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All Journal Medula SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JURNAL PENELITIAN PERAWAT PROFESIONAL JK Unila (Jurnal Kedokteran Universitas Lampung) Jurnal Kesehatan Tambusai Jurnal Pengabdian Masyarakat JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Hanna Mutiara, Hanna
Bagian Parasitologi, Fakultas Kedokteran, Universitas Lampung
Agriculture, Biological Sciences & Forestry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Hubungan Determinan Sosial Kesehatan dengan Infeksi Toksoplasma gondii Jasmine, Almaina Puteri; Mutiara, Hanna; Suwandi, Jhons Fatriyadi; Putri, Giska Tri
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.938

Abstract

Toxoplasma gondii is an obligate intracellular protozoan that causes toxoplasmosis. The high rate of toxoplasmosis infection in the Lampung region reaches 88.23%. Typically, toxoplasmosis presents no symptoms but can pose serious problems for individuals with compromised immune systems or pregnant women. The purpose of this study is to identify the relationship between social health determinant factors such as age, gender, educational level, occupation, and residence address with the incidence of T. gondii infection among patients at Dr. H. Abdul Moeloek Hospital. The aim is to identify individuals at risk of toxoplasmosis infection early so prevention can be done immediately. This study is an analitic quantitative research with a cross-sectional design. The study population consists of patients at Dr. H. Abdul Moeloek Hospital who have been screened for toxoplasmosis from 2017 to 2023, with a sample size of 93 samples. A total of 67 samples were tested positive for toxoplasmosis, while 26 samples tested negative with the sampling technique using total sampling. Data were collected from patients medical records and were analyzed by univariate and bivariate analysis using Chi-square method. The results indicate a relationship between age (p 0.002), gender (p <0.001), and educational level (p <0.001) with the incidence of Toxoplasma gondii infection among patients at Dr. H. Abdul Moeloek Hospital from 2017 to 2023.
Literature Review: Helminthiasis pada Kehamilan Cahyani, Faradhila Azqiah; Septiani, Linda; Mutiara, Hanna; Suwandi, Jhons Fatriyadi
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.944

Abstract

Helminthiasis is a disease caused by intestinal nematode worms that are transmitted through soil orSoil Transmitted Helminth (STH). The types of STH are:Ascaris lumbricoides, Trichuris trichiura, Ancylostoma duodenale, and Necator americanus. Helminthiasis has infected as many as 1.5 billion of the world's population. Helminthiasis is often found in countries with tropical, subtropical climates and countries that are still categorized as poor. Helminthiasis falls into the categoryNeglected Tropical Disease (NTD) which if left untreated can cause health problems. Purpose ofliterature review This provides a review of the epidemiology, clinical manifestations, necessary examinations, and management of helminthiasis, especially in pregnant women. This research uses a literature study method from 2016-2023. The results of this literature study show that clinical manifestations are influenced by the severity or lightness of the infection, gold standardTo find out the incidence of helminthiasis is to do a stool examination, and helminthiasis can be treated by providing care servicesantenatal care. The conclusion is that helminthiasis in pregnant women can affect the condition of the mother and fetus in the womb.
Infeksi Protozoa Usus dan Anemia Sebagai Ancaman Kesehatan Global: Literature Review Rahmah, Nisrina Nur; Mutiara, Hanna; Septiani, Linda; Himayani, Rani
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1291

Abstract

Intestinal protozoan infections are a global health issue that needs to be monitored due to the high morbidity and mortality rates, particularly in areas with poor hygiene and sanitation. Intestinal protozoan infections are diseases caused by protozoan parasites, which are single-celled eukaryotic microorganisms generally classified under the Kingdom Protista. The most frequently reported intestinal protozoa species responsible for human infections are Blastocystis hominis, Cryptosporidium parvum, and Giardia lamblia. There are two key factors contributing to the occurrence of intestinal protozoan infections: individual and environmental factors. Intestinal protozoan infections are known to cause various harmful consequences, particularly regarding the nutritional status of the affected individuals. As a result, intestinal protozoan infections are often associated with iron deficiency anemia, which can ultimately disrupt growth and development in children and decrease productivity in adults. This study aims to identify the pathways through which intestinal protozoan infections cause iron deficiency anemia. The study method involved a literature review and problem analysis. The results indicate that there are three main pathways through which intestinal protozoan infections lead to iron deficiency anemia: the metabolism of pathogenic microorganisms within the human body, the activation of the immune response to pathogenic microorganisms, and the reduction in micronutrient levels. To prevent these infections, the public is advised to improve personal hygiene, such as regularly washing hands, and to enhance environmental sanitation by treating water through filtration or disinfection.
Manifestasi Klinis Infeksi Parasi Usus pada Anak: Literature Review Nirwan, Qurratul Aina; Mutiara, Hanna; Suharmanto, Suharmanto; Wardani, Dyah Wulan Sumekar Rengganis
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1394

Abstract

Intestinal parasitic infection is a disease that still neglated, more likely found in developing countries. This infection is caused by a group of intestinal protozoa and worms, generally intestinal nematodes. In children, the STH group is the most common cause of infection. Infection often occurs via the fecal-oral route. Children more often consume infective stages to other age groups due to their poor hygiene behavior.  Intestinal parasitic infections in children can cause high mortality and mobility. This infection causes a decline in health conditions, nutritional absorption, intelligence and productivity. This can simultaneously cause disruption of growth and development in children. These manifestations are related to the virulence of the parasite strain, the number of infective stages consumed, the age of the patient, and the state of the immune system at the time of infection. Apart from that, the manifestations that arise are widespread, asymptomatic to chronic. The manifestions are related to the digestive tract as the target organ of infections. However, manifestations can also be found outside the digestive tract. This is because organisms move to other organs through blood vessels. Manifestations that arise in the digestive tract are usually nausea, vomiting, abdominal pain, constipation, and diarrhea which is sometimes accompanied by blood. Not only that, weakness, fatigue, lethargy, and eating disorders are the manifestation of these infections. This is what causes growth and development disorders in children. Meanwhile, the extraintestinal mainifestations are liver abscess due to amoeba infection, Loeffler syndrome due to Ascaris lumbricoides infection and other manifestations. Usually, the intestinal nematoda infections caused have their own characteristics.
Kandungan Senyawa Aktif Metabolit Sekunder dalam Biolarvasida Annasya, Benazhir Saninah; Mutiara, Hanna; Marcellia, Selvi
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1252

Abstract

Larvicide is a compound that can be toxic, inhibit growth and development, affect behavior, affect hormones, inhibit feeding, and act as a larval killer. Larvicide is divided into two types, namely chemical larvicide and biolarvicide. Chemical larvicide is the larvicide most widely used by the community because it has a large substance strength. However, the use of chemical larvicide can cause damage, especially insects become resistant to drugs, in addition to causing environmental pollution because synthetic larvicide is difficult to decompose and causes poisoning in humans. The use of chemical larvicide can cause damage, especially insects become resistant to drugs, in addition to causing environmental pollution because synthetic larvicide is difficult to decompose and causes poisoning in humans. Therefore, a substitute for chemical larvicide in the form of biolarvicide is needed. Biolarvicide can act as a larval killer, attractant, antifertility agent (sterilization tool), biocide, and other forms that minimally cause drug resistance in insects. Biolarvicide comes from plant materials containing active compounds of secondary metabolites such as essential oils, saponins, steroids, terpenoids, tannins, alkaloids, flavonoids, and phenolics that can kill mosquito larvae and are obtained by extraction. This article provides a broader explanation of the content of secondary metabolite compounds in biolarvicide so that it can be more effectively used as a larvicide from natural materials. The contents of the article were obtained through searches of several national and international journals through the search keywords: Biolarvicide, secondary metabolites, and active compounds.
Infeksi Cryptosporidium pada Manusia: Patogenesis, Diagnosis dan Terapi Hatimi, Fahmi Ilham; Mutiara, Hanna; Islami, Suryadi; Sukohar, Asep
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1261

Abstract

Cryptosporidium is a zoonotic protozoan parasite capable of infecting humans and animals, primarily transmitted through contaminated water or food. This infection is a leading cause of moderate to severe diarrhea, particularly in children from low-income regions and immunocompromised individuals, contributing to significant global morbidity and mortality. The pathogenesis of Cryptosporidium involves the invasion of intestinal epithelial cells, resulting in mucosal damage, villous atrophy, and increased intestinal permeability, leading to watery diarrhea. Local inflammatory responses exacerbate symptoms, while immunocompromised individuals often experience chronic infections with serious complications. Diagnosis relies on microscopy, immunofluorescence, and molecular techniques such as PCR, which offer high sensitivity and specificity. Supportive care is the mainstay of treatment, with nitazoxanide being the preferred therapeutic option for selected patients. For immunocompromised individuals, management is more complex and may involve immune restoration therapies, such as antiretroviral treatment for HIV/AIDS patients. However, resistance to conventional treatments remains a significant challenge, necessitating further research into novel therapeutic agents, such as KDU731, which has shown promising efficacy in preliminary studies. This review provides a comprehensive analysis of the pathogenesis, diagnostic methods, and therapeutic strategies for Cryptosporidium infections. Additionally, it highlights the importance of prevention measures, including improved access to clean water and public health education. Enhanced control efforts are crucial to mitigating the global health impact of this infection, particularly among vulnerable populations such as children and immunocompromised individuals.
Analysis of Malathion Insecticide Resistance in Aedes aegypti Mosquitoes Using the CDC Bottle Bioassay Method Kirche, Agnes Angelina; Kurniawan, Betta; Putri, Giska Tri; Mutiara, Hanna
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1376

Abstract

Dengue is an infectious disease transmitted by the Aedes aegypti mosquito, which breeds rapidly in Indonesia's tropical environment, increasing the risk of spreading this disease. Vector control using malathion insecticide can be effective, but repeated use and inappropriate dosage can cause resistance in mosquitoes which ultimately increases the risk of dengue infection. CDC Bottle Bioassay is a test method for evaluating mosquito resistance to insecticides with a standardized procedure and is carried out using bottles containing insecticides with different diagnostic doses. Research using this method shows that Aedes aegypti mosquitoes in various locations show resistance to malathion at certain doses and tolerance at other doses. Several studies have also shown that mosquitoes exposed to malathion show categories of resistance or tolerance based on the mortality rate recorded during the test. Malathion, which is a class of organophosphorus insecticides, works by irreversibly binding to acetylcholinesterase and effectively kills mosquitoes, but repeated use can trigger resistance. Factors influencing resistance include biological factors such as migration, operational factors such as insecticide dosage and application, as well as genetic factors associated with the resistant allele. If mosquitoes carrying resistant alleles move or interbreed, this can increase the resistance status in an area, which is seen in Aedes aegypti populations in several regions of the world.
Peran Faktor Determinan Sosial Kesehatan, Personal Hygiene, dan Lingkungan dalam Penularan Protozoa Usus Khuluq, Muhammad Khusnul; Irawati, Nur Ayu Virginia; Mutiara, Hanna; Suwandi, Jhons Fatriyadi
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1406

Abstract

Intestinal protozoan infections are a significant health issue, particularly in developing countries with low socioeconomic conditions, poor sanitation, and inadequate personal hygiene practices. The transmission of intestinal protozoa is closely linked to various social determinants of health, including education level, occupation, and household income. Parents with lower education levels tend to have limited knowledge about hygiene and infection prevention, increasing the risk of transmission to children. Certain occupations, such as farming, are also associated with a higher risk of infection due to exposure to contaminated environments. Personal hygiene plays a crucial role in preventing intestinal protozoan infections. Habits such as washing hands before eating, after defecation, and maintaining overall cleanliness can reduce the risk of transmission through the fecal-oral route. Additionally, inadequate environmental sanitation, including the absence of toilets, poor waste management, and limited access to clean water, contributes to high infection rates. Several studies indicate that communities living in areas with poor sanitation are more vulnerable to infection, mainly due to high fecal contamination in water and soil. Beyond social and environmental factors, the presence of pets or livestock can also serve as a source of transmission. Animals exposed to intestinal protozoa pose a risk of spreading the infection if not properly managed. Therefore, preventing intestinal protozoan infections requires a comprehensive approach, including health education, increased awareness of personal hygiene, improved sanitation facilities, and access to safe drinking water for communities.
Peran Terapi Farmakologi dan Non-Farmakologi dalam Pengelolaan Dry Eye Disease Sitanggang, Grety; Himayani, Rani; Iyos, Rekha Nova; Mutiara, Hanna
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1469

Abstract

Dry Eye Disease (DED) is a multifactorial disorder of the ocular surface characterized by tear system imbalance, inflammation, and tissue damage, often leading to discomfort, visual disturbances, and a decline in quality of life. Managing DED requires a holistic approach that integrates both pharmacological and non-pharmacological therapies to alleviate symptoms while addressing underlying causes. Pharmacological treatments, such as artificial tears, anti-inflammatory agents (corticosteroids and cyclosporine), diquafosol tetrasodium, and oral pilocarpine, aim to restore ocular surface homeostasis. Non pharmacological approaches, including punctal plugs, lifestyle modifications, intense pulsed light (IPL) therapy, and nutritional supplementation with vitamin D and omega-3, are increasingly recognized for their supportive role in treatment. A comprehensive understanding of these therapeutic strategies is expected to improve DED management, enhance patients' quality of life, and prevent further complications.
Hubungan Antara Status Gizi dengan Siklus Menstruasi pada Mahasiswi Pendidikan Dokter Universitas Lampung Angkatan 2021 Hasanah, Sabila; Zuraida, Reni; Suharmanto, Suharmanto; Mutiara, Hanna
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1473

Abstract

A normal menstrual cycle reflects good reproductive health and plays an important role in preparing the body for pregnancy. Based on the 2018 Basic Health Research, around 13.7% of women aged 10-59 years experienced irregular menstruation. One of the factors that can interfere with the normalcy of the menstrual cycle is abnormal nutritional status. This study aims to determine whether there is a relationship between nutritional status and the menstrual cycle in University of Lampung Medical Education students class of 2021. The type of research used was analytical observational with a cross-sectional approach, which was carried out from November 2024 to January 2025, involving 123 female students selected through simple random sampling technique. Data on nutritional status was obtained from the calculation of Body Mass Index (BMI), while menstrual cycle data was obtained using a menstrual cycle sheet. The results of the analysis using the mann-whitney test showed a p-value of 0.083 (p-value>0.05), which indicated that there was no significant relationship between nutritional status and menstrual cycle among University of Lampung medical education students Class of 2021.
Co-Authors Achmad, Bilal Andana, Luthfi Shiba Anggraeni Janar Wulan, Anggraeni Janar Annasya, Benazhir Saninah Asep Sukohar Bawono, Aloysius Krishartadi Damar Betta Kurniawan, Betta Cahyani, Faradhila Azqiah Dewi Nur Fiana Din, Bahesty Cut Nyak Dwi Indria Anggraini Dyah Wulan Sumekar Dyah Wulan Sumekar Rengganis Wardani Eliza Techa Fattima, Eliza Techa Ety Apriliana Fitria Saftarina Giska Tri Putri Gustiar, Husaini Hamzah, Muhammad Syafei Hardiansyah, Ridwan Hasanah, Sabila Hatimi, Fahmi Ilham Indri Windarti Irawati, Nur Ayu Virginia Jasmine, Almaina Puteri Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi Kartika, Juspeni Khuluq, Muhammad Khusnul Kirche, Agnes Angelina Kurniawaty, Evi Manik, Ipan Jeremia Marcellia, Selvi Mayasari, Diana Muhammad Ricky Ramadhian Muhammad Yusran Nirwan, Qurratul Aina Nugraha, Dian Sastra Nurul Utami Oktafany, Oktafany Puspita, Ratna Dewi Rahmadian, M. Ricky Rahmah, Nisrina Nur Rani Himayani Rekha Nova Iyos, Rekha Nova Reni Zuraida Rika Lisiswanti Saputri, Chyntia Septiani, Linda Sitanggang, Grety Suharmanto Suryadi Islami Susianti, Susianti Sutyarso Sutyarso Suwandi, Jhons F. Syazili Mustofa Tri Umiana Soleha Tsanya, Nayla Priyanka Dara Wulan, Anggraini Janar Zahran, Muhammad Alif