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All Journal Journal of Food and Pharmaceutical Science Jurnal Ilmiah Farmasi Indonesian Journal of Pharmaceutical Science and Technology MEDISAINS AJIE (Asian Journal of Innovation and Entrepreneurship) JURNAL PHARMASCIENCE Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) CHEESA: Chemical Engineering Research Articles JSFK (Jurnal Sains Farmasi & Klinis) AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Abdimas Madani dan Lestari (JAMALI) Jurnal Ners Medfarm: Jurnal Farmasi dan Kesehatan Journal of Pharmaceutical and Health Research Hydrogen: Jurnal Kependidikan Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Khazanah: Jurnal Mahasiswa SWARNA Journal of Food and Pharmaceutical Sciences Parapemikir Jurnal Ilmiah Farmasi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Pharmascience
Lutfi Chabib, Lutfi
Department Of Pharmacy, Islamic University Of Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Review Rheumatoid Arthritis: Terapi Farmakologi, Potensi Kurkumin dan Analognya, serta Pengembangan Sistem Nanopartikel Lutfi Chabib; Zullies Ikawati; Ronny Martien; Hilda Ismail
Journal of Pharmascience Vol. 3 No. 1 (2016): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v3i1.5830

Abstract

 ABSTRAK  Rheumatoid arthritis  (RA) adalah  penyakit  autoimun  yang menyebabkan  peradangan  kronis  pada sendi. Penatalaksanaan RA harus agresif dan sedini mungkin sehingga mampu meningkatkan hasil jangka pendek maupun panjang penderita. Rheumatoid arthritis akibat reaksi autoimun dalam jaringan sinovial yang melibatkan proses fagositosis. Tujuan dari pengobatan rheumatoid arthritis tidak hanya mengontrol gejala penyakit, tetapi juga penekanan aktivitas penyakit untuk mencegah kerusakan permanen. Penderita RA memulai pengobatan mereka dengan DMARDs (Disease Modifying Anti-Rheumatic Drugs) seperti metotreksat, sulfasalazin dan leflunomid. Alternatif pengobatan yang dapat dijadikan salah satu pilihan dalam penanganan RA yaitu senyawa kurkumin dan analognya. Sistem nanopartikel mampu meningkatan efektifitas dalam pengobatan terutama keadaan RA. Kata kunci : rheumatoid arthritis, Disease Modifying Anti-Rheumatic Drugs, kurkumin, nanopartikel. ABSTRACT Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Management of RA must be aggressive and as early as possible so as to increase the yield of short and long term patients. Rheumatoid arthritis due to an autoimmune reaction in the synovial tissue that involves the process of phagocytosis. The purpose of the treatment of rheumatoid arthritis not only control the symptoms of the disease, but also suppressed disease activity to prevent permanent damage. RA patients begin their treatment with DMARDs (Disease Modifying Anti-Rheumatic Drugs) such as methotrexate, sulfasalazine and leflunomid. Alternative treatments that can be used as an option in the treatment of RA are compounds curcumin and its analogs. Nanoparticle systems is able to increase the effectiveness in the treatment of RA, especially state. Keywords: rheumatoid arthritis, Disease Modifying Anti-Rheumatic Drugs, curcumin, nanoparticles.
Pengujian Toksisitas Seluler SNEDDS Ekstrak Daun Kangkung (Ipomoea reptans, Poir) Terstandar Lutfi Chabib; Farida Hayati; Rizki Awaluddin; Muh Iqbal Pangestu
Journal of Pharmascience Vol. 6 No. 2 (2019): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v6i2.7350

Abstract

ABSTRAK Kangkung darat (Ipomea reptans Poir) adalah salah satu tanaman di Indonesia yang secara empiris telah dimanfaatkan oleh masyarakat sebagai obat untuk terapi Diabetes Melitus (DM).  Riset sebelumnya telah dilakukan untuk memperoleh data ilmiah dari pemanfaatan kangkung darat sebagai terapi DM, dan pengembangannya dalam bentuk sediaan Self Nano Emulsifying Drug Delivery System (SNEDDS). Penelitian ini bertujuan untuk mengetahui sitotoksisitas sediaan SNEDDS ekstrak daun kangkung terstandar dengan menggunakan metode MTT (Methyl-Thiazolyl-Tetrazolium). Pengujian MTT dilakukan dengan cara well plate diplotkan terlebih dahulu untuk sampel uji 70 sumuran (well), kontrol sel 6 sumuran, dan kontrol media 6 sumuran.  Terakhir tiap sumuran ditambahkan stopper SDS sebanyak 100µl. Plate dibungkus alumunium foil dan diinkubasi semalaman pada suhu ruang. Hari berikutnya dilakukan pembacaan absorbansi sampel, kontrol media, dan kontrol sel menggunakan ELISA reader. Uji sitotoksik SNEEDS kangkung pada sel vero diperoleh hasil bahwa SNEEDS kangkung tidak menyebabkan kematian pada sel uji. Pada pengujian sel dilakukan pemaparan sampel excipient dari SNEEDS kangkung sebagai pembanding, dengan hasil menyebabkan kematian <50% sel uji pada dua kadar tertinggi dari sampel excipient. Namun pada hasil uji SNEEDS kangkung diperoleh data bahwa toksisitas excipient pada kadar tersebut tidak mempengaruhi timbulnya toksisitas pada sampel SNEEDS kangkung. Sehingga berdasarkan uji in vitro, SNEEDS kangkung tidak toksik terhadap sel vero. Kata kunci: Ipomoea reptans, sitotoksisitas, SNEDDS  ABSTRACT Kangkong (Ipomea reptans Poir) is a type of Indonesian plant empirically utilized by many people to treat diabetes mellitus (DM). A study has been conducted to obtain scientific data from the use of kangkong for DM treatment as well as to develop kangkong in SNEDDS preparation. This current study aimed to examine the cytotoxicity of kangkong leaf standardized extract in SNEDDS preparation through the MTT (Methyl-Thiazolyl-Tetrazolium) method. MTT assay was performed by initially plotting well plates for test sample (70 wells), control cell (6 wells), and control medium (6 wells). As much as 100µl SDS stopper was added into each well, and then plates were wrapped in aluminum foil and incubated all night at ambient temperature. On the following day, the absorbance of test sample, control medium, and control cell was identified using ELISA reader. The cytotoxicity test of kangkong SNEDDS on Vero cell lines showed that kangkong SNEDDS did not cause cell death. The cell was tested through exposure of excipient sample from kangkong SNEDDS as a comparison, resulting in <50% cell death by the two highest concentrations of excipient sample. However, the test result of kangkong SNEDDS indicated that excipient toxicity at such concentrations did not affect kangkong SNEDDS. Therefore, based on in vitro test, kangkong SNEDDS is not toxic against Vero cell lines. Keywords: Ipomoea reptans, cytotoxicity, SNEDDS
Optimization and Physical Characterization of Kojic Acid Nanoemulsion Formula As A Whitening Agent Yovi Guanse; Rini Dwiastuti; Brigita Tuelvin Jenita Gandi; Lutfi Chabib
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009968

Abstract

Kojic acid (KA) as a topical formulation prevents hyperpigmentation through the inhibition of tyrosinase activity. However, KA has higher solubility in nonpolar solvents. Nanoparticle technology can be a novel innovation to enhance KA absorption into the skin. This study aims to improve the delivery of topically applied KA by enhancing absorption into the stratum corneum by optimizing the concentration of surfactant Tween 80 and co-surfactant Span 80. The nanoemulsion uses KA as an active ingredient and virgin coconut oil as the oil phase. The optimum area was analyzed using Design-Expert® 13 software, with a pure experimental design based on a 2x2 factorial design. The results indicate that all formulas are within the optimal region. Therefore, the determination of the optimal point can be grounded on the smallest composition within the optimal region with the objective of maximizing material efficiency, which is a formula with a concentration of Tween 80 and Span 80 of 10 grams and 3 grams, respectively. The particles are a spherical smooth shape and demonstrate an efficacy of 94.117% in inhibiting tyrosinase activity.
Edukasi dan Demonstrasi Pengolahan Limbah Kulit Nanas Menjadi Teh Herbal di Desa Kualu Nenas Ferdy Firmansyah; Rickha Octavia; Ilham Syahbandi; Artha Carolina; Febry Azizah; Tengku Shella; Saskira Windy; Wistiqomah Indasari; Lutfi Chabib
SWARNA: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 7 (2026): SWARNA : Jurnal Pengabdian Kepada Masyarakat, Juli, 2026
Publisher : LPPM Sekolah Tinggi Ilmu Ekonomi 45 Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/swarna.v5i7.3187

Abstract

Desa Kualu Nenas merupakan salah satu sentra produksi nanas di Kabupaten Kampar, tetapi kulit nanas dari kegiatan konsumsi dan pengolahan belum dimanfaatkan secara optimal. Kegiatan pengabdian ini bertujuan meningkatkan pengetahuan masyarakat mengenai hipertensi serta memperkenalkan pengolahan kulit nanas menjadi teh herbal berbasis potensi lokal. Kegiatan dilaksanakan pada 3 Agustus 2023 di Aula Kantor Desa Kualu Nenas dan diikuti oleh 70 peserta, terdiri atas 60 perempuan dan 10 laki-laki. Metode kegiatan meliputi penyuluhan, demonstrasi pembuatan Herjakunas Tea dari campuran serbuk kulit nanas dan jahe merah, serta evaluasi pengetahuan menggunakan kuesioner pretest dan posttest. Data dianalisis secara deskriptif berdasarkan persentase jawaban yang sesuai. Hasil menunjukkan peningkatan pengetahuan pada seluruh kelompok peserta dengan rentang 1,37–24,27 poin persentase. Skor peserta perempuan meningkat dari 66,80% menjadi 76,80%, sedangkan peserta laki-laki meningkat dari 63,33% menjadi 75,83%. Peningkatan tertinggi berdasarkan wilayah terdapat pada Dusun 4 sebesar 23,25 poin persentase, sedangkan berdasarkan pendidikan terdapat pada kelompok SMA sebesar 24,27 poin persentase. Penyuluhan yang dipadukan dengan demonstrasi praktis diikuti oleh peningkatan deskriptif persentase respons peserta sekaligus memperkenalkan pemanfaatan limbah kulit nanas.
Co-Authors Agenilia Permatasari Aghna Mafruha Zahrah, Aghna Mafruha Agus Santosa Aji Winanta Akhmad Fauzy Akhmad Nabil Akhmad Nabil, Akhmad Ali Djamhuri Alviansyah, Muhammad Rizal Anggara Setyabawana Putra Aprianto . Aprianto Aprianto Arba Pramundita Arba Pramundita Ramadani Arifa Caryn Dea Utami Hasyono Arismunandar, Arif Artha Carolina Asih Triastuti Awaluddin, Rizki Baharuddin Yusuf Baharudin Yusuf Baruna, Renno Ramadhani Ika Brigita Tuelvin Jenita Gandi Cermenda, Riska Cynthia Astiti Putri Dimas Adhi Pradana Dzihni Meytasari Farah Deastasa Nabilah Febry Azizah Ferdy Firmansyah Gandhi Barajana Vedha Hady Anshory Hamzah, Hasyrul Hani’atul Kharimah Hanida Destriana Fatmawati Hani’atul Kharimah Hannie Fitriani Hasnaeni hasnaeni, Hasnaeni Hastri Kholifah Hayati, Farida Herman Felani Hilda Ismail, Hilda Ilham Syahbandi Ipaenin, Jahiria Kamarulzaman, Ezatul Ezleen Kholidah, Ziyyatul Lumakso, Fajar Aji M. Pandoman febrian Maemonah, Maemonah Martien, Ronny Maulana Ardhi Mimiek Murrukmihadi Mufrod Mufrod Muh Iqbal Pangestu Muhammad Ikhwan Rizki Muhammad Iqbal Pangestu Muhammad Safarullah Muhtadi, Wildan Khairi Muslim, M. Rifqi Fadillah Mutiara Herawati, Mutiara Muzakir, Mellisa Nurul Afifi Lobubun Oktavia Indrati, Oktavia Prima Aulia Putra Reihan Khairiati Renno Ramadhani Ika Baruna Ria Cahya Andriana Rickha Octavia Rini Dwiastuti Rischi Dwi Irianti Rischi Dwi Irianti, Rischi Dwi Rizqi, Syifa Maulidia Rochmy Istikharah Ronny Martien Ronny Martien Samsul Hadi Saskira Windy Siti Zahliyatul Munawiroh Suryani, Arman Syarif Hidayatullah Taufikurrahmi Taufikurrahmi Tengku Shella Trianloka, A. M. Bagas Tunny, Risman Uzulul Hikmah Viviane Annisa Wahyu, Imron Wistiqomah Indasari Yandi Syukri Yosi Febrianti, Yosi Yovi Guanse Ziyyatul Kholidah