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Fabrikasi dan Studi Stabilitas Self-Nano Emulsifying Propolis menggunakan Minyak Kesturi sebagai Pembawa Syukri, Yandi; Kholidah, Ziyyatul; Chabib, Lutfi
JSFK (Jurnal Sains Farmasi & Klinis) Vol 6 No 3 (2019): J Sains Farm Klin 6(3), Desember 2019
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.6.3.265-273.2019

Abstract

Propolis merupakan resin yang sukar larut dalam air yang dihasilkan lebah, berkhasiat sebagai antibakteri, antioksidan, serta antiinflamasi. Salah satu metode untuk meningkatkan kelarutan obat adalah teknologi self-nano emulsifying (SNE). Penelitian ini bertujuan untuk melakukan formulasi, karakterisasi, dan studi stabilitas SNE propolis dengan pembawa minyak kesturi, cremophor RH 40, dan PEG 400. Preparasi SNE dilakukan dengan mencampurkan propolis dengan pembawa. Area nanoemulsi ditentukan dengan konstruksi diagram fase terner. Karakterisasi dilakukan dengan penentuan ukuran partikel, zeta potensial, transmitan, stabilitas termodinamika, uji ketahanan, dan uji stabilitas dipercepat. Daerah nanoemulsi terdapat pada F1-F9 dengan range komposisi minyak kesturi (10-30%), cremophor RH 40 (40-80%), dan PEG 400 (10-40%). Kesembilan formula menghasilkan nilai transmitan pada 96-99%, ukuran partikel 10-40 nm, serta zeta potensial kurang dari -40 mV. Uji ketahanan menunjukkan hasil yang baik pada F4 (1: 5: 4), F5 (2: 7: 1), dan F6 (2: 6: 2). Uji stabilitas dipercepat, F5 (2: 7: 1) menghasilkan SNE yang paling optimal karena tidak teramati pemisahan fase dan pengendapan, dengan karakterisasi nilai transmitan antara 97-99%, ukuran partikel antara 16-19 nm, dan nilai PDI 0,1-0,2. Dapat disimpulkan bahwa SNE propolis dengan pembawa minyak kesturi, cremophor RH 40, dan PEG 400 menghasilkan karakteristik dan profil stabilitas yang baik.
A Literature Review: Antimicrobial Phenolic Compounds in Nutmeg (Myristica fragrans Houtt) Ipaenin, Jahiria; Chabib, Lutfi; Hasnaeni, Hasnaeni; Tunny, Risman
Hydrogen: Jurnal Kependidikan Kimia Vol 13, No 1 (2025): February 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i1.14583

Abstract

In various countries, testing of phenolic compounds in plants is always carried out because these compounds have various health benefits such as antioxidant, anti-inflammatory, and antimicrobial activities. The types of medicinal plants in Indonesia are known to be very diverse where those included in the medicinal plant group reach more than 1000 species, one of which is nutmeg (Myristica fragrans Houtt.) Nutmeg (Myristica fragrans Houtt.) itself is native to the Maluku Islands, Indonesia. However, besides the Moluccas, nutmeg is also cultivated in several other tropical countries. The main objective of this literature review is to critically examine the antimicrobial properties and identify the specific antimicrobial components of phenolic compounds contained in nutmeg (Myristica fragrans Houtt.) The methodology used in this study involved a comprehensive literature review by utilizing reputable academic databases such as Google Scholar, PubMed, and Science Direct related to articles published between 2019 and 2024. The results of this study were obtained through a thorough search process, resulting in eight articles that were considered to meet the established inclusion criteria. A number of articles showed the effectiveness of nutmeg as an antimicrobial because nutmeg contains phenolic compounds that have antibacterial and antifungal properties, which make it effective as an antimicrobial agent. Therefore, with a more comprehensive understanding of the content of phenolic compounds and their mechanism of action, nutmeg can be a further basis for study in the health sector and the pharmaceutical industry.
A Literature Review: Antimicrobial Phenolic Compounds in Nutmeg (Myristica fragrans Houtt) Ipaenin, Jahiria; Chabib, Lutfi; Hasnaeni, Hasnaeni; Tunny, Risman
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 1 (2025): February 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i1.14583

Abstract

In various countries, testing of phenolic compounds in plants is always carried out because these compounds have various health benefits such as antioxidant, anti-inflammatory, and antimicrobial activities. The types of medicinal plants in Indonesia are known to be very diverse where those included in the medicinal plant group reach more than 1000 species, one of which is nutmeg (Myristica fragrans Houtt.) Nutmeg (Myristica fragrans Houtt.) itself is native to the Maluku Islands, Indonesia. However, besides the Moluccas, nutmeg is also cultivated in several other tropical countries. The main objective of this literature review is to critically examine the antimicrobial properties and identify the specific antimicrobial components of phenolic compounds contained in nutmeg (Myristica fragrans Houtt.) The methodology used in this study involved a comprehensive literature review by utilizing reputable academic databases such as Google Scholar, PubMed, and Science Direct related to articles published between 2019 and 2024. The results of this study were obtained through a thorough search process, resulting in eight articles that were considered to meet the established inclusion criteria. A number of articles showed the effectiveness of nutmeg as an antimicrobial because nutmeg contains phenolic compounds that have antibacterial and antifungal properties, which make it effective as an antimicrobial agent. Therefore, with a more comprehensive understanding of the content of phenolic compounds and their mechanism of action, nutmeg can be a further basis for study in the health sector and the pharmaceutical industry.
Ultra-High Performance Liquid Chromatography Method Validation for Micro-dissolution Analysis of Ketoconazole in Alginate-Acacia Gum Composite Capsules Lumakso, Fajar Aji; Annisa, Viviane; Cermenda, Riska; Chabib, Lutfi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24078

Abstract

Ketoconazole, a BCS Class 2 antifungal drug, has good absorption but suffers from low solubility and poor bioavailability. To address this, a natural polymer-based matrix of alginate and acacia gum was formulated to enhance dissolution. This study aimed to validate a Ultra High Performance Liquid Chromatography method for analyzing ketoconazole content in micro-dissolution testing of capsule formulations. The method employed a C18 column with a mobile phase of acetonitrile:WFI (0.15% TEA, pH 3.5; 50:50) at 1 mL/min and detection at 265 nm. Validation demonstrated compliance with selectivity, linearity (r = 0.9996), sensitivity (LoD 6.51 µg/mL; LoQ 19.74 µg/mL), accuracy (99.6–101.3%), and precision (<2%, except one interday result at 2.08%). Micro-dissolution testing showed sustained ketoconazole release, exceeding 100% within 240 minutes. Data modeling (performed using DDSolver) indicated comparable fit for the Higuchi (R²_adj = 0.96) and Korsmeyer (R²_adj = 0.93) models, suggesting diffusion-controlled release of ketokonazole. The validated UHPLC method is suitable for micro-dissolution studies, and the alginate-acacia gum formulation effectively modulates drug release.
Ultra-High Performance Liquid Chromatography Method Validation for Micro-dissolution Analysis of Ketoconazole in Alginate-Acacia Gum Composite Capsules Lumakso, Fajar Aji; Annisa, Viviane; Cermenda, Riska; Chabib, Lutfi
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.24078

Abstract

Ketoconazole, a BCS Class 2 antifungal drug, has good absorption but suffers from low solubility and poor bioavailability. To address this, a natural polymer-based matrix of alginate and acacia gum was formulated to enhance dissolution. This study aimed to validate a Ultra High Performance Liquid Chromatography method for analyzing ketoconazole content in micro-dissolution testing of capsule formulations. The method employed a C18 column with a mobile phase of acetonitrile:WFI (0.15% TEA, pH 3.5; 50:50) at 1 mL/min and detection at 265 nm. Validation demonstrated compliance with selectivity, linearity (r = 0.9996), sensitivity (LoD 6.51 µg/mL; LoQ 19.74 µg/mL), accuracy (99.6–101.3%), and precision (<2%, except one interday result at 2.08%). Micro-dissolution testing showed sustained ketoconazole release, exceeding 100% within 240 minutes. Data modeling (performed using DDSolver) indicated comparable fit for the Higuchi (R²_adj = 0.96) and Korsmeyer (R²_adj = 0.93) models, suggesting diffusion-controlled release of ketokonazole. The validated UHPLC method is suitable for micro-dissolution studies, and the alginate-acacia gum formulation effectively modulates drug release.
Riview Literatur : Aktivitas Daun Yakon (Smallanthus Sonchifolus) Sebagai Antibakteri Terhadap Staphylococcus Aureus Lutfi Chabib; Arba Pramundita; Prima Aulia Putra; Hady Anshory
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.44403

Abstract

Kulit merupakan organ tubuh terluas yang menutupi seluruh bagian tubuh dan memiliki peran penting untuk melindungi organ tubuh. Posisi kulit terluar menyebabkan kulit rentan terkena penyakit kulit dan terjadi infeksi. Mayoritas infeksi kulit disebabkan oleh bakteri Staphylococcus aureus (S.aureus), yaitu bakteri gram positif yang dapat menyerang kekebalan tubuh. Salah satu cara untuk membunuh bakteri adalah menggunakan zat yang mengandung antibakteri. Salah satu tanaman yang berpotensi menjadi antibakteri adalah Yakon (Smallanthus sonchifolius). Skrining fitokimia menunjukkan bahwa daun yakon memiliki kandungan flavonoid, alkaloid, tanin, saponin, dan steroid yang berfungsi sebagai antibakteri. Senyawa lain yaitu seskuiterpen lakton juga ditemukan pada daun yakon dan memiliki aktivias antibakteri. Penggunaan ekstrak daun yakon pada konsentrasi 15% menghasilkan aktivitas antibakteri yang sangat kuat. Metodologi yang digunakan dalam tinjauan jurnal ini adalah tinjauan naratif, yang melibatkan pemeriksaan ekstensif literatur nasional dan internasional. Temuan pustaka menunjukkan bahwa daun yakon memiliki sifat antibakteri dan menghasilkan zona hambat terhadap bakteri Staphylococcus aureus (S.aureus).
Analytical Method Validation of High Performance Liquid Chromatography for Ketoconazole Tablets Lumakso, Fajar Aji; Annisa, Viviane; Alviansyah, Muhammad Rizal; Chabib, Lutfi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.69415

Abstract

Ketoconazole is an azole antifungal with low solubility and classified as Biopharmaceutical Classification System (BCS) Class II. A tablet formulation based on an alginate-acacia gum matrix is developed to enhance the solubility of ketoconazole. This study aims to validate the analytical method using High-Performance Liquid Chromatography (HPLC) for the assay of ketoconazole in these tablet formulations. The analysis was performed using a C18 column (250×4.6 mm, 5 μm) with a mobile phase consisting of water for injection (WFI) containing 0.15% TEA (pH 3.3) and acetonitrile (50:50 v/v), flow rate 1.0 mL/min, and detection at 232 nm. Method validation included system suitability testing, linearity, accuracy, precision, specificity, LOD, and LOQ. Specificity testing indicated no interference at the retention time of ketoconazole. Good linearity was achieved over 10–250 ppm (r = 0.9996), with good accuracy (99.8–101.75%) and precision (intraday and interday; %RSD < 2%). LOD and LOQ were 2.357 ppm and 7.142 ppm, respectively. The developed HPLC method was shown to be valid, accurate, precise, selective, and reliable for the assay of ketoconazole in tablets formulated with an alginate-acacia gum matrix. This method can be used for routine quality control.
Pengaruh Variasi Bahan Penghancur terhadap Sifat Fisikokimia dan Disolusi Tablet Aminofilin sebagai Terapi Asma Taufikurrahmi Taufikurrahmi; Hani’atul Kharimah; Hanida Destriana Fatmawati; Syarif Hidayatullah; Lutfi Chabib
Journal of Pharmascience Vol. 4 No. 1 (2017): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v4i1.5759

Abstract

ABSTRAK Pembuatan tablet Aminofilin menggunakan metode granulasi basah dikarenakan memiliki sifat alir dan kompaktibilitas yang kurang baik. Granulasi basah memerlukan bahan penghancur agar formula tablet sangat berlawanan dengan fungsi bahan pengikat. semakin kuat daya ikat bahan pengikat maka dipilih bahan penghancur dengan daya hancur yang semakin besar. Konsentrasi dari bahan penghancur akan mempengaruhi kecepatan disintegrasi. Tujuan dari penelitian adalah untuk mengetahui pengaruh dari konsentrasi bahan penghancur yaitu primojel yang digunakan terhadap kualitas tablet aminophilin yang dihasilkan. Pada penelitian akan dibuat sediaan tablet aminofilin dengan variasi bahan penghancur yaitu primojel. Dilakukan evaluasi granul seperti uji sifat alir serta evaluasi tablet seperti keseragaman bobot, ukuran, kandungan, kekerasan, kerapuhan, waktu hancur dan disolusi. Hasil yang diperoleh dari penelitian ini dapat disimpulkan bahwa formula tablet yang mengandung bahan penghancur pada formula I, formula II, Formula III menghasilkan tablet yang memenuhi persyaratan tablet yang baik. Kata Kunci: Aminofilin, Granulasi Basah, Variasi Primojel ABSTRAK Aminophylline tablet manufacturing using wet granulation method due to having flow properties and compactibility unfavorable. Wet granulation requires a shredder material that tablet formula is in contrast with the function of the binder. The stronger the power tie then selected binder material crushers with crushed greater power. The concentration of disintegrant will affect the speed of disintegration. The purpose of the study was to determine the effect of the concentration of primojel crushers are used to the quality of the resulting tablet aminophylline. The research will be made with a variety of aminophylline tablet dosage shredder material that is primojel. Test to evaluate the granules as flow properties and evaluation of tablets such as uniformity of weight, size, content, hardness, friability, disintegration time and dissolution. The results obtained from this study can be concluded that the formula tablets containing material crusher of formula I, Formula II, Formula III to produce a tablet that meets the requirements of a good tablet. Keywords: Aminophylline, Wet Granulation, Variation Primojel
Tanaman dengan Aktivitas Anti-Asma Muhammad Ikhwan Rizki; Lutfi Chabib; Akhmad Nabil; Baharudin Yusuf
Journal of Pharmascience Vol. 2 No. 1 (2015): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v2i1.5807

Abstract

Abstrak            Asma merupakan gangguan inflamasi kronis pada saluran pernafasan ditandai episode berulang mengi, sesak nafas, sesak dada, dan batuk.  Berbagai sel inflamasi berperan terutama sel mast, eosinofil, sel limfosit T, makrofag, neutrofil dan sel epitel. Masyarakat di Indonesia turun temurun secara tradisional menggunakan bahan alam dalam mengatasi berbagai penyakit. Tanaman dapat menghasilkan metabolit sekunder yang memiliki banyak khasiat dalam mengatasi berbagai penyakit disebabkan adanya efek sinergisme antar senyawa metabolit sekunder dan polivalent activity, sehingga memungkinkan mengatasi berbagai penyakit. Berdasarkan hal tersebut, asma dapat diatasi dengan menggunakan bahan alam diantaranya Putri Malu (Mimosa pudica, Linn.), Kelor (Moringa oleifera), Jintan Hitam (Nigella sativa L.), Rumput Fatimah (Labisia pumila), Ciplukan (Physalis minima L), Senggugu (Clerodendrum  serratumat), Jeringau (Acorus gramineus), dan Sirih (Piper betle Linn.). Kata Kunci: Tanaman, Anti-Asma AbstractAsthma is a chronic inflammatory disorder of the airways characterized by recurrent episodes of wheezing, breathlessness, chest tightness, and coughing. Various inflammatory cells play a role, especially mast cells, eosinophils, T lymphocytes, macrophages, neutrophils and epithelial cells. Indonesia people used natural materials to overcome various diseases. Plants can produce secondary metabolites that have many benefits in addressing a variety of diseases caused by the synergism between the effects of secondary metabolites and polivalent activity, making it possible to overcome various diseases. Based on this, asthma can be overcome by using natural medicines including Putri Malu (Mimosa pudica, Linn.), Kelor (Moringa oleifera), Jintan Hitam (Nigella sativa L.), Rumput Fatimah (Labisia pumila), Ciplukan (Physalis minima L), Senggugu (Clerodendrum  serratumat), Jeringau (Acorus gramineus), Sirih (Piper betle Linn.) Keywords: Asthma, Plants
Formulasi Tablet Effervescent Ekstrak Lidah Buaya (Aloe vera) Lutfi Chabib; Oktavia Indrati; Muhammad Ikhwan Rizki
Journal of Pharmascience Vol. 2 No. 1 (2015): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v2i1.5816

Abstract

Abstrak            Lidah buaya (Aloe vera) mengandung komponen seperti  acetylated mannans, polymannans, anthraquinone C-glycosides, anthrones, anthraquinones dan  berbagai jenis lectins. Komponen dalam lidah buaya yang bermanfaat sebagai laksatif adalah anthraquinon glycoside. Salah satu sediaan farmasi yang menarik adalah tablet effervescent, dimana bentuk sediaan ini mempunyai beberapa keuntungan, diantaranya adalah mudah untuk dikonsumsi dan bisa dikembangkan variasi rasa, sehingga diharapkan masyarakat dapat tertarik untuk mengkonsumsi sediaan lidah buaya dalam bentuk tablet effervescent. Tujuan penelitian ini yaitu mendapat formulasi optimum dari  tablet effervescent ekstrak lidah buaya. Lidah buaya dihaluskan lalu dimaserasi. Ekstrak lidah buaya diformulasi dalam empat bentuk formula yang berbeda dengan metode peleburan. Dilakukan pemeriksaan sifat fisik granul dan tablet yang terbentuk. Hasil penelitian menunjukkan lidah buaya (Aloe vera) dapat diformulasikan kedalam sediaan tablet  effervescent. Dari data evaluasi formulasi sediaan tablet effervescent lidah buaya (Aloe vera) yang paling baik untuk dibuat tablet effervescent yaitu formula I yang berisi granul ekstrak 150 mg, laktosa 1890 mg, asam sitrat 100 mg, asam tartat 300 mg, natrium bikarbonat 400 mg, PEG 6000 60 mg, aspartame 100 mg, dan pengaroma secukupnya. Kata Kunci: Aloe vera, tablet effervescent, formulasi AbstractAloe vera containing components such as acetylated mannans, polymannans, anthraquinone C-glycosides, anthrones, anthraquinones and various types of lectins. Components in aloe vera useful as laksatife is anthraquinon glycoside. One of the interesting pharmaceutical preparations is effervescent tablets, where has several advantages, is easy to take the variation flavors, so hopefully people can be interested to consume aloe vera preparations in the form of effervescent tablets. The purpose of this study was to get optimum formulation of Aloe vera effervescent tablets. Aloe vera is pulverized and then macerated. Aloe vera extract was formulated in six different formulas with fusion method. Then, physical properties of the granules and tablets were examinated. Results showed aloe (Aloe vera) could be formulated into effervescent tablets. The best formula for Aloe vera effervescent tablets was formula I which containing 150 mg of granule extract 150 mg, 1890 mg of lactose, 100 mg of citric acid, 300 mg of tartat acid, 400 mg of sodium bicarbonate, 60 mg of PEG 6000, 100 mg of aspartame, and flavor to taste. Keywords: Aloe vera, effervescent tablets, formulation  
Co-Authors Agenilia Permatasari Aghna Mafruha Zahrah, Aghna Mafruha Agus Santosa Aji Winanta Akhmad Fauzy Akhmad Nabil Akhmad Nabil, Akhmad Ali Djamhuri Alviansyah, Muhammad Rizal Anggara Setyabawana Putra Aprianto . Aprianto Aprianto Arba Pramundita Arba Pramundita Ramadani Arifa Caryn Dea Utami Hasyono Arismunandar, Arif Artha Carolina Asih Triastuti Awaluddin, Rizki Baharuddin Yusuf Baharudin Yusuf Baruna, Renno Ramadhani Ika Brigita Tuelvin Jenita Gandi Cermenda, Riska Cynthia Astiti Putri Dimas Adhi Pradana Dzihni Meytasari Farah Deastasa Nabilah Febry Azizah Ferdy Firmansyah Gandhi Barajana Vedha Hady Anshory Hamzah, Hasyrul Hani’atul Kharimah Hanida Destriana Fatmawati Hani’atul Kharimah Hannie Fitriani Hasnaeni hasnaeni, Hasnaeni Hastri Kholifah Hayati, Farida Herman Felani Hilda Ismail, Hilda Ilham Syahbandi Ipaenin, Jahiria Kamarulzaman, Ezatul Ezleen Kholidah, Ziyyatul Lumakso, Fajar Aji M. Pandoman febrian Maemonah, Maemonah Martien, Ronny Maulana Ardhi Mimiek Murrukmihadi Mufrod Mufrod Muh Iqbal Pangestu Muhammad Ikhwan Rizki Muhammad Iqbal Pangestu Muhammad Safarullah Muhtadi, Wildan Khairi Muslim, M. Rifqi Fadillah Mutiara Herawati, Mutiara Muzakir, Mellisa Nurul Afifi Lobubun Oktavia Indrati, Oktavia Prima Aulia Putra Reihan Khairiati Renno Ramadhani Ika Baruna Ria Cahya Andriana Rickha Octavia Rini Dwiastuti Rischi Dwi Irianti Rischi Dwi Irianti, Rischi Dwi Rizqi, Syifa Maulidia Rochmy Istikharah Ronny Martien Ronny Martien Samsul Hadi Saskira Windy Siti Zahliyatul Munawiroh Suryani, Arman Syarif Hidayatullah Taufikurrahmi Taufikurrahmi Tengku Shella Trianloka, A. M. Bagas Tunny, Risman Uzulul Hikmah Viviane Annisa Wahyu, Imron Wistiqomah Indasari Yandi Syukri Yosi Febrianti, Yosi Yovi Guanse Ziyyatul Kholidah