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Acute Toxicity Test of Toman Fish Extract on Erythrocyte Number and Hemoglobin Level in Normal and Diabetic Wistar Rat Model Amy Nindia Carabelly; Beta Widya Oktiani; Nurashfia Nurashfia; Maharani Laillyza Apriasari; Dewi Puspitasari
Berkala Kedokteran Vol 19, No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v19i1.15703

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Abstract: Patients with diabetes mellitus (DM) may experience vascular impairment, wounds that emerged from dental practice require special attention in people who suffer from DM. Toman fish has the potential as an alternative medicine to accelerate the healing process in normal and diabetic wound. Erythrocyte and hemoglobin are two components of blood profile which can be used as the parameter to identify the effect of material toxicity. This study aims to test the acute toxicity of Toman fish extract at 16 mL/Kg BW dosage on the number of erythrocyte and the level of hemoglobin in normal and diabetic Wistar rat model after 14 days treatment. This is a true experimental study with post-test only and control group design. Samples were comprised of 21 male Wistar rats allocated to three different groups; normal rats given Toman fish extract (A), diabetic rats given Toman fish extract (B), and diabetic rats given BR2 feed only (C). The results showed that in group A, the number of erythrocytes was 8.67x106/mm3 and the level of hemoglobin was 17.30 g/dL. In group B, the number of erythrocytes was 7.39x106/mm3 and the level of hemoglobin was 16.32 g/dL. In group C, the erythrocyte number was 4.88x106/ mm3 and the hemoglobin level was 11.54 g/dL. It can be concluded that Toman fish extract at the dosage of 16 mL/Kg BW after 14 days administration is not toxic which was indicated by erythrocyte number and hemoglobin level in the blood of normal and diabetic Wistar rats models.
QUANTITATIVE PHYTOCHEMICAL TEST OF METHANOL EXTRACT OF TABAT BARITO LEAVES (Ficus deltoidea Jack.) I Wayan Arya Krishnawan Firdaus; Asphia Rahmah; Maharani Laillyza Apriasari; Yusrinie Wasiaturrahmah
Dentino : Jurnal Kedokteran Gigi Vol 8, No 1 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i1.16085

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ABSTRACTBackground: Tabat barito is a medicinal plant that has long been used by various ethnic groups in Indonesia, especially on the islands of Sumatra and Kalimantan. The people of Kalimantan use tabat barito as a traditional medicine for women who have just given birth, enhance blood circulation and get energy. Tabat barito leaves contain alkaloids, flavonoids, steroids, and phenolic compounds. Because of its use only based on the results of community trials and passed down orally, scientific research is needed for the chemical content or compounds contained therein. It aims to determine the bioactive profile of plants that play a role in therapy and their use can be accounted for. Purpose: To analyze the quantitative phytochemical test results of the methanol extract of tabat barito leaves (Ficus deltoidea Jack.) 100% concentration. Methods: Non-experimental research with quantitative laboratory examination to determine sample content. Results: The results showed that the total alkaloids content 154.31 mg/ml, flavonoids 62.917 mg/ml, steroids 49.036, and phenolic 99.689 mg/ml. Conclusion: The methanol extract of tabat barito leaves showed the content of alkaloid compounds at 154.31 mg/ml, flavonoids at 62.917 mg/ml, steroids at 49.036 mg/ml, and phenolics at 99.689 mg/ml. The compound with the highest total content was alkaloid at 154.31 mg/ml and the compound with the lowest total content was steroid at 49.036 mg/ml. Keywords: gravimetric, tabat barito leaves, uv-vis spectrophotometry, quantitative phytochemical test
ANTIBACTERIAL ACTIVITY OF MIXED MAULI BANANA STEM AND BASIL LEAVES AGAINST Staphylococcus aureus Melisa Budipramana; Yunike Christanti; Maharani Laillyza Apriasari; Juliyatin Putri Utami
Dentino : Jurnal Kedokteran Gigi Vol 8, No 1 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i1.16069

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ABSTRACTBackground: Mauli banana is a typical plant in South Kalimantan which contains tannins (67.59%), saponins (14.49%), alkaloids (0.34%), and flavonoids (0.25%) as natural antiseptics inhibiting the growth of Streptococcus mutans. Basil is plant that contain eugenol (70%), flavonoids (4.75%), tannins (4.6%), and alkaloids (1%) as natural antiseptics inhibiting the growth of Candida albicans. This study was to examine the antibacterial activity of a mixture of banana mauli stem stems and basil leaves against Staphylococcus aureus. Purpose: to analyze the antibacterial activity against Staphylococcus aureus in the mixture of banana mauli stems and basil leaves extracts. Method: true experiment using pretest and posttest with control group design with 11 treatments consisting of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, and aquadest. Antibacterial activity test was conducted using dilution method. Determination of Minimum Inhibitory Concentration (MIC) was determined by contrasting the absorbance value before and after incubation. Minimum Bactericidal Concentration (MBC) was obtained by testing the concentration with negative absorbance value on MSA media incubated for 24 hours. Results: The results of this study indicated that the concentration of 40%, 50%, 60%, 70%, 80%, 90%, and 100% could inhibit the growth of Staphylococcus aureus but these concentrations had yet been able to kill Staphylococcus aureus. Conclusion: The MIC of mauli banana and basil leaves extract combination against S aureus presentts at 40% concentration yet MBC cannot be obtained.Keywords : Antibacterial activity, Basil leaf, Dilution method, Mauli banana stem, Staphylococcus aureus
The social resilience of fishermen to oral diseases during the covid-19 pandemic in puger jember east java Koko Komarudin; Mustain Mashud; Retno Andriati; Maharani Laillyza Apriasari
Odonto : Dental Journal Vol 9, No 2 (2022): December 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1216.543 KB) | DOI: 10.30659/odj.9.2.279-289

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Background: Puger fishermen are able to survive and develop (resilience) in carrying out their activities in the form of natural disturbances and various diseases, especially during the COVID-19 pandemic. Oral diseases are the lowest of the seven diseases recorded at the Puger Health Center. This disease can make patients exposed to COVID-19 worse, but the Puger area is included in the green zone. The Purpose of this study is to analyze the effect of knowledge, behavior and health services to the social resilience ability of Puger fishermen.Method: It used a quantitative approach with the method of structural equation modelling (SEM). Confirmatory factor analysis tests and path analysis were conducted to analyze the effect among variables according to the research purpose. Questionnaires were distributed to fishermen who were sampled as respondents. Respondents amounted to 111 people. It used is simple random sampling.Result: The knowledge has a positive effect, but it is not significant to social resilience with a significance level (β= 0.001 p: 0.314>0.05), behavior has a positive effect, but it is not significant to social resiliance with a significance level (β= 0.005 p: 0.649>0.05) and Health service has a positive effect, but it is not significant to social resilience with a significance level (β= 0.003 p: 0.218>0.05).Conclusion: Puger Fishermen has social resilience ability to oral diseases underpinned by knowledge, behavior as well as health service. These variables have a positive correlation with resilience. Yet the level is not quite significant.
STUDY ANALYSIS OF ORAL TUBERCULOSIS LESION IN SOUTH KALIMANTAN, INDONESIA Maharani Laillyza Apriasari; Monita Valentine Silalahi; Isnur Hatta; Juliyatin Putri Utami
Odonto : Dental Journal Vol 7, No 1 (2020): July 2020
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (730.641 KB) | DOI: 10.30659/odj.7.1.1-8

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Background: Tuberculosis is an infectious disease which is the second-largest cause of death in the world after HIV / AIDS. Tuberculosis caused by Mycobacterium tuberculosis that usually attacks the lungs but can manifest in the oral mucosa. Clinical manifestations of oral Tuberculosis related to age, sex, duration of treatment, systemic disease, and Multi-Drug Resistant therapy. There is no research on descriptive studies of oral manifestations of tuberculosis patients in South Kalimantan, specifically in Banjarmasin. This study aims to analyze the clinical manifestations of oral Tuberculosis descriptively in South Kalimantan, Indonesia. Method: This was a descriptive analysis with cross-sectional study design, based on history and clinical oral examination. It was used 30 respondents by purposive sampling method. Data were analyzed by Chi-square (p<0.05). Results: During treatment, it showed the correlation between xerostomia and systemic disease (diabetes mellitus and HIV/AIDS) are (p=0.007) and a correlation between xerostomia and duration of treatment (p=0.024). The correlation between candidiasis and systemic disease (p=0.024). The correlation between angular cheilitis and age, sex, duration of treatment, systemic disease, and Multi-Drug Resistant therapy (p>0.05). The clinical manifestations of oral Tuberculosis are xerostomia, candidiasis, and angular cheilitis.Conclusion: The duration of treatment and the systemic diseases are associated with xerostomia and candidiasis in the oral cavity of TB patients.
PREVALENCE OF ORAL DISEASES AT ULIN HOSPITAL BANJARMASIN IN 2017-2019 Maharani Laillyza Apriasari; Serenada Audria Sundah; Riky Hamdani
Odonto : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.552 KB) | DOI: 10.30659/odj.9.1.62-72

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Background: Oral disease is a condition that causes lesions in the oral cavity, which can be influenced by age, gender, and level of education. Oral health is still becoming a problem in society that needs attention. According to basic health research 2018, the prevalence of oral disease in Indonesia remains considerably high reaching 57.6%. Oral diseases have practically been observed in Banjarmasin, yet no research has presented the prevalence of oral diseases in Ulin General Hospital, Banjarmasin. The purpose of this study was to determine the prevalence of oral disease in Ulin Hospital, Banjarmasin in 2017-2019Method: This research is a descriptive study using secondary data from medical record. Sampling method was carried out by total population sampling of oral disease patients who were treated at Oral and Dental Clinic, Ulin Hospital in 2017-2019Result: It showed that out of 102 oral disease patients, there were 78 patients suffering from recurrent aphthous stomatitis (76.5%), 8 patients from oral candidiasis (7.8%), 7 patients from oral squamous cell carcinoma (6.9%), 4 patients from oral submucous fibrosis (3.9%), 3 patients from burning mouth syndrome (2.9%), and 2 patients from allergic stomatitis (2%). Oral diseases were mostly found in over-45-years age group (54.9%), with the highest gender proportion is female reaching of 64.7%. Approximately 31.4% patients had completed high school education. Medical management was given to 60,8% patients with oral diseases.Conclusion: Recurrent aphthous stomatitis was the most common oral disease in Ulin Hospital, in 2017-2019, followed by oral candidiasis and oral squamous cell carcinoma.
ANTIBACTERIAL EFFECT OF KELAKAI LEAF EXTRACT (STENOCHLAENA PALUSTRIS (BURM) BEDD.) FOR INHIBITING ENTEROCOCCUS FAECALIS I Wayan Arya Krishnawan Firdaus; Nurdiana Dewi; Ridwan Ichshalul Fuady; Maharani Laillyza Apriasari
Odonto : Dental Journal Vol 9, No 1 (2022): July 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (453.642 KB) | DOI: 10.30659/odj.9.1.110-118

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Background: Root canal treatment is a stage of treating pulp infection by removing the necrotic tissue and eliminating microorganisms. Inadequate sterilization cause persistent root canal bacteria, including Enterococcus faecalis. The irrigation solution that has become the gold standard in root canal treatment is Sodium hypochlorite but it has some weaknesses. Kelakai leaf extract can be an alternative root canal irrigation because it has minimal side effects and antibacterial compounds such as flavonoid, saponin, alkaloid, and tannin.Methods: This research was a true experimental laboratory with posttest only and control group design. The research using 5 treatment groups with 3 replications, so that total sample was 15 samples. Group 1-4 were kelakai leaf extract concentrations of 25%, 50%, 75%, 100% and group 5 was Sodium hypochlorite 2,5%. The parameter measured was the diameter of the inhibition zone (mm) formed on MHA.Results: One Way Anova and Post Hoc LSD test results showed a significant difference between each treatment group of kelakai leaf extract compared with Sodium hypochlorite 2,5%. Kelakai leaf extract 25%, 50%, 75%, 100% concentrations, and Sodium hypochlorite 2,5% had an average inhibition zone diameter which were 9.47 mm, 14.64 mm, 17.91 mm, 21.24 mm, and 23.27 mm.Conclusion: Kelakai leaf extract concentrations of 25%, 50%, 75%, and 100% had inhibitory activity against Enterococcus faecalis but had not been equivalent to Sodium hypochlorite 2,5%.
HEALTH BEHAVIOR AND DENTAL CARRIES IN COASTAL COMMUNITY: LITERATURE REVIEW Koko Komarudin; Maharani Laillyza Apriasari; Aulia Azizah
Odonto : Dental Journal Vol 8, No 2 (2021): December 2021
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (272.208 KB) | DOI: 10.30659/odj.8.2.74-80

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ABSTRACTBackground: The important role of coastal communities is not directly in line with their living conditions, which are mostly poor. Dental caries is basically a disease that is also suffered by the general public in Indonesia, even in the world. RISKESDAS 2018 shows the prevalence of caries in Indonesia is 88.8%. Dental caries is caused by the bacterium Streptococcus mutans. People who live in coastal areas are at risk of suffering from dental caries. Brushing behavior also has a relationship with the incidence of dental caries. Method: All articles reviewed were obtained from Pubmed, Science Direct, and Google Scholar with a period of 10 years in full text. using the keywords behavior, caries, and coastal area.Result: Based on reviews from several journals, it was found that the brushing behavior of coastal communities was good, but the frequency of brushing teeth was not appropriate and the behavior of using drinking water had no known fluoride content. There are variations in the category of dental caries at the age level of people in coastal areas.Conclusion: Knowledge and healthy behavior can reduce the risk of dental caries related to the behavior of coastal communities, so that life productivity can be much better than ever.
THE RELATIONSHIP BETWEEN STRESS AND RECURRENT APHTHOUS STOMATITIS AMONG STUDENTS OF THE DENTISTRY FACULTY OF LAMBUNG MANGKURAT UNIVERSITY: Hubungan Stres Terhadap Kejadian Stomatitis Aftosa Rekuren pada Mahasiswa Fakultas Kedokteran Gigi Universitas Lambung Mangkurat Riky Hamdani; Anita Fitriani; Maharani Laillyza Apriasari
Jurnal Berkala Epidemiologi Vol. 11 No. 2 (2023): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V11I22023.135-141

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Background: Recurrent aphthous stomatitis (RAS) is a yellowish-white ulcer-shaped lesion in the oral mucosa. The prevalence of RAS is estimated to be 20% of the world population. Based on Basic Health Search Indonesia in 2018, the prevalence of RAS was 8% of all oral health problems in Indonesia. Stress is one of the risk factors for recurrent aphthous stomatitis. Someone who is stressed will experience a decrease in the immune system, resulting in tissue destruction in the oral cavity. Purpose: To analyze the relationship between stress and RAS in Faculty of Dentistry, Lambung Mangkurat University students. Methods: This is analytical observational research with a cross-sectional study design. The study used a simple random sampling technique with a total sample of 57 co-assistants of the Dentistry at Lambung Mangkurat University. RAS was examined using a questionnaire, and the stress level was measured using the Perceived Stress Scale (PSS) questionnaire. The results of the study were analyzed using the chi-square test. Results: The result shows that the stress level suffered by the respondents is mainly in the moderate category, with a percentage of 44%. In comparison, the incident of RAS with positive results is mainly experienced by respondents with a percentage of 70.18%. The analysis using the chi-square test showed a significant relationship between stress and SAR with a significance value of 0.01 (p <0.05). Conclusion: The higher the stress level experienced will increase the risk of developing SAR.
FOURIER-TRANSFORM INFRARED SPECTROSCOPY ANALYSIS OF MAULI BANANA (MUSA ACUMINATA) EXTRACT AS A POTENTIAL PULP WOUND HEALING Dewi Puspitasari; Muhammad Yanuar Ichrom Nahzi; Yosi Kusuma Eriwati; Erni Marlina; Maharani Laillyza Apriasari; Maria Tanumihardja; Juliyatin Putri Utami; Amy Nindia Carabelly
Dentino : Jurnal Kedokteran Gigi Vol 8, No 2 (2023)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v8i2.17536

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Background: Pulp wound healing is a critical aspect of endodontics, aiming to preserve the vitality and function of dental pulp tissues. Natural compounds have gained attention for their potential therapeutic applications in dentistry. Mauli banana (Musa acuminata) is a tropical fruit in South Kalimantan as one of the natural plants that have the ability as antibacterial, antifungal, anti-inflammatory, antioxidant, and immunomodulatory effects contains various bioactive molecules with potential pulp wound healing properties. Purpose: to identify and evaluate the functional groups present in mauli banana stem extracts. Methods: This study is true experimental research, the samples were mauli banana stem that were extracted with maceration technique and were subjected to Fourier-Transform Infrared Spectroscopy test. Results: Identification of functional groups of organic compounds from mauli banana are as follows: a) Peak 3638.95 cm-1  show O-H (nonbonded hydroxy group, OH stretch primary) component alcohol, b) Peak 3265.82 cm-1is C-H (alkane), c) Peak 2928.09 cm-1  refer to OH (carboxylic acid hydrogen bonds) and aldehydes groups, d) peak 1571.35 cm-1 refers to amide, C=O - asymetric stretching, e) peak 1400.82 cm-1, refers to CO2- symetric stretching and carboxylate (carboxylic acid salt) CH2 scissoring, f) peak 1030.17 cm-1 refers to C=C (alkanes), aliphatic phosphate, g)  Peak 520.53 cm-1 refers to inorganic phosphates. Conclusion: FTIR spectra analysis of mauli banana stem extract show the presence of O-H hydroxy groups, aldehydes groups, carbonyl groups, aliphatic groups, carbonyl groups, amides groups and C-O stretching vibrations suggests that the extract contains various bioactive molecules with potential pulp wound healing properties.
Co-Authors Adhiya, Geyanina Melda Agung Satria Wardhana Almadina Latanza Amy Nindia Carabelly Anita Fitriani Annisa Vara Nurdianty Aprilyani, Nur Ariska Endariantari Asphia Rahmah Astuti, Nadia Dewi Aulia Azizah Aulia Rahma Annisa Bagus Soebadi Beta Widya Oktiani Beta Widya Oktiani Cane Lukisari, Cane Debby Saputera, Debby Destri Khusnul Khotimah Dewi Nurdiana Dewi Puspitasari Dewi Puspitasari Dewi Rahayu Diah Savitri Ernawati Dita Permatasari Dita Permatasari Dwi Kurniawan, Fajar Kusuma Dwi Setyaningtyas, Dwi Eko Suhartono Eriwati, Yosi Kusuma Erni Marlina Fajriani, Nuril Firdaus, I Wayan Arya Krishnawan Hadi Waskito Hamdani, Riky Hatta, Isnur Hening Tuti Hendarti Husma, Emma Annahal I Wayan Arya K. Firdaus I Wayan Arya Khrisnawan Firdaus I Wayan Arya Krishnawan Firdaus I Wayan Arya Krishnawan Firdaus I Wayan Arya Krisnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Ika Kustiyah Oktaviyanti Khairunnisa Amalia Pratami Koko Komarudin Koko Komarudin Krishnawan Firdaus, I Wayan Arya Kurnia Fatwati Lia Yulia Budiarti M. Jusri M. Ridhotama Wibowo Maria Tanumihardja, Maria Marina Arum Syahadati Mashud, Mustain Melisa Budipramana, Melisa Moh. Ihsan Rifasanto Monica Thiodora Limay Monita Valentine Silalahi Muhammad Ikhlasul Amal Sangadji MUHAMMAD RAYHAN Nadia Dewi Astuti Nafi’ah, Nafi’ah Nor Kamalia Novie Aprianti Novie Aprianti, Novie Nurashfia Nurashfia Nurdiana Dewi Nuril Fajriani Nurrahman, Tri Nurul Ikhsani Umar Pramitha, Selviana Rizky Priyawan Rachmadi Rahmadella, Afifah Renie Kumala Dewi Resha Yusnida Retno Andriati, Retno Retno Pudji Rahayu Ridwan Ichshalul Fuady Rifasanto, Moh. Ihsan Saldy Rizky Saputra Saldy Rizky Saputra, Saldy Rizky Sari, Tiara Intan Permata Serenada Audria Sundah Sherli Diana Tri Putri, Deby Kania Utami, Juliyatin Putri Wenda Fitriati Noor Wenda Fitriati Noor, Wenda Fitriati Yunike Christanti Yusrinie Wasiaturrahmah