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Formulation of Transparent Solid Soap from Palm Kernel Oil Andri Prasetiyo; Lungguk Hutagaol; Lidya Luziana
Jurnal Jamu Indonesia Vol. 5 No. 2 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v5i2.159

Abstract

Palm kernel oil contains fatty acids, especially lauric acid at 46-52%. Lauric acid has the properties of hardening, cleaning, producing foam and softening that is needed in making soap. The purpose of this study is to make transparent solid soap from a combination of glycerin, sucrose, and ethanol 96% as a transparent agent that meets the requirements of quality tests and organoleptic tests. Made 9 (nine) formulas with some combination of glycerin, sucrose, ethanol 96% by a semi-boiled method that is mixing palm kernel oil and stearic acid which has been melted at 60˚C, then adding 30% NaOH, stirring at 70- 80˚C. Transparent agent and other additives are mixed into the soap mass obtained from the saponification process, then poured into a soap mold and carried out a curing process for 2 weeks. The result of this research is obtained a transparent yellow solid soap that is the bright and distinctive smell of coconut perfume with a pH of 8.35-8.64, the hardness of 21.30-38.13 10-1 mm, moisture content of 21.48-33.33%, free fatty acid content 0,88-0,96%, unsaturated fat content 1,45-2,38%, surface tension 27,93-32,34 dyne/cm. Transparent solid soap that meets the quality requirements and the organoleptic test is formula A with PH 8.64, hardness 25.80 10-1 mm, moisture content 25.55%, free fatty acids 0,94%, unsaturated fat 1,45%, surface tension 30.02 dyne/cm.
In Silico Study of Bioactive Compounds in Herba Sambiloto (Andrographis paniculata Burm. F. Nees) as HIV-1 Reverse Transcriptase Inhibitor Andri Prasetiyo; Titiek Martati; Putri Windari Saputra
Jurnal Jamu Indonesia Vol. 9 No. 2 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i2.300

Abstract

A medicinal plant known as sambiloto (Andrographis paniculata Burm. F. Nees) contains certain active compounds that potentially are anti-HIV. However, it is not yet known which compounds are involved in inhibiting HIV activity. This study aimed to identify potentially active compounds from the sambiloto plant that could inhibit the HIV-1 reverse transcriptase enzyme using the in-silico method. In silico methods that will be carried out are internal validation, molecular docking, ADMET prediction, and molecular dynamics. The molecular docking results showed that the five best compounds have potential as anti-HIV drugs compared to efavirenz with the rerank score -152.119 until -125.177 kcal/mol. In contrast, the rerank score of the comparison ligand is -94.7639 kcal/mol. The ADMET prediction showed that the selected compounds have a good pharmacokinetics profile and are nontoxic. The molecular dynamic results showed that deoxy-11,12-didehydroandrographiside and andropraphiside are stable and have potential as anti-HIV drugs with average RMSD values of 1.88 and 2.02 Å while the comparison ligand is 1.67 Å.
STUDI IN SILICO SENYAWA AKTIF DAUN KELOR (Moringae oleifera F) SEBAGAI ANTI SARS-CoV-2 Amin Saeful; Julian Rahmat; Prasetyo Andri
Pharmacoscript Vol. 7 No. 2 (2024): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v7i2.1661

Abstract

SARS-CoV-2 adalah virus RNA untai positif yang dapat menginfeksi semua orang. Senyawa metabolit sekunder yang terkandung pada daun kelor berpotensi sebagai antivirus yang bekerja spesifik. Tujuan penelitian adalah untuk mengetahui aktivitas antivirus senyawa metabolit daun kelor pada reseptor SARS-CoV-2 main protease. Metode yang digunakan adalah studi komputasi dengan molekular docking, dan simulasi molecular dynamic serta prediksi sintesis dari senyawa uji. Dari hasil studi komputasi molecular docking senyawa uji daun kelor terhadap 4 reseptor SARS-CoV-2 dengan kode PDB 5R7Y, 7JKV, 7TLL, 7VH8 yang sudah divalidasi didapatkan 2 senyawa terbaik dari 29 senyawa dan obat pembanding pada masing-masing reseptor, untuk senyawa uji terbaik dari reseptor 7TLL yaitu senyawa 4-(4-asetilrhamnosida) dan pada reseptor 5R7Y, 7JKV, dan 7VH8, yaitu senyawa 4-O-alpha-L-Rhamnopyranosylglucosinalbin dengan binding affinity terendah dari senyawa terbaik ada pada reseptor 7JKV yakni dengan skor docking -108,15. Hasil uji molecular dynamic masing masing senyawa uji terbaik didapatkan hasil yang stabil terhadap ligan reseptor rata-rata nilai RMSD dan RMSF masing-masing tidak melebihi parameter yang ditentukan. Hasil prediksi sintesis dari masing-masing senyawa uji, senyawa bisa disintesis dengan menggunakan prosedur yang dihasilkan oleh chemical.ai. Hasil in silico kedua senyawa dapat dikatakan berpotensi sebagai pengobatan Anti SARS-CoV-2.
Docking Molekular dari Trigonella foenum-graceum sebagai Antidiabetes menggunakan Molegro Virtual Docking Prasetiyo, Andri; Mumpuni, Esti; Tjandrawinata, Raymond R
Jurnal Jamu Indonesia Vol. 4 No. 2 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v4i2.132

Abstract

Trigonella foenum-graceum atau fenugreek digunakan secara luas sebagai obat tradisional untuk pengobatan diabetes tetapi mekanisme kerjanya masih belum jelas. Penelitian bertujuan memprediksi senyawa dalam fenugreek yang berkhasiat sebagai antidiabetes secara in-silico dengan menggunakan perangkat lunak Molegro Virtual Docking . Docking dilakukan 10 Senyawa uji dalam fenugreek yaitu 4-hidroxyisoleucine, coumarine, diosgenin, galactomannan, isovitexin, quarcetin, tigogenin, trigoneline, vitexin dan yamogenin dengan 3 reseptor yaitu sugar beet alpha-glucosidase- (PDB ID : 3W37), human dipeptidyl peptidase-4 (PDB ID : 1X70), human peroxisome proliferator activated gamma (PDB: 2PRG) serta senyawa pembanding acarbose, sitagliptin dan rosiglitazone. Dari 10 senyawa uji, galactomanann memiliki nilai Rerank Score/RS paling rendah di dua reseptor yaitu alpha glucosidase dan peroxisome proliferator activated gamma dengan nilai berturut turut -116.56 kcal/mol dan -131.18 kcal/mol dan nilai RS acarbose -113.60 kcal/mol dan rosiglitazone -124.54 kcal/mol . Dari 10 senyawa uji, tigogenin memiliki nilai RS paling rendah direseptor dipeptidyl peptidase-4 dengan nilai RS -86.54 kcal/mol dan nilai RS sitagliptin -87.02 kcal/mol. Berdasarkan nilai RS, galactomannan diprediksi memiliki aktivitas antidiabetes yang bekerja pada reseptor alpha-glucosidase dan peroxisome proliferator activated gamma sedangkan tigogenin diprediksi memiliki aktivitas antidiabetes yang bekerja pada reseptor dipeptidyl peptidase-4.
Analisis Pengaruh Bauran Pemasaran (7P) Terhadap Keputusan Pembelian Produk Non Resep dan Loyalitas Pelanggan Apotek 24 Jam di Kota Administrasi Jakarta Utara Utami, Santi Yanuarti; Prasetiyo, Andri; Ahmar, Nurmala
Ranah Research : Journal of Multidisciplinary Research and Development Vol. 7 No. 3 (2025): Ranah Research : Journal Of Multidisciplinary Research and Development
Publisher : Dinasti Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/rrj.v7i3.1413

Abstract

During the implementation of National Health Insurance (JKN), 24-hour pharmacies without a doctor's practice in North Jakarta Administrative City face a number of significant problems that affect their operations and sustainability. Currently, the development of pharmacies is increasing. This has led to business competition between pharmacies, especially 24-hour pharmacies without a doctor's practice and fluctuations in terms of visits and sales. This study seeks to investigate the effect along with results by interviews related to The marketing elements (7P), non-prescription product buying behavior and customer retention of 24-hour pharmacies on North Jakarta Administrative City. This investigation adopts a descriptive-analytical approach. The research method is a mix methods explanatory sequential method, namely this study is quantitative and continued with qualitative. Product, price, persons, procedure and tangible evidence make a substantial difference to the choice to purchase non-prescription products and customer loyalty of 24-hour pharmacies in North Jakarta City Administration, while place and promotion do not exert a considerable effect on the buying choice non-prescription goods and customer loyalty of 24-hour pharmacies in North Jakarta City Administration. Product is seen from the side of being safe, useful, in a state of intact and good physical form or condition, complete, varied and always available or never empty. Price is viewed from the perspective of being in accordance with quality, benefits and cheaper than other pharmacies. Place is analyzed from the angle of distance, easy to find and easy to access. Promotion is observed from the standpoint of recommendations, discounts or prizes or draws and the use associated with social networking platforms. People serve as seen from this side by having broad and good knowledge, being friendly, always ready and fast to serve customers. Process is seen from the side of providing clear information, providing health education outside of the required treatment, waiting time for taking medicine right according to the queue, fast and easy to get medicine after 10 pm. Physical evidence is seen from the neat layout, comfortable pharmacy waiting room, spacious vehicle parking area. Purchasing decisions are seen from the purchasing side according to what is needed, searching for information first, comparing prices with other pharmacies, purchasing according to ability and purchasing because it is useful. Customer loyalty is seen from the side of returning and making purchases because they are satisfied, will not switch to another pharmacy and continue to make purchases, recommending the pharmacy, defending and supporting the pharmacy when facing criticism or competition.
PROFIL OLAHRAGA TRADISIONAL PAKU SUKHA DI KECAMATAN BELALAU KABUPATEN LAMPUNG BARAT PROVINSI LAMPUNG Rachman, Fadlu; Rahmat, Ayi; Prasetiyo, Andri
Jurnal Penjaskesrek Vol. 10 No. 2 (2023)
Publisher : Program Studi Pendidikan Jasmani, FKIP Universitas Bina Bangsa Getsempena

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46244/penjaskesrek.v10i2.2134

Abstract

Olahraga tradisional merupakan permainan yang dihasilkan oleh tradisi masyarakat sekitar karena di dasarkan oleh alam, budaya, dan kultur masyarakat. Olahraga tradisional Paku Sukha khas Kabupaten Lampung Barat Provinsi Lampung sudah mulai terlupakan oleh generasi muda saat ini. Tujuan dari penelitian ini untuk merevitaliasi olahraga tradisional Paku Sukha di Kabupaten Lampung Barat yang sudah mulai terlupakan oleh generasi muda. Penelitian kualitatif tentang olahraga tradisional "Paku Sukha" di Kecamatan Belalau, Kabupaten Lampung Barat, Provinsi Lampung, dengan sumber data berupa wawancara dan data tertulis. Teknik pengumpulan data yang digunakan yaitu pengamatan langsung pada objek peneltian , wawancara, dan dokumentasi. Untuk menganalisis data penulis menggunakan beberapa cara diantaranya: (1) reduksi data. (2) penyajian data, dan (3) verifikasi data atau penarikan kesimpulan. Hasil penelitian menunjukan bahwa sejarah olahraga tradisional Paku Sukha dijumpai khususnya didaerah Lampung Barat yang berada didaratan kecamatan Belalau. Olahraga tradisonal Paku Sukha tercipta berdasarkan kebiasaan masyarakat setelah pulang bekerja mereka inisiatif membuat permainan yang berasal dari sumber daya alam sekitar yaitu sejenis tumbuhan pakis/paku lalu ditambahkan dengan Injang (Kain Sarung), net dan lapangan sebagai media bermainnya. pemain olahraga tradisional Paku Sukha dalam satu tim terdiri dari lima orang pemain. empat orang pemain bertugas memegang dua Injang (Kain Sarung), membentuk dua pasang di dalam lapangan permainan. Sementara itu, satu orang lainnya bertugas sebagai pelempar bola, yang melemparkan bola kepada salah satu pemain di dalam lapangan pada awal permainan dan saat mengumpulkan hasil bola dari poin yang akan didapat. Setiap kelompok harus mencapai poin sembilan agar bisa memenangkan permainan.AbstractTraditional sports are games that are produced by the traditions of the surrounding community because they are based on nature, culture and the culture of the community. The traditional sport of Paku Sukha, typical of West Lampung Regency, Lampung Province, has begun to be forgotten by today's young generation. The aim of this research is to revitalize the traditional sport of Paku Sukha in West Lampung Regency which has begun to be forgotten by the younger generation. Qualitative research on the traditional sport "Paku Sukha" in Belalau District, West Lampung Regency, Lampung Province, with data sources in the form of interviews and written data. The data collection techniques used are direct observation of the research object, interviews and documentation. To analyze the data the author used several methods including: (1) data reduction. (2) data presentation, and (3) data verification or drawing conclusions. The results of the research show that the history of the traditional sport Paku Sukha is found especially in the West Lampung area which is on the mainland of Belalau sub-district. The traditional sport of Paku Sukha was created based on people's habits after returning home from work, they took the initiative to make games that came from the surrounding natural resources, namely a type of fern/fern plant and then added Injang (Song Cloth), a net and a field as playing media. Paku Sukha traditional sports players in a team consisting of five players. Four players are tasked with holding two Injang (cloth sarongs), forming two pairs on the playing field. Meanwhile, another person serves as the ball thrower, who throws the ball to one of the players on the field at the start of the game and when collecting the ball results from the points that will be obtained. Each group must reach nine points in order to win the game.
Utilizing Canva as an Innovative Solution in Developing Digital Teaching Media in Schools Pratama, Rendy Yudha; Bungsudi; Syaifurrohman, Amir; Kurnia, Ulfa Isni; Prasetiyo, Andri; Bastian, Arif Alexander; Gumay, Jovana Renaldy; Nuruhidin, Ahmad
Aktual: Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 2 (2025): Aktual: Jurnal Pengabdian Kepada Masyarakat May 2025
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/aktual.v3i2.416

Abstract

Background of the study:Most teachers in primary and secondary schools continue to rely on conventional teaching materials. A key issue is the limited knowledge and skills in using digital design tools such as Canva, which hinders their ability to create engaging and interactive teaching media.Purpose and scope of the paper:This community service program aims to enhance teachers’ digital literacy and creative capacity by introducing Canva as a practical and innovative tool for developing digital teaching media, specifically targeting educators in Pringsewu Regency.Methods:The program engaged 20 teachers from various disciplines. It employed a combination of workshops, hands-on training, guided tutorials, and evaluations. Data collection methods included pre- and post-training questionnaires, observations, and documentation of participants’ teaching media outputs.Results:Following the program, 95% of participants showed improved skills in using Canva. Additionally, more than 25 digital teaching products were created. Teachers also reported increased confidence and motivation in integrating digital media into their instructional practices.Conclusion:Canva proves to be an effective and accessible tool for enhancing teachers’ capabilities in designing digital teaching materials. With proper training and support, teachers can independently develop innovative teaching media to foster better student engagement and improve learning outcomes
Molecular Docking Study of Bioactive Compounds in Senggugu (Clerodendrum serratum (L.) Moon) as Antidiabetics Rhahmadini, Yahdi Thia; Mulatsari, Esti; Taqwa, Iqbal Ananda; Dhani, Muhammad; Mawijaya, Agus; Susanti, Evi; Simanjuntak, Josua Donrio; Mumpuni, Esti; Prasetiyo, Andri
Jurnal Kimia Riset Vol. 10 No. 1 (2025): June
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v10i1.68455

Abstract

Senggugu has the potential to be a source of natural medicine through its compounds. Using in silico approaches is an effective strategy for exploring compounds from natural products in the screening process. In vivo studies on senggugu have indicated that the plant has antidiabetic activity, although the active compounds involved in this activity are unknown. This study aims to explore the content of bioactive compounds of Senggugu (Clerodendrum serratum (L.) Moon) and its mechanism of action as an antidiabetic in silico with Molegro Virtual Docker software, ChemDraw, visualization with Discovery Studio, and ADMET prediction with pkCSM. The study was conducted by simulating the molecular docking of 31 bioactive compounds in Senggugu (Clerodendrum serratum (L.) Moon) with comparison compounds using glibenclamide, miglitol, rosiglitazone, linagliptin, and empagliflozin. The validated target proteins comprised 5 (five) receptors with PDB ID codes 4YVP, 5NN6, 7AWC, 6Y0F, and 7VSI. Based on this study, the compound predicted to be active as an antidiabetic is [(1S,2S,6R,7S,11R)-11-hydroxy-5,9,13-trimethylidene-4-oxo-3,14-dioxatricyclo [9.2.1.02,6] tetradecan-7-yl]2-methylprop-2-enoate at receptor 4YVP with a rerank score of -107.663 kcal/mol with glibenclamide -94.8299 kcal/mol and [3-hydroxy-4-[(2R)-6-methylhept-5-en-2yl]phenyl]methyl3-methylbut-2-enoate at 5NN6 receptor with a rerank score of -87.8719 with miglitol -64.7212 kcal/mol.
In Silico Exploration of Orthosiphon stamineus Compounds as Potential Angiotensin Receptor Blockers for Hypertension Therapy Prasetiyo, Andri; Indriani, Aqilah Idelia; Ramadhani, Karina Natasya; Natthawani, Amitta; Ramadhan, Islami Al-Kaffah; Yogaswara, Amira Thufailla; Audrey, Cresentia; Mulatsari, Esti; Mumpuni, Esti; Zahra, Nurulita Az
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.370

Abstract

Orthosiphon stamineus has demonstrated antihypertensive potential, but the specific bioactive compounds involved remain unclear. This study aimed to evaluate selected phytochemicals from O. stamineus as angiotensin receptor blockers (ARBs) targeting protein 4ZUD using in-silico methods. Molecular docking was conducted to assess binding affinity, while ADMET analysis evaluated pharmacokinetics and toxicity. Salvianolic acid E showed the strongest binding affinity with a rerank score of −134.02 kcal/mol, surpassing olmesartan (−124.52 kcal/mol). Key interactions were observed with amino acid residues Arg167, Tyr92, and Asp281. ADMET predictions revealed that Salvianolic acid E has good aqueous solubility, moderate intestinal absorption (HIA 45.99%), and low membrane permeability (Caco-2 < 0.4). It does not inhibit major cytochrome P450 isoenzymes and is predicted to be non-hepatotoxic, suggesting favorable safety and metabolic profiles. These findings highlight Salvianolic acid E as a promising phytochemical candidate for antihypertensive drug development.
Analysis of the Influence of Content Marketing, Influencer Marketing and Online Customer Reviews on Purchase Decisions that Impact Customer Loyalty of Skintific Sunscreen Products in Dki Jakarta Marlien Bokko; Andri Prasetiyo; Nana Nawasiah
Jurnal Ilmiah Multidisiplin Indonesia (JIM-ID) Vol. 4 No. 09 (2025): Jurnal Ilmiah Multidisplin Indonesia (JIM-ID) October 2025
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The development of social media has changed people's consumption patterns and encouraged cosmetics companies to optimize their digital marketing strategies. Facing a competitive market, Skintific is required to maximize the role of content marketing, influencers, and online customer reviews to strengthen purchase decisions and maintain customer loyalty. The purpose of this study is to analyze the effect of content marketing, influencer marketing, and online customer reviews on purchase decisions and their impact on the loyalty of Skintific sunscreen customers in DKI Jakarta. The type of research is causal associative. Sampling was conducted using non probability sampling with purposive sampling techniques, and data collection was carried out using an online questionnaire. The sample size was 250 people. Data analysis was performed using PLS-SEM method. The results of the study indicate that content marketing, influencer marketing, and online customer reviews partially have a positive and significant effect on purchase decisions and customer loyalty. Purchase decisions are also proven to have a positive and significant effect on customer loyalty, and indirectly, content marketing, influencer marketing, and online customer reviews affect loyalty through purchase decisions for Skintific sunscreen in DKI Jakarta.
Co-Authors Ade Yeni Aprilia Aey Fadilah, Yasin Ahmad Nuruhidin Armanjaya, Satria Audrey, Cresentia Bambang Pontjo Priosoeryanto Bastian, Arif Alexander Bella Rofi Bungsudi Desi Nadya Aulena Dhani, Muhammad Elvi Sahri Maulinda Esti Mumpuni Esti Mumpuni Esti Mumpuni, Esti Evi Susanti Fadlu Rachman Fitry Angger Pangestu Gayatri Indah Pramesti Gumay, Jovana Renaldy Haikal Shaquille Hutagaol, Lungguk Indriani, Aqilah Idelia Julian Rahmat Lalu Sanik Wahyu Fadil Amrulloh Lidya Luziana Lilik Sulastri Lilik Sulastri LUNGGUK HUTAGAOL Lungguk Hutagaol Marlien Bokko Martati, Titiek Mawijaya, Agus Megawati Megawati Muhamad Yamin Muhamad Yamin Muhammad Yamin Muhammad Zulfadhli Mulatsari, Esti Nabila Prihantini Khairunnisa Natthawani, Amitta Nawasiah, Nana Novi Yantih Noviyantih, Noviyantih Nuraini Harmastuti Nurmala Ahmar Nuruhidin, Ahmad Panca Bayu Chandra, Pra Pratama, Rendy Yudha Putri Windari Saputra Rachman, Fadlu Rachmi Ridho Rahmat, Ayi Rakhmat Ramdhani Alwie Ramadhan, Islami Al-Kaffah Ramadhani, Karina Natasya Raymond R. Tjandrawinata Rhahmadini, Yahdi Thia Rini Agustia Risna Rosmiyati Saeful Amin Saeful Amin Salsabila Adlina Saputra, Putri Windari Sarah Annisaa Nurwan Sari Dewi, Rika Sari, Felinda Sekar Harsti Rahmadhani Shirly Kumala Simanjuntak, Josua Donrio Siswandono, Siswandono Sofyan Ramani Syaifurrohman, Amir Syamsudin Abdillah Syifa Aulia Taqwa, Iqbal Ananda Titiek Martati Ulfa Isni Kurnia Utami, Santi Yanuarti Vino Soaduon Simanjuntak Winana Kartika Dewi Wiwi Winarti Wiwi Winarti Yogaswara, Amira Thufailla Zahra, Nurulita Az Zainur Rahman Hakim Ziko Fajar Ramadhan, Ziko Fajar