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All Journal Journal of Food and Pharmaceutical Science Jurnal Ilmiah Farmasi Jurnal Farmasi Udayana Indonesian Journal of Pharmaceutical Science and Technology MEDISAINS AJIE (Asian Journal of Innovation and Entrepreneurship) JURNAL PHARMASCIENCE Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Pharmascience Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) CHEESA: Chemical Engineering Research Articles JSFK (Jurnal Sains Farmasi & Klinis) AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Abdimas Madani dan Lestari (JAMALI) Jurnal Ners Medfarm: Jurnal Farmasi dan Kesehatan Journal of Pharmaceutical and Health Research Hydrogen: Jurnal Kependidikan Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Khazanah: Jurnal Mahasiswa Eduvest - Journal of Universal Studies Journal of Food and Pharmaceutical Sciences Parapemikir Jurnal Ilmiah Farmasi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Lutfi Chabib, Lutfi
Department Of Pharmacy, Islamic University Of Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Analysis of the Influence of Brand Image, Product Quality and Perception of EduBP Product Price on Customer Loyalty with Customer Satisfaction Mediation Variables Fachrodji, Achmad; Wulandari, Ririn; Chabib, Lutfi
Eduvest - Journal of Universal Studies Vol. 5 No. 5 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i5.49984

Abstract

Indonesia’s literacy crisis, evidenced by its low PISA rankings (score: 371; rank: 74/79) and the collapse of major bookstores (e.g., Gunung Agung, Kinokuniya), underscores the urgency for innovative solutions like Balai Pustaka’s EduBP, a digital literacy platform. Despite its potential, EduBP’s sales remain low (16.5% of revenue), necessitating research into consumer behavior to enhance adoption. This study investigates how brand image, product quality, and price perception influence customer loyalty, mediated by customer satisfaction, in the context of EduBP’s digital platform. Using purposive sampling, 125 EduBP users were surveyed via Likert-scale questionnaires. Data were analyzed using SEM-PLS, with validity (KMO > 0.5; loading factor > 0.4) and reliability (Cronbach’s Alpha > 0.6) tests ensuring robustness. Brand image significantly drives satisfaction (β = 0.476, *p* = 0.001) and loyalty (β = 0.295, *p* = 0.004), while product quality shows no effect. Price perception indirectly affects loyalty (β = 0.703, *p* = 0.000) but not satisfaction. Customer satisfaction strongly mediates loyalty (β = 0.703, *p* = 0.000). Balai Pustaka must prioritize brand reputation and CRM strategies (e.g., after-sales service) over quality enhancements. Future research should explore market segmentation and technology acceptance factors (TAM) to refine digital literacy strategies. This study contributes to the nascent literature on digital product loyalty in emerging markets.
A Literature Review: Antimicrobial Phenolic Compounds in Nutmeg (Myristica fragrans Houtt) Ipaenin, Jahiria; Chabib, Lutfi; Hasnaeni, Hasnaeni; Tunny, Risman
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 1 (2025): February 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i1.14583

Abstract

In various countries, testing of phenolic compounds in plants is always carried out because these compounds have various health benefits such as antioxidant, anti-inflammatory, and antimicrobial activities. The types of medicinal plants in Indonesia are known to be very diverse where those included in the medicinal plant group reach more than 1000 species, one of which is nutmeg (Myristica fragrans Houtt.) Nutmeg (Myristica fragrans Houtt.) itself is native to the Maluku Islands, Indonesia. However, besides the Moluccas, nutmeg is also cultivated in several other tropical countries. The main objective of this literature review is to critically examine the antimicrobial properties and identify the specific antimicrobial components of phenolic compounds contained in nutmeg (Myristica fragrans Houtt.) The methodology used in this study involved a comprehensive literature review by utilizing reputable academic databases such as Google Scholar, PubMed, and Science Direct related to articles published between 2019 and 2024. The results of this study were obtained through a thorough search process, resulting in eight articles that were considered to meet the established inclusion criteria. A number of articles showed the effectiveness of nutmeg as an antimicrobial because nutmeg contains phenolic compounds that have antibacterial and antifungal properties, which make it effective as an antimicrobial agent. Therefore, with a more comprehensive understanding of the content of phenolic compounds and their mechanism of action, nutmeg can be a further basis for study in the health sector and the pharmaceutical industry.
Optimization and Physical Characterization of Kojic Acid Nanoemulsion Formula As A Whitening Agent Guanse, Yovi; Dwiastuti, Rini; Jenita Gandi, Brigita Tuelvin; Chabib, Lutfi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009968

Abstract

Kojic acid (KA) as a topical formulation prevents hyperpigmentation through the inhibition of tyrosinase activity. However, KA has higher solubility in nonpolar solvents. Nanoparticle technology can be a novel innovation to enhance KA absorption into the skin. This study aims to improve the delivery of topically applied KA by enhancing absorption into the stratum corneum by optimizing the concentration of surfactant Tween 80 and co-surfactant Span 80. The nanoemulsion uses KA as an active ingredient and virgin coconut oil as the oil phase. The optimum area was analyzed using Design-Expert® 13 software, with a pure experimental design based on a 2x2 factorial design. The results indicate that all formulas are within the optimal region. Therefore, the determination of the optimal point can be grounded on the smallest composition within the optimal region with the objective of maximizing material efficiency, which is a formula with a concentration of Tween 80 and Span 80 of 10 grams and 3 grams, respectively. The particles are a spherical smooth shape and demonstrate an efficacy of 94.117% in inhibiting tyrosinase activity.
Ultra-High Performance Liquid Chromatography Method Validation for Micro-dissolution Analysis of Ketoconazole in Alginate-Acacia Gum Composite Capsules Lumakso, Fajar Aji; Annisa, Viviane; Cermenda, Riska; Chabib, Lutfi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24078

Abstract

Ketoconazole, a BCS Class 2 antifungal drug, has good absorption but suffers from low solubility and poor bioavailability. To address this, a natural polymer-based matrix of alginate and acacia gum was formulated to enhance dissolution. This study aimed to validate a Ultra High Performance Liquid Chromatography method for analyzing ketoconazole content in micro-dissolution testing of capsule formulations. The method employed a C18 column with a mobile phase of acetonitrile:WFI (0.15% TEA, pH 3.5; 50:50) at 1 mL/min and detection at 265 nm. Validation demonstrated compliance with selectivity, linearity (r = 0.9996), sensitivity (LoD 6.51 µg/mL; LoQ 19.74 µg/mL), accuracy (99.6–101.3%), and precision (<2%, except one interday result at 2.08%). Micro-dissolution testing showed sustained ketoconazole release, exceeding 100% within 240 minutes. Data modeling (performed using DDSolver) indicated comparable fit for the Higuchi (R²_adj = 0.96) and Korsmeyer (R²_adj = 0.93) models, suggesting diffusion-controlled release of ketokonazole. The validated UHPLC method is suitable for micro-dissolution studies, and the alginate-acacia gum formulation effectively modulates drug release.
Ultra-High Performance Liquid Chromatography Method Validation for Micro-dissolution Analysis of Ketoconazole in Alginate-Acacia Gum Composite Capsules Lumakso, Fajar Aji; Annisa, Viviane; Cermenda, Riska; Chabib, Lutfi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24078

Abstract

Ketoconazole, a BCS Class 2 antifungal drug, has good absorption but suffers from low solubility and poor bioavailability. To address this, a natural polymer-based matrix of alginate and acacia gum was formulated to enhance dissolution. This study aimed to validate a Ultra High Performance Liquid Chromatography method for analyzing ketoconazole content in micro-dissolution testing of capsule formulations. The method employed a C18 column with a mobile phase of acetonitrile:WFI (0.15% TEA, pH 3.5; 50:50) at 1 mL/min and detection at 265 nm. Validation demonstrated compliance with selectivity, linearity (r = 0.9996), sensitivity (LoD 6.51 µg/mL; LoQ 19.74 µg/mL), accuracy (99.6–101.3%), and precision (<2%, except one interday result at 2.08%). Micro-dissolution testing showed sustained ketoconazole release, exceeding 100% within 240 minutes. Data modeling (performed using DDSolver) indicated comparable fit for the Higuchi (R²_adj = 0.96) and Korsmeyer (R²_adj = 0.93) models, suggesting diffusion-controlled release of ketokonazole. The validated UHPLC method is suitable for micro-dissolution studies, and the alginate-acacia gum formulation effectively modulates drug release.
Riview Literatur : Aktivitas Daun Yakon (Smallanthus Sonchifolus) Sebagai Antibakteri Terhadap Staphylococcus Aureus Lutfi Chabib; Arba Pramundita; Prima Aulia Putra; Hady Anshory
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.44403

Abstract

Kulit merupakan organ tubuh terluas yang menutupi seluruh bagian tubuh dan memiliki peran penting untuk melindungi organ tubuh. Posisi kulit terluar menyebabkan kulit rentan terkena penyakit kulit dan terjadi infeksi. Mayoritas infeksi kulit disebabkan oleh bakteri Staphylococcus aureus (S.aureus), yaitu bakteri gram positif yang dapat menyerang kekebalan tubuh. Salah satu cara untuk membunuh bakteri adalah menggunakan zat yang mengandung antibakteri. Salah satu tanaman yang berpotensi menjadi antibakteri adalah Yakon (Smallanthus sonchifolius). Skrining fitokimia menunjukkan bahwa daun yakon memiliki kandungan flavonoid, alkaloid, tanin, saponin, dan steroid yang berfungsi sebagai antibakteri. Senyawa lain yaitu seskuiterpen lakton juga ditemukan pada daun yakon dan memiliki aktivias antibakteri. Penggunaan ekstrak daun yakon pada konsentrasi 15% menghasilkan aktivitas antibakteri yang sangat kuat. Metodologi yang digunakan dalam tinjauan jurnal ini adalah tinjauan naratif, yang melibatkan pemeriksaan ekstensif literatur nasional dan internasional. Temuan pustaka menunjukkan bahwa daun yakon memiliki sifat antibakteri dan menghasilkan zona hambat terhadap bakteri Staphylococcus aureus (S.aureus).
Analytical Method Validation of High Performance Liquid Chromatography for Ketoconazole Tablets Lumakso, Fajar Aji; Annisa, Viviane; Alviansyah, Muhammad Rizal; Chabib, Lutfi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.69415

Abstract

Ketoconazole is an azole antifungal with low solubility and classified as Biopharmaceutical Classification System (BCS) Class II. A tablet formulation based on an alginate-acacia gum matrix is developed to enhance the solubility of ketoconazole. This study aims to validate the analytical method using High-Performance Liquid Chromatography (HPLC) for the assay of ketoconazole in these tablet formulations. The analysis was performed using a C18 column (250×4.6 mm, 5 μm) with a mobile phase consisting of water for injection (WFI) containing 0.15% TEA (pH 3.3) and acetonitrile (50:50 v/v), flow rate 1.0 mL/min, and detection at 232 nm. Method validation included system suitability testing, linearity, accuracy, precision, specificity, LOD, and LOQ. Specificity testing indicated no interference at the retention time of ketoconazole. Good linearity was achieved over 10–250 ppm (r = 0.9996), with good accuracy (99.8–101.75%) and precision (intraday and interday; %RSD < 2%). LOD and LOQ were 2.357 ppm and 7.142 ppm, respectively. The developed HPLC method was shown to be valid, accurate, precise, selective, and reliable for the assay of ketoconazole in tablets formulated with an alginate-acacia gum matrix. This method can be used for routine quality control.
Co-Authors Achmad Fachrodji Agenilia Permatasari Aghna Mafruha Zahrah, Aghna Mafruha Agus Santosa Agustina Setiawati Aji Winanta Akhmad Fauzy Akhmad Nabil Akhmad Nabil, Akhmad Ali Djamhuri Alviansyah, Muhammad Rizal Anggara Setyabawana Putra Annisa, Viviane Aprianto . Aprianto Aprianto Arba Pramundita Arba Pramundita Ramadani Arifa Caryn Dea Utami Hasyono Arismunandar, Arif Asih Triastuti Baharuddin Yusuf Baharudin Yusuf Baruna, Renno Ramadhani Ika Cermenda, Riska Cynthia Astiti Putri Dewi, Melynia Sintha Dimas Adhi Pradana Dzihni Meytasari Farah Deastasa Nabilah Ferdy Firmansyah Gandhi Barajana Vedha Gani, Michael Raharja Gelu, Maria Andriani Guanse, Yovi Hady Anshory Hamzah, Hasyrul Hanida Destriana Fatmawati Hani’atul Kharimah Hannie Fitriani Hasnaeni hasnaeni, Hasnaeni Hastri Kholifah Hayati, Farida Herman Felani Hilda Ismail, Hilda Ipaenin, Jahiria Jenita Gandi, Brigita Tuelvin Kamarulzaman, Ezatul Ezleen Kholidah, Ziyyatul Kinanti, Valentina Putri Embun Lumakso, Fajar Aji M. Pandoman febrian Maemonah, Maemonah Martien, Ronny Maulana Ardhi Mimiek Murrukmihadi Mufrod Mufrod Muh Iqbal Pangestu Muhammad Faisal Muhammad Ikhwan Rizki Muhammad Iqbal Pangestu Muhammad Safarullah Muhtadi, Wildan Khairi Muslim, M. Rifqi Fadillah Mutiara Herawati, Mutiara Muzakir, Mellisa Nurul Afifi Lobubun Oktavia Indrati, Oktavia Prima Aulia Putra Reihan Khairiati Renno Ramadhani Ika Baruna Ria Cahya Andriana Rini Dwiastuti Ririn Wulandari Rischi Dwi Irianti Rischi Dwi Irianti, Rischi Dwi Rizki Awaluddin Rizqi, Syifa Maulidia Rochmy Istikharah Ronny Martien Ronny Martien Samsul Hadi Siti Zahliyatul Munawiroh Suryani, Arman Syarif Hidayatullah Taufikurrahmi Taufikurrahmi Trianloka, A. M. Bagas Tunny, Risman Uzulul Hikmah Wahyu, Imron Yandi Syukri Yosi Febrianti, Yosi Ziyyatul Kholidah