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Hafsan
Universitas Islam Negeri Alauddin Makassar
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Molecular Docking Analysis of Compounds in Coleus blumei Leaves as Potential Antibiotics Against Methicillin-Resistant Staphylococcus aureus Sukmawaty, Eka; Amanda, Sabilla Suryaning; Hafsan; Nur, Fatmawati; Pratiwi, Afryanti
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 2 (2025): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i2.7419

Abstract

This study investigated the potential of phytochemical compounds from Coleus blumei leaves as anti-Methicillin-Resistant Staphylococcus aureus (MRSA) candidates through a validated molecular docking and absorption-distribution-metabolism-excretion-toxicology (ADMET)-based screening approach. The ligand structures were energy-minimized using MMFF94 followed by PM7 to obtain stable conformers prior to docking. Protein targets consisted of PBP2a and the extracellular antibiotic-sensing domain of MecR1 (benzylpenicilloyl- and oxacilloyl-acylated forms), both of which play central roles in the mecA-mediated resistance pathway of MRSA. Docking simulations were performed using AutoDock Vina v1.2.7 and validated through redocking of co-crystallized ligands, yielding RMSD values <2.0 Å. Among the eight tested compounds, Hexahydro-3H-1[2’-trifluoromethyl]-6’[4’’-trifluoromethylphenyl]- exhibited the strongest binding affinities, surpassing reference β-lactam antibiotics and demonstrating key interactions with residues involved in allosteric activation of PBP2a and ligand sensing in MecR1. ADMET predictions further supported its drug-likeness and safety profile, although experimental confirmation remains necessary. These findings highlight this compound as a promising anti-MRSA lead candidate and underscore the need for subsequent in vitro and in vivo evaluations to substantiate its mechanistic and therapeutic potential.
PERSPEKTIF NEUROBIOLOGI KORBAN KEKERASAN SEKSUAL DAN TANGGUNG JAWAB MORAL DALAM ISLAM (MINI REVIEW) Hafsan, Hafsan; Firdaus, Firdaus; Pratiwi, Afryanti
JURNAL SIPAKALEBBI Vol 9 No 2 (2025): Desember
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Sexual violence on university campuses represents a multidimensional crisis that violates not only moral integrity but also inflicts deep and lasting biological damage on survivors. Neurobiological research reveals that trauma from sexual violence can alter the structure and function of the brain, particularly the amygdala, hippocampus, and prefrontal cortex which are critical for emotional regulation, memory, and decision-making. Disruptions in these brain systems may lead to long-term conditions such as dissociation, chronic anxiety, and post-traumatic stress disorder (PTSD). In the Indonesian academic context, sexual violence often remains concealed behind institutional hierarchies, power imbalances, and a normalized culture of silence, as reflected in various studies and official reports. This article integrates findings from neuroscience with Islamic ethical principles to formulate a holistic approach to victim protection and recovery. Islam, through the framework of maqāṣid al-sharī‘ah, upholds personal dignity (al-‘irḍ) as a fundamental value that must be safeguarded. Social responsibility to protect survivors and prevent injustice is strongly emphasized in the Qur'an and prophetic tradition. Thus, the Islamic response to sexual violence goes beyond legalism, encompassing spiritual, biological, and psychosocial dimensions. In this view, an integrative framework combining scientific insight and moral-spiritual values is essential to build a just, compassionate, and trauma-informed response to sexual violence on campus. Kekerasan seksual di lingkungan kampus merupakan krisis multidimensi yang tidak hanya mencederai integritas moral, tetapi juga meninggalkan dampak biologis yang mendalam bagi korban. Kajian neurobiologi menunjukkan bahwa trauma akibat kekerasan seksual dapat mengubah struktur dan fungsi otak, terutama pada area seperti amigdala, hipokampus, dan prefrontal cortex, yang berperan dalam pengaturan emosi, memori, dan pengambilan keputusan. Gangguan pada sistem saraf ini tidak jarang menghasilkan gejala jangka panjang seperti disosiasi, kecemasan kronis, dan gangguan stres pascatrauma (PTSD). Dalam konteks akademik di Indonesia, kasus-kasus kekerasan seksual sering tersembunyi di balik relasi kuasa, hierarki institusional, dan normalisasi budaya diam, sebagaimana terbaca dalam sejumlah laporan riset dan catatan lembaga negara. Artikel ini memadukan temuan-temuan ilmu saraf dengan etika Islam untuk merumuskan pendekatan holistik dalam perlindungan dan pemulihan korban. Islam, melalui kerangka maqāṣid al-syarī‘ah, menempatkan kehormatan (al-‘irḍ) sebagai nilai yang harus dijaga secara serius. Tanggung jawab sosial untuk melindungi korban dan mencegah kezaliman ditegaskan dalam ajaran Al-Qur’an dan hadis. Maka, penanganan kekerasan seksual dalam kerangka Islam tidak hanya bersifat legalistik, tetapi juga menyentuh aspek spiritual, biologis, dan psikososial secara integral. Dengan demikian, dibutuhkan integrasi antara sains dan nilai moral sebagai fondasi respons yang lebih adil, manusiawi, dan menyembuhkan.  
Analisis kualitas sperma dan proporsi kromosom X–Y Sapi Bali (Bos indicus) hasil sexing metode swim-up dengan variasi kadar albumin dan waktu inkubasi Amalia, Andi Dewi Reski; Permatasari, Artha Rezki; Hajrah, Hajrah; Muthiadin, Cut; Hafsan, Hafsan; Dirhamzah, Dirhamzah
Teknosains Vol 20 No 1 (2026): Januari-April
Publisher : Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/teknosains.v20i1.64695

Abstract

Seleksi hewan berdasarkan jenis kelamin merupakan strategi penting dalam program pemuliaan dan produksi ternak karena berpengaruh terhadap efisiensi produksi dan nilai ekonomi. Peningkatan kebutuhan daging sapi mendorong penerapan teknologi reproduksi yang efisien, salah satunya melalui sexing sperma. Metode swim-up merupakan teknik sexing sperma yang relatif sederhana dan ekonomis. Namun, pada sapi bali, efektivitas metode ini masih perlu dikaji lebih spesifik terutama terkait pengaruh durasi inkubasi dan kadar albumin terhadap pemisahan spermatozoa X dan Y serta kualitas spermatozoa yang dihasilkan. Penelitian ini bertujuan untuk menganalisis pengaruh variasi durasi inkubasi dan kadar albumin terhadap kualitas semen beku sapi bali hasil sexing menggunakan metode swim-up, serta mengevaluasi proporsi spermatozoa X dan Y dan kualitas kromosom sperma setelah proses sexing. Penelitian menggunakan pendekatan eksperimental kuantitatif dengan parameter pengamatan meliputi motilitas, viabilitas, abnormalitas, morfometrik sperma, proporsi spermatozoa X dan Y, serta kualitas kromosom sperma. Hasil penelitian menunjukkan bahwa variasi durasi inkubasi dan kadar albumin berpengaruh signifikan (p<0,05) terhadap kualitas sperma. Perlakuan inkubasi 15 menit dengan albumin 3% menghasilkan kualitas sperma terbaik dengan motilitas 14,00±6,02, viabilitas 26,67±7,57, dan abnormalitas terendah 5,67±5,50. Morfometrik sperma pasca sexing masih berada dalam kisaran normal. Proporsi spermatozoa X dan Y menunjukkan variasi antar perlakuan, dengan kecenderungan fraksi kromosom kelamin tertentu pada perlakuan optimal. Hasil skrining kromosom menunjukkan mayoritas spermatozoa memiliki kromosom yang utuh. Dengan demikian, metode swim-up diharapkan efektif digunakan untuk memisahkan spermatozoa berdasarkan kromosom kelamin tanpa menurunkan kualitas kromosom sperma sapi bali.
Immunomodulatory Effects of Synbiotic Lactic Acid Bacteria from Dangke and Inulin from Dahlia Tubers Ayu Febriani; Hafsan Hafsan; St Aisyah Sijid; Fatmawati Nur; Cut Muthiadin; Faten Khudaer
Al Jahiz Vol 6 No 2 (2025): Al-Jahiz: Journal of Biology Education Research, July-December 2025
Publisher : Faculty of Tarbiyah and Teacher Training UIN Jurai Siwo, Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32332/al-jahiz.v6i2.10393

Abstract

Synbiotics, the synergistic combination of probiotics and prebiotics, have attracted growing scientific interest due to their potential to modulate immune responses. However, the immunomodulatory effects of synbiotics derived from traditional foods remain underexplored. This study aimed to evaluate the immune-enhancing potential of synbiotics formulated from Lactobacillus fermentum isolated from Dangke (a traditional South Sulawesi cheese) and inulin extracted from Dahlia tubers. The novelty of this work lies in the utilization of culturally unique, locally sourced microbial and prebiotic components that have not previously been tested for immunological impact. A total of 28 mice were randomly divided into four groups: one negative control group (P0) and three treatment groups (P1, P2, P3) receiving different doses of synbiotics over a 20-day treatment period. Parameters observed included changes in body weight, macrophage phagocytosis activity, and organ indices (liver and spleen). Results showed that mice in P1 and P2 groups exhibited significant increases in body weight (P1: +12.5%, P2: +15.3%, p < 0.05) compared to the control. Moreover, macrophage phagocytic activity was markedly improved in the treatment groups (p < 0.01). Liver and spleen indices were also significantly elevated (p < 0.05), indicating enhanced organ function. These findings suggest that synbiotics containing L. fermentum and Dahlia inulin have promising immunomodulatory effects, highlighting their potential for development as novel functional food ingredients with health-promoting benefits.
Karakteristik Fisikokimia dan Aktivitas Antioksidan Susu Kedelai Fermentasi Spontan Tanpa Bleaching sebagai Pangan Fungsional Fahira, Nurul; Rachmawati, Wulan; Nur, Fatmawati; Muthiadin, Cut; Hafsan, Hafsan
Filogeni: Jurnal Mahasiswa Biologi Vol 6 No 1 (2026): Januari-April
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/filogeni.v6i1.59084

Abstract

Permintaan masyarakat terhadap pangan fungsional terus meningkat, termasuk produk berbasis kedelai seperti susu kedelai. Salah satu proses teknologi yang lazim dilakukan adalah bleaching, namun metode ini berpotensi menghilangkan senyawa bioaktif penting. Penelitian ini bertujuan mengevaluasi karakteristik fisikokimia, dinamika pertumbuhan bakteri asam laktat (BAL), serta aktivitas antioksidan susu kedelai fermentasi spontan tanpa bleaching sebagai alternatif pangan fungsional alami. Penelitian bersifat eksperimental dengan fermentasi spontan susu kedelai pada suhu ruang selama 6, 12, 18, 24, dan 30 jam. Parameter yang diamati meliputi warna, rasa, kekentalan, pH, kadar asam laktat, populasi BAL, serta aktivitas antioksidan menggunakan metode DPPH. Hasil menunjukkan terjadinya perubahan signifikan pada karakteristik fisikokimia, meliputi warna kekuningan, rasa lebih asam, dan kekentalan menurun. Jumlah BAL meningkat dari 0,4 × 10⁶ CFU/mL pada jam ke-6 menjadi 4,7 × 10⁶ CFU/mL pada jam ke-30, disertai kenaikan kadar asam laktat hingga 0,077% dan penurunan pH dari 5 menjadi 2. Aktivitas antioksidan produk sangat tinggi dengan nilai IC50 sebesar 47,06 ppm. Fermentasi spontan tanpa bleaching berpotensi menghasilkan susu kedelai sebagai pangan fungsional alami dengan kandungan bioaktif yang tetap terjaga.
The Utilization of Coconut Water Waste As a Growth Media of the In-Vitro Potato Cutting Hafsan Hafsan; Muhammad Khalifah Mustami; Masriany Masriany; Isna Rasdianah Aziz; Mustakim Mustakim
Scientiae Educatia: Jurnal Pendidikan Sains Vol. 7 No. 2 (2018): December (2018)
Publisher : Tadris Biologi Fakultas Ilmu Tarbiyah dan Keguruan IAIN SYEKH NURJATI CIREBON

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24235/sc.educatia.v7i2.2636

Abstract

The limited number of potato seed caused the demand  The demand to be unfulfilled especially in South Sulawesi. The use of pathogen-free seeds is absolutely necessary that can be obtained through tissue culture. This study aims to determine the effect of adding coconut water on the growth of in vitro potato plant cuttings and the most effective type of treatment. This research used Varying Concentration of the coconut water, then measure its effect on potato growth (a high number of leaves and plantlets). This study consisted of 4 treatments: TQ0 (without coconut milk), TQ1 (100 ml/l), TQ2 (150ml/l), and TQ3 (200 ml/l). The results showed that the addition of coconut water on the growth of micro cuttings of potato (Solanum tuberosum L.) gave significant effect on the observed parameters, leaf number and plantlets weight. While TQ2 gave the best effect on the growth of in vitro micro cutting of potato.
Standardisasi Rumah Potong Unggas Berbasis Prinsip Halal, Thayyib dan Ihsan: Tinjauan Integratif Multi-Perspektif Sains dan Syariat Hajah Thaha, Aminah; Ahmad, Arifuddin; Dirhamzah, Dirhamzah; Hafsan, Hafsan
Anoa: Journal of Animal Husbandry Vol 5 No 1 (2026): Februari
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/anoa.v5i1.70035

Abstract

The acceleration of the commercial poultry industry demands a paradigm shift in quality assurance, moving from formal halal certification to a holistic fulfillment of halal, thayyib, and ihsan principles. Operational deviations in the field, such as introducing birds that are not completely dead into the scalding tank, represent a fatal critical control point that diminishes both sharia validity and carcass biological quality. This comprehensive review aims to synthesize prior scientific findings to construct a future Poultry Slaughterhouse standardization framework that integrates animal science, biology, and Islamic sharia perspectives. The methodology applied a systematic review approach of indexed scientific articles from Scopus, ScienceDirect, Sinta, and Garuda databases published between 2016 and 2026. The extracted data were tabulated into a synthesis matrix for critical analysis. The findings indicate that bleeding failure causes live chickens to drown in hot water, altering the carcass's legal status into carrion (maitah). Biologically, this phenomenon triggers extreme distress, causing a corticosterone spike that disrupts postmortem glycolysis, reduces water-holding capacity, and produces Pale, Soft, Exudative (PSE) meat characteristics highly susceptible to pathogenic bacterial contamination. Animal science engineering recommends calibrating conveyor speed to secure a minimum bleeding time of 90–120 seconds, or utilizing cone killers in non-industrial settings to mitigate pre-slaughter stress and ensure single-cut accuracy. Modern PSH standardization must unify administrative religious audits with empirical laboratory parameters by establishing new critical control points and appointing dual-competence quality control officers.
Co-Authors Abbas Abbas, Abbas AHMAD MUZAKKI Ahyar Ahmad Alfian Alfian Amalia, Andi Dewi Reski Amanda, Sabilla Suryaning Amin, Abd Rauf Muh Andi Nur Fadhilah, Andi Andi Wahdiniar, Andi Anwar, Zulfahri Ar. Syarif Hidayat Arifuddin Ahmad Arsyad, Muh Ali Asaad, Andi Indra Jaya Asmuddin Nasir Asmuddin Natsir Asri asri Asriani A Ayu Febriani Ayu Febriyanti, Ayu Cut Muthiadin Cut Muthiadin Delima Engga Maretha Devi Armita Dewi Paramitasari Dirhamzah, Dirhamzah Elkheir Hassaballah Abdallah Ernitasari, Ernitasari Fahira, Nurul Faten Khudaer Faten Khudair Fatimah Mansir Fatmawati Nur Fatmawati Nur Fatmawati Nur Fifi Dismayanti Indriani Nainu Firdaus Firdaus Hadidarma, Nasyrah Hafizhah Al Amanah Hajah Thaha, Aminah Hajrah Hajrah Hajrah Hajrah, Hajrah Hamina , Hamina, Hamina Hasrawati, Hasrawati Ibrahim Ibrahim Inaya, Nur Inna Shintia Irna, Ade Irwan Misbach Isna Rasdianah Aziz Isna Rasdianah Aziz Jumriani Rusli Khaerani Kiramang Khudaer , Faten Khudaer, Faten Kurnia Makmur Kurnia Ramadani Kurniati Kurniati Laily Agustina Laily Agustina, Laily Lianah Lianah, Lianah Lutvianti, Rizqi Maharani Retna Duhita Marliana Marliana Mashuri Masri Maslan Maslan Maslan, Muhammad Masriany Masriany Masriany Masriany Masriany, Masriany Melinda, Nurul Meriem, Selis Muh. Khalifah Muhammad Khalifah Mustami Muhammad Maslan Muhammad Rusdi Rasyid Mustakim Mustakim Muthmainna, Nur Nur Alfisah Nur Hanisa, Andi NUR, FATMAWATY Nurhidayah Nurhidayah Nurhikmah Nurhikmah Nurjannah Nurjannah Permatasari, Artha Rezki Pratiwi, Afryanti RACHMAWATI, WULAN Rahmaniah Rahmaniah Retno Prayudyaningsih Rezki Ramadani Djamaluddin Rini Anggraeni Rusli, Jumriani Rusmadi Rukmana Rusny Rusny Sakinah Sakinah Sinar Wahyuni Siska Tri Desianti Siti Rabiatul Adawiyah St Aisyah S St. Aisyah Sijid Sukmawaty, Eka Suryaning Amanda, Sabilla Syahrul Gunawan Tridesianti, Siska Ulfa Nur Alfriani Amir Ulfa Triyani A Latif Ulfa Triyani A Latif, Ulfa Triyani A Wahdaniyah Wahdaniyah Wirawan, Hadi Purnama Yuniar Harviyanti Yusminah Hala Zainuddin, Dhea Nanda Zulkarnain ZURAIDAH ZURAIDAH