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All Journal Jurnal Kesehatan Andalas Majalah Obat Tradisional Sari Pediatri Molecular and Cellular Biomedical Sciences (MCBS) Jurnal Biologi Tropis Oto Rhino Laryngologica Indonesiana Majalah Kedokteran Andalas Health and Medical Journal Andalas obstetrics and gynecology journal Indonesian Journal of Global Health research Jurnal Kebidanan Indonesia Jurnal EduHealth Jurnal Ilmu Kesehatan Indonesia (JIKSI) Mandala of Health : A Scientific Journal Innovative: Journal Of Social Science Research Madani: Multidisciplinary Scientific Journal Jurnal Otorinolaringologi Kepala dan Leher Indonesia (JOKLI) Jurnal Kedokteran Meditek Malahayati International Journal of Nursing and Health Science
Hirowati Ali, Hirowati
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Efficacy of Autologous Platelet-Rich Plasma (PRP) on Perineal Wound Healing: A Controlled Non-Randomized Clinical Trial. Fadli, Muhammad; Utama, Bobby Indra; Ali, Hirowati
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.153-162.2026

Abstract

Introduction: Perineal wounds are a very common complication of vaginal birth. Perineal trauma associated with childbirth is defined as damage to the skin, perineal muscles, as well as the sphincter and anal epithelium complex. This study aims to determine the effect of PRP use on perineal wounds.  Method: A single-center, controlled, non-randomized, non-blinded clinical trial was designed in patients with perineal wounds after vaginal delivery. PRP was taken from each patient's serum (autologous). Perineal wound healing after intervention was assessed using the Redness, Oedema, Ecchymosis, Discharge, Approximation (REEDA) scale. Perineal wound pain was assessed using the Visual Analog Scale (VAS). Result: The current study involved 56 samples, 28 people per group. The average age of the patients was 28.38 ± 6.280 years. The highest education was high school, 42.9%, while the lowest was elementary school (21.4%). The highest VAS scale was 3 (42.9%) and the lowest was 1 (5.4%). The prevalence of the highest degree of perineal wounds in general was degree 2 (98.2%). The highest score was in the moderately healed group on PRP administration (92.9%). In contrast to the control group, the mildly healed category was 21.4% and not healed 14.4%.  Conclusion: There is a significant relationship between the PRP to healing perineal wounds in vaginal delivery patients at the Seberang Padang Health
The Effect of Inositol On Malondialdehyde Serum Levels in Medical Students With PCOS Nofityari, Eldisha; Saputra, Mondale; Ali, Hirowati
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.117-123.2026

Abstract

Introduction: Polycystic ovary syndrome involves the endocrine system, metabolic system, as well as the reproductive system contributing to anovulatory infertility. Polycystic ovary syndrome affects 5-20% of reproductive age and 6-12% of adolescents. Oxidative stress is known to play an important role in the pathogenesis of PCOS resulting in excessive formation of ROS (malondialdehyde). ROS can be controlled by the antioxidant inositol and has minimal side effects.  To determine the effectivity of inositol antioxidant on malondialdehyde serum levels in female students Medical faculty, Andalas University with clinical PCOS. Methods: This study is a clinical trial research with a pure experimental study design (true experimental design). There were 23 samples for the experimental group and 23 samples for the control group selected by probability sampling. Normality test using Shapiro-Wilk test. Data analysis using Independent T test and Mann Whitney Test. Results: There was a significant decrease in malondialdehyde serum levels in PCOS students who consumed inositol therapy for 3 months. Conclusion: There is an effect of inositol antioxidant consumption on malondialdehyde serum levels in female students Medical faculty, Andalas University with clinical polycystic ovary syndrome.
The Relationship Between Microplastic Samples in Blood and The Stage of Epithelial Ovarian Cancer at Dr. M. Djamil Padang General Hospital Aprilianti, Annisa Anzar; Antonius, Puja Agung; Ali, Hirowati
Andalas Obstetrics And Gynecology Journal Vol. 10 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.10.1.108-116.2026

Abstract

Introduction: Ovarian cancer is the primary cause of cancer-related mortality in women, with epithelial ovarian cancer (EOC) ranking as the second greatest cause of death among gynaecological malignancies.  The rising use of plastics has resulted in increased microplastic exposure among the population.  This exposure aligns with recognised risk factors for ovarian cancer, including genetic, hormonal, and lifestyle elements. This study aimed to investigate the relationship between microplastics in blood samples and the stage of epithelial ovarian cancer at Dr. M. Djamil General Hospital, Padang. Methods: Between August 2024 and January 2025, a cross-sectional analytical correlational investigation was carried out.  Forty individuals with histopathologically verified epithelial ovarian carcinoma were consecutively recruited.  Blood samples were examined for di(2-ethylhexyl) phthalate (DEHP) microplastics utilizing Liquid Chromatography–Mass Spectrometry (LCMS).  Data were evaluated utilizing descriptive statistics and the Chi-square test, with p < 0.05 being significant. Results: The average age of patients was 49.1±10.59 years, with the majority being multiparous, married, and of normal weight.  The histological subtypes comprised mucinous (37.5%), serous (30%), endometrioid (20%), and clear cell (12.5%).  Microplastics were identified in 30% of blood samples, with the greatest prevalence observed in mucinous (40%) and endometrioid (37.5%) subtypes. Statistical study indicated no significant correlation between microplastic occurrence and the stage of epithelial ovarian cancer (p = 0.869). Conclusion: Microplastics were identified in the blood of around one-third of patients with epithelial ovarian cancer, present across all histological subtypes. However, no substantial link was identified between the presence of microplastics and the cancer stage.
Pengaruh Ekstrak Kemangi terhadap Ekspresi Gen Interleukin-1β pada Tikus Diabetes Melitus Gestasional Medison, Sultan Rafli Putra; Decroli, Eva; Ali, Hirowati
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 1 (2026): Maret 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i1.1464

Abstract

Latar Belakang: Istilah Diabetes Melitus Gestasional (DMG) mengacu pada adanya intoleransi glukosa yang ditemukan pertama kali pada kehamilan, menyebabkan terjadinya inflamasi yang ditandai dengan peningkatan ekspresi gen Interleukin-1β (IL-1β) dan dapat memicu terjadi stres oksidatif. Kemangi (Ocimum basilicum) merupakan tanaman herbal dengan kandungan zat aktif yang mempunyai efek antidiabetes, antiinflamasi maupun antioksidan. Objektif: Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak daun kemangi (Ocimum basilicum) terhadap ekspresi gen IL-1β pada tikus model diabetes melitus gestasional. Metode: Penelitian ini adalah eksperimental dengan menggunakan metode post test only control group design. Penelitian ini dilakukan di Laboratorium Biomedik Fakultas Kedokteran Universitas Andalas. Penelitian dilakukan selama bulan September 2023 sampai Januari 2024. Besar sampel yang digunakan ditentukan dengan rumus Federer. Jumlah sampel setiap kelompok adalah 6. Penelitian ini terdiri dari 4 kelompok yaitu 2 kontrol dan 2 perlakuan sehingga jumlah total sampel adalah sebanyak 24 serum. Hasil: Rerata hasil ekspresi gen IL-1β yang pada kelompok K- (kontrol negatif), K+ (kontrol positif), P1 (perlakuan 1), dan P2 (perlakuan 2) adalah masing masing 1,16, 1,24, 0,86, dan 0,81. Terdapat perbedaan bermakna pada setiap kelompok dengan nilai p = 0,000 (p<0,05). Hasil penelitian ini memperlihatkan  terdapat perbedaan bermakna penurunan ekspresi IL-1β antara K+ dengan P1 dan P2 (p<0,001) namun tidak terdapat perbedaan yang bermakna antara P1 dan P2. Kesimpulan: Pemberian ektrak kemangi dapat mempengaruhi ekspresi gen IL-1β pada tikus DMG.
Effect of Kawa Gambir (Uncaria gambir Roxb.) Leaves on Serum LDL in Diabetic Model Rats Siregar, Muhammad Abi Ghoffari; Rita, Rauza Sukma; Reza, Mohamad; Ali, Hirowati; Rofinda, Zelly Dia; Welan, Rahmani
Jurnal Kedokteran Meditek Vol 32 No 2 (2026): MARET
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i2.4012

Abstract

Background: Kawa gambir leaves, dried in a furnace and brewed as tea, are rich in flavonoids, phenolics, steroids, and tannins and have antioxidant, antihyperglycemic, and antidyslipidemic properties. In diabetes, elevated low-density lipoprotein (LDL) is a dyslipidemic abnormality that increases atherogenic risk. However, the effect of Kawa gambir on LDL in diabetic conditions remains unclear. Objective: To evaluate the effect of Kawa gambir leaf administration on LDL in alloxan-induced diabetic rats. Methods: This experimental study used a post-test-only control group design in 36 Wistar rats randomized into six groups: K−, K+, MET, P1, P2, and P3. Diabetes was induced with alloxan in K+, MET, and P1–P3. MET received metformin, whereas P1, P2, and P3 received Kawa gambir infusions at 1, 2, and 4 g/100 mL once daily for 4 weeks. Serum LDL was estimated using the Friedewald formula. Data were analyzed by one-way ANOVA followed by Least Significant Difference post hoc testing. Results: Mean±SD LDL levels (mg/dL) were 37.16±3.03, 59.90±8.91, 41.30±6.74, 40.60±5.75, 38.95±10.15, and 40.33±7.01 in K−, K+, MET, P1, P2, and P3, respectively. Group differences were significant (p=0.001). The largest numerical reduction versus K+ was found in P2, with a difference of 20.95 mg/dL (95% CI 8.64–33.26). Conclusion: Kawa gambir infusion significantly reduced LDL compared with the untreated diabetic control. Although the 2 g/100 mL group showed the lowest LDL numerically, no significant differences were observed among active treatment groups. These findings support Kawa gambir as an antidyslipidemic agent in diabetic dyslipidemia.
Perbedaan Ekspresi Transforming Growth Factor Beta 1 antara Rinosinusitis Kronis dengan Polip dan Tanpa Polip Rahmadona, Rahmadona; Budiman, Bestari Jaka; Huriyati , Effy; Ali, Hirowati; Bachtiar, Hafni
Jurnal Otorinolaringologi Kepala dan Leher Indonesia Vol. 1 No. 1 (2022)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jokli.v1i1.23

Abstract

Latar belakang: Rinosinusitis kronis (RSK) merupakan inflamasi pada mukosa hidung dan sinus paranasal. Rinosinusitis kronis berdasarkan perbedaan ekspresi sitokin dan pola remodeling inflamasi dibedakan menjadi dua fenotipe, RSK dengan polip dan RSK tanpa polip. Transforming growth factor–?1 (TGF–?1) merupakan salah satu sitokin yang berperan pada remodeling jaringan.       Tujuan: Mengetahui ekspresi gen TGF–?1 pada RSK dengan polip dan RSK tanpa polip. Metode: Penelitian analitik komparatif menggunakan desain potong lintang (cross sectional comparative study) pada 12 responden RSK dengan polip dan 12 responden RSK tanpa polip. Sampel diambil saat operasi Bedah Sinus Endoskopi Fungsional (BSEF) pada jaringan polip dan mukosa sinus etmoid atau maksila. Semua sampel dilakukan pemeriksaan ekspresi gen dengan metode Real Time Polymerase Chain Reaction (RT-PCR). Data dianalisis dengan SPSS, dikatakan bermakna jika p<0,05. Hasil: Ekspresi TGF-?1 pada RSK tanpa polip lebih tinggi (18,63±24,58) dibandingkan RSK dengan polip (2,82±4,02). Secara statistik perbedaan antara RSK polip dan RSK tanpa polip ini bermakna (p<0,05). Kesimpulan: Terdapat peningkatan ekspresi TGF-?1 pada RSK tanpa polip yang bermakna secara statistik dibandingkan dengan RSK dengan polip.  
In Vitro Analysis of SCUBE1 Expression in Aortic Vascular Smooth Muscle Cells on Atherosclerosis Progression Rasya, Salsabila Faiha Wiendra; Ali, Hirowati; Yanni, Mefri; Rita , Rauza Sukma; Asri , Aswiyanti; Mahata , Liganda Endo; Putri , Biomechy Oktomalio; Yarni , Sisca Dwi
Jurnal Kedokteran Meditek Vol 32 No 3 (2026): MEI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i3.4015

Abstract

Background:  Signal peptide-CUB-EGF domain-containing protein-1 (SCUBE1) is a platelet–endothelial glycoprotein implicated in thrombosis and vascular inflammation, and has been detected within atherosclerotic lesions. Whether vascular smooth muscle cells (VSMCs) upregulate SCUBE1 under inflammatory stimuli remains unclear. Objective:  To quantify SCUBE1 mRNA expression in rat aortic VSMCs following lipopolysaccharide (LPS) exposure in an organ-culture model of atherogenesis. Methods: This study aimed to analyze SCUBE1 expression in aortic VSMCs in atherosclerosis using real-time PCR. This study was a true experimental-post test control group design using organ culture. The aorta from six wistar rats were divided into two groups, consisting of five samples that were not induced with LPS and five samples exposed to LPS at a concentration of 10 µg/mL for 48 hours. Expression of the SCUBE1 gene was then analyzed using real-time PCR. The data was then processed using the dependent T-Test. Results: The result showed LPS increased SCUBE1 transcript levels compared with control (mean ± SD: 0.78 ± 0.22 vs 0.44 ± 0.35), representing a non-significant trend toward induction (p=0.07). These preliminary data are consistent with SCUBE1’s inducibility in inflammatory states and its presence in atherosclerotic tissue. Conclusion: This study revealed increased SCUBE1 gene expression in aortic VSMCs in the LPS-treated group. These data suggest that SCUBE1 has the potential to be a marker of endothelial dysfunction in atherosclerosis.
Co-Authors Afriwardi Afriwardi Aizah, Havina Nurul Almurdi Almurdi Amel Yanis Anggraini, Debie Annita ., Ansharina, Hafiznie Antonius, Puja Agung Aprilianti, Annisa Anzar Asri , Aswiyanti Atmi, Serly Rahma Basyir, Vaulinne , Beni Indra, Beni Bestari Jaka Budiman Cimi Ilmiawati, Cimi Desmawati Desmawati Dessy Arisanty Dian Pertiwi Diflayzer, Diflayzer Dina Arfiani Rusjdi Djong Hon Tjong Eryati Darwin Eva Decroli Fadila, Zurayya Fathiyyatul Khaira, Fathiyyatul Febrina, Widia Ferdinand Ferdinand, Ferdinand Finny Fitry Yani Gestina Aliska Gusti Revilla Hafni Bachtiar Hakikah, Tika Hasmiwati Huriyati , Effy Husna Yetti Husnil Kadri Julita, Ema Kencana, Gita Lydia Aswati, Lydia Mahata , Liganda Endo Mahata, Liganda Endo Mahendika, Devin Mazara, Fitria Medison, Sultan Rafli Putra Muhammad Abi Ghoffari Siregar Muhammad Arif Muhammad Fadli Muthara, Indah Nofityari, Eldisha Nora Harminarti Noverial, Noverial Nur'aisyah, Shafira Perdanakusuma, David Sontani Putri , Biomechy Oktomalio Putri, Biomechy Oktomalio Putri, Nabila Priscilla Rahmadian, Rizki Rahmadona, Rahmadona Rahmatini . Ramadhani, Hafifa Rasya, Salsabila Faiha Wiendra Rauza Sukma Rita Restu Susanti Reza, Mohamad Rita , Rauza Sukma Sahputra, Roni Eka Saputra, Mondale Saputri, Rahmi Agu Setiawati, Yessy Silviam, Nelmi Siti Aisyah Sriyanti, Roza Sukri Rahman Tofrizal Utama, Bobby Indra Wydya, Satya Yanni, Mefri Yarni , Sisca Dwi Yarni, Sisca Dwi Yusrawati Yusrawati Yusri, Elfira Zelly Dia Rofinda