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All Journal Indonesia Medicus Veterinus Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Biology, Medicine, & Natural Product Chemistry Aceh Journal of Animal Science Medical Laboratory Technology Journal JMM (Jurnal Masyarakat Mandiri) Global Health Management Journal Oceana Biomedicina Journal Jurnal Sains dan Teknologi Peternakan Community Empowerment OISAA Journal of Indonesia Emas Journal of Experimental and Clinical Pharmacy (JECP) Pengabdian Kampus: Jurnal Informasi Kegiatan Pengabdian Pada Masyarakat Kontribusi: Jurnal Penelitian dan Pengabdian Kepada Masyarakat Oceana Biomedicina Journal International Journal of Sustainable Applied Sciences (IJSAS) Media Kesehatan Politeknik Kesehatan Makassar Barigas: Jurnal Riset Mahasiswa Tropis: Jurnal Riset Teknologi Laboratorium Medis Mosaic: Jurnal Pengabdian Kepada Masyarakat
Rian Ka Praja
Program Studi Kedokteran, Fakultas Kedokteran Universitas Palangka Raya
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Education on the integration of probiotic fish pellet production with aquaponic technology as a solution for food self-sufficiency Praja, Rian Ka; Dwijayanti, Rts. Sherly; Saputra, Rizki Rachmad; Decenly, Decenly; Suma, Joy Angel Aria; Harianja, Henrigen
Community Empowerment Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.12345

Abstract

This community service program was carried out in Talian Kereng Village, Katingan Regency, Central Kalimantan, with the aim of enhancing food self-sufficiency through training on probiotic-based fish pellet production and the implementation of aquaponic technology. The program involved 15 participants and included theoretical training sessions, practical fish feed production, and aquaponic system installation. Evaluation results indicated a significant increase in knowledge, with the average score rising from 40% to 85%. A total of 90% of participants successfully practiced fish pellet production with the correct composition, while 80% were able to independently operate the aquaponic system. The program also featured the handover of fish pellet production technology and the aquaponic system to the local fish farming group. Despite challenges related to the availability of probiotic ingredients and aquaponic system management, this initiative has opened opportunities for further development in rural fisheries and agriculture.
Presence of Salmonella sp. In Tilapia and Catfish from Cages in Pahandut Seberang Along the Kahayan River Flow Kurniawan, Mutiara; Praja, Rian Ka; Widiarti, Astri; Hanasia, Hanasia; Toemon, Angeline Novia
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.185-191

Abstract

Salmonellosis is a zoonosis, which means that it may be spread from animals to people through fish meat. It is a sickness brought on by an infection with the salmonella bacteria that infect humans and animals and invade the digestive tract. According to data from the Institute for Health Metrics and Evaluation, the global rate of salmonellosis in 2019 was 4.22 cases per 100,000 people, with a 1.72 fatality rate. Indonesia had a mortality rate of 2.42 and 5.82 per 100,000 people 2019. The objective of this study is to identify Salmonella sp. bacteria in 14 samples of river water, catfish (Clariidae), and tilapia (Oreochromis niloticus) raised in rivers. This study includes two water samples, three catfish samples, and nine tilapia samples from the cage of the Pahandut Seberang River in Palangka Raya City. It employs a descriptive research design using an experimental technique. Among the metrics noted is the detection of Salmonella sp. The study found that all water samples, tilapia, and catfish tested positive for Salmonella sp bacteria in the selective media Salmonella Shigella Agar (SSA), that 14 samples (100%) in the gram staining test displayed the traits of Salmonella sp bacteria, and that 5 samples (B N1, C N2-3 samples in tilapia, B L1 samples in catfish, and water sample 2 showed the type of Salmonella paratyphoid b bacteria) and 9 samples, namely samples Salmonella tyhpimarium bacteria were found in samples A L1, C L1 in catfish, B N2-3, C N1 in tilapia, and water 1. As a result, every sample surpassed the SNI 7388:2009 maximum level of microbial contamination, which is positive/25g. According to the Indonesian National Standardization Agency's SNI 7388:2009 guidelines for the upper limit of microbial contamination in food, the tilapia meat, catfish, and river water in the river cage of Kahayan Pahandut Seberang Palangka Raya City do not satisfy the requirements.
The Antivirulence Mechanisms of Phytate Against Pathogenic Bacteria in Skin Infections Zhofiroh, Nabilatul; Praja, Rian Ka; Trinovita, Elsa; Ysrafil, Ysrafil; Surbakti, Ranintha BR
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.731-738

Abstract

Skin infections caused by the bacteria Staphylococcus aureus, Streptococcus pyogenes, and Propionibacterium acnes are often a common health problem. One treatment is antibiotics, but the cases of antibiotic resistance are increasing. Thus, new treatment alternatives are needed. This study aimed to analyze the molecular mechanism of phytate antivirulence against pathogenic bacteria of skin infection. This study used a bioinformatics approach involving analysis of phytate interactions with bacterial virulent proteins via STITCH, functional classification of proteins with VICMpred, and prediction of virulence properties using VirulentPred. B-cell and MHC epitopes were analyzed using IEDB, while protein subcellular location was determined through PSORTb. The results showed that phytate interacted specifically with virulent proteins in all three bacteria, most of which functioned in cellular and metabolic processes. These virulent proteins also have immunologically relevant epitopes. Subcellular location analysis showed that phytate protein targets were dispersed in the cytoplasmic membrane and cytoplasm. These findings indicated that phytate has a significant antivirulence mechanism by targeting virulent proteins of skin pathogenic bacteria, thus potentially becoming a therapeutic agent to treat skin infections while reducing antibiotic resistance.
The Effects Of Kelakai Leaf Infusion Kalakai (Stenochlaena palustris (Burm.F) Bedd) On The Levels of AST and ALT Enzymes in Wistar White Rats Induced with CCl4 Salsabila, Ivah; Carmelita, Austin Bertilova; Shinta, Herlina Eka; Toemon, Angeline Novia; Praja, Rian Ka
Barigas: Jurnal Riset Mahasiswa Vol. 3 No. 2 (2025): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v3i2.12011

Abstract

The liver plays a crucial role in the body, including protein synthesis, bile secretion, metabolism, and xenobiotic excretion, making it susceptible to damage from exposure to toxic substances. Carbon tetrachloride (CCl4) is a free radical known to cause liver injury. Abundant in Kalimantan, kelakai contains flavonoids, alkaloids, steroids, and tannins, suggesting its metabolites may have hepatoprotective potential. This study aimed to assess the antioxidant content of kelakai leaf infusion for potential protection CCl4-induced liver damage. Kelakai leaves (Stenochlaena palustris (Burm.F) Bedd). were infused at a 20% concentration, then divided into three different doses: P1 (300 mg/kgBW), P2 (400 mg/kgBW) and P3 (5—mg/kgBW). The 14-day study evaluated whether kelakai leaf infusion could prevent the elevation of AST dan ALT enzyme ativities. The results indicated increased levels of AST dab AKT enzymes in each treatment group. Though the statistical analisis showed non-significant differences.
siRNAs targeting icaD Gene of Staphylococcus aureus to Inhibit Biofilm Formation: Structural Analysis and Efficacy Sulistina, Dinda Ananda; Praja, Rian Ka; Anugerahny, Margaretha Yayu Indah; Hanasia, Hanasia; Ysrafil, Ysrafil
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.921-926

Abstract

Antibiotic resistance in Staphylococcus aureus infections, especially those involving biofilm formation, is a global health issue. Biofilm protects bacteria from the immune system and antibiotic treatment, making them 10 to 1000 times more resistant. The icaD gene, part of the ica operon, is crucial for biofilm synthesis by enhancing the enzymes responsible for forming the biofilm matrix. The icaD gene sequence of Staphylococcus aureus was obtained from the GenBank NCBI database with the accession code CP140612.1, with a gene sequence length of 306 bp and employed several bioinformatics methods, including siDirect for designing and evaluating effective siRNA sequences to select the most promising candidates. Additionally, siRNA Scales, MaxExpect, Duplex Fold, and siPred were employed to analyze the siRNA sequence length, secondary structure, binding energy, and efficacy predictions of siRNAs targeting the icaD gene. The study found that out of 54 siRNA candidates, siRNA22, siRNA50, and siRNA25 achieved inhibition rates of 93.69%, 92.82%, and 92.52%, respectively. These results bioinformatically demonstrated their potential to suppress the expression of the icaD gene and highlight their promise as siRNA-based antibacterial therapies to combat biofilm-related infections. The designed siRNA computationally shows potential as an innovative therapy to combat biofilm infections caused by Staphylococcus aureus.
The Effect of Physical Activity on Blood Pressure in the Community of Tumbang Tahai District, Palangka Raya, Indonesia Anwar, Muhammad Naufa; Hartoyo, Riccardo; Sandhikarana, I Dewa Gede; Widhiyanto, Hendrykus Theo Damar; Praja, Rian Ka
GHMJ (Global Health Management Journal) Vol. 7 No. 1 (2024)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-71973

Abstract

Background: Cardiovascular diseases, including hypertension, pose significant health challenges globally. Physical activity has long been recognized as a modifiable factor that can influence various aspects of cardiovascular health, including blood pressure. However, the relationship between physical activity and blood pressure is complex and can be influenced by various factors such as cultural and regional differences. Aims: The primary objective of this research was to examine the association between physical activity and blood pressure using a quasi-experimental design. Methods: This study utilized a quasi-experimental design with a one-group pre-test post-test approach. The sample was selected using a total sampling technique. The independent and dependent variables in this research were physical activity and blood pressure. Data collection instruments employed in this study consisted of observation sheets, an aneroid sphygmomanometer, and a stethoscope. Data analysis was performed using the Wilcoxon test. Results: This study showed that there was an association between physical activity and blood pressure.     Conclusion: this research sheds light on the relationship between physical activity and blood pressure. The findings underscore the importance of considering cultural and regional factors in designing health interventions.   Received: 20 November 2023, Reviewed: 21 November 2023, Revised: 14 March 2024, Accepted: 03 April 2024.
Edukasi Bahaya Hepatitis Akut Di Unit Pelaksana Teknis Daerah Puskesmas Panarung Kota Palangka Raya Turnip, Oktaviani Naulita; Nawan; Hanasia; Praja, Rian Ka; Martani, Natalia Sri; Furtuna, Dewi Klarita
Jurnal Pengabdian Kampus Vol 10 No 2 (2023): Jurnal Pengabdian Kampus
Publisher : LPPM Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52850/jpmupr.v10i2.10875

Abstract

Hepatitis is a type of acute disease caused by a virus. Hepatitis virus itself is divided into several types, namely Hepatitis A, B, C, D, and E. The global prevalence of hepatitis is reported to be 2 billion patients in the world, 240 million people with chronic hepatitis B, followed by hepatitis C with 170 million patients. Every year, 1.5 million people die from hepatitis. Indonesia has the highest hepatitis B endemicity, making WHO set a global level evaluation of hepatitis control every two years. In early 2022, a case of hepatitis was found that was claimed to be acute hepatitis. The first case of acute hepatitis was reported in the United Kingdom and was designated as an Extraordinary Event in 2022. Cases of acute hepatitis spread to various countries in the world, including Indonesia. A total of 18 suspected cases of hepatitis were reported in North Sumatra, West Sumatra, Bangka Belitung Islands, DKI Jakarta, West Java, East Java, East Kalimantan, and DKI Jakarta. The main transmission of acute hepatitis is thought to be through body fluids, so the Ministry of Health has initiated procedures to prevent the transmission of acute hepatitis among the community, especially children. The low public understanding of the dangers of acute hepatitis makes us the UPR FK Microbiology team to provide understanding and education to the public regarding the dangers of hepatitis, handling, prevention and management of acute hepatitis if it occurs in the community.
The Role of Metformin on the Expression of Apoptosis-Related Caspase Family Members Praja, Rian Ka
Oceana Biomedicina Journal Vol 7 No 1 (2024): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v7i1.151

Abstract

Metformin is the main line drug in the treatment of type 2 diabetes mellitus. However, now metformin has been widely studied for its potential for the treatment of various diseases. Apoptosis is a programmed cell death mechanism mediated by various proteins from the caspase family. Furthermore, the apoptotic caspases are subdivided into the initiators (caspase-2, -8, -9, and -10) and the effectors (caspase-3, -6, and -7). Various studies have reported that metformin could induce apoptosis, while other studies have reported otherwise. This study aimed to reveal the role of metformin on the expression of caspase proteins associated with apoptosis. Bioinformatics analysis using STITCH v.5.0 was performed to predict the metformin-caspase interactions. The results showed that metformin could directly activate caspase3 and -7. However, at the same time, metformin could also inhibit the expression of caspase-3 and -8. Furthermore, metformin did not interact directly with caspases -2, -6, -9, and -10. Through this study, it can be concluded that metformin has dual roles (activation and inhibition) in the expression of apoptosisrelated caspase proteins.
Hubungan Rinitis Alergi Dengan Kejadian Sinusitis Di Rsud Dr Doris Sylvanus Toemon, Angeline Novia; Hasan, Muhamad Umar Muhtar; Jabal, Arif Rahman; Teresa, Astrid; Praja, Rian Ka
Media Kesehatan Politeknik Kesehatan Makassar Vol 19 No 1 (2024): Media Kesehatan
Publisher : Direktorat Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v19i1.402

Abstract

Sinusitis is an inflammation of the paranasal sinus mucosa and is one of the world's health problems and is often found in medical practice. The National Health Interview survey in 2012, found that 12% of the total sample of 34,525 adults experienced sinusitis. Allergic rhinitis is one of the factors causing sinusitis due to bacterial infection of the sinus tract due to blockage of the sinus ostium and mucus that cannot be drained due to allergic reactions. This study aims to analyze the relationship between allergic rhinitis and the incidence of sinusitis in patients at RSUD dr Doris Sylvanus Palangka Raya. This research is an analytical observational study with a cross section study design conducted at RSUD dr Doris Sylvanus Palangka Raya. The subjects in this study were patients with a history of allergic rhinitis and sinusitis for the period 2021-2023 who met the inclusion and exclusion criteria. There were 271 research samples where the statistical test showed a p value = 0.000 and OR = 0.092. Allergic rhinitis has an association with sinusitis and allergic rhinitis has a chance of developing sinusitis.
PELATIHAN DAN PENDAMPINGAN PRODUKSI TEPACHE BERPREBIOTIK SEBAGAI PRODUK OLAHAN BERNILAI TAMBAH Decenly, Decenly; Rosalina, Reny; Priyadi, Muhammad; Praja, Rian Ka; Saputra, Rizky Rachmad; Hermayantiningsih, Dwi; Dwijayanti, Rts. Sherly
JMM (Jurnal Masyarakat Mandiri) Vol 10, No 1 (2026): Februari
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v10i1.37108

Abstract

Abstrak: Kelompok tani di salah satu wilayah perkotaan Kalimantan Tengah menghadapi permasalahan rendahnya nilai jual nanas segar, khususnya buah berukuran kecil, akibat ketergantungan pada tengkulak dan minimnya pengolahan pascapanen. Kegiatan pengabdian ini bertujuan meningkatkan nilai tambah nanas melalui pengembangan produk Tepache berprobiotik sebagai minuman fermentasi fungsional. Kegiatan dilaksanakan kepada 20 orang anggota kelompok tani melalui tahapan penyuluhan, praktik pembuatan produk, pendampingan, dan evaluasi. Evaluasi keberhasilan dilakukan menggunakan metode pretest–posttest berbasis kuesioner untuk mengukur peningkatan pemahaman peserta. Hasil menunjukkan adanya peningkatan nilai rerata pemahaman dari 75 pada pretest menjadi 80 pada posttest. Selain itu, peserta mampu memproduksi Tepache berprebiotik secara mandiri serta memahami dasar pengemasan dan pemasaran produk. Kegiatan ini berkontribusi pada peningkatan kapasitas petani, penguatan ekonomi lokal, dan pemanfaatan sumber daya pertanian secara berkelanjutan.Abstract: Farmer groups in an urban area of Central Kalimantan face low market value of fresh pineapples, particularly small-sized fruits, due to dependence on middlemen and limited postharvest processing. This community service program aimed to increase pineapple value through the development of probiotic Tepache as a functional fermented beverage. The program involved 20 farmer group members and was conducted through counseling sessions, hands-on production practice, mentoring, and evaluation. Program effectiveness was assessed using a pretest–posttest questionnaire to measure participants’ knowledge improvement. The results showed an increase in the average score from 75 in the pretest to 80 in the posttest. Participants were able to independently produce probiotic Tepache and gained basic understanding of product packaging and marketing. Overall, this activity enhanced farmers’ capacity, supported local economic empowerment, and promoted sustainable utilization of agricultural resources.
Co-Authors Akmal, Rizqy Fajar Syaikhul Amanda, Nadia Keisha Angeline Novia Toemon, Angeline Novia Anggita Ratri Pusporini Anugerahny, Margaretha Yayu Indah Anwar, Muhammad Naufa Arif Rahman Jabal Arini Ratnasari Astrid Ekkelsia Saputri Astrid Ekklesia Saputri Auliazar, Tarra Austin Bertilova Carmelita, Austin Bertilova Balyas, Abi Bakring Bustomi, Qonita Sari Cereymo Ewaldo Cici Meriliyani Cici Meyriliani Sensia Cristin, Mery Enjelica Decenly, Decenly Dwi Putri Safnurbaiti Dwijayanti, Rts. Sherly Elsa Trinovita Estilia Ledyani Ewaldo, Cereymo Frethernety, Agnes Furtuna, Dewi Klarita Habib, Yusril Hanasia Hanasia, Hanasia Harianja, Henrigen Hartoyo, Riccardo Hasan, Muhamad Umar Muhtar Herlina Eka Shinta Hermayantiningsih, Dwi I Dewa Gede Sandhikarana I Dewa Made Sukrama I Wayan Muda Suta Arta I Wayan Suardana Jessica Elisabeth Suharis Kahanjak, Donna Novina Karamo, Beatrice Benita Komang Januartha Putra Pinatih Kurniawan, Mutiara Lauren Maretha Lavefolia, Raissa Amanda Ledyani, Estilia Lusi Ulina Simanungkalit Maretha, Lauren Marta Monika Simamora Mery Enjelica Cristin Muhammad Alif Muhammad Naufa Anwar Muhammad Ricko Fahrizal Nadia Keisha Amanda Nadia Kesiha Amanda Br Ginting Nadiah Romadhona Putri Nasywa Putri Rahmadina Natalia Sri Martani Nawan Nawan, Nawan Nazhifah, Annida Kholifatun Ni Nengah Dwi Fatmawati Ni Nengah Dwi Fatmawati Ni Nyoman Sri Yuliani Nuha, Alya Firyal Nur Khalifah Putri Utami Permatasari, Silvani Purba, Yohana Catherine Debyola Putri, Nadiah Romadhona Qonita Sari Bustomi Rahmadina, Nasywa Putri Raissa Amanda Lavefolia Ranintha br Surbakti Ranti, Dalia Reny Rosalina Reny Rosalina Reny Rosalina, Reny Riccardo Hartoyo Rizki Rachmad Saputra Rizqy Fajar Syaikhul Akmal Salsabila, Ivah Sandhikarana, I Dewa Gede Saputra, Rizky Rachmad Saputri, Astrid Ekklesia Sensia, Cici Meyriliani Simamora, Marta Monika Simanungkalit, Lusi Ulina Sintice Dhea Valerie Sri Martani, Natalia Suharis, Jessica Elisabeth Sulistina, Dinda Ananda Suma, Joy Angel Aria Tarra Auliazar Teresa, Astrid Trisia, Adelgrit Turnip, Oktaviani Naulita Utami, Nur Khalifah Putri Valerie, Sintice Dhea Wahyu Hidayati Widayati, Ratna Widhiyanto, Hendrykus Theo Damar Widiarti, Astri Yan Antonio Yohana Catherine Debyola Purba Ysrafil, Ysrafil Yusril Habib Zhofiroh, Nabilatul