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Anchoring Analysis and Simulation of Molecular Dynamics of Dayak Onion Plant Compounds (Eleutherine bulbosa (Mill.) URB.) As an Antibacterial Candidate for Methicillin Resistant Staphylococcus aureus Pratamaa, Yuga; Rina Herowati; Nuraini Harmastuti; Andri Prasetiyo
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 3 (2024): January 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v2i1.8334

Abstract

MRSA infection that is growing and limited treatment is evidence that the handling and treatment of the disease is still inadequate so that appropriate drugs are needed as antibacterial against MRSA, the development of natural products, one of which is the dayak onion plant (Eleutherine bulbosa) which has the potential as antibacterial can be done with computational methods, one of which is molecular tethering, molecular dynamics and ADMET prediction. This study aims to predict the ability of natural compounds from dayak onions as antibacterial MRSA. Tethering and molecular dynamics are performed using AutoDock 4.2 and Yasara Dynamic software. The results showed that compounds with the greatest antibacterial potential were eleucanainones with binding energy of -11.91kcal / mol. The results of molecular tethering are then continued with molecular dynamics simulations. The results of molecular dynamics simulations show that the compound has a Root Mean Square Deviation (RMSD) value that is close to the native ligand. Conclusion: Dayak onion compounds (Eleutherine bulbosa) have potential as antibacterial MRSA
SOSIALISASI OLAHRAGA TRADISIONAL DALAM RANGKA PEMAJUAN KEBUDAYAAN INDONESIA Rachman, Fadlu; Armanjaya, Satria; Fajar Ramadhan, Ziko; Prasetiyo, Andri; Sari, Felinda; Nuruhidin, Ahmad; Gumay, Jovana Renaldy; Sodik, Alfan Nur
Mitra Mahajana: Jurnal Pengabdian Masyarakat Vol. 6 No. 2 (2025): Volume 6 Nomor 2 Juli 2025
Publisher : LPPM Universitas Flores

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37478/mahajana.v6i2.5854

Abstract

Cultural advancement is an essential component of maintaining national identity, including the preservation of traditional sports that are being abandoned by the younger generation. This Community Service activity aims to increase students' knowledge and participation in traditional sports as a form of preserving local culture. The targets of the activity are students at three partner schools: SMAN 1 Gading Rejo, SMAN 2 Gading Rejo, and SMK Patria, who have not received direct learning about traditional sports. The implementation method includes education through interactive counselling, direct practice of various conventional games (engklek, running blocks, congklak, dompu), and provision of learning media such as modules, leaflets, and video documentation. Evaluation was carried out through participatory observation, questionnaires, and interviews with students and teachers. The results of the activity showed that 87% of students were new to and playing traditional games, while 92% expressed interest in playing them again. In addition, teachers welcomed this activity and saw its potential for integration into PJOK learning and extracurricular activities. It was concluded that the socialisation of traditional sports was effective in fostering cultural awareness and students' love for local heritage. It is hoped that this activity can be replicated in other schools as part of the strategy to advance Indonesian culture.
Systematic Literature Review: Pengaruh Permainan Tradisional Terhadap Kelincahan Siswa Sekolah Dasar Rachman, Fadlu; Prasetiyo, Andri; Rahmat, Ayi; Nuruhidin, Ahmad
Jurnal Porkes Vol 8 No 3 (2025): December: Article in Progress
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/porkes.v8i3.31872

Abstract

Traditional games contribute significantly to improving the agility of elementary school students. However, technological developments and lifestyle changes have led to a decline in physical activity among children. This study aims to systematically examine the impact of traditional games on the agility of elementary school students. The method used is a systematic literature review (SLR) by analyzing published research between 2019 and 2024 through Google Scholar, SINTA, and Publish or Perish. Of the 40 articles identified, 7 articles met the inclusion criteria. The results of the analysis showed that gobak sodor was able to increase agility by up to 67.5%, while bentengan increased agility by 9.7%. In addition, the games of lari balok, hadang, and sepak beleg were also proven to be effective in increasing students' agility. Compared to conventional exercises, traditional games are more interactive and can increase students' motivation to practice. In conclusion, traditional games can be applied as an effective strategy in physical education to develop the agility of elementary school students. Therefore, teachers, policymakers, and parents need to integrate traditional games into children's physical activities to support their motor development and fitness.
Formulasi Gel Kombinasi Ekstrak Buah Asam Gelugur (Garcinia atroviridis Griff. Ex T. Anderson) dan Daun Perilla (Perilla frutescens L. Britton) serta Uji Aktivitas Antijerawat dan Antioksidan Agustin, Vina; Taurhesia, Shelly; Prasetiyo, Andri
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.1059

Abstract

Penggunaan bahan-bahan alami sebagai agen antibakteri dan antioksidan topikal semakin mendapat perhatian, terutama dalam pengembangan formulasi untuk kulit berjerawat. Penelitian ini bertujuan untuk memformulasi dan mengevaluasi gel yang mengandung kombinasi ekstrak buah asam gelugur dan ekstrak daun perilla, serta untuk menilai aktivitas antibakteri, antioksidan, dan keamanan topikalnya. Tiga formulasi gel dibuat, gel dasar tanpa ekstrak (F0), gel dengan konsentrasi ekstrak optimal (F1), dan gel dengan konsentrasi ekstrak dua kali lipat (F2). Formulasi gel dievaluasi untuk sifat organoleptik, homogenitas, pH, daya sebar, viskositas, dan stabilitas fisik menggunakan cycling test. Aktivitas antibakteri diuji terhadap Cutibacterium acnes dan Staphylococcus epidermidis menggunakan metode difusi cakram, aktivitas antioksidan dinilai melalui uji penangkal radikal bebas DPPH. Uji iritasi kulit primer dilakukan pada kelinci albino untuk menentukan keamanan topikal gel. Hasil menunjukkan bahwa semua formulasi memenuhi karakteristik fisik dan stabilitas gel topikal yang dipersyaratkan. Sebelum dan sesudah cycling test stabil pada bakteri C.acnes F0 (0,00 mm), F1 (14,35 ± 0,32 mm), dan F2 (26,42 ± 0,08 mm). Sedangkan pada bakteri S.epidermidis F0 (0,00 mm), F1 (11,20 ± 0,24 mm), dan F2 (20,15 ± 0,05 mm). Nilai IC50 sebelum dan sesudah cycling test F0 (664,857 ppm), F1 (106,518 ppm menjadi 113,25 ppm), dan F2 (63,01 ppm menjadi 71,50 ppm). Uji iritasi menunjukkan skor 0,0 ± 0,0, yang menunjukkan bahwa gel aman untuk aplikasi topikal.
Education on the use of herbal medicine against Hypertension with Joyoboyo Health Community, Kediri Maulida Mazaya; Ratna Surya Alwi; Reza Alrayan; Esti Ambar Widyaningrum; Evi Kurniawati; Maratu Soleha; Mukh Fajar Nasrulloh; Andri Prasetiyo; Inggrid Tania
Abdimas: Jurnal Pengabdian Masyarakat Universitas Merdeka Malang Vol. 10 No. 2 (2025): May 2025
Publisher : University of Merdeka Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26905/abdimas.v10i2.14824

Abstract

Hypertension (high blood pressure) is a major global health concern. According to the National Health Profile (Riskesdas), it was reported that 450.126 cases occurred in Indonesia (2022), with 38.204 confirmed in Kediri Regency (2023), where hypertension has become the most common non-communicable condition in East Java, which was detected in the aged 15 years old. Generally, people still consume conventional medicine to lower their blood pressure. Contrarily, herbal medicine, often regarded as a complementary or alternative option. Thus, educational strategies for integrating herbal medicine into hypertension management are needed. In Kediri, the Joyoboyo health community plays an important role in spreading awareness about hypertension. During the community service activity, 61 Joyoboyo health cadre volunteers participated in these educational sessions to help them share accurate information with the wider community. These sessions covered topics such as correct dosage, possible interactions with prescription drugs, and the importance of evidence-based herbal use for treatment. These points were reinforced through discussion and supported by analyzing the recent clinical research. A statistical evaluation was conducted to assess the program's effectiveness. Overall, the results of this activity underline the need for a multidisciplinary approach combining traditional and scientific knowledge to optimize the management of hypertension. 
Analisis Pengendalian Persediaan Obat Di Instalasi Farmasi Rumah Sakit Umum Proklamasi Kabupaten Karawang Dengan Metode ABC Nurul Laily Fadhillah; Andri Prasetyo; Rafrini Amyulianthy
Management Studies and Entrepreneurship Journal (MSEJ) Vol. 7 No. 3 (2026): Management Studies and Entrepreneurship Journal (MSEJ)
Publisher : Yayasan Pendidikan Riset dan Pengembangan Intelektual (YRPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37385/msej.v7i3.10479

Abstract

Manajemen persediaan obat di Rumah Sakit Umum Proklamasi dilakukan oleh Instalasi farmasi yang dimulai dari perencanaan, pengadaan, penerimaan dan penyimpanan. Menjamin ketersediaan obat adalah tanggung jawab yang harus dipenuhi oleh rumah sakit dengan menyesuaikan antara kebutuhan dengan anggaran yang tersedia. Penelitian ini bertujuan untuk melakukan analisis ABC berdasarkan nilai pemakaian dan nilai investasi. Penelitian ini merupakan penelitian deskriptif kualitatif dan kuantitatif dengan pengambilan data secara retrospektif. Pendekatan kuantitatif dengan analisis ABC dengan mempertimbangkan pemakain periode 2022 dan 2023 di Rumah Sakit Umum Proklamasi Karawang dan pendekatan kualitatif dilakukan dengan melakukan wawancara mendalam. Pengelolaan data menggunakan Microsoft Excel. Hasil analisis ABC berdasarkan nilai pemakaian tahun 2022 dari total item obat kelompok A memiliki persentase 32,50%; kelompok B 31,54% dan kelompok C 35,96% dan hasil nilai pemakaian tahun 2023 dari total item obat kelompok A memiliki persentase 28,92%; kelompok B 32,51% dan kelompok C 38,57%. Hasil analisis berdasarkan nilai investasi tahun 2022 dari total item obat kelompok A memiliki persentase 69,81%; kelompok B 20,14% dan kelompok C 10,05% dan hasil nilai investasi tahun 2023 dari total item obat kelompok A memiliki persentase 69,92%; kelompok B 20,00% dan kelompok C 10,09%.
Studi In Silico Senyawa Bioaktif pada Daun Yakon (Smallanthus sonchifolius), Kayu Secang (Caesalpinia sappan L.), Daun Salam (Syzygium polyanthum) Sebagai Antidiabetes Mekanisme Kerja Inhibitor SGLT-2 Andri Prasetyo Prasetyo; Esti Mumpuni; Sekar Harsti Rahmadhani; Saeful Amin
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.39508

Abstract

Diabetes melitus adalah penyakit metabolik yang ditandai dengan hiperglikemia dimana pankreas tidak memproduksi cukup insulin atau tubuh tidak dapat menggunakan insulin secara efektif. Daun yakon, kayu secang dan daun salam memiliki beberapa yang berpotensi sebagai antidiabetes, namun belum diketahui senyawa spesifik mana yang terlibat dalam mekanisme inhibitor SGLT-2. Penelitian ini bertujuan untuk menganalisis potensi senyawa bioaktif yang terkandung dalam Daun yakon, kayu secang dan daun salam dalam menghambat enzim SGLT-2 secara in silico. Data senyawa aktif didapatkan dari laman PubChem. Kristal struktur dari Structure of human SGLT2-MAP17 complex bound with empagliflozin didapatkan dari Protein Data Bank dengan PDB ID: 7VSI. Molecular docking menggunakan Molegro Virtual Docker dan simulasi molecular dynamic menggunakan YASARA Dynamics. Hasil molecular docking didapatkan 4 senyawa memiliki nilai rerank score lebih negative dari senyawa pembanding (empagliflozi). Hasil visualisasi menunjukan residu asam amino yang berperan penting ialah PHE 98 dan VAL 157. Hasil molecular dynamics menunjukan kompleks ligan memiliki kestabilan ikatan paling baik dan stabil dari ligan uji lainnya. Dihasilkan senyawa yang stabil, yaitu 3,4-Dicaffeoyquinic acid.
Pengaruh Latihan Naik Turun Tangga dan Latihan Tanjakan Terhadap Peningkatan Lari 100 Meter Prasetiyo, Andri; Renaldy Gumay, Jovana; Nuruhidin, Ahmad; Armanjaya, Satria; Ariansyah, Edward
SPORT GYMNASTICS : Jurnal Ilmiah Pendidikan Jasmani Vol. 7 No. 1 (2026): April
Publisher : Universitas Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/gymnastics.v7i1.48832

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh latihan naik turun tangga dan latihan tanjakan terhadap peningkatan kecepatan lari 100 meter pada atlet U18 binaan club yang ada di kabupaten Pesawaran yaitu Atletik Teluk Pandan Club & Haidar Running Club. Metode penelitian menggunakan eksperimen dengan desain two group pretest-posttest. Sampel penelitian berjumlah 10 atlet sprint Putra dengan rata-rata Latihan diatas 1 tahun yang dibagi menjadi dua kelompok perlakuan. Kelompok pertama diberikan latihan naik turun tangga dan kelompok kedua diberikan latihan tanjakan. Instrumen yang digunakan adalah tes lari 100 meter. Perlakuan diberikan selama 6 minggu dengan frekuensi latihan tiga kali per minggu dengan tambahan program lainya sama. Analisis data menggunakan uji t. Hasil penelitian menunjukkan bahwa kedua metode latihan memberikan pengaruh yang signifikan terhadap peningkatan kecepatan lari 100 meter, namun latihan tanjakan menunjukkan peningkatan yang lebih besar dibandingkan latihan naik turun tangga. Disimpulkan bahwa latihan tanjakan lebih efektif dalam meningkatkan performa sprint 100 meter dan Latihan naik turun tangga juga dapat digunakan, guna meningkatkan kecepatan frekuensi ayunan kaki dan tangan serta power. Abstract This study aimed to determine the effect of stair up-and-down training and hill training on improving 100-meter sprint speed in U18 athletes fostered by clubs in Pesawaran Regency, namely Atletik Teluk Pandan Club and Haidar Running Club. The research method used was an experimental design with a two-group pretest–posttest design. The sample consisted of 10 male sprint athletes with an average training experience of more than one year, divided into two treatment groups. The first group was given stair up-and-down training, while the second group received hill training. The instrument used was a 100-meter sprint test. The treatment was conducted for 6 weeks with a training frequency of three times per week, while other additional training programs were kept the same. Data analysis used the t-test. The results showed that both training methods had a significant effect on improving 100-meter sprint speed. However, hill training showed a greater improvement compared to stair up-and-down training. It can be concluded that hill training is more effective in improving 100-meter sprint performance, while stair training can also be used to increase the frequency of arm and leg swing as well as power.
Analysis of Molecular Docking and Dynamics Simulation of Mahogany (Swietenia macrophylla King) Compounds Against the PLpro Enzyme SARS-COV-2 Lalu Sanik Wahyu Fadil Amrulloh; Nuraini Harmastuti; Andri Prasetiyo; Rina Herowati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 3 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i32023.347-359

Abstract

Background: Using natural ingredients as antivirals can be considered a treatment for SARS-CoV-2. One of the potential plants, mahogany (Swietenia macrophylla King), is widely used in various countries as an antiviral treatment. Paparin-like protease (PLpro) is an essential cysteine "‹"‹protease that regulates viral replication and interferes with the regulation of immune sensing. Objective: This study aims to predict which compounds in the mahogany plant have good affinity, patterns, and stability interaction against the target protein of SARS-CoV-2. Methods: The drug-likeness parameter using SwissADME was used to screen compounds that will be docked against PLpro using the Autodock program. The parameters observed in molecular docking analysis are the value of bond energy and interaction model to amino acid residues. The compounds in mahogany plants that have the best interactions were then analyzed using molecular dynamics simulation methods to determine the stability of their bonds based on the values of Root Mean Square Deviation (RMSD) and Root Mean Square Fluctuation (RMSF). Results: Twenty-two compounds met the drug-likeness requirements. Molecular docking analysis showed that the compounds predicted to have the best binding affinity and have an interaction pattern similar to natural ligands towards the molecular target of PLpro are 7-deacetoxy-7-oxogedunin and 3β-hydroxy-stigmast-5-en-7-one. The molecular dynamics simulation results revealed that based on the RMSD and RMSF values, the compound 3β-hydroxy-stigmast-5-en-7-one showed higher stability than 7-deacetoxy-7-oxogedunin. Conclusion: 3β-hydroxy-stigmast-5-en-7-one and 7-deacetoxy-7-oxogedunin were predicted to have good interaction with PLPro; however, 3β-hydroxy-stigmast-5-en-7-one showed the higher interaction stability.
Analisis Pengendalian Persediaan Obat Di Instalasi Farmasi Rumah Sakit Umum Proklamasi Kabupaten Karawang Dengan Metode ABC Nurul Laily Fadhillah; Andri Prasetyo; Rafrini Amyulianthy
Management Studies and Entrepreneurship Journal (MSEJ) Vol. 7 No. 3 (2026): Management Studies and Entrepreneurship Journal (MSEJ)
Publisher : Yayasan Pendidikan Riset dan Pengembangan Intelektual (YRPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37385/msej.v7i3.10479

Abstract

Manajemen persediaan obat di Rumah Sakit Umum Proklamasi dilakukan oleh Instalasi farmasi yang dimulai dari perencanaan, pengadaan, penerimaan dan penyimpanan. Menjamin ketersediaan obat adalah tanggung jawab yang harus dipenuhi oleh rumah sakit dengan menyesuaikan antara kebutuhan dengan anggaran yang tersedia. Penelitian ini bertujuan untuk melakukan analisis ABC berdasarkan nilai pemakaian dan nilai investasi. Penelitian ini merupakan penelitian deskriptif kualitatif dan kuantitatif dengan pengambilan data secara retrospektif. Pendekatan kuantitatif dengan analisis ABC dengan mempertimbangkan pemakain periode 2022 dan 2023 di Rumah Sakit Umum Proklamasi Karawang dan pendekatan kualitatif dilakukan dengan melakukan wawancara mendalam. Pengelolaan data menggunakan Microsoft Excel. Hasil analisis ABC berdasarkan nilai pemakaian tahun 2022 dari total item obat kelompok A memiliki persentase 32,50%; kelompok B 31,54% dan kelompok C 35,96% dan hasil nilai pemakaian tahun 2023 dari total item obat kelompok A memiliki persentase 28,92%; kelompok B 32,51% dan kelompok C 38,57%. Hasil analisis berdasarkan nilai investasi tahun 2022 dari total item obat kelompok A memiliki persentase 69,81%; kelompok B 20,14% dan kelompok C 10,05% dan hasil nilai investasi tahun 2023 dari total item obat kelompok A memiliki persentase 69,92%; kelompok B 20,00% dan kelompok C 10,09%.
Co-Authors Ade Yeni Aprilia Aey Fadilah, Yasin Agustia, Rini Agustin, VIna Ahmad Nuruhidin Alwie, Rakhmat Ramdhani Ariansyah, Edward Armanjaya, Satria Audrey, Cresentia Bambang Pontjo Priosoeryanto Bella Rofi Desi Nadya Aulena Dhani, Muhammad Diva Dwi Putri Permatasari Esti Ambar Widyaningrum Esti Mumpuni Esti Mumpuni Esti Mumpuni, Esti Evi Kurniawati Evi Susanti Fadlu Rachman Fajar Ramadhan, Ziko Faridah Faridah Fitry Angger Pangestu Gayatri Indah Pramesti Gumay, Jovana Renaldy Hakim, Zainur Rahman Hutagaol, Lungguk Indriani, Aqilah Idelia Inggrid Tania Intan Permata Sari Julian Rahmat Lalu Sanik Wahyu Fadil Amrulloh Lidya Luziana Lilik Sulastri Lilik Sulastri LUNGGUK HUTAGAOL Lungguk Hutagaol Luziana, Lidya Maratu Soleha Marlien Bokko Martati, Titiek Maulida Mazaya Maulinda, Elvi Sahri Mawijaya, Agus Megawati - Muhamad Yamin Muhammad Yamin Muhammad Zulfadhli, Muhammad Mukh Fajar Nasrulloh Mulatsari, Esti Nabila Prihantini Khairunnisa Natthawani, Amitta Nawasiah, Nana Novi Yantih Noviyantih, Noviyantih Nuraini Harmastuti NURAINI HARMASTUTI Nurmala Ahmar Nuruhidin, Ahmad Nurul Laily Fadhillah Panca Bayu Chandra, Pra Pratamaa, Yuga Rachman, Fadlu Rachmi Ridho Rafrini Amyulianthy Rahmat, Ayi Ramadhan, Islami Al-Kaffah Ramadhani, Karina Natasya Ramani, Sofyan Ratna Surya Alwi Raymond R. Tjandrawinata Renaldy Gumay, Jovana Reza Alrayan Rhahmadini, Yahdi Thia Rina Herowati Risna Rosmiyati Saeful Amin Saeful Amin Salsabila Adlina Saputra, Putri Windari Sarah Annisaa Nurwan Sari Dewi, Rika Sari, Felinda Sekar Harsti Rahmadhani Shaquille, Haikal Shirly Kumala Simanjuntak, Josua Donrio Simanjuntak, Vino Soaduon Siswahyudianto Siswandono, Siswandono Sodik, Alfan Nur Syamsudin Abdillah Syifa Aulia Taqwa, Iqbal Ananda Taurhesia, Shelly Utami, Santi Yanuarti Winana Kartika Dewi Wiwi Winarti Yogaswara, Amira Thufailla Zahra, Nurulita Az Ziko Fajar Ramadhan, Ziko Fajar