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All Journal Universa Medicina Jurnal Media Analis Kesehatan Jurnal Kesehatan ISM (Intisari Sains Medis) : Jurnal Kedokteran YARSI Medical Journal Poltekita : Jurnal Ilmu Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Kesmas (Kesehatan Masyarakat) Khatulistiwa Cermin Dunia Kedokteran Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Ebers Papyrus Journal Of Health Science Community Strada Jurnal Ilmiah Kesehatan (SJIK)

Liong Boy Kurniawan, Liong Boy

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Author-ID : 511983

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Analisis rasio monosit terhadap High Density Lipoprotein (HDL) pada pasien Diabetes Melitus Tipe 2 (DM-2) dengan dan tanpa nefropati diabetik Yunita Rapa; Yuyun Widaningsih; Ani Kartini; Liong Boy Kurniawan
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Background: Diabetic nephropathy is one of the microvascular complications of type 2 diabetes mellitus (DM-2)—pathophysiology of diabetic nephropathy resulting from the interaction between hemodynamic and metabolic factors. High-Density Lipoprotein (HDL) functions as anti-atherosclerosis, protects the endothelium, and anti-inflammatory, whereas monocytes are associated with atherosclerosis and vascular inflammation. The HDL monocyte ratio is used as a marker of endothelial dysfunction and inflammation. This study aimed to determine the value of the HDL monocyte ratio in DM-2 patients with diabetic nephropathy and without diabetic nephropathy.Methods: This study was conducted at Dr. Wahidin Sudirohusodo, Makassar, by taking the medical record data of DM-2 patients treated in January 2018-June 2019. There were 86 DM-2 patients with diabetic nephropathy and 56 DM-2 patients without diabetic nephropathy who participated in this study. The statistical tests used were Chi-Square, Independent T test, and Mann Whitney test on SPSS version 17 for Windows.Results: The HDL monocyte ratio value was higher in type 2 diabetes mellitus with diabetic nephropathy than type 2 diabetes mellitus without diabetic nephropathy (35±56 vs. 23±24; p = 0.023). There was no significant difference in HDL cholesterol levels in the DM-2 patients' group with diabetic nephropathy and without diabetic nephropathy (p> 0.05), and so did the number of monocytes (p = 0.065). Based on the Youden index, a cutoff ratio of monocyte/HDL of 15.5 was chosen, which gave a sensitivity of 69% and a specificity of 55%.Conclusion: HDL monocyte ratio was significantly higher in type 2 DM patients with diabetic nephropathy than type 2 diabetes mellitus without diabetic nephropathy. The HDL monocyte ratio can be used as a marker of endothelial dysfunction and inflammation in diabetic nephropathy. Latar Belakang: Nefropati diabetik merupakan salah satu komplikasi mikrovaskuler diabetes melitus tipe 2 (DM Tipe 2). Patofisiologi nefropati diabetik sebagai akibat interaksi antara faktor hemodinamik dan metabolik. High Density Lipoprotein (HDL) berfungsi sebagai anti-aterosklerosis, melindungi endotel dan anti-inflamasi; sedangkan monosit berhubungan dengan aterosklerosis dan inflamasi vaskuler. Rasio monosit HDL digunakan sebagai penanda disfungsi endotel dan inflamasi. Tujuan penelitian ini adalah untuk engetahui nilai rasio monosit HDL pada pasien DM tipe 2 dengan nefropati diabetik dan tanpa nefropati diabetik.Metode: Penelitian ini dilaksanakan di RSUP Dr. Wahidin Sudirohusodo, Makassar dengan mengambil data rekam medis pasien DM tipe 2 yang dirawat pada bulan Januari 2018-Juni 2019. Terdapat 86 pasien DM tipe 2 dengan nefropati diabetik dan 56 pasien DM tipe 2 tanpa nefropati diabetik ikut serta dalam penelitian ini. Uji statistik yang digunakan adalah Chi Square, Independent T test dan uji Mann Whitney pada SPSS versi 17 untuk Windows.Hasil: Nilai rasio monosit HDL lebih tinggi pada DM tipe 2 dengan nefropati diabetik dibandingkan DM tipe 2 tanpa nefropati diabetik (35±56 vs 23±24, p=0,023). Tidak terdapat perbedaan bermakna kadar kolesterol HDL pada kelompok DM tipe 2 dengan nefropati diabetik dan tanpa nefropati diabetik (p>0,05) dan begitu juga pada jumlah monosit (p=0,065). Berdasarkan indeks Youden, dipilih cutoff rasio monosit/HDL sebesar 15,5 yang memberikan sensitivitas 69% dan spesifisitas 55%.Kesimpulan: Rasio monosit HDL lebih tinggi secara bermakna pada pasien DM tipe 2 dengan nefropati diabetik dibandingkan DM tipe 2 tanpa nefropati diabetik. Rasio monosit HDL dapat digunakan sebagai penanda disfungsi endotel dan inflamasi pada nefropati diabetik.

IL-6 Levels Analysis Controlled in Type 2 Diabetes Mellitus Patients and Uncontrolled Moonika Todingan; Rachmawati Muhiddin; Liong Boy Kurniawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 2 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i2.1972

Interleukin 6 (IL-6) is one of the pro-inflammatory cytokines responsible for inducing tissue-specific and/or systemic inflammation, which is a major contributor to the induction of inflammation of pancreatic islet cells. Inflammation of pancreatic cells causes impaired insulin secretion and Type 2 Diabetes Mellitus (T2DM). This study aims to determine the levels of IL-6 in T2DM patients with different levels of severity. A cross-sectional study of 46 subjects was performed with 21 in the controlled T2DM group and 25 in the uncontrolled T2DM group. Interleukin-6 levels were measured using the ELISA method. The statistical tests used were the Mann-Whitney test and the Spearman test. The test results were significant if the p-value <0.05. The level of IL-6 in uncontrolled T2DM was higher (64.00±77.65 pg/mL) than in controlled T2DM (31.25±11.04 pg/mL). Although the levels in both groups were different, the value was not statistically significant (p=0.120). There was no significant correlation found between HbA1c and IL-6 (p=0.125, r =0.230). Several experimental studies have shown that IL-6 inhibits glucose-stimulated insulin secretion from pancreatic islets in experimental animals. However, some of them revealed that acute exposure to IL-6 did not appear to affect pancreatic islet cell function, which is still controversial today. This study found a tendency of increased IL-6 in high-severity T2DM compared to low-severity T2DM although not statistically significant. Further studies with more clinically homogeneous samples are still needed.

Hypotestosterone in Male with Obesity Liong Boy Kurniawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1525

Obesity can be defined as the excess of body fat. The prevalence of obesity worldwide increases in the last decades andcauses a higher risk of cardiovascular diseases. Male subjects tend to develop visceral (abdominal) obesity, which producespro-inflammatory adipokines. Obesity in males is associated with low testosterone levels. Several mechanisms have beenproposed to explain the link between male obesity and hypotestosterone, including increased aromatization oftestosterone to form estradiol, suppressing the Hypothalamus-Pituitary (HPT) axis due to pro-inflammatory adipokines, anddecrease of Sex Hormone Binding Globulin (SHBG) production. Because hypotestosterone in males with obesity is afunctional but reversible condition, it is essential to screen testosterone levels in obese males for early intervention andtreatment.

Congenital Hypothyroidism: Incidence, Etiology and Laboratory Screening Liong Boy Kurniawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 3 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i3.1527

Congenital hypothyroidism is a condition resulting from a deficiency of thyroid hormone in newborns. Congenital hypothyroidism has no specific signs and symptoms at birth. It may lead to severe mental retardation and growth, and developmental disorders. Therefore, it is essential to perform newborn laboratory screening tests for prompt diagnosis and treatment to minimize the sequels. Laboratory screening tests are performed by taking prick blood from the heel of newborn and testing either TSH or T4 or both of them. Currently, the congenital hypothyroidism screening is not mandatory in Indonesia, but some multicentered screening programs have been performed. In Indonesia, a TSH level above 20 µU/mL is used as a cutoff that needs a confirmatory test using serum samples to confirm congenital hypothyroidism diagnosis. Once the diagnosis is established, prompt treatment and laboratory monitoring are needed for a better outcome.

Central Precocious Puberty in a Three-Year-Old Girl Suryani Jamal; Liong Boy Kurniawan; Suci Aprianti; Ratna Dewi Artati; Ruland DN Pakasi; R Satriono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 27 No. 3 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i3.1568

Precocious puberty is defined as the onset of secondary sexual characteristics before 8 years of age in girls and 9 years in boys. Central Precocious Puberty (CPP) is caused by early activation of the hypothalamic-pituitary-gonadal axis. Laboratory test of LH, FSH, and Estradiol is recommended for monitoring suppressive effects from GnRHa therapy in the early three months and every six months. This study aimed to report a case of CPP in a 3-year and 3-month-old girl. A 3-year and 3-month-old girl went to the hospital with vaginal bleeding (menstruation), breast development, and pubic and axilla hair for 7-month-old. Physical examination found moderately ill with obesity, body weight 20 kg, height 98 cm. Tanner stage was A2M3P2, café au lait was found in the left forehead with size 7x3.5 cm. In March 2015 before GnRHa therapy, LH, FSH and Estradiol level increased with levels of 4.32 mlU/mL, 6.01 mlU/mL, and 67 pg/mL, and after 3 months of the treatment was 0.87 mlU/mL, 2.51 mlU/mL and <20 pg/mL. Pelvic ultrasonography showed suggestive precocious puberty, bone age 5-year and 9-month (Greulich and Pyle), CT-Scan of the brain showed hypothalamic tumor suspected hypothalamic hamartoma. This patient was treated with a GnRHa injection every 4 weeks. Leuprorelin is a synthetic non-peptide analogue of natural GnRH. The diagnosis was based on medical history, physical examination, laboratory, and radiological findings. The prognosis of the patient was good.

Omentin-1 Levels in Obesity Putri Hidayasyah Purnama Lestari; Nurahmi Nurahmi; Tenri Esa; Liong Boy Kurniawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 1 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i1.1737

Omentin-1 is an anti-inflammatory adipokine secreted by stromal vascular cells. Inflammation and apoptosis of adipocyte tissue in obesity lead to decreased production of omentin-1. This study aims to find the difference in omentin-1 levels in the obese and non-obese groups and the correlation between levels of omentin-1 with BMI and waist circumference. This study was a cross-sectional study involving 70 subjects with 37 people in the obese group and 33 people in the non-obese group. Anthropometric data including weight, height, waist circumference, and BMI were measured. Serum omentin-1 levels were measured by ELISA. The statistical tests used were Chi-square, T-test, Mann-Whitney test, and Spearman test. Test results were significant if p-value < 0.05. Significant difference was observed in serum omentin-1 levels between obese and non-obese group (median 140,31 range (88.08 – 382.76) vs. 210,97 range (124,44–577,96) ng/mL), respectively; p < 0.001). Serum omentin-1 correlated negatively with BMI (p=0.001, r = - 0.398) and waist circumference (p=0.017, r = - 0.286). Obesity causes inflammation and increased death of adipocyte tissues due to apoptosis, autophagy, and fibrosis resulting in decreased production of omentin-1 by stromal vascular cells. Anthropometric parameters of waist circumference and BMI describe the distribution of adipocyte tissue and affect the secretion of omentin-1. Omentin-1 levels in the obese group were lower than in the non-obese group. The higher the BMI and waist circumference, the lower the omentin-1 level.

Analysis of Neutrophil Gelatinase-Associated Lipocalin in Type 2 Diabetes Mellitus Patients Yunita Rapa'; Liong Boy Kurniawan; Asvin Nurulita; Fitriani Mangarengi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 28 No. 2 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v28i2.1807

Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a small protein with a molecular weight of 21 kDa, belongs to the lipocalin protein family and functions as a growth factor and differentiation of various cell types such as renal tubular epithelial cells. This aim of study was to determine the level of NGAL in controlled and uncontrolled type 2 Diabetes Mellitus (DM) patients. This study was a cross sectional study involving 70 type 2 DM patients with 30 patients with controlled type 2 DM and 40 uncontrolled type 2 DM groups. HbA1c, urea, creatinine, and urinalysis data were measured. NGAL level was measured using the ELISA method. The statistical tests used were Chi-Square, unpaired T test, Mann-Whitney test and Spearman test. The test result is significant if the p-value <0.05. NGAL normally found in the circulation will be filtered by the glomerulus and reabsorbed by the epithelial cells of the proximal renal tubule. Increased levels of NGAL can be found 2-6 hours in the blood and urine after injury to the kidneys. Excretion of NGAL in blood occurs when there is damage to the epithelial cells of the proximal tubule of the kidney. There was a significant difference in NGAL levels in the controlled and uncontrolled groups of type 2 DM patients. Positive correlation indicates that the higher the HbA1c and creatinine levels, the higher the NGAL level. There was a significant difference in NGAL levels in the controlled and uncontrolled type 2 DM groups (25.09 ± 6.83 vs 112.54 ± 170.38 ng / mL, with p value <0.001). There was a positive correlation between NGAL and HbA1c levels with p value <0.001, r =0.507 and creatinine levels with p value <0.001, r =0.769. NGAL normally found in the circulation will be filtered by the glomerulus and reabsorbed by the epithelial cells of the proximal renal tubule. Increased levels of NGAL can be found 2-6 hours in the blood and urine after injury to the kidneys. Excretion of NGAL in blood occurs when there is damage to the epithelial cells of the proximal tubule of the kidney. There was a significant difference in NGAL levels in the controlled and uncontrolled groups of type 2 DM patients. Positive correlation indicates that the higher the HbA1c and creatinine levels, the higher the NGAL level.

Analisis Kadar Hemoglobin Terhadap Mortalitas Pasien Infark Miokard Akut Selama Perawatan Liong Boy Kurniawan; Uleng Bahrun; Darmawaty Rauf; Mansyur Arif
Ebers Papyrus Vol. 20 No. 1 (2014): EBERS PAPYRUS
Publisher : Medical Faculty Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar

Pemeriksaan darah rutin merupakan tes yang umum diperiksa pada pasien yang dirawat di rumah sakit. Sebagian pasien infark miokard akut mengalami anemia dan berpotensi menyebabkan peningkatan mortalitas selama perawatan. Penelitian in bertujuan untuk mengetahui kadar hemoglobin pada pasien infark miokard akut saat masuk rumah sakit dan menilai pengaruhnya terhadap mortalitas pasien selama perawatan di rumah sakit. Penelitian ini merupakan studi potong silang dengan mengambil data sekunder dari rekam medik 81 pasien infark miokard akut yang dirawat di Unit Perawatan Jantung Intensif Rumah Sakit Dr. Wahidin Sudirohusodo Makassar periode Juli 2010 hingga Juni 2011. Kadar hemoglobin yang diteliti diperoleh saat pasien masuk rumah sakit dan diklasifikasikan sebagai anemia,hemoglobin normal dan polisitemia. Uji statistik dilakukan dengan Uji {Student T} dan Mann Whitney. Rerata kadar hemoglobin pada penderita infark miokard akut yang survive dan meninggal selama perawatan adalah 14,13±1,73 g/ddl an 13,59±2,59 g/d(lp=0,269). Risiko mortalitas pada pasien dengan anemia sebesar 2,96 kali dibandingkan dengan kadar hemoglobin normal (interval kepercayaan 95%, 0,71-12,25; p=0,144) dan pasien dengan polisitemia sebesar 2,37 kali dibandingkan dengan kadar hemoglobin normal (interval kepercayaan 95%,0,54-10,47; p=0,257). Pasien infark miokard akut yang disertai dengan anemia atau polisitemia memiliki kecenderungan mortalitas yang lebih tinggi dibandingkan dengan kadar hemoglobin yang normal.

Analysis of the Relationship between Serum Magnesium Levels and Severity of COVID-19 Patients Muyadhil Nurindar; Ruland DN. Pakasi; Liong Boy Kurniawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 3 (2023)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i3.2045

Magnesium (Mg) plays an important role in the homeostasis functions of the lungs and heart for humankind. However, there is limited information concerning the importance of such an electrolyte mineral to COVID-19 pathogenesis. The Mg level is not primarily considered for the analysis of infectious diseases in the laboratory. The purpose of this study was to analyze the relationship between Mg levels and COVID-19 patient severity at Dr. Wahidin Sudirohusodo Hospital, Makassar. This research was a retrospective study with a cross-sectional design. Samples were prepared from 186 patients. Serum Mg levels were measured using an ABX Pentra 400C analyzer and the patients diagnosed with COVID-19 were then classified into abnormal and normal magnesemia. Based on the severity of COVID-19, patients were then categorized into severe and non-severe. The obtained data were then statistically analyzed using the Kolmogorov-Smirnov test, Mann-Whitney test, Chi-Square, and odd ratio with a significant level of p <0.05. The mean values of serum Mg levels of severe COVID-19 patients (2.53±2.03 mg/dL) were not significantly different compared to those of non-severe COVID-19 patients (2.12±0.83 mg/dL) with p=0.712. Patients with abnormal magnesemia had a 2.625 times higher risk of severe COVID-19 (95% CI = 1.499 – 4.757, p-value=0.001) compared to those with normal magnesemia. There was a significant relationship between serum Mg levels and the severity of COVID-19 patients at Dr. Wahidin Sudirohusodo Hospital. Patients with abnormal Mg levels had a 2.625 times higher risk of severe COVID-19. Magnesium concentration is an important parameter, which must be monitored in the laboratory analyses of COVID-19 patients.

Hubungan Rasio APO-B/APOA-I dengan Index Massa Tubuh Megawati, Megawati; Kurniawan, Liong Boy; Bahrun, Uleng
Jurnal Kesehatan Vol 13 No 1 (2022): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v13i1.2686

Body Mass Index (BMI) is a simple way to monitor weight. Overweight as a result of excessive body fat accumulation which is characterized by a decrease in HDL (High-Density Lipoprotein), namely the atherogenic side represented by levels of Apolipoprotein AI (ApoA-I), increased triglycerides (TG), VLDL (Very Low-Density Lipoprotein). ), LDL (Low-Density Lipoprotein), and Total Cholesterol which is the anti-atherogenic side represented by the levels of Apolipoprotein B (Apo-B). If we measure both Apo-B and ApoA-I and express them as the Apo-B/ApoA-I ratio, we get a strong marker of cardiovascular risk. By combining the two markers in the ratio, we get synergies and increase predictive power. This study aims to analyze the levels of Apo-B, ApoA-I, and the ratio of Apo-B/ApoA-I to BMI. An experimental study with a cross-sectional design using 72 subjects during April 2021. Apo-B and ApoA-I were examined using the Cobas c311/501 instrument with the immunoturbidimetric test method. The results of this study showed a significant relationship between Apo-B levels and BMI, while ApoA-I levels and Apo-B/ApoA-I ratios did not have a significant relationship. In conclusion, there is no relationship between BMI and the ApoB/ApoA-I ratio in male and female subjects.

Co-Authors Adnan, Endy Afandi, Ichlas Nanang Aminuddin Aminuddin Anaam, Andi Khairul Andi Alfian Zainuddin Andi Munawirah Ani Kartini Arif Santoso Ariyandy, Andi Asvin Nurulita Asvin Nurulita Basri, Muhammad Iqbal Chika Pratiwi Darmawati E R Darmawaty ER Darmawaty ER, Darmawaty Darmawaty Rauf Darwati Muhadi Darwati Muhadi Esa, Tenri Fadillah, Ismirayanti Fitriani Mangarengi Fitriani Mangarengi FITRIANI MANGARENGI, FITRIANI Fitry Hamka Gustamin Gustamin Habibah S. Muhiddin Hardyansa Hasna, Hasna IRFAN IDRIS Kasimat, Maria Magdalena Mansyur Arif Mansyur Arif Mansyur Arif Mansyur Arif Mansyur Arif Martina Rentauli Megawati - Moonika Todingan Muh Taufiq Muh Taufiq Muhammad Fachrul Hidayat Mulyamin, Winda Mustakin Mustakin Mutiah Dwi Humairah Muyadhil Nurindar Nadhifah, Naurah Nurahmi Nurahmi Nurahmi Nurahmi Nurahmi Nurahmi Nurahmi Nurahmi Nurahmi Nurahmi, Nurahmi Nurhayana Sennang Nurhayana Sennang, Nurhayana Nuril Sofiantin Oktarina, Nur Hasni Pratiwi, Chika Putri Hidayasyah Purnama Lestari Putri Hidayasyah Purnama Lestari R Satriono Rachmawati Muhiddin Rafiah, Sitti Ratna Dewi Artati Rauf, Darmawaty Ruland DN Pakasi Ruland DN Pakasi Ruland DN Pakasi Ruland DN. Pakasi Samad , Raehana Sheridan, Sabilla Sri Anita Suci Aprianti suci aprianti sukmawaty - Surur, Andi Ainun Zulkiah Suryani Jamal Syafaat, Andi Wali Tenri Esa Uleng Bahrun Uleng Bahrun Uleng Bahrun Uleng Bahrun, Uleng Wali Syafaat, Andi Wandani Syahrir Widaningsih, Yuyun Yunita Rapa Yunita Rapa' Yunita Rapa' Yustisia, Ika Yuyun Widaningsih

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