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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Berkala Epidemiologi STOMATOGNATIC- Jurnal Kedokteran Gigi ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Berkala Kedokteran Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Dentin Jurnal Insan Farmasi Indonesia Jurnal Pengabdian Ilung (Inovasi Lahan Basah Unggul) Odonto dental journal
Maharani Laillyza Apriasari
Departement Of Oral Medicine, Faculty Of Dentistry, Lambung Mangkurat University
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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ANTIFUNGUS EFFECTIVENESS OF CITRUS AMBLYCARPA PEEL, CITRUS HYSTRIX DC PEEL AND CITRUS AURANTIFOLIA PEEL EXTRACT (Against the Growth of Candida albicans) Resha Yusnida; Debby Saputera; Sherli Diana; Fajar Kusuma Dwi Kurniawan; Maharani Laillyza Apriasari
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22204

Abstract

Background: Candida albicans is a microorganism that causes many infections in the oral cavity. To treat infections caused by Candida albicans, antifungal therapy is needed. Alternative treatments for fungal infections can utilize traditional medicines, namely by using citrus amblycarpa peel extract, citrus hystrix DC peel, and citrus aurantifolia peel because they contain alkaloids, flavonoids, saponins, and tannins. Objective: Analyzing the antifungal effects of 100% concentration of citrus amblycarpa peel extract, 100% concentration of citrus hystrix DC peel, and 100% concentration of citrus aurantifolia peel on the growth of Candida albicans. Method: This study was a true experimental laboratory study with a post test only control group design, consisting of four treatment groups. Minimum Inhibitory Concentration (MIC) and Minimum Killing Concentration (MKC). Result: Parametric analysis using One Way Anova and Post Hoc Bonferroni KHM showed that there were significant differences in each treatment group and Post Hoc Games Howell test analysis showed that citrus amblycarpa peel extract showed no significant difference to citrus hystrik DC peel, citrus aurantifolia peel extract 100% concentration, while the aquades as a negative control there is a significant difference. Conclusion: Citrus amblycarpa peel extract, citrus hystrix DC peel extract, citrus aurantifolia peel 100% concentration, and aquades as a negative control had inhibitory effect on Candida albicans. Citrus amblycarpa peel extract concentration of 100% has killing power.
UJI TOKSISITAS KAPSUL EKSTRAK IKAN TOMAN (Channa micropeltes) TERHADAP PERUBAHAN PROFIL DARAH TIKUS WISTAR Muhammad Ikhlasul Amal Sangadji; Amy Nindia Carabelly; Maharani Laillyza Apriasari; I Wayan Arya Krishnawan Firdaus
Dentin Vol 9, No 2 (2025)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v9i2.17745

Abstract

ABSTACTBackground: The people of South Kalimantan traditionally use Haruan fish as an alternative medicine to accelerate wound healing. However, Haruan fish is difficult to cultivate, making Toman fish a potential alternative. Toman fish contains 5.35% albumin, whereas Haruan fish contains 4.35% albumin. Objective: To determine whether Toman fish extract capsules exert toxic effects on hematological profiles. Methods: This study consisted of three treatment groups: a group receiving Toman fish extract capsules at a dose of 0.7 grams, a positive control group receiving Haruan fish extract capsules at a dose of 0.7 grams, and a negative control group receiving only BR2 feed. The treatments were administered twice daily for 28 days. For administration, the capsule shells were opened, and 500 grams of dried extract were mixed with distilled water and given to Wistar rats using an oral gavage. After 28 days, blood samples were collected from the rats and analyzed using a Sysmax hematology analyzer. Results: The mean hemoglobin levels in the treatment, positive control, and negative control groups were 11.8 g/dl, 12.02 g/dl, and 12.12 g/dl, respectively. The mean erythrocyte counts in the treatment, positive control, and negative control groups were 6.46 million/mm³, 7.07 million/mm³, and 5.50 million/mm³, respectively. The mean leukocyte counts in the treatment, positive control, and negative control groups were 17.86 million/mm³, 13.62 million/mm³, and 9.24 million/mm³, respectively. Conclusion: Administration of Toman fish extract capsules at a dose of 0.7 grams produced negative effects on erythrocyte and leukocyte levels, while hemoglobin levels were not affected. These findings indicate that Toman fish extract capsules exhibit toxic effects on hematological profiles.Keywords: haruan fish, hematological profile, toman fish, toxicity test  ABSTRAK  Latar Belakang: Masyarakat Kalimantan Selatan menggunakan ikan Haruan sebagai obat alternatif mempercepat penyembuhan luka. Akan tetapi  ikan Haruan sulit dibudidayakan sehingga dipilih ikan Toman untuk alternatif. Ikan Toman mengandung albumin 5,35%, sedangkan ikan Haruan mengandung albumin 4,35%. Tujuan : Untuk mengetahui apakah kapsul ekstrak ikan Toman memiliki efek toksik terhadap profil hematologi. Metode : Penelitian ini meliputi tiga kelompok perlakuan yaitu pemberian kapsul ekstrak ikan Toman dosis 0,7 gram, kontrol positif berupa kapsul ekstrak ikan Haruan dosis 0,7 gram serta kontrol negatif yang hanya diberikan pakan BR2. Perlakuan dilakukan sebanyak 2 kali sehari selama 28 hari. Cara perlakuan adalah dengan membuka cangkang kapsul, kemudian ekstrak kering 500 gram ditambahkan aquades dan diberikan ke tikus Wistar menggunakan sonde lambung. Setelah 28 hari, tikus diambil sampel darah dan diuji menggunakan alat Hematology analyzer sysmax. Hasil : Rata-rata jumlah hemoglobin pada kelompok perlakuan, kelompok kontrol positif, dan kelompok kontrol negatif masing-masing adalah 11,8 g/dl, 12,02 g/dl, dan 12,12 g/dl. Rata-rata dari jumlah eritrosit pada kelompok perlakuan, kelompok kontrol positif, dan kelompok kontrol negatif masing-masing adalah 6,46 juta/mm3, 7,07 juta/mm3, dan 5,50  juta/mm3. Rata-rata dari jumlah leukosit pada kelompok perlakuan, kelompok kontrol positif, dan kelompok kontrol negatif masing-masing adalah 17,86 juta/mm3, 13,62 juta/mm3, dan 9,24 juta/mm3. Kesimpulan : Terdapat pengaruh negatif pemberian kapsul ekstrak ikan Toman dosis 0,7 gram terhadap perubahan kadar eritrosit dan leukosit, sedangkan pada hemoglobin tidak terdapat pengaruh. Hal ini menunjukkan bahwa kapsul ekstrak ikan Toman memiliki efek toksik terhadap profil darah.Kata Kunci : ikan haruan, ikan toman, uji toksisitas, profil hematologi
UJI TOKSISITAS EKSTRAK DAUN KARAMUNTING (Rhodomyrtus tomentosa (Aiton) Hassk.) TERHADAP GINJAL TIKUS WISTAR (Berdasarkan Ureum dan Kreatinin) M. Ridhotama Wibowo; Beta Widya Oktiani; Melisa Budipramana; Maharani Laillyza Apriasari; I Wayan Arya Krishnawan Firdaus
Dentin Vol 8, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v8i2.13113

Abstract

ABSTRACTBackground: Karamunting leaf have been used among community as traditional medication. Karamunting leaf have many properties because they contain secondary metabolite compounds such as flavonoids, triterpenoids, phenols, saponins and tannins. Administration as medicine is usually through oral. Oral administration of karamunting leaf in high dosage is considered to damage kidney microscopically. In vivo toxicity testing can be done to determine the toxicity effects of caramunting leaf extract at doses 600, 1200, 2400 mg/kg body weight before being tested on humans. Purpose: This study was conducted to determine whether karamunting leaf extract is toxic to the kidneys of Wistar rats subchronically with the parameters ureum and creatinine. Methods: The Rhodomyrtus Tomentosa (Aiton) Hassk. leaf were extracted using 96% ethanol and then given to male Wistar strain (Rattus norvegicus) with a 600, 1200, and 2400 mg/kg/body weight two times a day for 28 days. Rat blood was taken to check the levels of urea and creatinine. Result: The kidney ureum levels of Wistar rats in all treatment groups were still normal and did not exceed the normal range of ureum (10-50 mg/dL) while creatinine levels in all treatment groups were potentially toxic because they exceeded normal limits (0.578-1.128 mg/dL). Conclusion: The parameters of ureum and creatinine levels are not toxic because both can reduce the average value of both levels although some decrease significantly and some do not.Keywords : Creatinine, Excretion, Karamunting leaf, Kidney, Toxicity, Ureum ABSTRAKLatar Belakang: Daun karamunting telah digunakan oleh masyarakat sebagai obat tradisional. Daun karamunting banyak memiliki khasiat karena memiliki kandungan senyawa metabolit sekunder seperti flavonoid, triterpenoid, fenol, saponin dan tanin. Pemberiannya sebagai obat biasanya melalui oral. Pemberian daun ini secara oral dengan dosis tinggi diduga dapat merusak ginjal secara mikroskopis. Pengujian toksisitas secara in vivo dapat dilakukan untuk mengetahui efek toksisitas ekstrak daun karamunting pada dosis 600, 1200, 2400 mg/kg BB sebelum diujikan pada manusia. Tujuan: Penelitian ini dilakukan untuk mengetahui apakah ekstrak daun karamunting bersifat toksik terhadap ginjal tikus Wistar secara subkronik dengan parameter ureum dan kreatinin. Metode: Daun Rhodomyrtus Tomentosa (Aiton) Hassk. diekstraksi menggunakan etanol 96% dan kemudian diberikan pada tikus jantan galur Wistar (Rattus norvegicus) dengan dosis 600, 1200, dan 2400 mg/kg BB dua kali sehari selama 28 hari. Darah tikus diambil untuk memeriksa kadar urea dan kreatinin. Hasil: Kadar ureum ginjal tikus Wistar pada semua kelompok perlakuan masih normal dan tidak melebihi kisaran normal ureum (10-50 mg/dL), dan kadar kreatinin pada semua kelompok perlakuan juga normal karena tidak melebihi batas normal (0,578-1,128 mg/dL). Kesimpulan: Parameter kadar ureum dan kreatinin tidak toksik karena keduanya dapat menurunkan nilai rata-rata dari kedua kadar walaupun ada yang turun secara signifikan dan ada     yang tidak. Kata kunci: Ekskresi, Ekstrak Daun Karamunting, Ginjal, Kreatinin, Toksisitas, Ureum
ANALISIS DAMPAK INDUSTRI PANDAI BESI TERHADAP KUALITAS AIR BERSIH DAN KESEHATAN MASYARAKAT DESA SUNGAI PINANG Maharani Laillyza Apriasari; Nurul Ikhsani Umar; Amy Nindia Carabelly
Dentin Vol 9, No 2 (2025)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentin.v9i2.17746

Abstract

ABSTACTBackground: River water and municipal water (PDAM) serve as primary sources of clean water for the residents of Sungai Pinang Village, Daha Selatan District, Hulu Sungai Selatan Regency, South Kalimantan Province. The presence of blacksmithing (metal forging) industries in the village has contributed to a decline in clean water quality, which in turn affects the health conditions of the local community. Objective: This study aims to analyze the impact of blacksmithing industries on clean water quality and to assess the resulting health effects on the residents of Sungai Pinang Village, Daha Selatan District, Hulu Sungai Selatan Regency. Methods: This descriptive quantitative study was conducted to illustrate the quality of clean water and the health status of the Sungai Pinang community. Research subjects were selected using purposive sampling, involving the Village Head, blacksmith industry workers, and residents knowledgeable about local health conditions and industrial activities. Data were collected through interviews, observations, and laboratory testing. The study applied the Pollution Index (IP) method, referring to the Decree of the Minister of Environment No. 115 of 2003 on Guidelines for Determining Water Quality Status. Results: Analysis using the Pollution Index (IP) method yielded a score of 4.6 for river water and 3.9 for municipal water (PDAM). Conclusion: Based on the Pollution Index (IP) calculation, both river water and municipal water (PDAM) in Sungai Pinang Village, Daha Selatan District, are categorized as Lightly Polluted.Keywords: blacksmithing industry, public health, water quality ABSTRAK  Latar Belakang: Air sungai dan air PDAM merupakan sumber air bersih yang dikonsumsi oleh masyarakat di Desa Sungai Pinang, Kecamatan Daha Selatan, Kabupaten Hulu Sungai Selatan (HSS), Provinsi Kalimantan Selatan. Keberadaan industri pandai besi yang dilakukan di desa tersebut berdampak pada penurunan kualitas air bersih sehingga berdampak pula bagi kondisi kesehatan masyarakat setempat. Tujuan: Tujuan penelitian ini ialah untuk menganalisis dampak industri pandai besi terhadap kualitas air bersih serta dampak kesehatan yang ditimbulkan dari industri pandai besi terhadap masyarakat Desa Sungai Pinang Kec. Daha Selatan Kab. Hulu Sungai Selatan. Metode: Penelitian ini merupakan penelitian deskriptif kuantitatif yang bertujuan menggambarkan kualitas air bersih dan tingkat kesehatan masyarakat di Desa Sungai Pinang. Subjek penelitian ditentukan melalui teknik purposive sampling, melibatkan Kepala Desa, pekerja industri pandai besi, serta masyarakat yang memahami kondisi kesehatan dan aktivitas industri setempat. Pengumpulan data dilakukan melalui wawancara, observasi, dan uji laboratorium. Penelitian ini menggunakan Metode IP (Indeks Pencemaran) yang merujuk pada Keputusan Menteri Lingkungan Hidup No. 115 Tahun 2003 tentang Pedoman Penentuan Status Mutu Air. Hasil: Analisis data menggunakan metode IP (Indeks Pencemaran) menunjukkan skor 4,6 pada air sungai dan 3,9 pada air PDAM. Kesimpulan: Kualitas air sungai dan air PDAM di Desa Sungai Pinang Kec. Daha Selatan dikategorikan pada status Cemar Ringan berdasarkan perhitungan menggunakan Metode IP (Indeks Pencemaran). Kata kunci: industri pandai besi, kesehatan masyarakat, kualitas air
Co-Authors Adhiya, Geyanina Melda Agung Satria Wardhana Almadina Latanza Amy Nindia Carabelly Anita Fitriani Annisa Vara Nurdianty Aprilyani, Nur Ariska Endariantari Asphia Rahmah Astuti, Nadia Dewi Aulia Azizah Aulia Rahma Annisa Bagus Soebadi Beta Widya Oktiani Beta Widya Oktiani Cane Lukisari, Cane Debby Saputera, Debby Destri Khusnul Khotimah Dewi Nurdiana Dewi Puspitasari Dewi Puspitasari Dewi Rahayu Diah Savitri Ernawati Dita Permatasari Dita Permatasari Dwi Kurniawan, Fajar Kusuma Dwi Setyaningtyas, Dwi Eko Suhartono Eriwati, Yosi Kusuma Erni Marlina Fajriani, Nuril Firdaus, I Wayan Arya Krishnawan Hadi Waskito Hamdani, Riky Hatta, Isnur Hening Tuti Hendarti Husma, Emma Annahal I Wayan Arya K. Firdaus I Wayan Arya Khrisnawan Firdaus I Wayan Arya Krishnawan Firdaus I Wayan Arya Krishnawan Firdaus I Wayan Arya Krisnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Ika Kustiyah Oktaviyanti Khairunnisa Amalia Pratami Koko Komarudin Koko Komarudin Krishnawan Firdaus, I Wayan Arya Kurnia Fatwati Lia Yulia Budiarti M. Jusri M. Ridhotama Wibowo Maria Tanumihardja, Maria Marina Arum Syahadati Mashud, Mustain Melisa Budipramana, Melisa Moh. Ihsan Rifasanto Monica Thiodora Limay Monita Valentine Silalahi Muhammad Ikhlasul Amal Sangadji MUHAMMAD RAYHAN Nadia Dewi Astuti Nafi’ah, Nafi’ah Nor Kamalia Novie Aprianti Novie Aprianti, Novie Nurashfia Nurashfia Nurdiana Dewi Nuril Fajriani Nurrahman, Tri Nurul Ikhsani Umar Pramitha, Selviana Rizky Priyawan Rachmadi Rahmadella, Afifah Renie Kumala Dewi Resha Yusnida Retno Andriati, Retno Retno Pudji Rahayu Ridwan Ichshalul Fuady Rifasanto, Moh. Ihsan Saldy Rizky Saputra Saldy Rizky Saputra, Saldy Rizky Sari, Tiara Intan Permata Serenada Audria Sundah Sherli Diana Tri Putri, Deby Kania Utami, Juliyatin Putri Wenda Fitriati Noor Wenda Fitriati Noor, Wenda Fitriati Yunike Christanti Yusrinie Wasiaturrahmah