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All Journal Journal of Food and Pharmaceutical Science Jurnal Ilmiah Farmasi Indonesian Journal of Pharmaceutical Science and Technology MEDISAINS AJIE (Asian Journal of Innovation and Entrepreneurship) JURNAL PHARMASCIENCE Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) CHEESA: Chemical Engineering Research Articles JSFK (Jurnal Sains Farmasi & Klinis) AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Abdimas Madani dan Lestari (JAMALI) Jurnal Ners Medfarm: Jurnal Farmasi dan Kesehatan Journal of Pharmaceutical and Health Research Jurnal Nuansa Akademik: Jurnal Pembangunan Masyarakat Hydrogen: Jurnal Kependidikan Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Khazanah: Jurnal Mahasiswa Eduvest - Journal of Universal Studies Journal of Food and Pharmaceutical Sciences Parapemikir Jurnal Ilmiah Farmasi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Pharmascience

Lutfi Chabib, Lutfi

Department Of Pharmacy, Islamic University Of Indonesia

Author-ID : 514334

Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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FORMULASI TABLET HISAP EKSTRAK GAMBIR (Uncaria gambir (Hunter) Roxb.) DENGAN VARIASI BAHAN PENGIKAT GOM ARAB (Gummi Acaciae) Lutfi Chabib; Asih Triastuti; Rischi Dwi Irianti
Majalah Obat Tradisional Vol 15, No 2 (2010)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Gambier is one of the medicinal plants commonly used for chewing, which has benefits for oral health and dental. Gambier has a property as a remedy lozenges, stomachache, toothache, and can be used to prevent the formation of dental plaque. This research aims to create a dosage of dried extract in the form of lozenges. In these lozenges we used variations gummi acaciae to obtain a binder concentration that can produce tablets that meet the requirements. Gambier extract was obtained by remaceration, with 80% ethanol. Tablets formulated with a binder concentration gom arabic 10%, 17.5% and 25% using direct compression method. The results showed that the concentration variation can minimize the variation of the gummi acaciae weight uniformity, increased hardness, lower % fragility, and increase the time dissolved lozenges. All of tablets have good physical tablets properties. The third formula is the most acceptable by the respondents in terms of color, taste, and time of dissolution.

Pengembangan Formula Nanoemulsi Air dalam Minyak Biji Anggur (Vitis vinifera L.) sebagai Basis Lipstik Siti Zahliyatul Munawiroh; Agenilia Permatasari; Lutfi Chabib
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 4 (2019): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v2i4.1780

The objective of this research is to develop water in grape seed oil nanoemulsions which prepared by low energy method to be used in lipstick base formulation. Water in grape seed oil nanoemulsions were prepared by low energy methods which was employed a Phase Inversion Composition (PIC) technique in elevated temperature at 80°C using mixed-surfactants (tween 20/span 80). In ternary phase diagram (oil:water:mixed-surfactants), the largest area of nanoemulsions was occurred in equal ratio tween 20:span 80 (1:1). The maximum water content of water in grape seed oil nanoemulsions was reached at 20% water with 60% mixed-surfactants (1:1). An unimodal size distribution of water in grape seed oil nanoemulsions with varied water content at 6, 10, and 14% were found with droplet size at 29.33 ± 5.30, 30.23 ± 7.33, and 29.83 ± 11.47 nm. Water content of water in grape seed oil nanoemulsions insignificantly affected to melting profile and hardness properties of lipstick. Water in grape seed oil nanoemulsions which was prepared by low energy can be developed as lipstick base formulation.

Nanocurcumin Preparation for Reducing Vcam-1 and IL-6 in High Fat Diet-Induced Hyperlipidemic Rats Dimas Adhi Pradana; Maulana Ardhi; Arifa Caryn Dea Utami Hasyono; Dzihni Meytasari; Farah Deastasa Nabilah; Rochmy Istikharah; Lutfi Chabib
Indonesian Journal of Pharmacy Vol 30 No 1, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Hyperlipidemia is a pathological condition due to lipid metabolism abnormalities. Increased and oxidized LDL in hyperlipidemia will trigger an inflammatory response and produce proinflammatory cytokines, such as vascular cell adhesion molecule-1 (VCAM-1) and Interleukin-6 (IL-6). Curcumin can be used as antioxidants, anti-inflammatory and antihyperlipidemia, but as it is practically insoluble in water, formulation of curcumin nanosuspension is made to improve the effects of curcumin therapy. This study was conducted to determine the activities of nanocurcumin preparation as preventive measures for rats induced with hyperlipidemia. The test animals used were 49 male Wistar rats divided into 7 test groups: normal control group, negative control group, 80mg/kg BW/day curcumin control group, and nanosuspension curcumin dose of 80mg/kg BW/day, nanoemulsion curcumin dose of 80mg/kg BW/day, SNEDDS curcumin dose of 80mg/kg BW/day and solid lipid nanoparticles dose of 80mg/kg BW/day. Provision of preventive measure was performed on days 1-67. On day 11-67, the induction of lard and egg yolk (1:1) was administered with a volume of 2mL/200g of rat BW. On the 68th day, blood samples were taken for the determination of VCAM-1 and IL-6 parameters using Biotin-Streptavidin-Amplified Enzyme-Linked Immuno-sorbent Assay method. Data analysis of VCAM-1 and IL-6 levels between test groups were conducted by means of normality test and One-way ANOVA (p<0.05). Based on the data of VCAM-1 and IL-6 levels, nanocurcumin dose of 80mg/kg BW preparation was able to significantly improve the preventive activity of curcumin compared to curcumin suspension dose of 80mg/kg BW by reducing VCAM-1 levels in SNEDDS (53.260%), nanoemulsion (52.737%), nanosuspension (52.325%) and solid lipid nanoparticles (51.444%) and decreasing IL-6 levels in SNEDDS (33.030%), nanoemulsion (31.568%), nanosuspension (29.898%), and solid lipid nanoparticles (28.875%).

FORMULASI TABLET EKSTRAK BUAH NAGA (Hylocereus polyrhizus) MENGUNAKAN AMILUM UBI JALAR PREGELATINASI SEBAGAI BAHAN PENGHANCUR Aji Winanta; Yandi Syukri; Lutfi Chabib
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 3 No 2 (2019)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Buah naga (Hylocereus polyrhizus) telah dikenal oleh masyarakat sebagai tanaman yang kaya akan kandungan antioksidan sehingga mempunyai manfaat sebagai antikanker. Sediaan dari buah naga belum banyak digunakan oleh masyarakat luas, oleh karena itu dibuat suatu formulasi sediaan tablet dari ekstrak buah naga yang dapat dikonsumsi oleh masyarakat sebagai suplemen kesehatan yang dapat dengan praktis dikonsumsi. Tablet ekstrak buah naga dibuat dengan menggunakan amilum pregelatinasi ubi jalar sebagai bahan penghancur. Penelitian ini bertujuan untuk mengetahui pengaruh variasi kadar amilum ubi jalar pregelatinasi (kadar 5%; 6,5%; 8%; dan 10%) terhadap sifat fisik tablet ekstrak buah naga. Ekstraksi buah naga dilakukan dengan metode maserasi dan proses penabletan menggunakan metode granulasi basah. Hasil yang diperoleh pada formula I mempunyai kekerasan 7,97 Kg, kerapuhan 0,29%,waktu hancurnya 41,69 menit. Formula II mempunyai kekerasan 6,23 Kg, kerapuhan 0,58%, waktu hancur 36,43 menit. Formula III memiliki kekerasan 7,65 Kg, kerapuhan 0,46%, waktu hancur 35,15 menit. Dan pada Formula IV mempunyai kekerasan 7,43 Kg, kerapuhan 1,18% dan waktu hancur 32,03 menit. Kesimpulannya semakin tinggi konsentrasinya akan membuat kekerasan tablet menurun, kerapuhan menjadi semakin besar dan waktu hancur tablet semakin cepat.

POTENSI DARI EKSTRAK DAN FRAKSI KULIT BUAH MUNDAR (Garcinia forbesii) SEBAGAI TABIR SURYA BERDASARKAN NILAI SUN PROTECTION FACTOR (SPF) Muhammad Ikhwan Rizki; Samsul Hadi; Lutfi Chabib
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

UV rays cause skin damage such as loss of skin elasticity, wrinkles, sagging, and skin cancer. South Kalimantan is a wetland area with more than 4,000 species of medicinal plants. Mundar (Garcinia forbesii) is one of the plants in South Kalimantan. Mundar pericarp is empirically used for cosmetics which is believed to protect the skin from ultraviolet rays. The purpose of the study was to determine the sunscreen potency of the extract and fraction from pericarp of mundar (Garcinia forbesii) based on the Sun Protection Factor (SPF) parameter. The research started from material drying, making simplicia powder, extraction, and fractions. The extracts and fractions were measured for SPF values ??using a UV-Vis Spectrophotometer. The results showed that the ethanol extract and ethyl acetate fraction had weak protection, while the n-hexane fraction had extreme protective power with SPF values ??in the range of 6.51 Ã¢â‚¬â€œ 30.00

Optimalisasi pelayanan apotik panjen di Desa Wedomartani Ngemplak Sleman Yogyakarta Lutfi Chabib; Akhmad Fauzy
Jurnal Abdimas Madani dan Lestari (JAMALI) Volume 02, Issue 02, September 2020
Publisher : UII

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jamali.vol2.iss2.art4

Community service activities have been completed to optimize Panjen Pharmacy services. Pharmaceutical services are integrated activities aimed to identify, prevent, and resolve drug problems and health-related problems. The demands of patients and society for improving the quality of pharmaceutical services require the expansion of the old drugs-oriented paradigm into a new patient-oriented paradigm with the philosophy of Pharmaceutical Care. The Panjen Pharmacy in Wedomartani Village, Sleman is still constrained in implementing pharmaceutical services. Based on the results of observations to partners, these problems resulted from A limited number of human resources, lack of facilities and infrastructure, the absence of standardized etiquette, no drug information handbook, and there is no counseling card. The average number of visits by patients who buy drugs at the Panjen Pharmacy per day reaches 35-70 people. So it is necessary to improve services to provide a sense of security to patients about the use of drugs to be consumed. The outcome of this service activity is to optimize Panjen Pharmacy services through increasing human resource capacity, improving infrastructure, availability of standard etiquette, counseling cards, and drug information book achieved with the Participatory Rural Appraisal (PRA) participatory community empowerment model. The continuity of this service activity is the achievement of consistency in the application of a good and correct rationing system, both in terms of Human Resources Utilization (Human Resources), as well as in terms of a management information system that can guarantee the availability of the right type of drug, the right amount, the right quality and the right time. , thus making the pharmacy better in terms of service to the community and healthier.

Fabrikasi dan Studi Stabilitas Self-Nano Emulsifying Propolis menggunakan Minyak Kesturi sebagai Pembawa Yandi Syukri; Ziyyatul Kholidah; Lutfi Chabib
Jurnal Sains Farmasi & Klinis Vol 6, No 3 (2019): J Sains Farm Klin 6(3), Desember 2019
Publisher : Fakultas Farmasi Universitas Andalas

Propolis merupakan resin yang sukar larut dalam air yang dihasilkan lebah, berkhasiat sebagai antibakteri, antioksidan, serta antiinflamasi. Salah satu metode untuk meningkatkan kelarutan obat adalah teknologi self-nano emulsifying (SNE). Penelitian ini bertujuan untuk melakukan formulasi, karakterisasi, dan studi stabilitas SNE propolis dengan pembawa minyak kesturi, cremophor RH 40, dan PEG 400. Preparasi SNE dilakukan dengan mencampurkan propolis dengan pembawa. Area nanoemulsi ditentukan dengan konstruksi diagram fase terner. Karakterisasi dilakukan dengan penentuan ukuran partikel, zeta potensial, transmitan, stabilitas termodinamika, uji ketahanan, dan uji stabilitas dipercepat. Daerah nanoemulsi terdapat pada F1-F9 dengan range komposisi minyak kesturi (10-30%), cremophor RH 40 (40-80%), dan PEG 400 (10-40%). Kesembilan formula menghasilkan nilai transmitan pada 96-99%, ukuran partikel 10-40 nm, serta zeta potensial kurang dari -40 mV. Uji ketahanan menunjukkan hasil yang baik pada F4 (1: 5: 4), F5 (2: 7: 1), dan F6 (2: 6: 2). Uji stabilitas dipercepat, F5 (2: 7: 1) menghasilkan SNE yang paling optimal karena tidak teramati pemisahan fase dan pengendapan, dengan karakterisasi nilai transmitan antara 97-99%, ukuran partikel antara 16-19 nm, dan nilai PDI 0,1-0,2. Dapat disimpulkan bahwa SNE propolis dengan pembawa minyak kesturi, cremophor RH 40, dan PEG 400 menghasilkan karakteristik dan profil stabilitas yang baik.

Formulasi Gel Hand Sanitizer Ekstrak Buah Belimbing Wuluh dengan Variasi Karbopol 940 dan HPMC Ferdy Firmansyah; Hastri Kholifah; Lutfi Chabib
Journal of Islamic Pharmacy Vol 7, No 1 (2022): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v7i1.13839

The hand hygiene is compulsory to keep maintain. It is one of the important things to prevent the diseases that caused by microorganisms infection or the other infectious diseases, especially during this COVID-19 pandemic. Most of the hand sanitizer (HS) products are used alcohol as an antibacterial. The right way to reduce the use of HS-containing alcohol is by replacing them with using the active substances derived from herbal plant extracts, one of it is the star fruit (BBW). Flavonoid is one of the component in BBW. Thus, the purpose of this study is to determine the effect of a good combination of Carbopol 940 base and HPMC on the physical properties of HS BBW gel preparations. The formulation of hand sanitizer gel was used a combination of Carbopol 940 and HPMC with the variation concentrations of 0.5%; 0.75%; 1% and 0.25%; 0.5%; 0.75%. Evaluation of the physical properties of the gel preparation was determined based on the observations of consistency, scent, colour, pH, homogeneity, dispersibility, and physical stability using the freeze and thaw method for 6 storage cycles at 4°C and 45°C. The results shown that the variations concentration of gelling agents affect pH and dispersion. The higher the concentration of the gelling agent, the lower pH value and dispersion. This can be seen in each formula in the first week with pH 6.31, 6.13, and 5.62, and spreadability of 6.2, 5.8, and 5.6. Tests on the fourth week in a row with pH of 5.53, 5.49, and 5.23 and a spread of 5.2, 5.0, and 4.5. Variations in the concentration of HPMC and Carbopol was not affected to the organoleptic, homogeneity, and also the stability.

FORMULASI TABLET HISAP EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) SEBAGAI ANTIOKSIDAN DENGAN VARIASI KONSENTRASI GELATIN SEBAGAI BAHAN PENGIKAT Ria Cahya Andriana; Mufrod Mufrod; Lutfi Chabib
Khazanah: Jurnal Mahasiswa Vol. VI, No. 2, Januari 2014
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/khazanah.vol6.iss2.art5

Peel of mangosteen (Garcinia mangostana L.) contains xanthones especially α-mangostin which have antioxidant activity. The aim on this study was to determine the physical of lozenges extract from mangosteen peel with variation concentration of gelatin 2%, 4%, 6%, 8% and 10%, also to determine the effect formulations of powder into lozenges made with wet granulation method to the percentage reduction of the free radical. The ability of neutralizing free radicals were tested by treating the extract in DPPH with ratio of 3:1. Results showed the tablet hardness were 10.75 kg, 11.13 kg, 11.94 kg, 12.14 kg and 12.35 kg. The friability were 0.84%, 0.73%, 0.71%, 0.60% and 0.50%. Time soluble of the tablet were 7.05 minutes, 9.44 minutes, 9.57 minutes, 11.51 minutes and 13.62 minutes, respectively. Data was analyzed by oneway ANOVA with 95% confidence level. The results showed that all formulas gave better physical properties on granules and tablets produced. Higher concentration of gelatin decreased friability, increased hardness and time-soluble of lozenges. Formula 5 showed the best physical tablet. Percentage reduction of free radicals of extract with DPPH decreased 70.72% after formulated into lozenges.

UJI AKTIVITAS ANTIBAKTERI SERUM EKSTRAK ETANOL BUAH BELIMBING WULUH TERHADAP Propionibacterium acnes, Staphylococcus aureus, dan Staphylococcus epidermis Ferdy Firmansyah; Reihan Khairiati; Wildan Khairi Muhtadi; Lutfi Chabib
Majalah Farmasi dan Farmakologi Vol. 26 No. 2 (2022): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v26i2.18578

Jerawat merupakan salah satu penyakit kulit yang disebabkan oleh bakteri Propionibacterium acnes, Staphylococcus aureus dan Staphylococcus epidermis. Salah satu bahan alam yang dapat dimanfaatkan yaitu ekstrak etanol buah belimbing wuluh (eBW) yang berkhasiat sebagai antibakteri. Penelitian ini bertujuan untuk memformulasi sediaan serum wajah yang stabil secara farmasetik dan memiliki aktivitas antibakteri terhadap bakteri Propionibacterium acnes, Staphylococcus aureus dan Staphylococcus epidermis dengan metode difusi cakram. Sediaan serum wajah diformulasi pada beberapa konsentrasi eBW yaitu FI (10%), FII (15%), dan FIII (20%). Evaluasi sediaan serum wajah meliputi pemeriksaan organoleptis, homogenitas, pH, daya sebar, freeze and thaw, serta aktivitas antibakteri. Analisa data secara deskriptif dan uji statistik One Way ANOVA. Berdasarkan penelitian yang dilakukan formulasi serum ekstrak etanol buah belimbing wuluh pada semua formula memiliki stabilitas fisik yang baik yang ditunjukkan dengan pengujian stabilitas freeze and thaw tidak mengalami pemisahan fase, tampilan fisik, bentuk, bau, warna tidak berubah serta susunan yang homogen pada semua sediaan. Namun pada bagian pemeriksaan pH dan daya sebar mengalami penurunan dari minggu pertama ke minggu terakhir. Hasil uji One way ANOVA terdapat perbedaan yang signifikan (p<0,05) antar formula terhadap diameter zona hambat. Semakin tinggi konsentrasi eBW, maka akan semakin tinggi aktivitas antibakterinya. Formula III (20%) memiliki daya hambat paling besar dibandingkan formula lainnya dengan daya hambat secara berurutan pada bakteri Propionibacterium acnes, Staphylococcus aureus, dan Staphylococcus epidermis yaitu 18,10±0,20 mm, 17,03±0,35 mm dan 17,00±0,26 mm.

Co-Authors Achmad Fachrodji Agenilia Permatasari Aghna Mafruha Zahrah, Aghna Mafruha Agus Santosa Agustina Setiawati Aji Winanta Akhmad Fauzy Akhmad Nabil Akhmad Nabil, Akhmad Ali Djamhuri Alviansyah, Muhammad Rizal Anggara Setyabawana Putra Annisa, Viviane Aprianto . Aprianto Aprianto Arba Pramundita Arba Pramundita Ramadani Ardiyanto, Abdul Mu’is Arifa Caryn Dea Utami Hasyono Arismunandar, Arif Asih Triastuti Awaluddin Nurmiyanto, Awaluddin Awaluddin, Rizki Baharuddin Yusuf Baharudin Yusuf Baruna, Renno Ramadhani Ika Cermenda, Riska Cynthia Astiti Putri Dewi, Melynia Sintha Dimas Adhi Pradana Dzihni Meytasari Farah Deastasa Nabilah Ferdy Firmansyah Gandhi Barajana Vedha Gani, Michael Raharja Gelu, Maria Andriani Guanse, Yovi Hady Anshory Hamzah, Hasyrul Haniâ€™atul Kharimah Hanida Destriana Fatmawati Hani’atul Kharimah Hannie Fitriani hartanto hartanto Hasnaeni hasnaeni, Hasnaeni Hastri Kholifah Hayati, Farida Herman Felani Hilda Ismail, Hilda Ipaenin, Jahiria Jenita Gandi, Brigita Tuelvin Kamarulzaman, Ezatul Ezleen Kholidah, Ziyyatul Kinanti, Valentina Putri Embun Lumakso, Fajar Aji M. Pandoman febrian Maemonah, Maemonah Martien, Ronny Maulana Ardhi Mimiek Murrukmihadi Mufrod Mufrod Muh Iqbal Pangestu Muhammad Faisal Muhammad Ikhwan Rizki Muhammad Iqbal Pangestu Muhammad Safarullah Muhtadi, Wildan Khairi Munawiroh, Siti Zahliyatul Muslim, M. Rifqi Fadillah Mutiara Herawati, Mutiara Muzakir, Mellisa Nurul Afifi Lobubun Oktavia Indrati, Oktavia Prabowo, Erlangga Prima Aulia Putra Pujimagfiroh, Isnaini Reihan Khairiati Renno Ramadhani Ika Baruna Ria Cahya Andriana Rifqi, Muhammad Nurur Rini Dwiastuti Ririn Wulandari Rischi Dwi Irianti Rischi Dwi Irianti, Rischi Dwi Rizqi, Syifa Maulidia Rochmy Istikharah Ronny Martien Ronny Martien Samsul Hadi Siti Zahliyatul Munawiroh Suryani, Arman Syarif Hidayatullah Taufikurrahmi Taufikurrahmi Trianloka, A. M. Bagas Tunny, Risman Uzulul Hikmah Wahyu, Imron Yandi Syukri Yosi Febrianti, Yosi Yulianto Yulianto Ziyyatul Kholidah

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