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HUBUNGAN OBESITAS DENGAN FUNGSI PARU PADA PEMERIKSAAN SPIROMETRI MAHASISWA PROGRAM STUDI PENDIDIKAN DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS ANDALAS Octavia, Fatharani Nabila; Anggraini, Fika Tri; Yetti, Husna; Irramah, Miftah; Ermayanti, Sabrina; Hanum, Fathiya Juwita
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 3 (2025): SINERGI : Jurnal Riset Ilmiah, Maret 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i3.1068

Background: Abnormal fat accumulation affects the compliance of the respiratory system which contributes to the process of normal lung expansion. Lung function can be evaluated through an examination using spirometry with the parameters assessed, namely FVC, FEV1, and FEV1/FVC. This study aims to determine the relationship between obesity and lungfunction in the spirometry examination of Andalas University Medical Education students. Methods: This study is an observational analytic study with a cross-sectional approach. The Number of samples in this study was 34 subjects. The sampling technique used wasconsecutive sampling from students of Medical Education at the Faculty of Medicine, AndalasUniversity, Class of 2018-2020. Evaluation of lung function was carried out using aspirometry examination with parameters assessed for FVC, FEV1, and FEV1/FVC while the evaluation of obesity was carried out using the BMI with a classification according toKemenkes RI. Data analysis was carried out using univariate and bivariate qualitative methods. Results: In this study, the majority of respondents were women (70.6%) with normal nutritional status (67.6%) followed by obesity (32.4%). The relationship between obesity and lung function was tested using fisher's exact test. The results showed that there was no relationship between obesity and lung function parameters FVC, FEV1, and FEV1/FVC on spirometry tests.

Efek Pemberian Larutan Ekstrak Akar Kayu Kuning terhadap Histopatologi Ginjal Mencit yang Diinduksi D-Galaktosa Zehan Afifa Yusran; Biomechy Oktomalio Putri; Miftah Irramah; Tofrizal; Liganda Endo Mahata; Novita Ariani
Jurnal Kesehatan Masyarakat Indonesia (JKMI) Vol. 2 No. 3 (2025): April
Publisher : Publikasi Inspirasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62017/jkmi.v2i3.4113

D-galactose is a reducing sugar that induces oxidative stress by increasing the production of Reactive Oxygen Species (ROS) and Advanced Glycation End-products (AGEs), processes also associated with aging. Akar kayu kuning (Arcangelisia flava Merr.) extract contains antioxidant compounds that neutralize free radicals and mitigate oxidative stress. This study aimed to evaluate the effect of akar kayu kuning extract on the histopathological alterations of the kidneys in D-galactose-induced mice (Mus musculus). A true experimental study with a post-test-only control group design was conducted using 25 mice, divided into five groups: a negative control, a positive control (administered D-galactose at 150 mg/kgBW), and three experimental groups that received akar kayu kuning extract at doses of 250 mg/kgBW, 500 mg/kgBW, and 750 mg/kgBW following D-galactose induction. Kidney tissues were stained with hematoxylin and eosin (HE), and the extent of histopathological damage was quantified using ImageJ software. Statistical analysis using the Kruskal-Wallis test revealed significant differences between the experimental groups and the positive control (p < 0.05). The findings demonstrate that akar kayu kuning extract significantly reduces kidney histopathological damage in D-galactose-induced mice, highlighting its potential as a natural antioxidant for preventing oxidative stress-related renal impairment.

Pengaruh Pemberian Mesenchymal Stem Cell Wharton’s Jelly Terhadap Kadar Malondialdehid Tikus Wistar Hiperglikemia Nadhira Isza Qushoyyi; Endrinaldi Endrinaldi; Miftah Irramah; Husnil Kadri; Aswiyanti Asri; Rahmani Welan; Husna Yetti
Jurnal Penelitian Kesehatan SUARA FORIKES 2023
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf14nk112

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, which causes damage to tissues and organs through the process of oxidative stress. Malondialdehyde (MDA) as a biomarker of oxidative stress has a significant increase in hyperglycemia. Stem cell therapy can be an option for diabetes mellitus such as Wharton's jelly mesenchymal stem cells. This study aimed to determine the effect of MSC-WJ administration on serum MDA levels of hyperglycemic Wistar rats. This experimental study applied a post-test only design with a control group. The sample consisted of 21 male Wistar rats divided into 3 groups, including the negative control group (K-), namely the group that was only given a standard feed diet, the positive control group (K+), namely the group that was injected with alloxan with a dose of 0.2 ml intraperitoneally, and the treatment group (P), which was the alloxan-induced group, and was given MSC-WJ at a dose of 3 million cells intravenously in the rat tails. In all three groups, blood was taken from the retro orbital plexus to measure serum MDA levels with the TBARS test. The results of the analysis showed that the mean serum MDA levels of the K-, K+, and P groups were 1.83 nmol/ml, 2.97 nmol/ml, and 1.73 nmol/ml, respectively. The results of the comparison test showed a value of p = 0.000. It was concluded that there was a significant difference in serum MDA levels between the three groups, which indicated that MSC-WJ administration could reduce alloxan-induced hyperglycemia Wistar rats serum MDA levels.Keywords: hyperglycemia; malondialdehyde; Wharton's jelly mesenchymal stem cells ABSTRAK Diabetes mellitus adalah gangguan metabolik yang ditandai dengan hiperglikemia, yang menyebabkan kerusakan jaringan dan organ melalui proses stress oksidatif. Malondialdehid (MDA) sebagai biomarker stress oksidatif mengalami peningkatan signifikan pada hiperglikemia. Terapi stem cell dapat menjadi pilihan untuk diabetes mellitus seperti mesenchymal stem cell wharton’s jelly. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian MSC-WJ terhadap kadar MDA serum tikus wistar hiperglikemia. Penelitian eksperimental ini menerapkan rancangan post-test only with control group. Sampel adalah 21 ekor tikus wistar jantan yang dibagi menjadi 3 kelompok, di antaranya kelompok kontrol negatif (K-) yaitu kelompok yang hanya diberi diet pakan standar, kelompok kontrol positif (K+) yaitu kelompok yang diinjeksi aloksan dengan dosis 0,2 ml secara intraperitoneal, dan kelompok perlakuan (P) yaitu kelompok yang diinduksi aloksan, serta diberi MSC-WJ dengan dosis 3 juta sel secara intravena pada ekor tikus. Pada ketiga kelompok dilakukan pengambilan darah dari pleksus retro orbitalis untuk pengukuran kadar MDA serum dengan tes TBARS. Hasil analisis menunjukkan kadar rerata MDA serum kelompok K-, K+, dan P secara berturut-turut adalah 1,83 nmol/ml, 2,97 nmol/ml, dan 1,73 nmol/ml. Hasil uji perbandingan menunjukkan nilai p = 0,000. Disimpulkan bahwa terdapat perbedaan kadar MDA serum yang bermakna di antara ketiga kelompok, yang menunjukkan bahwa pemberian MSC-WJ dapat menurunkan kadar MDA serum tikus wistar hiperglikemia yang diinduksi aloksan.Kata kunci: hiperglikemia; malondialdehid; mesenchymal stem cell wharton’s jelly

Six-Minute Walk Test Performance in Non-Dialysis Chronic Kidney Disease: An Observational Study from a Tertiary Hospital Setting Irena Fathin Amelia; Harun, Harnavi; Miftah Irramah; Selfi Renita Rusjdi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1324

Background: Functional capacity dramatically declines in non-dialysis chronic kidney disease (CKD-ND), impacting patient prognosis and quality of life. Accurate, practical assessment is crucial for timely intervention. This study evaluated functional capacity using Six-Minute Walk Test (6MWT) and explored associated clinical factors in Indonesian CKD-ND patients. Methods: We conducted a cross-sectional study at RSUP Dr. M. Djamil Padang, enrolling 44 patients with CKD stages 3-5 not on dialysis. Using purposive sampling, we collected 6MWT distance (6MWD) following ATS guidelines and extracted demographic/clinical data (age, gender, BMI, eGFR, etiology) from medical records. Functional capacity, expressed as Metabolic Equivalents (METs), was estimated from 6MWD and patient data using the Nury formula. Descriptive statistics summarized the findings. Results: The cohort (54.5% male, mean age 56-65 years) predominantly had advanced CKD (43.2% Stage 5) and hypertension etiology (45.4%). Functional capacity was severely impaired: mean 6MWD was low (Men: 291m, Women: 255m), and a striking 70.5% of patients exhibited low functional capacity (<3.0 METs). No participants achieved high capacity (>6.0 METs). Lower mean 6MWD and a higher prevalence of low METs were distinctly observed in patients with lower eGFR and advanced age. Conclusion: This study reveals profound functional limitations in Indonesian CKD-ND patients well before dialysis initiation. Lower eGFR and older age were strongly associated with poorer performance. The 6MWT effectively quantifies this impairment, highlighting its utility for routine screening and emphasizing the urgent need for functional assessment and rehabilitation strategies in CKD-ND management.

Perbedaan Fungsi Sistolik Ventrikel Kanan antara Hipertensi Arteri Pulmonal dan Hipertensi Vena Pulmonal Rayhansyah, Vito; Yanni, Mefri; Irramah, Miftah; Hamdani, Rita; Revilla, Gusti; Linosefa, Linosefa
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.14-25

Background Pulmonary arterial hypertension (PAH) and pulmonary venous hypertension (PVH) are both associated with increased right ventricular (RV) afterload, potentially leading to RV systolic dysfunction. Despite its prognostic value in predicting right heart failure (RHF), echocardiographic evaluation of RV function remains underutilized in the routine assessment of patients with PAH and PVH. Methods This study aims to evaluate differences in RV systolic function between PAH and PVH patients. A total of 116 patients (58 PAH and 58 PVH) were selected through consecutive sampling from medical records at RSUP Dr. M. Djamil Padang. Echocardiographic parameters were analyzed using appropriate statistical tests based on data distribution and type, including Chi-square, Fisher’s exact, and Mann-Whitney U tests. Results Significant differences were observed between PAH and PVH groups in terms of tricuspid regurgitation (TR) severity (p = 0.003), tricuspid annular plane systolic excursion (TAPSE) (p = 0.013), and tissue Doppler-derived systolic velocity of the tricuspid annulus (S′) (p = 0.001). No significant differences were found in ejection fraction (EF), systolic pulmonary artery pressure (sPAP), mean pulmonary artery pressure (mPAP), or TR velocity (TR Vmax). Overall, RV systolic function differed significantly between the PAH and PVH groups (p = 0.006). Conclusions The findings demonstrate a statistically significant difference in RV systolic function between patients with PAH and PVH. These results underscore the need for more comprehensive and routine echocardiographic evaluation of RV function in these populations to enhance risk stratification and management.

Six-Minute Walk Test Performance in Non-Dialysis Chronic Kidney Disease: An Observational Study from a Tertiary Hospital Setting Irena Fathin Amelia; Harun, Harnavi; Miftah Irramah; Selfi Renita Rusjdi
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 7 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i7.1324

Background: Functional capacity dramatically declines in non-dialysis chronic kidney disease (CKD-ND), impacting patient prognosis and quality of life. Accurate, practical assessment is crucial for timely intervention. This study evaluated functional capacity using Six-Minute Walk Test (6MWT) and explored associated clinical factors in Indonesian CKD-ND patients. Methods: We conducted a cross-sectional study at RSUP Dr. M. Djamil Padang, enrolling 44 patients with CKD stages 3-5 not on dialysis. Using purposive sampling, we collected 6MWT distance (6MWD) following ATS guidelines and extracted demographic/clinical data (age, gender, BMI, eGFR, etiology) from medical records. Functional capacity, expressed as Metabolic Equivalents (METs), was estimated from 6MWD and patient data using the Nury formula. Descriptive statistics summarized the findings. Results: The cohort (54.5% male, mean age 56-65 years) predominantly had advanced CKD (43.2% Stage 5) and hypertension etiology (45.4%). Functional capacity was severely impaired: mean 6MWD was low (Men: 291m, Women: 255m), and a striking 70.5% of patients exhibited low functional capacity (<3.0 METs). No participants achieved high capacity (>6.0 METs). Lower mean 6MWD and a higher prevalence of low METs were distinctly observed in patients with lower eGFR and advanced age. Conclusion: This study reveals profound functional limitations in Indonesian CKD-ND patients well before dialysis initiation. Lower eGFR and older age were strongly associated with poorer performance. The 6MWT effectively quantifies this impairment, highlighting its utility for routine screening and emphasizing the urgent need for functional assessment and rehabilitation strategies in CKD-ND management.

Upaya Membangun Kesadaran Tentang Hidrasi Anak Sekolah Full Day di Padang Fasrini, Ulya Uti; Ilhami, Yose Ramda; Lailani, Mutia; Welan, Rahmani; Irramah, Miftah
Poltekita: Jurnal Pengabdian Masyarakat Vol. 5 No. 2 (2024)
Publisher : Pusat Penelitian & Pengabdian Masyarakat Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/pjpm.v5i2.3582

Adequate fluid intake is associated with students' attention, memory function, and cognitive performance. Sekolah Alam Ar Royyan, one of the schools highlighted in the G20, needs assistance with students' low water drinking behavior. The hydration team's preliminary research found that most students were mild-moderate dehydrated, which was closely related to action. This activity aims to build awareness of the school and its community to build a culture of drinking enough water at school. The method used was action research involving school administrators, students, and teachers. The researcher identifies specific problems, collects relevant data, analyzes the data, and then decides on the needed actions to overcome these problems. After implementing a series of activities, the team conducted the evaluation. The results showed that eight out of ten students were moderately dehydrated, had low water drinking habits at school, and had limited availability of clean drinking water. After conducting activities with a participatory approach, water drinking at school began to increase, although yet to be significant, and the school has provided drinking water in gallons that students can access while at school in each classroom. This activity concludes that there has been an increase in awareness from the entire school academic community about fulfilling the adequacy of students' drinking water at school.

Hubungan Pengetahuan dengan Tindakan Pencegahan terhadap Toksoplasmosis pada Mahasiswa Fakultas Kedokteran UNAND Swandi, Khairfani; Rusjdi, Selfi Renita; Burhan, Ida Rahmah; Adrial, Adrial; Irramah, Miftah; Fadila, Zurayya
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1058

Latar belakang: Toksoplasmosis merupakan penyakit asimtomatik yang tersebar di seluruh dunia. Sampai saat ini, Toksoplasmosis termasuk dalam kelompok Neglected Tropical Diseases (NTD’s). Seroprevalensi toksoplasmosis beberapa daerah di Indonesia tergolong cukup tinggi. Tingkat higienitas masyarakat di Indonesia juga tergolong rendah. Oleh karena itu, mahasiswa perlu memiliki pengetahuan dan tindakan pencegahan yang baik sebagai langkah awal untuk menurunkan risiko terinfeksi toksoplasmosis. Objektif: Mengetahui hubungan pengetahuan dengan tindakan pencegahan terhadap toksoplasmosis pada mahasiswa Fakultas Kedokteran Universitas Andalas. Metode: Penelitian ini merupakan penelitian model analitik cross sectional. Pengumpulan data dilakukan melalui kuesioner. Pemilihan sampel menggunakan metode stratified random sampling dari mahasiswa/I program studi Pendidikan Dokter Fakultas Kedokteran Universitas Andalas Angkatan 2019 dan 2020. Analisis data dilakukan dengan menggunakan uji chi-square Hasil: Hasil penelitian didapatkan bahwa 143 responden memiliki pengetahuan baik terkait toksoplasmosis dan 146 responden menerapkan tindak pencegahan yang baik terhadap toksoplasmosis. Kesimpulan: Kesimpulan yang didapatkan bahwa tidak terdapat hubungan antara pengetahuan dengan tindakan pencegahan terhadap toksoplasmosis pada mahasiswa Fakultas Kedokteran Universitas Andalas. Kata kunci: toksoplasmosis, Toksoplasma gondii, pengetahuan, tindak pencegahan

Pengaruh Pemberian Ekstrak Akar Kayu Kuning (Arcangelisia Flava Merr.) terhadap Aktivitas Enzim Katalase pada Mencit (Mus Musculus) yang Diinduksi D-Galaktosa Cesar, Afifah Raudhati; Putri, Biomechy Oktomalio; Irramah, Miftah; Rita, Rauza Sukma; Rahmatini, Rahmatini; Hanum, Fathiya Juwita
Innovative: Journal Of Social Science Research Vol. 5 No. 3 (2025): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v5i3.19551

Abstrak Studi ini merupakan studi eksperimental sejati (true experimental) dengan rancangan post-test only control group design. Objek studi ini menggunakan 25 ekor mencit dan dibagi secara acak ke dalam lima kelompok perlakuan. Kelompok kontrol negatif (K−) hanya diberikan pakan standar, sedangkan kelompok kontrol positif (K+) diinduksi dengan D-galaktosa dosis 150 mg/kgBB. Tiga kelompok perlakuan lainnya, yaitu P1, P2, dan P3, masing-masing diinduksi dengan D-galaktosa dosis 150 mg/kgBB serta diberikan ekstrak akar kayu kuning dengan dosis berturut-turut 250 mg/kgBB, 500 mg/kgBB, dan 750 mg/kgBB. Hasil studi menyatakan rerata aktivitas enzim katalase pada kelompok K- sebesar 5,75 ± 0,27 Unit/mg, K+ sebesar 3,28 ± 0,21 Unit/mg, P1 sebesar 3,87 ± 0,96 Unit/mg, P2 sebesar 4,86 ± 0,68 Unit/mg, dan P3 sebesar 4,87 ± 0,87 Unit/mg. Dapat disimpulkan terdapat pengaruh pemberian ekstrak akar kayu kuning dosis 250 mg/kgBB, 500 mg/kgBB, 750 mg/kgBB terhadap aktivitas enzim katalase. Kata Kunci : Antioksidan; D-galaktosa; Ekstrak Akar Kayu Kuning; Katalase

Pengaruh Ekstrak Akar Kayu Kuning (Arcangelisia flava Merr.) terhadap Kadar MDA Mencit (Mus musculus) Model Penuaan yang Diinduksi D-Galaktosa Tafdil, Zhafirah Khairunnisa; Putri, Biomechy Oktomalio; Alioes, Yustini; Irramah, Miftah; Asterina, Asterina; Mahata, Liganda Endo
Innovative: Journal Of Social Science Research Vol. 5 No. 3 (2025): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v5i3.19575

Ekstrak akar kayu kuning (Arcangelisia flava Merr.) diketahui bisa memperlambat stres oksidatif dan menurunkan kadar MDA serum. Jenis studi ini yakni true experimental research dengan desain post test only control group dengan 25 ekor mencit yang dibagi menjadi 5 kelompok. Hasil studi menunjukkan rerata kadar MDA serum mencit pada kelompok K- sebesar 2,73 ± 0,33 nmol/ml, K+ sebesar 4,12 ± 0,26 nmol/ml, P1 sebesar 3,47 ± 0,26 nmol/ml, P2 sebesar 3,22 ± 0,29 nmol/ml dan P3 sebesar 3,05 ± 0,28 nmol/ml. Uji One Way ANOVA menghasilkan nilai p sebesar 0,000 (p kurang dari 0,05), hal ini dapat diartikan bahwa terdapat pengaruh pemberian ekstrak akar kayu kuning terhadap kadar MDA serum. Hasil studi ini menunjukkan bahwa ekstrak akar kayu kuning pada dosis 250 mg/kgBB, 500 mg/kgBB, dan 750 mg/kgBB mampu menurunkan kadar MDA dalam serum.

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