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All Journal bionature AL KAUNIYAH Jurnal Sains dan Teknologi Proceeding Buffalo International Conference Biogenesis: Jurnal Ilmiah Biologi Teknosains: Media Informasi Sains dan Teknologi BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan Prosiding Seminar Biologi JURNAL SIPAKALEBBI MPI (Media Pharmaceutica Indonesiana) At-Taqaddum Scientiae Educatia: Jurnal Pendidikan Sains Celebes Biodiversitas : Jurnal Sains dan Pendidikan Biologi Jurnal SOLMA Scripta Biologica Jurnal Biotek Journal of Islam and Science Jurnal Triton Jurnal Pijar MIPA Al Jahiz: Journal of Biology Education Research Anoa: Journal of Animal Husbandry Filogeni: Jurnal Mahasiswa Biologi Bionature Berita Biologi Scientiae Educatia: Jurnal Pendidikan Sains Sainsmat : Jurnal Ilmiah Ilmu Pengetahuan Alam
Hafsan
Universitas Islam Negeri Alauddin Makassar
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Analisis kualitas sperma dan proporsi kromosom X–Y Sapi Bali (Bos indicus) hasil sexing metode swim-up dengan variasi kadar albumin dan waktu inkubasi Amalia, Andi Dewi Reski; Permatasari, Artha Rezki; Hajrah, Hajrah; Muthiadin, Cut; Hafsan, Hafsan; Dirhamzah, Dirhamzah
Teknosains Vol 20 No 1 (2026): Januari-April
Publisher : Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/teknosains.v20i1.64695

Abstract

Seleksi hewan berdasarkan jenis kelamin merupakan strategi penting dalam program pemuliaan dan produksi ternak karena berpengaruh terhadap efisiensi produksi dan nilai ekonomi. Peningkatan kebutuhan daging sapi mendorong penerapan teknologi reproduksi yang efisien, salah satunya melalui sexing sperma. Metode swim-up merupakan teknik sexing sperma yang relatif sederhana dan ekonomis. Namun, pada sapi bali, efektivitas metode ini masih perlu dikaji lebih spesifik terutama terkait pengaruh durasi inkubasi dan kadar albumin terhadap pemisahan spermatozoa X dan Y serta kualitas spermatozoa yang dihasilkan. Penelitian ini bertujuan untuk menganalisis pengaruh variasi durasi inkubasi dan kadar albumin terhadap kualitas semen beku sapi bali hasil sexing menggunakan metode swim-up, serta mengevaluasi proporsi spermatozoa X dan Y dan kualitas kromosom sperma setelah proses sexing. Penelitian menggunakan pendekatan eksperimental kuantitatif dengan parameter pengamatan meliputi motilitas, viabilitas, abnormalitas, morfometrik sperma, proporsi spermatozoa X dan Y, serta kualitas kromosom sperma. Hasil penelitian menunjukkan bahwa variasi durasi inkubasi dan kadar albumin berpengaruh signifikan (p<0,05) terhadap kualitas sperma. Perlakuan inkubasi 15 menit dengan albumin 3% menghasilkan kualitas sperma terbaik dengan motilitas 14,00±6,02, viabilitas 26,67±7,57, dan abnormalitas terendah 5,67±5,50. Morfometrik sperma pasca sexing masih berada dalam kisaran normal. Proporsi spermatozoa X dan Y menunjukkan variasi antar perlakuan, dengan kecenderungan fraksi kromosom kelamin tertentu pada perlakuan optimal. Hasil skrining kromosom menunjukkan mayoritas spermatozoa memiliki kromosom yang utuh. Dengan demikian, metode swim-up diharapkan efektif digunakan untuk memisahkan spermatozoa berdasarkan kromosom kelamin tanpa menurunkan kualitas kromosom sperma sapi bali.
Immunomodulatory Effects of Synbiotic Lactic Acid Bacteria from Dangke and Inulin from Dahlia Tubers Ayu Febriani; Hafsan Hafsan; St Aisyah Sijid; Fatmawati Nur; Cut Muthiadin; Faten Khudaer
Al Jahiz Vol 6 No 2 (2025): Al-Jahiz: Journal of Biology Education Research, July-December 2025
Publisher : Faculty of Tarbiyah and Teacher Training UIN Jurai Siwo, Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32332/al-jahiz.v6i2.10393

Abstract

Synbiotics, the synergistic combination of probiotics and prebiotics, have attracted growing scientific interest due to their potential to modulate immune responses. However, the immunomodulatory effects of synbiotics derived from traditional foods remain underexplored. This study aimed to evaluate the immune-enhancing potential of synbiotics formulated from Lactobacillus fermentum isolated from Dangke (a traditional South Sulawesi cheese) and inulin extracted from Dahlia tubers. The novelty of this work lies in the utilization of culturally unique, locally sourced microbial and prebiotic components that have not previously been tested for immunological impact. A total of 28 mice were randomly divided into four groups: one negative control group (P0) and three treatment groups (P1, P2, P3) receiving different doses of synbiotics over a 20-day treatment period. Parameters observed included changes in body weight, macrophage phagocytosis activity, and organ indices (liver and spleen). Results showed that mice in P1 and P2 groups exhibited significant increases in body weight (P1: +12.5%, P2: +15.3%, p < 0.05) compared to the control. Moreover, macrophage phagocytic activity was markedly improved in the treatment groups (p < 0.01). Liver and spleen indices were also significantly elevated (p < 0.05), indicating enhanced organ function. These findings suggest that synbiotics containing L. fermentum and Dahlia inulin have promising immunomodulatory effects, highlighting their potential for development as novel functional food ingredients with health-promoting benefits.
Karakteristik Fisikokimia dan Aktivitas Antioksidan Susu Kedelai Fermentasi Spontan Tanpa Bleaching sebagai Pangan Fungsional Fahira, Nurul; Rachmawati, Wulan; Nur, Fatmawati; Muthiadin, Cut; Hafsan, Hafsan
Filogeni: Jurnal Mahasiswa Biologi Vol 6 No 1 (2026): Januari-April
Publisher : Program Studi Biologi Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/filogeni.v6i1.59084

Abstract

Permintaan masyarakat terhadap pangan fungsional terus meningkat, termasuk produk berbasis kedelai seperti susu kedelai. Salah satu proses teknologi yang lazim dilakukan adalah bleaching, namun metode ini berpotensi menghilangkan senyawa bioaktif penting. Penelitian ini bertujuan mengevaluasi karakteristik fisikokimia, dinamika pertumbuhan bakteri asam laktat (BAL), serta aktivitas antioksidan susu kedelai fermentasi spontan tanpa bleaching sebagai alternatif pangan fungsional alami. Penelitian bersifat eksperimental dengan fermentasi spontan susu kedelai pada suhu ruang selama 6, 12, 18, 24, dan 30 jam. Parameter yang diamati meliputi warna, rasa, kekentalan, pH, kadar asam laktat, populasi BAL, serta aktivitas antioksidan menggunakan metode DPPH. Hasil menunjukkan terjadinya perubahan signifikan pada karakteristik fisikokimia, meliputi warna kekuningan, rasa lebih asam, dan kekentalan menurun. Jumlah BAL meningkat dari 0,4 × 10⁶ CFU/mL pada jam ke-6 menjadi 4,7 × 10⁶ CFU/mL pada jam ke-30, disertai kenaikan kadar asam laktat hingga 0,077% dan penurunan pH dari 5 menjadi 2. Aktivitas antioksidan produk sangat tinggi dengan nilai IC50 sebesar 47,06 ppm. Fermentasi spontan tanpa bleaching berpotensi menghasilkan susu kedelai sebagai pangan fungsional alami dengan kandungan bioaktif yang tetap terjaga.
The Utilization of Coconut Water Waste As a Growth Media of the In-Vitro Potato Cutting Hafsan Hafsan; Muhammad Khalifah Mustami; Masriany Masriany; Isna Rasdianah Aziz; Mustakim Mustakim
Scientiae Educatia: Jurnal Pendidikan Sains Vol. 7 No. 2 (2018): December (2018)
Publisher : Tadris Biologi Fakultas Ilmu Tarbiyah dan Keguruan IAIN SYEKH NURJATI CIREBON

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24235/sc.educatia.v7i2.2636

Abstract

The limited number of potato seed caused the demand  The demand to be unfulfilled especially in South Sulawesi. The use of pathogen-free seeds is absolutely necessary that can be obtained through tissue culture. This study aims to determine the effect of adding coconut water on the growth of in vitro potato plant cuttings and the most effective type of treatment. This research used Varying Concentration of the coconut water, then measure its effect on potato growth (a high number of leaves and plantlets). This study consisted of 4 treatments: TQ0 (without coconut milk), TQ1 (100 ml/l), TQ2 (150ml/l), and TQ3 (200 ml/l). The results showed that the addition of coconut water on the growth of micro cuttings of potato (Solanum tuberosum L.) gave significant effect on the observed parameters, leaf number and plantlets weight. While TQ2 gave the best effect on the growth of in vitro micro cutting of potato.
Standardisasi Rumah Potong Unggas Berbasis Prinsip Halal, Thayyib dan Ihsan: Tinjauan Integratif Multi-Perspektif Sains dan Syariat Hajah Thaha, Aminah; Ahmad, Arifuddin; Dirhamzah, Dirhamzah; Hafsan, Hafsan
Anoa: Journal of Animal Husbandry Vol 5 No 1 (2026): Februari
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/anoa.v5i1.70035

Abstract

The acceleration of the commercial poultry industry demands a paradigm shift in quality assurance, moving from formal halal certification to a holistic fulfillment of halal, thayyib, and ihsan principles. Operational deviations in the field, such as introducing birds that are not completely dead into the scalding tank, represent a fatal critical control point that diminishes both sharia validity and carcass biological quality. This comprehensive review aims to synthesize prior scientific findings to construct a future Poultry Slaughterhouse standardization framework that integrates animal science, biology, and Islamic sharia perspectives. The methodology applied a systematic review approach of indexed scientific articles from Scopus, ScienceDirect, Sinta, and Garuda databases published between 2016 and 2026. The extracted data were tabulated into a synthesis matrix for critical analysis. The findings indicate that bleeding failure causes live chickens to drown in hot water, altering the carcass's legal status into carrion (maitah). Biologically, this phenomenon triggers extreme distress, causing a corticosterone spike that disrupts postmortem glycolysis, reduces water-holding capacity, and produces Pale, Soft, Exudative (PSE) meat characteristics highly susceptible to pathogenic bacterial contamination. Animal science engineering recommends calibrating conveyor speed to secure a minimum bleeding time of 90–120 seconds, or utilizing cone killers in non-industrial settings to mitigate pre-slaughter stress and ensure single-cut accuracy. Modern PSH standardization must unify administrative religious audits with empirical laboratory parameters by establishing new critical control points and appointing dual-competence quality control officers.
Heparanase inhibitor and antimetastasis: A mini-review of recent progress in cancer therapy and an Islamic perspective Febriani, Ayu; Hafsan, Hafsan; Pratiwi, Afryanti; Ahmad, Arifuddin
Teknosains Vol 20 No 1 (2026): Januari-April
Publisher : Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/teknosains.v20i1.63256

Abstract

Heparanase is a critical enzyme involved in cancer metastasis through its role in degrading the extracellular matrix (ECM), which allows cancer cells to invade surrounding tissues and spread to distant organs. This mini-review explores recent advancements in understanding heparanase's function in cancer progression and the development of targeted therapies aimed at inhibiting its activity. Heparanase inhibitors, such as Roneparstat, have demonstrated significant potential in reducing tumor metastasis and improving the efficacy of existing treatments, including chemotherapy and immunotherapy. By altering the tumor microenvironment, these inhibitors enhance immune cell infiltration, improving response rates in otherwise resistant tumors. Additionally, heparanase has emerged as a promising biomarker for early cancer detection and prognosis, offering a new dimension to personalized treatment approaches. The review also incorporates an Islamic ethical perspective, emphasizing the obligation to preserve life and alleviate suffering through medical innovation. Continued research in this field is essential to refine therapeutic strategies and improve outcomes, particularly in cancers with high metastatic potential.
Pemanfaatan limbah kulit pisang kepok sebagai sumber prebiotik alami terhadap pertumbuhan Lactobacillus plantarum secara in vitro Hariani, Hariani; Jamilah, Jamilah; Nur, Fatmawati; Masri, Mashuri; Hafsan, Hafsan
Teknosains Vol 20 No 1 (2026): Januari-April
Publisher : Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/teknosains.v20i1.67043

Abstract

Kulit pisang kepok (Musa paradisiaca var. balbisiana) merupakan biomassa agro-industri yang melimpah dengan potensi aplikasi sebagai sumber prebiotik alami. Penelitian ini bertujuan untuk mengevaluasi potensi ekstrak kulit pisang sebagai substrat prebiotik dalam mendukung pertumbuhan Lactobacillus plantarum pada kondisi in vitro. Ekstrak disiapkan menggunakan metode dekoksi dan diinkorporasikan ke dalam media pertumbuhan bakteri. Parameter pertumbuhan yang diamati meliputi kerapatan optik (OD), jumlah sel hidup (CFU/mL), pH, laju pertumbuhan spesifik (μ), dan waktu generasi (gt) selama 48 jam inkubasi. Hasil penelitian menunjukkan bahwa penambahan ekstrak kulit pisang berpengaruh signifikan terhadap pertumbuhan Lactobacillus plantarum. Perlakuan menggunakan kulit pisang matang memberikan kinerja paling optimal, ditandai dengan nilai OD lebih tinggi, jumlah sel hidup dan laju pertumbuhan spesifik yang lebih besar, serta waktu generasi yang lebih singkat dibandingkan perlakuan lainnya (p < 0,05). Penurunan pH yang lebih nyata juga teramati, menunjukkan peningkatan aktivitas fermentatif. Ekstrak kulit pisang memiliki potensi sebagai substrat fermentabel yang mampu mendukung pertumbuhan bakteri asam laktat secara in vitro. Temuan ini memberikan dasar ilmiah bagi pemanfaatan limbah kulit pisang sebagai sumber prebiotik alami. Penelitian lanjutan diperlukan untuk mengevaluasi efektivitasnya secara in vivo, termasuk selektivitas terhadap mikrobiota usus serta stabilitasnya dalam kondisi gastrointestinal.
ISOLASI DAN KARAKTERISASI KONSORSIUM BAKTERI INDIGEN POTENSIAL PENDEGRADASI LIMBAH CAIR RUMAH POTONG UNGGAS Lutfianti, Sri; Natsir, Dhela; Dirhamzah, Dirhamzah; Hafsan, Hafsan; Rukmana, Rusmadi
Teknosains Vol 20 No 2 (2026): Mei-Agustus
Publisher : Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/teknosains.v20i2.69315

Abstract

Limbah cair rumah potong unggas (RPU) mengandung konsentrasi tinggi polutan organik kompleks, terutama protein dan lipid, yang sulit didegradasi secara efektif menggunakan sistem berbasis mikroorganisme tunggal. Penelitian ini bertujuan untuk mengisolasi, mengarakterisasi, dan memformulasikan konsorsium bakteri indigenous yang mampu meningkatkan efisiensi biodegradasi limbah cair RPU. Isolat bakteri indigenous diperoleh dari sedimen laguna anaerob rumah potong unggas dan diseleksi berdasarkan aktivitas proteolitik dan lipolitiknya. Tiga isolat unggul, yaitu RPU-1, RPU-3, dan RPU-7, dipilih serta diuji kompatibilitasnya sebelum diformulasikan menjadi suatu konsorsium. Konsorsium yang dihasilkan (KBP-RPU) kemudian dievaluasi pada reaktor batch aerob skala laboratorium yang berisi limbah cair RPU tanpa perlakuan awal selama 96 jam. Hasil penelitian menunjukkan penurunan yang signifikan pada parameter utama pencemar, yaitu Chemical Oxygen Demand (COD) sebesar 91,4 ± 1,4%, Biochemical Oxygen Demand (BOD) sebesar 88,7 ± 1,2%, dan total lipid sebesar 94,2% setelah 96 jam inkubasi. Pola penurunan parameter pencemar yang berlangsung secara bertahap selama masa inkubasi mengindikasikan bahwa konsorsium bakteri memiliki kemampuan biodegradasi yang efektif terhadap senyawa organik dan lipid dalam limbah cair RPU. Dibandingkan dengan sistem pengolahan biologis yang telah dilaporkan sebelumnya, konsorsium KBP-RPU menunjukkan efisiensi biodegradasi yang relatif tinggi dengan waktu retensi yang lebih singkat. Temuan ini menunjukkan bahwa konsorsium bakteri indigenous berpotensi dikembangkan sebagai agen bioaugmentasi untuk mendukung pengolahan limbah cair rumah potong unggas yang berkelanjutan.
Harnessing Enzymes for Optimal Poultry Feed Formulations (Mini Review) St. Aisyah Sijid; Hafsan; Faten Khudaer
SAINSMAT: Jurnal Ilmiah Ilmu Pengetahuan Alam Vol. 13 No. 1 (2024): Volume 13 Nomor 1 (Maret 2024)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This paper focuses on the use of enzymes in effective and efficient poultry feed formulations. The introduction highlights the importance of good nutrition for poultry and the increasing need for innovative feed formulations due to limited availability and rising prices of feed ingredients. Enzymes are introduced as protein compounds that enhance nutrient digestion and absorption in poultry, potentially reducing feed production costs. However, their widespread use in Indonesia is still limited due to a lack of knowledge. The paper discusses the role of enzymes in poultry nutrition, including their involvement in digestion and nutrient absorption. It also emphasizes the essential nutrients required for poultry growth and development and the factors influencing their nutritional needs. The types of enzymes commonly used in poultry feed formulations, such as phytase, amylase, protease, and lipase, are explored along with their mechanisms of action. Research findings demonstrate the effectiveness and efficiency of using enzymes in improving nutrient availability and feed efficiency, ultimately enhancing poultry production productivity and sustainability. The paper concludes with recommendations for the development and application of enzymes in poultry feed formulations, highlighting the need for careful enzyme selection, dosage adjustment, and consideration of environmental conditions. Furthermore, the importance of integrating enzymes with other feed ingredients and adopting a comprehensive nutrition strategy is emphasized. Overall, the use of enzymes in poultry feed formulations offers significant advantages for modern poultry farming, but careful implementation and further research are necessary to optimize their effectiveness and efficiency.
Mini Review: Controlling of Blood Glucose Levels Utilizing Lactic Acid Bacteria Fatmawati Nur; Hafsan; Faten Khudair
Bionature Vol. 24 No. 2 (2023): Oktober 2023
Publisher : Jurusan Biologi FMIPA Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Lactic acid bacteria (LAB) interest promises a prospective dietary approach for enhancing the management of blood sugar levels in individuals diagnosed with diabetic and those presenting with pre-diabetic conditions. This review article summarizes the available evidence on the role of LAB in blood sugar regulation, focusing on the mechanisms underlying its effects and relevant research results. LAB supplementation has been shown to improve glucose tolerance and insulin sensitivity in animal and human studies, as well as to reduce fasting blood glucose levels in individuals with type 2 diabetes. Potential mechanisms underlying the effects of LAB on blood glucose control include improving insulin sensitivity, reducing inflammation, and improving intestinal barrier function. However, further supporting studies are needed to fully understand the optimal strain and dose of LAB for blood glucose control and to elucidate the mechanisms by which they exert their effects. Despite promising results, the safety and potential side effects of LAB supplements should also be carefully considered. Overall, this review highlights the potential of LAB as a dietary strategy for blood sugar regulation in individuals with diabetic and pre-diabetic.
Co-Authors Abbas Abbas, Abbas AHMAD MUZAKKI Ahyar Ahmad Alfian Alfian Amalia, Andi Dewi Reski Amanda, Sabilla Suryaning Amin, Abd Rauf Muh Andi Nur Fadhilah, Andi Andi Wahdiniar, Andi Anwar, Zulfahri Ar. Syarif Hidayat Arifuddin Ahmad Asaad, Andi Indra Jaya Asmuddin Nasir Asmuddin Natsir Asri asri Asriani A Ayu Febriani Ayu Febriyanti, Ayu Cut Muthiadin Cut Muthiadin Delima Engga Maretha Devi Armita Dewi Paramitasari Dirhamzah, Dirhamzah Elkheir Hassaballah Abdallah Ernitasari, Ernitasari Fahira, Nurul Faten Khudaer Faten Khudaer Faten Khudair Fatimah Mansir Fatmawati Nur Fatmawati Nur Fatmawati Nur Febriani, Ayu Fifi Dismayanti Indriani Nainu Firdaus Firdaus Hadidarma, Nasyrah Hafizhah Al Amanah Hajah Thaha, Aminah Hajrah Hajrah Hajrah Hajrah, Hajrah Hamina , Hamina, Hamina Hariani Hariani, Hariani Hasrawati, Hasrawati Ibrahim Ibrahim Inaya, Nur Inna Shintia Irna, Ade Irwan Misbach Isna Rasdianah Aziz Isna Rasdianah Aziz Jamilah Jamilah Jumriani Rusli Khaerani Kiramang Khudaer , Faten Khudaer, Faten Kurnia Makmur Kurnia Ramadani Kurniati Kurniati Laily Agustina Laily Agustina, Laily Lianah Lianah, Lianah Lutfianti, Sri Lutvianti, Rizqi Maharani Retna Duhita Marliana Marliana Mashuri Masri Maslan Maslan Maslan, Muhammad Masriany Masriany Masriany Masriany Masriany, Masriany Melinda, Nurul Meriem, Selis Muh. Ali Arsyad Muh. Khalifah Muhammad Khalifah Mustami Muhammad Maslan Muhammad Rusdi Rasyid Mustakim Mustakim Muthmainna, Nur Natsir, Dhela Nur Alfisah Nur Hanisa, Andi NUR, FATMAWATY Nurhidayah Nurhidayah Nurhikmah Nurhikmah Nurjannah Nurjannah Permatasari, Artha Rezki Pratiwi, Afryanti RACHMAWATI, WULAN Rahmaniah Rahmaniah Retno Prayudyaningsih Rezki Ramadani Djamaluddin Rini Anggraeni Rusli, Jumriani Rusmadi Rukmana Rusny Rusny Sakinah Sakinah Sinar Wahyuni Siska Tri Desianti Siti Rabiatul Adawiyah St Aisyah S St. Aisyah Sijid Sukmawaty, Eka Suryaning Amanda, Sabilla Syahrul Gunawan Tridesianti, Siska Ulfa Nur Alfriani Amir Ulfa Triyani A Latif Ulfa Triyani A Latif, Ulfa Triyani A Wahdaniyah Wahdaniyah Wirawan, Hadi Purnama Yuniar Harviyanti Yusminah Hala Zainuddin, Dhea Nanda Zulkarnain ZURAIDAH ZURAIDAH