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All Journal Jurnal Kesehatan Andalas Majalah Obat Tradisional Sari Pediatri Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Biologi Tropis Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Health and Medical Journal Andalas obstetrics and gynecology journal Indonesian Journal of Global Health research Jurnal Kebidanan Indonesia Jurnal EduHealth Mandala of Health : A Scientific Journal Innovative: Journal Of Social Science Research Madani: Multidisciplinary Scientific Journal Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Malahayati International Journal of Nursing and Health Science
Hirowati Ali, Hirowati
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Efficacy of Autologous Platelet-Rich Plasma (PRP) on Perineal Wound Healing: A Controlled Non-Randomized Clinical Trial. Fadli, Muhammad; Utama, Bobby Indra; Ali, Hirowati
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.153-162.2026

Abstract

Introduction: Perineal wounds are a very common complication of vaginal birth. Perineal trauma associated with childbirth is defined as damage to the skin, perineal muscles, as well as the sphincter and anal epithelium complex. This study aims to determine the effect of PRP use on perineal wounds.  Method: A single-center, controlled, non-randomized, non-blinded clinical trial was designed in patients with perineal wounds after vaginal delivery. PRP was taken from each patient's serum (autologous). Perineal wound healing after intervention was assessed using the Redness, Oedema, Ecchymosis, Discharge, Approximation (REEDA) scale. Perineal wound pain was assessed using the Visual Analog Scale (VAS). Result: The current study involved 56 samples, 28 people per group. The average age of the patients was 28.38 ± 6.280 years. The highest education was high school, 42.9%, while the lowest was elementary school (21.4%). The highest VAS scale was 3 (42.9%) and the lowest was 1 (5.4%). The prevalence of the highest degree of perineal wounds in general was degree 2 (98.2%). The highest score was in the moderately healed group on PRP administration (92.9%). In contrast to the control group, the mildly healed category was 21.4% and not healed 14.4%.  Conclusion: There is a significant relationship between the PRP to healing perineal wounds in vaginal delivery patients at the Seberang Padang Health
The Effect of Inositol On Malondialdehyde Serum Levels in Medical Students With PCOS Nofityari, Eldisha; Saputra, Mondale; Ali, Hirowati
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.117-123.2026

Abstract

Introduction: Polycystic ovary syndrome involves the endocrine system, metabolic system, as well as the reproductive system contributing to anovulatory infertility. Polycystic ovary syndrome affects 5-20% of reproductive age and 6-12% of adolescents. Oxidative stress is known to play an important role in the pathogenesis of PCOS resulting in excessive formation of ROS (malondialdehyde). ROS can be controlled by the antioxidant inositol and has minimal side effects.  To determine the effectivity of inositol antioxidant on malondialdehyde serum levels in female students Medical faculty, Andalas University with clinical PCOS. Methods: This study is a clinical trial research with a pure experimental study design (true experimental design). There were 23 samples for the experimental group and 23 samples for the control group selected by probability sampling. Normality test using Shapiro-Wilk test. Data analysis using Independent T test and Mann Whitney Test. Results: There was a significant decrease in malondialdehyde serum levels in PCOS students who consumed inositol therapy for 3 months. Conclusion: There is an effect of inositol antioxidant consumption on malondialdehyde serum levels in female students Medical faculty, Andalas University with clinical polycystic ovary syndrome.
The Relationship Between Microplastic Samples in Blood and The Stage of Epithelial Ovarian Cancer at Dr. M. Djamil Padang General Hospital Aprilianti, Annisa Anzar; Antonius, Puja Agung; Ali, Hirowati
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.108-116.2026

Abstract

Introduction: Ovarian cancer is the primary cause of cancer-related mortality in women, with epithelial ovarian cancer (EOC) ranking as the second greatest cause of death among gynaecological malignancies.  The rising use of plastics has resulted in increased microplastic exposure among the population.  This exposure aligns with recognised risk factors for ovarian cancer, including genetic, hormonal, and lifestyle elements. This study aimed to investigate the relationship between microplastics in blood samples and the stage of epithelial ovarian cancer at Dr. M. Djamil General Hospital, Padang. Methods: Between August 2024 and January 2025, a cross-sectional analytical correlational investigation was carried out.  Forty individuals with histopathologically verified epithelial ovarian carcinoma were consecutively recruited.  Blood samples were examined for di(2-ethylhexyl) phthalate (DEHP) microplastics utilizing Liquid Chromatography–Mass Spectrometry (LCMS).  Data were evaluated utilizing descriptive statistics and the Chi-square test, with p < 0.05 being significant. Results: The average age of patients was 49.1±10.59 years, with the majority being multiparous, married, and of normal weight.  The histological subtypes comprised mucinous (37.5%), serous (30%), endometrioid (20%), and clear cell (12.5%).  Microplastics were identified in 30% of blood samples, with the greatest prevalence observed in mucinous (40%) and endometrioid (37.5%) subtypes. Statistical study indicated no significant correlation between microplastic occurrence and the stage of epithelial ovarian cancer (p = 0.869). Conclusion: Microplastics were identified in the blood of around one-third of patients with epithelial ovarian cancer, present across all histological subtypes. However, no substantial link was identified between the presence of microplastics and the cancer stage.
Co-Authors Afriwardi Afriwardi Aizah, Havina Nurul Almurdi Almurdi Amel Yanis Anggraini, Debie Annita, Annita Ansharina, Hafiznie Antonius, Puja Agung Aprilianti, Annisa Anzar Atmi, Serly Rahma Basyir, Vaulinne , Beni Indra, Beni Cimi Ilmiawati, Cimi Desmawati Desmawati Dessy Arisanty Dian Pertiwi Diflayzer, Diflayzer Dina Arfiani Rusjdi Djong Hon Tjong Eryati Darwin Fadila, Zurayya Fathiyyatul Khaira, Fathiyyatul Febrina, Widia Ferdinand Ferdinand, Ferdinand Finny Fitry Yani Gestina Aliska Gusti Revilla Hakikah, Tika Hasmiwati Husna Yetti Husnil Kadri Julita, Ema Kencana, Gita Lydia Aswati, Lydia Mahata, Liganda Endo Mahendika, Devin Mazara, Fitria Muhammad Arif Muhammad Fadli Muthara, Indah Nofityari, Eldisha Nora Harminarti Noverial, Noverial Nur'aisyah, Shafira Perdanakusuma, David Sontani Putri, Biomechy Oktomalio Putri, Nabila Priscilla Rahmadian, Rizki Rahmatini . Ramadhani, Hafifa Rasya, Salsabila Faiha Wiendra Restu Susanti Sahputra, Roni Eka Saputra, Mondale Saputri, Rahmi Agu Setiawati, Yessy Silviam, Nelmi Siregar, Muhammad Abi Ghoffari Siti Aisyah Sriyanti, Roza Sukri Rahman Tofrizal Utama, Bobby Indra Wydya, Satya Yarni, Sisca Dwi Yusrawati Yusrawati Yusri, Elfira Zelly Dia Rofinda