Article Per Year (5 Year)
p-Index From 2020 - 2025
4.689
P-Index
This Author published in this journals
All Journal Universa Medicina Jurnal Media Analis Kesehatan Jurnal Kesehatan ISM (Intisari Sains Medis) : Jurnal Kedokteran YARSI Medical Journal Poltekita : Jurnal Ilmu Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Kesmas (Kesehatan Masyarakat) Khatulistiwa Cermin Dunia Kedokteran Ebers Papyrus Journal Of Health Science Community Strada Jurnal Ilmiah Kesehatan (SJIK)
Liong Boy Kurniawan, Liong Boy
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 59 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 59 Documents
Search

 2   3   4   5   6 
CREATINE KINASE RELATED TO THE MORTALITY IN MYOCARDIAL INFARCTION (Creatine Kinase terhadap Angka Kematian di Infark Miokard) Liong Boy Kurniawan; Uleng Bahrun; Darmawaty Rauf; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 1 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i1.1178

Abstract

Creatine Kinase (CK) merupakan salah satu uji yang sering diperiksakan untuk mendiagnosis infark miokard akut. Peningkatanenzim ini menunjukkan ada nekrosis sel otot meskipun tidak khas di otot jantung. Kenaikan tingkat CK di infark miokard akutmenggambarkan luas serta beratnya penyakit dan dihubungkan dengan peningkatan angka kematian pasien. Untuk mengetahui tingkatCK di pasien infark miokard akut saat masuk rumah sakit dan menilai pengaruhnya terhadap angka kematian pasien selama perawatandi rumah sakit. Penelitian ini merupakan kajian potong lintang dengan mengambil data sekunder dari rekam medik 62 pasien infarkmiokard akut yang dirawat di Unit Perawatan Jantung Intensif Rumah Sakit Dr. Wahidin Sudirohusodo Makassar masa waktu bulanJuli 2010 hingga Juni 2011. Kadar CK yang diteliti diperoleh saat pasien masuk rumah sakit. Uji statistic dilakukan dengan uji MannWhitney, T Test dan Chi-Kuadrat. Rerata kadar CK di pasien infark miokard akut yang tetap hidup dan meninggal selama perawatanadalah 507,38+749,62 U/L dan 1995,39+2290,06 U/L (p=0,002). Perbedaan tingkat angka kematian yang bermakna ditemukanantar kuartil CK (p=0,021). Kebahayaan relatif angka kematian pada kuartil keempat (4) sebesar 13 kali dibandingkan dengan kuartilkesatu (1) (selang kepercayaan 95%, 2,07-81,5; p=0,006), kuartil ketiga (3) sebesar 4,8 kali dibandingkan dengan kuartil kesatu (1)(selang kepercayaan 95%, 1,07-21,45; p=0,04) dan kuartil kedua (2) sebesar 3 kali dibandingkan dengan kuartil kesatu (1) (selangkepercayaan 95%, 0,68-13,3; p=0,148).Didasari telitian ini, ditemukan perbedaan bermakna kadar CK ditemukan saat masuk rumahsakit di pasien infark miokard akut yang tetap hidup maupun yang meninggal selama perawatan. Semakin tinggi kadar CK saat pasienmasuk rumah sakit semakin tinggi tingkat angka kematiannya.
VERY SEVERE HYPERTRIGLYCERIDEMIA IN SUSPECTED FAMILIAL CHYLOMICRONEMIA INFANT Fitry Hamka; Liong Boy Kurniawan; Suci Aprianti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1165

Abstract

Seorang bayi perempuan berusia 6 bulan, masuk rumah sakit dengan keluhan utama muntah dialami sejak satu hari sebelummasuk rumah sakit dengan kekerapan lebih dari sepuluh kali dalam sehari dan demam dialami sejak 6 jam sebelum masuk rumah sakit.Pasien ini lahir prematur secara sectio secarea dengan berat badan lahir 1,5 kg. Serum pasien lipemik seperti susu. Kadar kolesterol totalserum pasien 477 mg/dL, trigliserida 4370 mg/dL (hipertrigliseridemia sangat berat), LDL direk 135 mg/dL, HDL 5 mg/dL dan kadarhemoglobinnya 8,0 gr/dL. Pasien ini mendapatkan cairan intravena, antibiotik dan transfusi darah akibat anemia yang diderita. Dikasus ini, hipertrigliseridemia sangat berat diduga terkait dengan kilomikronemia familial. Penapisan profil lipid dari orang tua bayidan keluarga lainnya sangat penting dilakukan untuk menegakkan diagnosis.
Hypotestosterone in Male with Obesity Liong Boy Kurniawan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 27, No 2 (2021)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v27i2.1525

Abstract

Obesity can be defined as the excess of body fat. The prevalence of obesity worldwide increases in the last decades andcauses a higher risk of cardiovascular diseases. Male subjects tend to develop visceral (abdominal) obesity, which producespro-inflammatory adipokines. Obesity in males is associated with low testosterone levels. Several mechanisms have beenproposed to explain the link between male obesity and hypotestosterone, including increased aromatization oftestosterone to form estradiol, suppressing the Hypothalamus-Pituitary (HPT) axis due to pro-inflammatory adipokines, anddecrease of Sex Hormone Binding Globulin (SHBG) production. Because hypotestosterone in males with obesity is afunctional but reversible condition, it is essential to screen testosterone levels in obese males for early intervention andtreatment.
ANALYSIS OF DECREASED GLUCOSE LEVEL IN STORED SAMPLES CORRELATED TO SERUM SEPARATION AND TEMPERATURE STORAGE Gustamin Gustamin; Liong Boy Kurniawan; Ruland DN Pakasi
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 1 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i1.1157

Abstract

Glukosa darah merupakan uji yang rutin untuk menilai bahaya penyakit diabetes melitus. Masalah utama yang dihadapi rumahsakit di daerah adalah sering terjadinya penundaan terhadap pemeriksaan glukosa darah, sehingga terjadi penurunan kadar glukosaakibat glikolisis. Penelitian ini bertujuan untuk mengetahui penurunan kadar glukosa darah berdasarkan suhu penyimpanan danpemisahan serum. Penelitian ini merupakan penelitian observasional dengan pendekatan kohort kajian yang dilakukan di RS Dr. WahidinSudirohusodo masa waktu Agustus 2016. Kadar glukosa diukur dengan menggunakan ABX-Pentra 400. Data yang didapat dianalisismenggunakan uji statistik Shapiro wilk dan wilcoxon. Hasil penelitian didapat dari 22 sampel darah lengkap dengan perlakuan berbedaberdasarkan suhu penyimpanan dan pemisahan serum. Hasil menunjukkan perbedaan bermakna antara glukosa serum dengan bekuanyang disimpan selama 2 jam pada suhu ruang yang mengalami penurunan sebesar 9,32 mg/dL jika dibandingkan dengan penyimpananselama 2 jam pada suhu freezer yaitu sebesar 0,8 mg/dL (p=0,000) dan jika dibandingkan dengan serum pada suhu ruang selama 2jam sebesar 1,38 mg/dL (p=0,000). Sampel untuk pemeriksaan glukosa yang tertunda sebaiknya dilakukan pemisahan antara serumdan bekuan eritrosit agar tidak terjadi penurunan glukosa.
ANALISIS HUBUNGAN KADAR KIDNEY INJURY MOLECULE -1 (KIM-1) DENGAN LAJU FILTRASI GLOMERULUS PADA PASIEN DIABETES MELITUS TIPE 2 Mutiah Dwi Humairah; Uleng Bahrun; Liong Boy Kurniawan
Jurnal Media Analis Kesehatan Vol 12, No 2 (2021): JURNAL MEDIA ANALIS KESEHATAN
Publisher : Poltekkes Kemenkes Pakassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mak.v12i2.2436

Abstract

Diabetes melitus type 2 (DM Type 2) is a disorder characterized by an increase in blood glucose and has become a world health problem due to high rates of morbidity and mortality. Complications of DM occur because glucose levels in the blood are not well controlled, one of which is diabetic nephropathy due to glomerular damage. Renal function monitoring is usually increased in patients with kidney damage, so KIM-1 plays a role in the development of interstitial fibrosis in kidney disease and can be used to indicate early kidney damage as in several studies that have shown the role of KIM-1 as a tubular biomarker in cases of DM. This study aims to analyze the relationship between levels of Kidney Injury Molecule – 1 (KIM-1) with Glomerular Filtration Rate (GFR) in patients with type 2 Diabetes melitus. The data in this study used 60 subjects consisting of 43.33% male and 56.67 % are female. KIM-1 levels were checked using the ELISA method. The results of this study showed that the mean GFR was 103.82 ml/min/1.73m2 and the average KIM-1 level was 1.887 ng/mL. Statistically, it shows that there is a strong correlation in a negative direction between the GFR and KIM-1 variables (r=-0.657 p=<0.001), the higher the GFR value, the lower the KIM-1 value, and vice versa. The conclusion shows that there is a relationship between Kidney Injury Molecule-1 levels and Glomerulus Filtration Rate in type 2 Diabetes melitus patients
Hasil Positif Palsu Tes Morfin pada Skrining Urin Narkoba Diduga Akibat Rifampisin Liong Boy Kurniawan; Yuyun Widaningsih; Nurhayana Sennang; Uleng Bahrun; Mansyur Arif
Cermin Dunia Kedokteran Vol 42, No 1 (2015): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i1.1054

Abstract

Hasil positif palsu pada tes skrining urin narkoba dengan metode imunologi jarang terjadi. Pemastian hasil memerlukan anamnesis yang baik mengenai konsumsi obat dan konfirmasi dengan tes yang lebih spesifik, biasanya dengan metode kromatografi gas/spektrometri massa. Beberapa substansi dilaporkan dapat menyebabkan hasil positif palsu. Dilaporkan satu kasus laki-laki 18 tahun dengan hasil positif morfin (tes urin narkoba) menggunakan metode imunologi kompetitif. Setelah anamnesis ketat diketahui bahwa pasien tersebut dalam pengobatan rifampisin selama 6 bulan karena tuberkulosis dan tidak pernah mengkonsumsi narkoba. Sampel urin berwarna kemerahan (hasil ekskresi metabolit rifampisin melalui urin). Diperlukan konfirmasi pasti dengan metode lebih spesifik dengan kromatografi gas/spektrometri massa (standar baku emas).False positive reports on urine drug screening using immunoassay method are rare. Confirmation should be done through detailed anamneses on consumed drugs that may interfere result and perform test with more specific method such as gas chromatography/mass spectrometry (GC-MS). Some substances have been reported as the causes of false positive test. A case reported to have positive on morphine urine drug test using competitive immunoassay from an 18 year-old male. The patient was on 6-month rifampicin treatment for tuberculosis and had no history of substance abuse. The urine sample was reddish due to rifampicin metabolite excretion. Confirmation with gas chromatography/mass spectrometry method should be performed as gold standard.
Patofisiologi, Skrining dan Diagnosis Laboratorium Diabetes Melitus Gestasional Liong Boy Kurniawan
Cermin Dunia Kedokteran Vol 43, No 11 (2016): Kesehatan Ibu - Anak
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v43i11.884

Abstract

Diabetes melitus gestasional (DMG) adalah gangguan toleransi glukosa yang pertama kali ditemukan pada saat kehamilan. Prevalensi DMG 7% hingga 11,6% di seluruh dunia dengan insidens lebih tinggi pada turunan Asia dan kepulauan Pasifik, insidens meningkat seiring meningkatnya kasus obesitas. Mayoritas penderita DMG mengalami disfungsi sel β akibat resistensi insulin kronik sebelum kehamilan, biasanya karena obesitas. Gangguan postreseptor pensinyalan insulin diduga sebagai penyebab DMG. Skrining dan diagnosis DMG dilakukan pada usia kehamilan 24-28 minggu dengan metode one-step atau two-step strategy. Penegakan diagnosis dan penatalaksaan DMG penting untuk mengurangi komplikasi maternal dan janin.Gestational diabetes mellitus is glucose intolerance found initially in pregnancy. Prevalence of gestational diabetes mellitus varies from 7% to 11.6% across the world with higher incidence in Asia and Pacific island, the incidence increases along with increase of obesity incidence. Majority of gestational diabetes mellitus patients have β cell dysfunction as the result of chronic insulin resistance developing before pregnancy, mostly due to obesity. Some studies reported post receptor disorder in insulin signaling as major finding in gestational diabetes mellitus. Screening and diagnosis between 24 and 28 weeks of gestational age are needed to confirm diagnosis using one-step or two-step strategy. Diagnosis and treatment are needed to reduce maternal and fetal complications.
Peran Anti Mullerian Hormone pada Penilaian Kapasitas Reproduksi Wanita Liong Boy Kurniawan
Cermin Dunia Kedokteran Vol 44, No 5 (2017): Gastrointestinal
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v44i5.795

Abstract

Unit fungsional ovarium pada manusia adalah folikel ovarium. Jumlah folikel pada pool folikel primordial merupakan faktor penentu penting lamanya usia reproduksi pada wanita. Kadar Anti Mullerian Hormone (AMH) serum secara esensial merefleksikan cadangan folikuler ovarium dan menjadi tidak terdeteksi pada saat menopause. Variasi kadar AMH sepanjang siklus menstruasi tidak berbeda signifikan sehingga pemeriksaan dapat dilakukan kapan saja. Pemeriksaan AMH plasma pada wanita subur digunakan untuk menilai cadangan ovarium dan dapat digunakan sebagai tes skrining status fertilitas wanita yang ingin memiliki anak pada usia di atas 35 tahun.Ovarian follicle is the functional unit of ovaries. The quantity of follicles in primordial follicle pool is important determinant of woman’s reproduction capacity. The serum Anti Mullerian Hormone (AMH) level essentially reflects ovarian follicular reserve capacity and become undetectable after menopause. AMH level does not vary significantly during menstruation cycle. AMH level in fertile woman refers to ovarian reserve capacity and can be used to measure fertility status of women above 35 years old who want to become pregnant.
Interferensi sampel lipemik pada bayi dengan lipemia retinalis dikarenakan primary mixed hyperlipidemia: laporan kasus Andi Munawirah; Habibah S. Muhiddin; Liong Boy Kurniawan; Ruland DN Pakasi
Intisari Sains Medis Vol. 10 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (383.855 KB) | DOI: 10.15562/ism.v10i2.370

Abstract

Background: Interference is a condition of which sample components cause an error in the analyte measurement in the analyzer.  The most common cause of interference is lipemic sample. Lipemic sample is characterized by turbidity of the serum or plasma caused by an accumulation of lipoprotein particles. Primary mixed hyperlipidemia (PMH) is a cause of primary hypertrigliseridemia with lipemia manifestation.Case report: A three month-old baby boy was admitted to a hospital, having white spots in his black eyes. The spots were seen clearer at light exposure, and ophthalmologic examination indicated lipemia retinalis. Patient’s sample was lipemic and its laboratory analysis resulted in as follow: WBC 13.103/μL, Hb 15.6 gr/dL, RBC 2.99 106/μL, triglyserida 10.435 mg/dL, total cholesterol 631 mg/dL, HDL 12 mg/dL, LDL 195 mg/dL, and apoprotein B 196 mg/dL. Due to a significant interference, SGOT, SGPT, ureum and creatinin were not obtained. Immunologic serum analysis of the patient and his mother showed an increasing of antibody IgG CMV: 28 dan 20 IU/ml, respectively.Conclusion: Lipemic samples could directly affect most of laboratory examination methods. Laboratory results with such lipemia interferences shoud be interpretated critically and accurately to produce precise diagnosis, and in turn, monitoring of patient with lipemia.
Analisis rasio profil lipid kolesterol total, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), dan trigliserida pada pasien Diabetes Melitus Tipe 2 (DM-2) dengan dan tanpa komplikasi ulkus kaki diabetik Putri Hidayasyah Purnama Lestari; Nurahmi Nurahmi; Tenri Esa; Liong Boy Kurniawan
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (504.595 KB) | DOI: 10.15562/ism.v11i3.764

Abstract

Background: One of the serious macrovascular complications in type 2 diabetes mellitus is a diabetic foot ulcer. Besides causing chronic complications of diabetes, poor glycemic control can also cause dyslipidemia, which plays a role in diabetic foot ulcers' pathophysiology. The ratio of total cholesterol/HDL cholesterol, LDL cholesterol/HDL cholesterol, and triglyceride/HDL ratio play a role in the pathophysiology of endothelial dysfunction closely related to diabetic foot ulcers.Methods: A retrospective study was performed at the DR. Wahidin Sudirohusodo Hospital, Makassar, by taking secondary data from type 2 DM patient medical records from January 2018 to September 2019. The study sample consisted of forty-seven patients with diabetic foot ulcer complications and 50 patients without diabetic foot ulcers. Chi-Square, Independent T test, and Mann-Whitney test were used as statistical analysis by SPSS version 17 for Windows.Results: Total cholesterol to HDL ratio and LDL to HDL ratio are significantly greater in type 2 DM patients with diabetic foot ulcer compare to those without diabetic foot ulcers (7.70±6.62 vs. 5.21±1.55, p=0.040 and 4.93±4.75 vs. 3.21±1.16, p=0.014, respectively). There is no significant difference in triglycerides to HDL ratio in type 2 DM with and without diabetic foot ulcers (7.73±8.82 vs. 4.43±3.44, p=0.053). Receiver Operating Curve (ROC) analysis has found cut-off of Total Cholesterol to HDL ratio is 7.13 and LDL to HDL ratio is 3.58.Conclusion: Total cholesterol to HDL ratio and LDL to HDL ratio are show more relationship with diabetic foot ulcer events.  Latar Belakang: Komplikasi makrovaskuler yang serius dari dari diabetes melitus tipe 2 salah satunya adalah ulkus kaki diabetik. Kontrol glikemik yang buruk, selain dapat menyebabkan komplikasi kronik dari diabetes, juga dapat menyebabkan dislipidemia yang berperan dalam patofisiologi terjadinya ulkus kaki diabetik. Rasio kolesterol total/kolesterol HDL, kolesterol LDL/kolesterol HDL, dan rasio trigliserida/HDL berperan dalam patofisiologi disfungsi endotel yang erat kaitannya dengan komplikasi ulkus kaki diabetik.Metode: Penelitian retrosepektif ini dilakukan pada Rumah Sakit DR. Wahidin Sudirohusodo Makassar dengan mengambil data rekam medis pasien diabetes melitus tipe 2 periode Januari 2018 sampai September 2019. Sampel penelitian terdiri dari empat puluh tujuh pasien diabetes melitus dengan komplikasi ulkus kaki diabetik dan lima puluh pasien tanpa komplikasi ulkus kaki diabetik. Uji statistik yang digunakan adalah Chi Square, uji T tidak berpasangan, dan uji Mann-Whitney dengan SPSS versi 17 untuk Windows.Hasil: Rasio kolesterol total/HDL dan LDL/HDL berturut-turut lebih besar pada pasien DM tipe 2 dengan ulkus kaki diabetik dibandingkan tanpa ulkus kaki diabetik (7,70±6,62 vs 5,21±1,55, p = 0,040 dan 4,93±4,75 vs 3,21±1,16, p=0,014). Tidak terdapat perbedaan bermakna rasio trigliserida/HDL pasien DM tipe 2 dengan ulkus kaki diabetik (7,73±8,82 vs 4,43±3,44, p=0,053). Menurut analisis Receiver Operating Curve (ROC) cutoff rasio kolesterol total/HDL sebesar 7,13 sedangkan untuk rasio LDL/HDL dipilih cutoff 3,58.Kesimpulan: Rasio Kolesterol total/HDL dan rasio LDL/HDL menunjukkan hubungan dengan kejadian ulkus kaki diabetik.
Co-Authors Adnan, Endy Afandi, Ichlas Nanang Aminuddin Aminuddin Andi Munawirah Ani Kartini Arif Santoso Ariyandy, Andi Asvin Nurulita Asvin Nurulita Basri, Muhammad Iqbal Chika Pratiwi Darmawati E R Darmawaty ER Darmawaty ER, Darmawaty Darmawaty Rauf Darwati Muhadi Darwati Muhadi Esa, Tenri Fadillah, Ismirayanti Fitriani Mangarengi Fitriani Mangarengi FITRIANI MANGARENGI, FITRIANI Fitry Hamka Gustamin Gustamin Habibah S. Muhiddin Hardyansa Hasna, Hasna IRFAN IDRIS Kasimat, Maria Magdalena Mansyur Arif Mansyur Arif Mansyur Arif Mansyur Arif Mansyur Arif Martina Rentauli Megawati - Moonika Todingan Muh Taufiq Muh Taufiq Muhammad Fachrul Hidayat Mulyamin, Winda Mustakin Mustakin Mutiah Dwi Humairah Muyadhil Nurindar Nadhifah, Naurah Nurahmi Nurahmi Nurahmi Nurahmi Nurahmi Nurahmi Nurahmi Nurahmi Nurahmi Nurahmi, Nurahmi Nurhayana Sennang Nurhayana Sennang, Nurhayana Nuril Sofiantin Oktarina, Nur Hasni Pratiwi, Chika Putri Hidayasyah Purnama Lestari Putri Hidayasyah Purnama Lestari R Satriono Rachmawati Muhiddin Ratna Dewi Artati Rauf, Darmawaty Ruland DN Pakasi Ruland DN Pakasi Ruland DN Pakasi Ruland DN. Pakasi Samad , Raehana Sheridan, Sabilla Sri Anita Suci Aprianti suci aprianti sukmawaty - Surur, Andi Ainun Zulkiah Suryani Jamal Syafaat, Andi Wali Tenri Esa Uleng Bahrun Uleng Bahrun Uleng Bahrun Uleng Bahrun, Uleng Wali Syafaat, Andi Wandani Syahrir Widaningsih, Yuyun Yunita Rapa Yunita Rapa&#039; Yunita Rapa' Yustisia, Ika Yuyun Widaningsih