent, followed by fractionation using Vacuum Liquid Chromatography (VLC) and Column Chromatography (CC) with gradient eluents: 100% hexane, n-hexane : Ethyl Acetate (5:1, 1:1, 1:5), 100% Ethyl Acetate, Ethyl Acetate : Methanol (1:1, 1:5), and 100% Methanol. The compounds were then identified using Thin Layer Chromatography (TLC). The isolation process used preparative Thin Layer Chromatography (PTLC) with eluent n-hexane: ethyl acetate: 25% ammonia (6.5:3:0.5 v/v/v), and the spots were observed under UV light at 245 nm and 366 nm. The visible spots were sprayed with Dragendorff's reagent to identify the alkaloid compounds. The results showed that the UV-Vis spectrophotometric characterization of isolate B6-b had two peaks at wavelengths of 288 nm and 294 nm.
CLINICAL OBSERVATION OF MALONDIALDEHYDE FREE RADICAL COMPOUND LEVELS IN URINE SAMPLES OF SMOKERS AND NON SMOKERS GIVEN JUICE WATERMELON (Citrullus Lanatus) ZAMRUDDIN, NUR MASYITHAH; Dwi Septiani, Kadek Ayu; Almeida, Maria; Rusman, Arman; Jafar, Fahriani Istiqamah; Herman, Herman
Jurnal Farmasi Klinik dan Sains Vol 5, No 2 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i2.1933

Abstract

Malondialdehid (MDA) merupakan biomarker stres oksidatif akibat keberadaan radikal bebas dalam tubuh. Penelitian ini bertujuan untuk mengetahui gambaran kadar MDA urin dan asam urat pada responden perokok dan non perokok dan mengetahui perubahan kadar MDA urin dan asam urat pada responden perokok dan non perokok yang diberikan minuman antioksidan jus buah semangka (Citrullus lanatus). Metode penelitian yang digunakan adalah pre-post test design. Hasil penelitian menunjukkan bahwa kadar MDA urin pada perokok aktif dan bukan perokok sebelum pemberian jus semangka adalah 2,666 nmol/mL dan 1,506 nmol/mL, sedangkan hasil penelitian setelah pemberian jus semangka pada hari ke-7 pada responden adalah 0,799 nmol/mL dan 0,539 nmol/mL. Sedangkan kadar asam urat awal masing-masing responden sebesar 7,5 mg/dL dan 6,6 mg/dL dan hasil penelitian setelah pemberian jus pada hari ke-7 kepada responden sebesar 6,1 mg/dL dan 5,7 mg/dL. Pada hasil analisis statistik menggunakan uji-t didapatkan nilai p0,05 pada kadar asam urat perokok dan nilai p
Clinical Observation of the Effect of the Combination of Red Drag-on Fruit Juice (Hylocereus polyrhizus) and Honey on Lowering Blood Pressure: Observasi Klinik Pengaruh Kombinasi Jus Buah Naga Merah (Hylocereus polyrhizus) dan Madu Terhadap penurunan tekanan darah Saputri, Meutia Ridha; Fadraersada, Jaka; Almeida, Maria; Herman
Jurnal Riseta Naturafarm Vol. 3 No. 1 (2026): J Riseta Naturafarm
Publisher : B-Creta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jrn.v3i1.0109

Abstract

Pitaya (as known as red dragon fruit in Indonesia) and honey contain high polyphenols and flavo-noids as the main source of antioxidants. Antioxidant compounds in pitaya and honey can reduce systolic and diastolic blood pressure. The aim of this study were to determine the characteristics of gender, age, and Body Mass Index of hypertensive respondents and determine the effect of the combination of pitaya juice and honey on the reduction in blood pressure and Body Mass Index for geriatric hypertensive respondents at the Puskesmas Sempaja Samarinda. This research used quasi-experimental method and data was taken with pre-test and post-test procedures. The data of respondent characteristics shown are women got the highest percentage of 58.9%, middle age of 57.8% and normal weight category (BMI) of 40.7%. The results of descriptive analysis in sys-tolic and diastolic blood pressure from pre-test are 138.64 mmHg and 82.28 mmHg, the post-test are 132.55 mmHg and 77.85 mmHg and decrease in the Body Mass Index of 0.22 kg/m2. The conclusion of this research is the combination of pitaya juice and honey was able to reduce the blood pressure and Body Mass Index
Edukasi Beyond Use Date (BUD) kepada Masyarakat di Puskesmas Lempake Samarinda Samsul, Erwin; Sari, Indah Dewi; Pasaribu, Handayani; Mus, Nurul Muhlisa; Hikmawan, Baso Didik; Arifuddin, M.; Rusman, Arman; Riki, Riki; Bone, Mahfuzun; Herman, Herman; Junaidin, Junaidin; Febrina, Lizma; Ibrahim, Arsyik; Rijai, Hifdzur Rashif; Ahmad, Islamudin; Almeida, Maria; Rijai, Laode; Arifian, Hanggara
Sevanam: Jurnal Pengabdian Masyarakat Vol 5 No 3 (2026): Maret
Publisher : Universitas Hindu Negeri I Gusti Bagus Sugriwa Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25078/sevanam.v5i3.5684

Abstract

ABSTRACT There are still some people who do not understand the difference between the expiration date (Expired Date/ED) and the drug usage limit (Beyond Use Date/BUD). BUD is the time limit for drug use after compounding or after the primary packaging is opened. This activity aims to increase public knowledge, understanding, and awareness regarding the importance of paying attention to the safe limit for drug use or Beyond Use Date (BUD), so that people can use drugs wisely, safely, and responsibly. The activity implementation method includes counseling, material presentation, distribution of leaflets or brochures, and filling out pre-tests and post-tests. The number of participants who took part in this activity was 26 people. The results of the health promotion activity at the Lempake Community Health Center, Samarinda City showed that the average knowledge of participants about Beyond Use Date before providing education was 31.92%, and increased to 88.08% after being given information. Thus, it can be concluded that this activity was successful in increasing public knowledge regarding Beyond Use Date in the Lempake Community Health Center area, Samarinda City.. Key words: Beyond Use date (BUD), Expired date (ED), Lempake Health Center Samarinda City
NMR-Based Metabolic Profiling and Anticancer Activity of Nephelium ramboutan-ake and Nephelium lappaceum Flesh Febrina, Lizma; Rusli, Rolan; Samsul, Erwin; Rijai, Laode; Ahmad, Islamudin; Rusman, Arman; Hikmawan, Baso Didik; Rija'i, Hifdzur Rashif; Almeida, Maria
Indonesian Journal of Chemistry Vol 26, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.104162

Abstract

In this research, 1H-NMR-based metabolomics assessed the metabolite profiles of two Nephelium species flesh, specifically Nephelium ramboutan-ake and Nephelium lappaceum. Our research findings indicate that the metabolite profile of N. ramboutan-ake is qualitatively identical, although numerically distinct from that of N. lappaceum. The PLSDA data indicate that N. ramboutan-ake possesses elevated concentrations of acetic acid, malic acid, GABA, and succinic acid compared to N. lappaceum. In N. lappaceum, alanine and glucose serve as the distinguishing metabolites. Additionally, the anticancer efficacy of two Nephelium samples was assessed. As a result, the anticancer properties of N. ramboutan-ake were superior to those of N. lappaceum. PLS analysis indicated that GABA exhibited the most positive connection with the anticancer activity of Nephelium samples. These results indicate that the higher GABA concentrations of N. ramboutan-ake have a beneficial effect on its anticancer activity.
Co-Authors Adam M. Ramadhan Agus Setiawaty Angga Cipta Narsa Arfiani, Putri Yuni Arief, Maryam Jamila Arifian, Hanggara Arifuddin, M Azmi, Fatur Rahman Baso Didik Hikmawan Bone, Mahfuzun Brilian Dwisaputra Bandu Daniel Happy Putra Devara, Rachel Difta, Rismania Shita Dwi Septiani, Kadek Ayu Dyah Ayu Puspo Rini Elit Dita Paradila Erwin Samsul Fadraersada, Jaka Fajar Prasetya Farah, Harra Ismi Farrah, Harra Ismi Febrina, Lizma FENNY MARTHA DWIVANY Fenny Martha Dwivany FITRIANI, VICTORIA YULITA Hadi Kuncoro Haeruddin Haeruddin Hafidzah, Nurul Haniko, Natashya Angelica Helmi Helmi Helmi Helmi Helmi Helmi Herman Herman Ibrahim, Arsyik Islamudin Ahmad Iswahyudi Iswahyudi ISWAHYUDI ISWAHYUDI Iswahyudi Iswahyudi Jafar, Fahriani Istiqamah Junaidin, Junaidin Laode Rijai Laode Rijai M. Arifuddin, M. M. Yogi Riyantama Isjoni Maharani, Dhea Nur Fadillah Maryam Jamila Arief Maryam Jamila Arief Muhammad Faisal Muhammad Faisal Muhammad Faisal Mus, Nurul Muhlisa Niken Indriyanti Nur Aini Nur Aini Buring Incau Nur Zakiyah Darajat Nur Zakiyah Darajat Pasaribu, Handayani Putri, Novita Eka Kartab Rahmadani, Agung Rahmayunitha Muriana Ridhotulloh, Yusuf Isro Rija'i, Hifdzur Rashif Rijai, Hifdzur Rashif Rija’i, Hifdzur Rashif RIKI RIKI, RIKI Rizkita Rachmi Esyanti Rolan Rusli Rusli, Rolan Rusman, Arman Sari, Indah Dewi Sinthary, Venna Sri Agung Fitri Kusuma, Sri Agung Sriwidodo Sriwidodo Supriatno Supriatno Salam Syamsiar, Syamsiar Vina Maulidya Yiska Priscilla Septilita Zamruddin, Nur Masyithah