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All Journal Indonesian Journal of Conservation JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Kimia Riset Jurnal Fitofarmaka Indonesia Jurnal Penjaskesrek PENDIPA Journal of Science Education CARADDE: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Pharmacoscript Jurnal Farmamedika (Pharmamedica Journal) SULUH: Jurnal Abdimas Jurnal PORKES Indonesia Natural Research Pharmaceutical Journal (INRPJ) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Mitra Mahajana: Jurnal Pengabdian Masyarakat PROFICIO: Jurnal Pengabdian Masyarakat Pharmaceutical And Biomedical Sciences Journal (PBSJ) Capacitarea : Jurnal Pengabdian Kepada Masyarakat Abdi Implementasi Pancasila: Jurnal Pengabdian kepada Masyarakat Ranah Research : Journal of Multidisciplinary Research and Development Jurnal Ilmiah Multidisiplin Indonesia Jurnal Ilmiah Farmasi Simplisia Aktual : Jurnal Pengabdian Kepada Masyarakat Jurnal Kesehatan Bakti Tunas Husada Aisyah Journal Of Physical Education International Journal of Contemporary Sciences (IJCS) Journal of Natural Product for Degenerative Diseases Indonesian Journal of Jamu
Andri Prasetiyo
Universitas Pancasila
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Other

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Utilizing Canva as an Innovative Solution in Developing Digital Teaching Media in Schools Pratama, Rendy Yudha; Bungsudi; Syaifurrohman, Amir; Kurnia, Ulfa Isni; Prasetiyo, Andri; Bastian, Arif Alexander; Gumay, Jovana Renaldy; Nuruhidin, Ahmad
Aktual: Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 2 (2025): Aktual: Jurnal Pengabdian Kepada Masyarakat May 2025
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/aktual.v3i2.416

Abstract

Background of the study:Most teachers in primary and secondary schools continue to rely on conventional teaching materials. A key issue is the limited knowledge and skills in using digital design tools such as Canva, which hinders their ability to create engaging and interactive teaching media.Purpose and scope of the paper:This community service program aims to enhance teachers’ digital literacy and creative capacity by introducing Canva as a practical and innovative tool for developing digital teaching media, specifically targeting educators in Pringsewu Regency.Methods:The program engaged 20 teachers from various disciplines. It employed a combination of workshops, hands-on training, guided tutorials, and evaluations. Data collection methods included pre- and post-training questionnaires, observations, and documentation of participants’ teaching media outputs.Results:Following the program, 95% of participants showed improved skills in using Canva. Additionally, more than 25 digital teaching products were created. Teachers also reported increased confidence and motivation in integrating digital media into their instructional practices.Conclusion:Canva proves to be an effective and accessible tool for enhancing teachers’ capabilities in designing digital teaching materials. With proper training and support, teachers can independently develop innovative teaching media to foster better student engagement and improve learning outcomes
Molecular Docking Study of Bioactive Compounds in Senggugu (Clerodendrum serratum (L.) Moon) as Antidiabetics Rhahmadini, Yahdi Thia; Mulatsari, Esti; Taqwa, Iqbal Ananda; Dhani, Muhammad; Mawijaya, Agus; Susanti, Evi; Simanjuntak, Josua Donrio; Mumpuni, Esti; Prasetiyo, Andri
Jurnal Kimia Riset Vol. 10 No. 1 (2025): June
Publisher : Universitas Airlangga, Campus C Mulyorejo, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkr.v10i1.68455

Abstract

Senggugu has the potential to be a source of natural medicine through its compounds. Using in silico approaches is an effective strategy for exploring compounds from natural products in the screening process. In vivo studies on senggugu have indicated that the plant has antidiabetic activity, although the active compounds involved in this activity are unknown. This study aims to explore the content of bioactive compounds of Senggugu (Clerodendrum serratum (L.) Moon) and its mechanism of action as an antidiabetic in silico with Molegro Virtual Docker software, ChemDraw, visualization with Discovery Studio, and ADMET prediction with pkCSM. The study was conducted by simulating the molecular docking of 31 bioactive compounds in Senggugu (Clerodendrum serratum (L.) Moon) with comparison compounds using glibenclamide, miglitol, rosiglitazone, linagliptin, and empagliflozin. The validated target proteins comprised 5 (five) receptors with PDB ID codes 4YVP, 5NN6, 7AWC, 6Y0F, and 7VSI. Based on this study, the compound predicted to be active as an antidiabetic is [(1S,2S,6R,7S,11R)-11-hydroxy-5,9,13-trimethylidene-4-oxo-3,14-dioxatricyclo [9.2.1.02,6] tetradecan-7-yl]2-methylprop-2-enoate at receptor 4YVP with a rerank score of -107.663 kcal/mol with glibenclamide -94.8299 kcal/mol and [3-hydroxy-4-[(2R)-6-methylhept-5-en-2yl]phenyl]methyl3-methylbut-2-enoate at 5NN6 receptor with a rerank score of -87.8719 with miglitol -64.7212 kcal/mol.
In Silico Exploration of Orthosiphon stamineus Compounds as Potential Angiotensin Receptor Blockers for Hypertension Therapy Prasetiyo, Andri; Indriani, Aqilah Idelia; Ramadhani, Karina Natasya; Natthawani, Amitta; Ramadhan, Islami Al-Kaffah; Yogaswara, Amira Thufailla; Audrey, Cresentia; Mulatsari, Esti; Mumpuni, Esti; Zahra, Nurulita Az
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.370

Abstract

Orthosiphon stamineus has demonstrated antihypertensive potential, but the specific bioactive compounds involved remain unclear. This study aimed to evaluate selected phytochemicals from O. stamineus as angiotensin receptor blockers (ARBs) targeting protein 4ZUD using in-silico methods. Molecular docking was conducted to assess binding affinity, while ADMET analysis evaluated pharmacokinetics and toxicity. Salvianolic acid E showed the strongest binding affinity with a rerank score of −134.02 kcal/mol, surpassing olmesartan (−124.52 kcal/mol). Key interactions were observed with amino acid residues Arg167, Tyr92, and Asp281. ADMET predictions revealed that Salvianolic acid E has good aqueous solubility, moderate intestinal absorption (HIA 45.99%), and low membrane permeability (Caco-2 < 0.4). It does not inhibit major cytochrome P450 isoenzymes and is predicted to be non-hepatotoxic, suggesting favorable safety and metabolic profiles. These findings highlight Salvianolic acid E as a promising phytochemical candidate for antihypertensive drug development.
Analysis of the Influence of Content Marketing, Influencer Marketing and Online Customer Reviews on Purchase Decisions that Impact Customer Loyalty of Skintific Sunscreen Products in Dki Jakarta Marlien Bokko; Andri Prasetiyo; Nana Nawasiah
Jurnal Ilmiah Multidisiplin Indonesia (JIM-ID) Vol. 4 No. 09 (2025): Jurnal Ilmiah Multidisplin Indonesia (JIM-ID) October 2025
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The development of social media has changed people's consumption patterns and encouraged cosmetics companies to optimize their digital marketing strategies. Facing a competitive market, Skintific is required to maximize the role of content marketing, influencers, and online customer reviews to strengthen purchase decisions and maintain customer loyalty. The purpose of this study is to analyze the effect of content marketing, influencer marketing, and online customer reviews on purchase decisions and their impact on the loyalty of Skintific sunscreen customers in DKI Jakarta. The type of research is causal associative. Sampling was conducted using non probability sampling with purposive sampling techniques, and data collection was carried out using an online questionnaire. The sample size was 250 people. Data analysis was performed using PLS-SEM method. The results of the study indicate that content marketing, influencer marketing, and online customer reviews partially have a positive and significant effect on purchase decisions and customer loyalty. Purchase decisions are also proven to have a positive and significant effect on customer loyalty, and indirectly, content marketing, influencer marketing, and online customer reviews affect loyalty through purchase decisions for Skintific sunscreen in DKI Jakarta.
Studi Molecular Docking dan Prediksi Toksisitas Senyawa Kimia dari Salvia officinalis sebagai Antidiabetes Panca Bayu Chandra, Pra; Siswandono, Siswandono; Prasetiyo, Andri; Mumpuni, Esti; Aey Fadilah, Yasin; Sari Dewi, Rika
JURNAL ILMIAH FARMASI SIMPLISIA Vol. 5 No. 2 (2025): Desember 2025
Publisher : Jurusan Farmasi, Politeknik Kesehatan Kementerian Kesehatan Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/jifs.v5i2.866

Abstract

Salvia officinalis digunakan secara luas sebagai obat tradisional untuk pengobatan diabetes tetapi mekanisme kerjanya masih belum jelas. Penelitian bertujuan memprediksi senyawa dalam Salvia officinalis yang berkhasiat sebagai antidiabetes secara in-silico dengan menggunakan perangkat lunak Molegro Virtual Docking. Docking dilakukan terhadap 17 senyawa uji dalam Salvia officinalis yaitu (-)-Camphor, (-)-Epicatechin, (3R)-Linalyl diphosphate, (E)-p-Coumaric acid, 1-Hydroxypinoresionol 1-glucoside, 3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoic acid, 5,7,3’,4’-Tetrahydroxyflavone, Apigenin, Borneol, Carnosolic acid, Gallocatechin 3-O-gallate, Geranyl diphosphate, Limonene, Methyl 2-[bis(2,2,2-trifluoroethoxy)phosphory]propanoate, Octadecanoic acid, Rosmadial, dan Rosmanol dengan reseptor peroxisome proliferator activated gamma (PDB: 3K8S) serta senyawa pembanding Pioglitazone HCl. Dari 17 senyawa uji, Gallocatechin 3-O-gallate diprediksi memiliki aktivitas sebagai antidiabetes yang bekerja pada peroxisome proliferator activated gamma dengan nilai rerank score -135.132 kcal/mol dengan aktivitas lebih baik dibandingkan obat Pioglitazone HCl. Gallocatechin 3-O-gallate diprediksi pada toksisitas berdasarkan AMES (mutagenik), Max. Tolerated Dose (human) (maximum recommended therapeutic dose atau MRTD rendah), oral rat acute toxicity (LD50) (tidak toksik), oral rat chronic toxicity (LOAEL) 4.209 (log dosis terendah yang bisa menimbulkan efek samping 4.209 mg/kg BB/hari), tidak hepatotoksis dan tidak menimbulkan sensitisasi pada kulit
In Silico Studies: Stigmastan-3,6-dione in the Ethyl Acetate Fraction of Momordica charantia L Fruit has immunostimulant and anti-inflammatory activity Rachmi Ridho; Bambang Pontjo Priosoeryanto; Esti Mumpuni; Andri Prasetiyo; Syamsudin Abdillah
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.6865

Abstract

Momordica charantia L fruit provides an immunomodulatory effect by stimulating certain components of the body's immune system. Bioactive phytochemicals from M. charantia L function as anti-inflammatory agents by reducing levels of pro-inflammatory cytokine secretion including IL-1, IL-6, IL-8, TNF-α, NF-kB. This research looks at the insilico mechanism of action of the active ingredient of the EtOAc fraction of M. charantia L fruit as an immunostimulant and anti-inflammatory. The materials and methods used were an Intel Core i7 10 Th Gen laptop, Chem Office Professional 17.1, Chem 2D, Chem 3D software, PDB code (6W9K) and ligand (TUA), Stigmastan-3,6 dione (C29H48O2) from the EtOAc fraction of fruit M. charantia L was docked using MVD software, RMSD and RMSF values ​​were viewed using Yasara Software, pkCSM online tool to predict compound toxicity, toxicity prediction (LD50) was used by Protox online tool. The results of molecular docking of standard compounds, namely Methylprednisolone and Prednisolone and Stigmastan-3,6-dione, have Rerank Score values of -120.62, -121.47, -79.50, respectively. The lower the Rerank score value, the lower the binding energy between the protein and the ligand, causing the protein and ligand bonds to be more stable and it is predicted that the activity of the compound will be greater. The movement of RMSD values ​​between 0.6-1.9 Å for the 3 (three) compounds, is still within stable limits and does not undergo conformation. The RMSF value of the 3 (three) compounds has the same amino acid residue pattern. The insilico toxicity prediction for the 3 (three) compounds is still within safe limits. The EtOAc fraction of M. charantia L fruit with the active compound Stigmastan-3,6-Dione in its mechanism of action in silico shows activity as an anti-inflammatory and immunostimulant that works on the NF-kB pathway.
Aktivitas Penghambatan Enzim α-Glukosidase Senyawa β-Sitosterol dari Fraksi Etil Asetat Daun Salam [Syzygium polyanthum (Wight.) Walp Sulastri, Lilik; Zulfadhli, Muhammad; Alwie, Rakhmat Ramdhani; Ramani, Sofyan; Prasetiyo, Andri; Simanjuntak, Vino Soaduon
Jurnal Fitofarmaka Indonesia Vol 11, No 1 (2024): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v11i1.981

Abstract

Diabetes mellitus, also known as diabetes, is an endocrine disease characterized by sustained high blood sugar levels. Diabetes is caused by the pancreas not producing enough insulin, or the body's cells becoming unresponsive to the effects of the hormone. Common symptoms include thirst, polyuria, weight loss, and blurred vision. If left untreated, the disease can lead to various health complications, such as disorders of the cardiovascular system, eyes, kidneys, and nerves. In general, the treatment of diabetes mellitus is done with insulin therapy and various synthetic drugs, but these treatments have side effects. Another alternative is treatment using herbs, including salam leaves (Syzygium polyanthum (Wight.) Walp) which can be used as an inhibitor for the α-glucosidase enzyme. This study aims to isolate and determine the levels of β-sitosterol from the ethyl acetate fraction of salam leaves which have α-glucosidase enzyme inhibitory activity. Extraction was carried out by maceration using 96% ethanol, then partitioned with ethyl acetate and water (1:1). The ethyl acetate fraction was tested for the inhibitory activity of the α-glucosidase enzyme, then isolated by column chromatography method (SiO2; i.n-hexane-ethylacetate = 10 : 1 ~ 1 : 1, ethylacetate; ii.n-hexane-ethylacetate = 5 : 1 guided by testing enzyme inhibitory activity until pure isolates were obtained. The isolates were identified by spectrophotometry (IR) compared with the standard β-sitosterol compound. The results showed that isolates F.4-5 was a β-sitosterol compound with a concentration of 177.13 mg/g extract and had α-glukosidase enzyme inhibitory activity with an IC50 of 93.7 μg/mL.
Tingkat Kemampuan Fisik Atlet Lari Jarak Pendek Club Atletik Teluk Pandan Kabupaten Pesawaran Prasetiyo, Andri
Aisyah Journal Of Physical Education (AJoPE) e-ISSN : 3046-790X Vol. 1 No. 1 (2022): Aisyah Journal Of Physical Education (AJoPE)
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/ajope.v1i1.737

Abstract

Penelitian ini bertujuan untuk mengetahui tingkat kemampuan fisik atlet lari jarak pendek club atletik teluk pandan Kabupaten Pesawaran. Penelitian ini merupakan penelitian kualitatif dengan menggunakan metode penelitian survei dan teknik pengumpulan data menggunakan tes kondisi fisik. Instrumen tes penelitian dengan pelaksanaan tes kemampuan fisik terdiri dari 6 item yaitu kekuatan otot tungkai menggunakan leg dynamometer, power otot tungkai menggunakan vertikal jump, kecepatan dengan lari 50 meter, kelentukan dengan flexsometer, daya tahan otot tungkai menggunakan squat-jump daya tahan otot petut menggunakan sit-up . Sample penelitian ini berjumlah 8 orang dengan menggunakan teknik pemilihan sample yaitu total sampling yang merupakan atlet lari jarak pendek club atletik teluk pandan kabupaten Pesawaran. Berdasarkan data hasil penelitian yang telah dilakukan dapat ditarik kesimpulan secara umum yaitu tingkat kemampuan fisik atlet lari jarak pendek club atletik teluk pandan Kabupaten Pesawaran masuk dalam kategori kemampuan fisik cukup.
Penghambatan Aktivitas Enzim α-Glukosidase oleh Ekstrak Etanol Terstandar Daun Abelmoschus manihot (L.) Medik Prasetiyo, Andri; Winarti, Wiwi; Agustia, Rini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1387

Abstract

People have long utilised the leaves of the red gedi, Abelmoschus manihot (L.) Medik is an anti-diabetic medication. The study’s objectives were to classify chemical constituent groups, assess extract quality, and evaluate the activity of α-glucosidase enzyme inhibitors. The extraction method employed kinetic maceration with a 70% ethanol solvent, identification was accomplished through phytochemical screening, a quality determination was based on both specific and non-specific parameters, and α-glucosidase inhibition was used in an in vitro antidiabetic activity test. Flavonoids, alkaloids, saponins, steroids, and triterpenoids were found in the phytochemical screening test results. The results of the quality parameter test obtained viscous extract, blackish green color, 70.58% water soluble extract, 49.46% ethanol soluble extract, 7.82% loss on drying, 4.19% water content, total ash content 6.97%, acid insoluble ash content 0.60%, water-soluble ash content 5.64%, residual solvent 0.76%, heavy metal content Pb 1.35 mg/kg, Cd 0.06 mg/kg, plate number total ≤10 colonies/g, yeast plate number 20.1995 colonies/g and total flavonoid content 1.20%. The α-glucosidase enzyme inhibitory activity test from the extract and acarbose (positive controls) obtained IC50 values of 81.84 μg/mL and 42.6 μg/mL, respectively. In conclusion, the α-glucosidase enzyme may be inhibited by the ethanolic extract of A. manihot (L.) Medik leaves.
Formulation of Transparent Solid Soap from Palm Kernel Oil Prasetiyo, Andri; Hutagaol, Lungguk; Luziana, Lidya
Jurnal Jamu Indonesia Vol. 5 No. 2 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v5i2.159

Abstract

Palm kernel oil contains fatty acids, especially lauric acid at 46-52%. Lauric acid has the properties of hardening, cleaning, producing foam and softening that is needed in making soap. The purpose of this study is to make transparent solid soap from a combination of glycerin, sucrose, and ethanol 96% as a transparent agent that meets the requirements of quality tests and organoleptic tests. Made 9 (nine) formulas with some combination of glycerin, sucrose, ethanol 96% by a semi-boiled method that is mixing palm kernel oil and stearic acid which has been melted at 60˚C, then adding 30% NaOH, stirring at 70- 80˚C. Transparent agent and other additives are mixed into the soap mass obtained from the saponification process, then poured into a soap mold and carried out a curing process for 2 weeks. The result of this research is obtained a transparent yellow solid soap that is the bright and distinctive smell of coconut perfume with a pH of 8.35-8.64, the hardness of 21.30-38.13 10-1 mm, moisture content of 21.48-33.33%, free fatty acid content 0,88-0,96%, unsaturated fat content 1,45-2,38%, surface tension 27,93-32,34 dyne/cm. Transparent solid soap that meets the quality requirements and the organoleptic test is formula A with PH 8.64, hardness 25.80 10-1 mm, moisture content 25.55%, free fatty acids 0,94%, unsaturated fat 1,45%, surface tension 30.02 dyne/cm.
Co-Authors Ade Yeni Aprilia Aey Fadilah, Yasin Agustia, Rini Ahmad Nuruhidin Alwie, Rakhmat Ramdhani Armanjaya, Satria Audrey, Cresentia Bambang Pontjo Priosoeryanto Bastian, Arif Alexander Bella Rofi Bungsudi Desi Nadya Aulena Dhani, Muhammad Esti Mumpuni Esti Mumpuni Esti Mumpuni, Esti Evi Susanti Fadlu Rachman Fajar Ramadhan, Ziko Fitry Angger Pangestu Gayatri Indah Pramesti Gumay, Jovana Renaldy Hakim, Zainur Rahman Hutagaol, Lungguk Indriani, Aqilah Idelia Julian Rahmat Lalu Sanik Wahyu Fadil Amrulloh Lidya Luziana Lilik Sulastri Lilik Sulastri LUNGGUK HUTAGAOL Lungguk Hutagaol Luziana, Lidya Marlien Bokko Martati, Titiek Maulinda, Elvi Sahri Mawijaya, Agus Megawati - Muhamad Yamin Muhamad Yamin Muhammad Yamin Muhammad Zulfadhli, Muhammad Mulatsari, Esti Nabila Prihantini Khairunnisa Natthawani, Amitta Nawasiah, Nana Novi Yantih Noviyantih, Noviyantih NURAINI HARMASTUTI Nurmala Ahmar Nuruhidin, Ahmad Panca Bayu Chandra, Pra Pratama, Rendy Yudha Pratamaa, Yuga Rachman, Fadlu Rachmi Ridho Rahmat, Ayi Ramadhan, Islami Al-Kaffah Ramadhani, Karina Natasya Ramani, Sofyan Raymond R. Tjandrawinata Rhahmadini, Yahdi Thia Risna Rosmiyati Saeful Amin Saeful Amin Salsabila Adlina Saputra, Putri Windari Sarah Annisaa Nurwan Sari Dewi, Rika Sari, Felinda Sekar Harsti Rahmadhani Shaquille, Haikal Shirly Kumala Shofiyah Simanjuntak, Josua Donrio Simanjuntak, Vino Soaduon Siswandono, Siswandono Sodik, Alfan Nur Syaifurrohman, Amir Syamsudin Abdillah Syifa Aulia Taqwa, Iqbal Ananda Ulfa Isni Kurnia Utami, Santi Yanuarti Winana Kartika Dewi Wirabrata, I Gede Made Wiwi Winarti Yogaswara, Amira Thufailla Zahra, Nurulita Az Ziko Fajar Ramadhan, Ziko Fajar