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Nanoparticles and Nanoliposomes for Hair Growth Serum Arismunandar, Arif; Chabib, Lutfi; Ramadani, Arba Pramundita; Suryani, Arman; Kamarulzaman, Ezatul Ezleen
CHEESA: Chemical Engineering Research Articles Vol. 7 No. 1 (2024)
Publisher : Universitas PGRI Madiun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/cheesa.v7i1.19908.57-66

Abstract

Solubility in penetrating the follicles is the main obstacle in the formulation of hair growth serum preparation with chemicals derived from natural or synthetic materials. Therefore, a delivery system is needed to deliver more chemical compounds into the follicles. Nanoparticles and nanoliposomes are potential chemical compound delivery systems in hair growth serum. Specifically, nanoparticles with a particle size of less than 200 nm can increase the transport of serum chemical compounds into the scalp. The small particle size makes the interaction between atoms and molecules faster and prevents clumping with the repulsive force of dispersed particles. Meanwhile, nanoliposomes with lipids as encapsulation in the delivery of lipophilic or hydrophilic chemical compounds with nanosizes can significantly increase serum diffusion on the scalp.
KARAKTERISTIK GEL-NANOLIPOSOM MINYAK ROSEMARI (Rosmarinus officinalis) UNTUK FORMULASI SEDIAAN PENINGKATAN PERTUMBUHAN RAMBUT Baruna, Renno Ramadhani Ika; Ramadani, Arba Pramundita; Chabib, Lutfi
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 13 No 1 (2024): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v13i1.253

Abstract

Hair loss occurs in many people, both men and women. Rosemari (Rosemarinus officinalis) is one of the plants shown to significantly improve hair growth in alopecia patients. Nanoliposome gel can enhance the activity of bioactive agents by increasing solubility, bioavailability, stability and preventing unnecessary interactions with other molecules in cosmetic preparations. The purpose of this study was to determine the physical characteristics and stability of nanoliposome gel as a carrier of rosemary oil produced. The nanoliposome formulations were evaluated: organoleptical, particle size and zeta potential, and morphological tests. The results of the physical characteristics of nanoliposomes in the form of a slightly cloudy clear gel, semi-liquid texture and typical aromatic odor of rosemary, particle size of 210.5 nm, zeta potential of -23.2 nV, and spherical morphology. Rosemary oil nanoliposome gel preparation has good physical characteristics and stability, so it can be used as a preparation formulation for hair growth.
EFEKTIVITAS DAN EFEK SAMPING DARI IMPLAN LEVONORGESTREL DAN IMPLAN ETONOGESTREL: REVIEW ARTICLE Chabib, Lutfi; M. Pandoman febrian; Hannie Fitriani; Uzulul Hikmah
Majalah Farmasi dan Farmakologi Vol. 27 No. 3 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i3.24910

Abstract

Implan levonorgestrel (LVN) dan etonogestrel (ENG) merupakan contoh long-acting reversible contraception (LARC) yang memiliki efektifitas yang tinggi dalam pencegahan kehamilan pada jangka waktu yang panjang. Penulisan review ini bertujuan untuk membandingkan efektifitas dan efek samping terkait LVN 2 batang dan ENG 1 batang sebagai alat kontrasepsi implan subdermal. Studi mengenai perbandingan efikasi implan LVN dengan implan ENG menunjukkan bahwa keduanya memiliki efikasi sebagai kontrasepsi yang baik diamati dari tingkat kejadian kehamilan yang sangat rendah. Perbedaan antara keduanya dapat dilihat dari berapa lama durasi yang disetujui untuk perlindungan dalam pencegahan kehamilan yaitu 3 tahun untuk implan ENG dan 5 tahun untuk implan LVN. Selain itu, Efektivitas kedua implan tersebut dalam mencegah kehamilan menunjukkan efek yang sebanding dari berbagai pengujian. Terkait studi mengenai efek samping menunjukkan bahwa efek samping pendarahan pada penggunaan ENG lebih besar dibandingkan pada implan LVN, sehingga LVN lebih dipilih dibandingkan dengan ENG.
Innovative insight: ChatGPT's contribution to advanced health research articles Muslim, M. Rifqi Fadillah; Chabib, Lutfi; Hamzah, Hasyrul; Santosa, Agus
MEDISAINS Vol 21, No 3 (2023)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v21i3.20211

Abstract

The current technological advancement follows a pattern of both disruptive and gradual changes. The field of communication is currently the most extensively utilized technology. The rapid development of AI has enabled those without a background in computer coding or specialized health knowledge to utilize this technology, which gives rise to numerous issues. This phenomenon elicits curiosity and engenders debate among the general public, scholars, healthcare providers, and researchers in the health industry. Utilizing AI in the composition of scientific publications necessitates explicit norms and regulations, a robust validation procedure, and effective collaboration between AI systems and human expertise. Ensuring transparency and acknowledgment of AI usage is crucial to maintaining human researchers' accountability for the ultimate outcomes of their research.
Potential advancement utilizing nanotechnology-based delivery system to enhance the therapeutic properties of lavender essential oil: a review article Trianloka, A. M. Bagas; Chabib, Lutfi; Ramadani, Arba Pramundita
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art6

Abstract

Background: Essential oils (EO), such as lavender (Lavandula spp.), which are derived from its flower, have become a growing trend in recent years as an alternative medicine in therapy. However, the poor physicochemical properties of EOs have several disadvantages for their application. Integrating nanotechnology into the formulation of medicinal dosage forms may provide a viable way to mitigate these limitations and improve the effectiveness of EO utilization.Objective: This literature review aims to gather information on the medicinal benefits of lavender EO and the prospective applications of nanotechnology-based delivery systems for EOs.Method: Online databases such as PubMed, Science Direct, Research Gate, Google Scholar, and other reliable sources were used to find 65 publications between 1991 and 2021, which are assessed in this review.Results: It is revealed that the main constituents of lavender EO are linalool, linalyl acetate, and lavandulyl acetate. Its effectiveness as an antibacterial, antioxidant, anticancer, anti-anxiety, and having effects on the central nervous system, along with other qualities including pain relief, has been demonstrated via numerous studies. Additionally, it was demonstrated to have dermatological properties that helped treat dermatitis and encouraged both hair growth and wound healing. Furthermore, it was also found that the application of nanotechnology in EOs has improved the concentration of active compounds in the blood and produced a stable dosage form while also increasing its efficacy.Conclusion: It is feasible to create nanoparticle dosage forms from lavender EO that can improve the substance's solubility, stability, and pharmacological effects. More research is necessary to formulate lavender EO by applying nanotechnology.
PKM KELOMPOK PKK DESA BANDUNGREJO KABUPATEN MAGELANG JAWA TENGAH DALAM PEMBUATAN MINUMAN HERBAL INSTAN Chabib, Lutfi; Wahyu, Imron; Felani, Herman; Muzakir, Mellisa
Amaliah: Jurnal Pengabdian Kepada Masyarakat Vol 8 No 2 (2024): Amaliah Jurnal: Pengabdian kepada Masyarakat
Publisher : LPPI UMN AL WASHLIYAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/ajpkm.v8i2.3789

Abstract

Desa Bandungrejo merupakan salah satu desa yang terletak di Kecamatan Ngablak, Kabupaten Magelang, Provinsi Jawa Tengah. Desa Bandungrejo terletak sekitar 10 km dari Kota Magelang dengan waktu tempuh 30 menit. Desa Bandungrejo memiliki luas 375 ha, dengan pekarangan/bangunan seluas 52 ha dan ladang seluas 292 ha. Kelurahan Bandungrejo terdapat 9 dusun yaitu: Noyogaten, Bakalan, Bandungrejo, Pendem, Citrogaten, Brongkol, Kayuares, Kenanggan, Soromayan. Kondisi tanah yang berada di daerah pegunungan menjadikan desa Bandungrejo sangat cocok untuk tanaman sayuran dan tanaman herbal berupa jahe, kunyit, temulawak dan kencur yang masih terbatas dalam pengolahan dan pemanfaatannya. Berdasarkan permasalahan tersebut maka pemberdayaan Masyarakat ini akan di laksanakan oleh Kelompok PKK Barokah Desa Bandungrejo, faktor tersebut akibat dari keterbatasan mitra dalam mengolah dan menghasilkan produk herbal yang siap konsumsi dan layak jual, faktor tersebut akibat dari aspek produksi, aspek sumber daya manusia, dan aspek manajemen. Tujuan pelaksanaan program pengabdian masyarakat ini adalah mendorong terciptanya peningkatan ekonomi warga yang selama ini terjadi dikarenakan rendahnya pengetahuan dan pemahaman teknologi dalam pengolahan produk herbal menjadi produk siap konsumsi dan layak jual bernilai ekonomis lebih tinggi. Metode yang digunakan dalam mencapai tujuan tersebut dengan pendampingan pengenalan tanaman herbal, pengolahan, produksi dan pemasaran. Luaran yang di capai dalam kegiatan pengabdian ini adalah peningkatan kapasitas sumber daya manusia kelompok PKK Desa Bandungrejo dalam membuat produk minuman herbal instan serta peningkatan kapasitas dalam motivasi berwirausaha, manajemen dan pemasaran.
Fabrikasi dan Studi Stabilitas Self-Nano Emulsifying Propolis menggunakan Minyak Kesturi sebagai Pembawa Syukri, Yandi; Kholidah, Ziyyatul; Chabib, Lutfi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 6 No 3 (2019): J Sains Farm Klin 6(3), Desember 2019
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.6.3.265-273.2019

Abstract

Propolis merupakan resin yang sukar larut dalam air yang dihasilkan lebah, berkhasiat sebagai antibakteri, antioksidan, serta antiinflamasi. Salah satu metode untuk meningkatkan kelarutan obat adalah teknologi self-nano emulsifying (SNE). Penelitian ini bertujuan untuk melakukan formulasi, karakterisasi, dan studi stabilitas SNE propolis dengan pembawa minyak kesturi, cremophor RH 40, dan PEG 400. Preparasi SNE dilakukan dengan mencampurkan propolis dengan pembawa. Area nanoemulsi ditentukan dengan konstruksi diagram fase terner. Karakterisasi dilakukan dengan penentuan ukuran partikel, zeta potensial, transmitan, stabilitas termodinamika, uji ketahanan, dan uji stabilitas dipercepat. Daerah nanoemulsi terdapat pada F1-F9 dengan range komposisi minyak kesturi (10-30%), cremophor RH 40 (40-80%), dan PEG 400 (10-40%). Kesembilan formula menghasilkan nilai transmitan pada 96-99%, ukuran partikel 10-40 nm, serta zeta potensial kurang dari -40 mV. Uji ketahanan menunjukkan hasil yang baik pada F4 (1: 5: 4), F5 (2: 7: 1), dan F6 (2: 6: 2). Uji stabilitas dipercepat, F5 (2: 7: 1) menghasilkan SNE yang paling optimal karena tidak teramati pemisahan fase dan pengendapan, dengan karakterisasi nilai transmitan antara 97-99%, ukuran partikel antara 16-19 nm, dan nilai PDI 0,1-0,2. Dapat disimpulkan bahwa SNE propolis dengan pembawa minyak kesturi, cremophor RH 40, dan PEG 400 menghasilkan karakteristik dan profil stabilitas yang baik.
A Literature Review: Antimicrobial Phenolic Compounds in Nutmeg (Myristica fragrans Houtt) Ipaenin, Jahiria; Chabib, Lutfi; Hasnaeni, Hasnaeni; Tunny, Risman
Hydrogen: Jurnal Kependidikan Kimia Vol 13, No 1 (2025): February 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i1.14583

Abstract

In various countries, testing of phenolic compounds in plants is always carried out because these compounds have various health benefits such as antioxidant, anti-inflammatory, and antimicrobial activities. The types of medicinal plants in Indonesia are known to be very diverse where those included in the medicinal plant group reach more than 1000 species, one of which is nutmeg (Myristica fragrans Houtt.) Nutmeg (Myristica fragrans Houtt.) itself is native to the Maluku Islands, Indonesia. However, besides the Moluccas, nutmeg is also cultivated in several other tropical countries. The main objective of this literature review is to critically examine the antimicrobial properties and identify the specific antimicrobial components of phenolic compounds contained in nutmeg (Myristica fragrans Houtt.) The methodology used in this study involved a comprehensive literature review by utilizing reputable academic databases such as Google Scholar, PubMed, and Science Direct related to articles published between 2019 and 2024. The results of this study were obtained through a thorough search process, resulting in eight articles that were considered to meet the established inclusion criteria. A number of articles showed the effectiveness of nutmeg as an antimicrobial because nutmeg contains phenolic compounds that have antibacterial and antifungal properties, which make it effective as an antimicrobial agent. Therefore, with a more comprehensive understanding of the content of phenolic compounds and their mechanism of action, nutmeg can be a further basis for study in the health sector and the pharmaceutical industry.
Nanoemulgel Formulation of Eleutherine palmifolia Onion Bulb Extract and Its Effectiveness in Wound Healing Faisal, Muhammad; Chabib, Lutfi; Dewi, Melynia Sintha; Gani, Michael Raharja; Dwiastuti, Rini
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007454

Abstract

Eleutherine palmifolia onion, an indigenous medicinal plant from Borneo, is empirically applied to treat wound healing. The objective of this study is to formulate its extract and assess its in vivo wound healing activity. Eleutherine palmifolia onion was extracted with a 96% ethanol solvent. The extract of the Dayak onion bulb was then formulated into a nanoemulsion by applying the DOE method of 2-level factorial design. Four nanoemulsion formulations were further analyzed to obtain the optimal formulation. The particle size analysis and % transmittance was performed using a particle size analyzer and an ultraviolet-visible spectrophotometer. Furthermore, the data were analyzed using the Minitab 19 application with the DOE factorial design method. The three nanoemulgel formulations containing 2.5, 5.0, and 7.5% extract were further investigated for wound healing efficacy in rats. The duration of wound closure was analyzed using paired t-tests. The best nanoemulsion formulation was made with 22.5 mL of Tween 80 and 2 mL of isopropyl myristate oil. This produced particles that were 12.13 nm in size and a 99.12% transmittance rate. Wound length measurements were taken daily for 15 days. The statistical test results of p0.05 indicate that the nanoemulgel of the extract has significant activity in wound healing. The optimal nanoemulsion formula is formula A, and the effective dose of Dayak onion extract nanoemulgel is 5% and 7.5% concentrations, with a wound healing time of 13 days.
Formulation of Nanoemulsion Sunscreen of Centella asiatica (L.) Extract and Its Effectivity Test Dwiastuti, Rini; Kinanti, Valentina Putri Embun; Gelu, Maria Andriani; Setiawati, Agustina; Chabib, Lutfi
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 1 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009910

Abstract

Sunscreen protects against ultraviolet (UV) rays. It has a Sun Protection Factor (SPF) value. Centella asiatica (L.) is a herbal plant that contains flavonoid and triterpenoid compounds as antiphotoaging agents. Development of Centella asiatica (L.) extract in nanoemulsion preparation increases its solubility in water and absorption. This study aims to obtain the optimum formula of Centella asiatica (L.) nanoemulsion preparation from the combined use of Tween-80 and Propylen glycol surfactants and determine the effectiveness of Centella asiatica (L.) extract in vitro. The effectiveness of Centella asiatica (L.) extract was tested in vitro using UV-Vis spectrophotometry expressed by SPF value. Development of Centella asiatica (L.) extract nanoemulsion formula using a combination of surfactants Tween-80 and Propylen glycol with factorial design 2 factors and 2 levels. P-value0.05 stated that there is a statistically significant difference in the formula. Centella asiatica (L.) extract has protective power against UV rays at concentrations of 120, 240, and 360 xg with SPF-values of 8.999, 19.219, and 29.569, respectively. Meanwhile, the nanoemulsion response analysis revealed the response of the nanoemulsion produced (p0.05). The optimum formula obtained was found in the nanoemulsion formula with a combination of Tween-80 and PG at a low level.
Co-Authors Achmad Fachrodji Agenilia Permatasari Aghna Mafruha Zahrah, Aghna Mafruha Agus Santosa Agustina Setiawati Aji Winanta Akhmad Fauzy Akhmad Nabil Akhmad Nabil, Akhmad Ali Djamhuri Anggara Setyabawana Putra Aprianto . Aprianto Aprianto Arba Pramundita Ramadani Arifa Caryn Dea Utami Hasyono Arismunandar, Arif Asih Triastuti Baharuddin Yusuf Baharudin Yusuf Baruna, Renno Ramadhani Ika Cynthia Astiti Putri Dewi, Melynia Sintha Dimas Adhi Pradana Dzihni Meytasari Farah Deastasa Nabilah Ferdy Firmansyah Gandhi Barajana Vedha Gani, Michael Raharja Gelu, Maria Andriani Guanse, Yovi Hamzah, Hasyrul Hanida Destriana Fatmawati Hani’atul Kharimah Hannie Fitriani Hasnaeni hasnaeni, Hasnaeni Hastri Kholifah Hayati, Farida Herman Felani Hilda Ismail, Hilda Ipaenin, Jahiria Jenita Gandi, Brigita Tuelvin Kamarulzaman, Ezatul Ezleen Kholidah, Ziyyatul Kinanti, Valentina Putri Embun M. Pandoman febrian Maemonah, Maemonah Martien, Ronny Maulana Ardhi Mimiek Murrukmihadi Mufrod Mufrod Muh Iqbal Pangestu Muhammad Faisal Muhammad Ikhwan Rizki Muhammad Iqbal Pangestu Muhammad Safarullah Muhtadi, Wildan Khairi Muslim, M. Rifqi Fadillah Mutiara Herawati, Mutiara Muzakir, Mellisa Nurul Afifi Lobubun Oktavia Indrati, Oktavia Pramundita, Arba Putra, Prima Aulia Reihan Khairiati Renno Ramadhani Ika Baruna Ria Cahya Andriana Rini Dwiastuti Ririn Wulandari Rischi Dwi Irianti Rischi Dwi Irianti, Rischi Dwi Rizki Awaluddin Rizqi, Syifa Maulidia Rochmy Istikharah Ronny Martien Ronny Martien Samsul Hadi Siti Zahliyatul Munawiroh Suryani, Arman Syarif Hidayatullah Tamhid, Hady Anshory Taufikurrahmi Taufikurrahmi Trianloka, A. M. Bagas Tunny, Risman Uzulul Hikmah Wahyu, Imron Yandi Syukri Yosi Febrianti, Yosi Ziyyatul Kholidah