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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Udayana MEDISAINS AJIE (Asian Journal of Innovation and Entrepreneurship) JURNAL PHARMASCIENCE Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Pharmascience Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) CHEESA: Chemical Engineering Research Articles JSFK (Jurnal Sains Farmasi & Klinis) AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Abdimas Madani dan Lestari (JAMALI) Jurnal Ners Medfarm: Jurnal Farmasi dan Kesehatan Journal of Pharmaceutical and Health Research Hydrogen: Jurnal Kependidikan Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Khazanah: Jurnal Mahasiswa Eduvest - Journal of Universal Studies Parapemikir Jurnal Ilmiah Farmasi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Lutfi Chabib, Lutfi
Department Of Pharmacy, Islamic University Of Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Optimalisasi pelayanan apotik panjen di Desa Wedomartani Ngemplak Sleman Yogyakarta Lutfi Chabib; Akhmad Fauzy
Jurnal Abdimas Madani dan Lestari (JAMALI) Volume 02, Issue 02, September 2020
Publisher : UII

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jamali.vol2.iss2.art4

Abstract

Community service activities have been completed to optimize Panjen Pharmacy services. Pharmaceutical services are integrated activities aimed to identify, prevent, and resolve drug problems and health-related problems. The demands of patients and society for improving the quality of pharmaceutical services require the expansion of the old drugs-oriented paradigm into a new patient-oriented paradigm with the philosophy of Pharmaceutical Care. The Panjen Pharmacy in Wedomartani Village, Sleman is still constrained in implementing pharmaceutical services. Based on the results of observations to partners, these problems resulted from A limited number of human resources, lack of facilities and infrastructure, the absence of standardized etiquette, no drug information handbook, and there is no counseling card. The average number of visits by patients who buy drugs at the Panjen Pharmacy per day reaches 35-70 people. So it is necessary to improve services to provide a sense of security to patients about the use of drugs to be consumed. The outcome of this service activity is to optimize Panjen Pharmacy services through increasing human resource capacity, improving infrastructure, availability of standard etiquette, counseling cards, and drug information book achieved with the Participatory Rural Appraisal (PRA) participatory community empowerment model. The continuity of this service activity is the achievement of consistency in the application of a good and correct rationing system, both in terms of Human Resources Utilization (Human Resources), as well as in terms of a management information system that can guarantee the availability of the right type of drug, the right amount, the right quality and the right time. , thus making the pharmacy better in terms of service to the community and healthier.
Fabrikasi dan Studi Stabilitas Self-Nano Emulsifying Propolis menggunakan Minyak Kesturi sebagai Pembawa Yandi Syukri; Ziyyatul Kholidah; Lutfi Chabib
Jurnal Sains Farmasi & Klinis Vol 6, No 3 (2019): J Sains Farm Klin 6(3), Desember 2019
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (636.244 KB) | DOI: 10.25077/jsfk.6.3.265-273.2019

Abstract

Propolis merupakan resin yang sukar larut dalam air yang dihasilkan lebah, berkhasiat sebagai antibakteri, antioksidan, serta antiinflamasi. Salah satu metode untuk meningkatkan kelarutan obat adalah teknologi self-nano emulsifying (SNE). Penelitian ini bertujuan untuk melakukan formulasi, karakterisasi, dan studi stabilitas SNE propolis dengan pembawa minyak kesturi, cremophor RH 40, dan PEG 400. Preparasi SNE dilakukan dengan mencampurkan propolis dengan pembawa. Area nanoemulsi ditentukan dengan konstruksi diagram fase terner. Karakterisasi dilakukan dengan penentuan ukuran partikel, zeta potensial, transmitan, stabilitas termodinamika, uji ketahanan, dan uji stabilitas dipercepat. Daerah nanoemulsi terdapat pada F1-F9 dengan range komposisi minyak kesturi (10-30%), cremophor RH 40 (40-80%), dan PEG 400 (10-40%). Kesembilan formula menghasilkan nilai transmitan pada 96-99%, ukuran partikel 10-40 nm, serta zeta potensial kurang dari -40 mV. Uji ketahanan menunjukkan hasil yang baik pada F4 (1: 5: 4), F5 (2: 7: 1), dan F6 (2: 6: 2). Uji stabilitas dipercepat, F5 (2: 7: 1) menghasilkan SNE yang paling optimal karena tidak teramati pemisahan fase dan pengendapan, dengan karakterisasi nilai transmitan antara 97-99%, ukuran partikel antara 16-19 nm, dan nilai PDI 0,1-0,2. Dapat disimpulkan bahwa SNE propolis dengan pembawa minyak kesturi, cremophor RH 40, dan PEG 400 menghasilkan karakteristik dan profil stabilitas yang baik.
Formulasi Gel Hand Sanitizer Ekstrak Buah Belimbing Wuluh dengan Variasi Karbopol 940 dan HPMC Ferdy Firmansyah; Hastri Kholifah; Lutfi Chabib
Journal of Islamic Pharmacy Vol 7, No 1 (2022): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v7i1.13839

Abstract

The hand hygiene is compulsory to keep maintain. It is one of the important things to prevent the diseases that caused by microorganisms infection or the other infectious diseases, especially during this COVID-19 pandemic. Most of the hand sanitizer (HS) products are used alcohol as an antibacterial. The right way to reduce the use of HS-containing alcohol is by replacing them with using the active substances derived from herbal plant extracts, one of it is the star fruit (BBW). Flavonoid is one of the component in BBW. Thus, the purpose of this study is to determine the effect of a good combination of Carbopol 940 base and HPMC on the physical properties of HS BBW gel preparations. The formulation of hand sanitizer gel was used a combination of Carbopol 940 and HPMC with the variation concentrations of 0.5%; 0.75%; 1% and 0.25%; 0.5%; 0.75%. Evaluation of the physical properties of the gel preparation was determined based on the observations of consistency, scent, colour, pH, homogeneity, dispersibility, and physical stability using the freeze and thaw method for 6 storage cycles at 4°C and 45°C. The results shown that the variations concentration of gelling agents affect pH and dispersion. The higher the concentration of the gelling agent, the lower pH value and dispersion. This can be seen in each formula in the first week with pH 6.31, 6.13, and 5.62, and spreadability of 6.2, 5.8, and 5.6. Tests on the fourth week in a row with pH of 5.53, 5.49, and 5.23 and a spread of 5.2, 5.0, and 4.5. Variations in the concentration of HPMC and Carbopol was not affected to the organoleptic, homogeneity, and also the stability.
FORMULASI TABLET HISAP EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) SEBAGAI ANTIOKSIDAN DENGAN VARIASI KONSENTRASI GELATIN SEBAGAI BAHAN PENGIKAT Ria Cahya Andriana; Mufrod Mufrod; Lutfi Chabib
Khazanah: Jurnal Mahasiswa Vol. VI, No. 2, Januari 2014
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/khazanah.vol6.iss2.art5

Abstract

Peel of mangosteen (Garcinia mangostana L.) contains xanthones especially α-mangostin which have antioxidant activity. The aim on this study was to determine the physical of lozenges extract from mangosteen peel with variation concentration of gelatin 2%, 4%, 6%, 8% and 10%, also to determine the effect formulations of powder into lozenges made with wet granulation method to the percentage reduction of the free radical. The ability of neutralizing free radicals were tested by treating the extract in DPPH with ratio of 3:1. Results showed the tablet hardness were 10.75 kg, 11.13 kg, 11.94 kg, 12.14 kg and 12.35 kg. The friability were 0.84%, 0.73%, 0.71%, 0.60% and 0.50%. Time soluble of the tablet were 7.05 minutes, 9.44 minutes, 9.57 minutes, 11.51 minutes and 13.62 minutes, respectively. Data was analyzed by oneway ANOVA with 95% confidence level. The results showed that all formulas gave better physical properties on granules and tablets produced. Higher concentration of gelatin decreased friability, increased hardness and time-soluble of lozenges. Formula 5 showed the best physical tablet. Percentage reduction of free radicals of extract with DPPH decreased 70.72% after formulated into lozenges.
UJI AKTIVITAS ANTIBAKTERI SERUM EKSTRAK ETANOL BUAH BELIMBING WULUH TERHADAP Propionibacterium acnes, Staphylococcus aureus, dan Staphylococcus epidermis Ferdy Firmansyah; Reihan Khairiati; Wildan Khairi Muhtadi; Lutfi Chabib
Majalah Farmasi dan Farmakologi Vol. 26 No. 2 (2022): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v26i2.18578

Abstract

Jerawat merupakan salah satu penyakit kulit yang disebabkan oleh bakteri Propionibacterium acnes, Staphylococcus aureus dan Staphylococcus epidermis. Salah satu bahan alam yang dapat dimanfaatkan yaitu ekstrak etanol buah belimbing wuluh (eBW) yang berkhasiat sebagai antibakteri. Penelitian ini bertujuan untuk memformulasi sediaan serum wajah yang stabil secara farmasetik dan memiliki aktivitas antibakteri terhadap bakteri Propionibacterium acnes, Staphylococcus aureus dan Staphylococcus epidermis dengan metode difusi cakram. Sediaan serum wajah diformulasi pada beberapa konsentrasi eBW yaitu FI (10%), FII (15%), dan FIII (20%). Evaluasi sediaan serum wajah meliputi pemeriksaan organoleptis, homogenitas, pH, daya sebar, freeze and thaw, serta aktivitas antibakteri. Analisa data secara deskriptif dan uji statistik One Way ANOVA. Berdasarkan penelitian yang dilakukan formulasi serum ekstrak etanol buah belimbing wuluh pada semua formula memiliki stabilitas fisik yang baik yang ditunjukkan dengan pengujian stabilitas freeze and thaw tidak mengalami pemisahan fase, tampilan fisik, bentuk, bau, warna tidak berubah serta susunan yang homogen pada semua sediaan. Namun pada bagian pemeriksaan pH dan daya sebar mengalami penurunan dari minggu pertama ke minggu terakhir. Hasil uji One way ANOVA terdapat perbedaan yang signifikan (p<0,05) antar formula terhadap diameter zona hambat. Semakin tinggi konsentrasi eBW, maka akan semakin tinggi aktivitas antibakterinya. Formula III (20%) memiliki daya hambat paling besar dibandingkan formula lainnya dengan daya hambat secara berurutan pada bakteri Propionibacterium acnes, Staphylococcus aureus, dan Staphylococcus epidermis yaitu 18,10±0,20 mm, 17,03±0,35 mm dan 17,00±0,26 mm.
Formulasi Granul Effervescent Ekstrak Aseton Rimpang Kencur (Kaempferia Galanga L.) dengan Variasi Konsentrasi Polivinilpirolidon Nurul Afifi Lobubun; Lutfi Chabib
Journal of Pharmaceutical and Health Research Vol 3 No 3 (2022): October 2022
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v3i3.2922

Abstract

Kencur is one of the plants that is useful as an anthelmintic drug. This study aims to formulate effervescent granules of acetone extract of Kencur rhizome (Kaempferia galanga L.) with various concentrations of polyvinylpyrrolidone. Kencur rhizome extraction was carried out by maceration method using acetone solvent for 3 days then filtered and concentrated with a rotary vacuum evaporator. The extract was granulated using the wet granulation method with a ratio of citric acid monohydrate and tartaric acid 1:2. Variations in PVP concentrations were 2%, 4%, and 6%. Physical evaluation of granules includes Density and Porosity, Compressibility Index (Carr Index), Flow Time, and Angle of Bed. The best porosity was in formula 3 with 30.47±1.471. The compressibility index (Carr Index) of the three formulas is in the range of 515%. The best dosage flow times were formulas 2 and 3 with 8.67±0.526 and 7.58±0.344. The Hausner Ratio of the three formulas is below 1.25. The angles of repose in formulas 1 and 2 are 24.94º and 29.74º with a recline angle <40. The foam stopping time is 23 seconds. From theresults abtained it can be concluded that the formula with good pharmaceutical properties is formula 3 with a variation of 6% pvp concentration.
KANDUNGAN SENYAWA SAMBILOTO DAN JAHE TERHADAP PROTEIN TARGET COVID-19 MENGGUNAKAN DOCKING MOLEKULER Renno Ramadhani Ika Baruna; Gandhi Barajana Vedha; Lutfi Chabib
Parapemikir : Jurnal Ilmiah Farmasi Vol 12, No 2 (2023): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v12i2.5056

Abstract

Virus corona yang mewabah pada 2020 atau yang lebih dikenal sebagai covid-19 bukanlah merupakan virus fari family baru melainkan masih 1 fanily dengan virus SARS (Zhu et al. 2020). Penggunaan tanaman merupakan alternatif untuk pengobatan seperti kandungan dari jahe mampu sebagai antivirus (Chang et al 2013), sementara ekstrak sambiloto mampu sebagai imunostimulan dan sebagai antivirus (Churiyah et al 2014). Sehingga pada penelitian ini bertujuan mencari potensi senyawa jahe dan sambiloto untuk berinteraksi dengan protein dari corona yaitu 3Clpro dan Plpro serta mengevaluasi parameter farmakokinetik senyawa terpilih. Menggunakan metode docking molekuler dengan software autodock dengan ligan uji dari 17 Senyawa dalam Jahe Asamenew et al. (2019) dan 16 senyawa sambiloto dalam penelitian Kumar et al. (2018). Hasil dipilih dengan memeprtimbangkan lowest binding energy dan num in clus. Hasil dilanjutkan dengna melihat interaksi ligan-protein menggunakan Discovery dan proteinplus selanjutnya senyawa dilakukan prediksi farmakokinetik dengan ADMETLab.Hasil dari proses docking didapati 16 senyawa dari jahe dan sambiloto berperan memiliki interaksi dengan protein target. Senyawa dari jahe maupun sambiloto untuk berinteraksi dengan protein 3Clpro memiliki interaksi yang sama dengan ligan asli sementara pada protein Plpro hanya 5,8,2’-Trihydroxy-7-Methoxyflavone dari sambiloto karena tipe interaksinya yang serupa dengan ligan asli. Senyawa untuk hasil prediksi farmakokinetik dari senyawa terpilih mendapati hasil beragam namun senyawa terbaik adalah 6-gingerol dari jahe dan Androgpraholide dari sambiloto karena potensinya
Acute Toxicity of Self-Nanoemulsifying Drug Delivery System of Ipomoea reptans Poir Leaves Extract on Female Wistar Rats Cynthia Astiti Putri; Farida Hayati; Lutfi Chabib; Muhammad Iqbal Pangestu
Borneo Journal of Pharmacy Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i1.2099

Abstract

Ipomoea reptans Poir has many health benefits, such as decreasing blood glucose and as an antioxidant. Self-nano emulsifying drug delivery systems (SNEDDS) are an innovation in pharmaceutical technology that minimizes drug molecules and maximizes surface area, thus increasing drug absorption. This study aimed to investigate SNEDDS of I. reptans acute toxicity in female Wistar rats. An acute toxicity test was done using a limit test of OECD 423. Female Wistar rats were divided into control and treatment groups, with three animals for each group being used per step. No animals died after they were given SNEDDS of I. reptans leaves extract at a dose of 2000 mg/kg. No toxic effect was detected at clinical examination and histopathology of the organ. SNEDDS of I. reptans leaves extract had an LD50 cut-off value of 5000 mg/kg.
FORMULASI TABLET EKSTRAK BUAH NAGA (Hylocereus polyrhizus) MENGUNAKAN AMILUM UBI JALAR PREGELATINASI SEBAGAI BAHAN PENGHANCUR Aji Winanta; Yandi Syukri; Lutfi Chabib
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 3 No 2 (2019)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v3i2.56

Abstract

Buah naga (Hylocereus polyrhizus) telah dikenal oleh masyarakat sebagai tanaman yang kaya akan kandungan antioksidan sehingga mempunyai manfaat sebagai antikanker. Sediaan dari buah naga belum banyak digunakan oleh masyarakat luas, oleh karena itu dibuat suatu formulasi sediaan tablet dari ekstrak buah naga yang dapat dikonsumsi oleh masyarakat sebagai suplemen kesehatan yang dapat dengan praktis dikonsumsi. Tablet ekstrak buah naga dibuat dengan menggunakan amilum pregelatinasi ubi jalar sebagai bahan penghancur. Penelitian ini bertujuan untuk mengetahui pengaruh variasi kadar amilum ubi jalar pregelatinasi (kadar 5%; 6,5%; 8%; dan 10%) terhadap sifat fisik tablet ekstrak buah naga. Ekstraksi buah naga dilakukan dengan metode maserasi dan proses penabletan menggunakan metode granulasi basah. Hasil yang diperoleh pada formula I mempunyai kekerasan 7,97 Kg, kerapuhan 0,29%,waktu hancurnya 41,69 menit. Formula II mempunyai kekerasan 6,23 Kg, kerapuhan 0,58%, waktu hancur 36,43 menit. Formula III memiliki kekerasan 7,65 Kg, kerapuhan 0,46%, waktu hancur 35,15 menit. Dan pada Formula IV mempunyai kekerasan 7,43 Kg, kerapuhan 1,18% dan waktu hancur 32,03 menit. Kesimpulannya semakin tinggi konsentrasinya akan membuat kekerasan tablet menurun, kerapuhan menjadi semakin besar dan waktu hancur tablet semakin cepat.
KOMPARASI METODE PENINGKATAN LAJU DISOLUSI OBAT Rizqi, Syifa Maulidia; Chabib, Lutfi
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p02

Abstract

The speed of dissolution becomes an important part in the manufacture of drugs, because it is related to drug absorption and bioavailability. In order to achieve a good dissolution rate, various methods with certain criteria are needed. This review article aims to find out various methods that can be used to increase the speed of drug dissolution, and can be used as a reference for choosing the most appropriate dissolution method. The article review method used is a narrative review type in the form of a description or explanation of methods for increasing dissolution as a comparison in terms of method selection. Journals were obtained through chrome, google scholar and researchgate using 16 journals. The results obtained are that there are several methods that can increase dissolution including amorphous co, the use of surfactants and so on. The conclusion obtained from this review of the article is that there are various methods of increasing dissolution such as the use of surfactants, co-crystals, amorphous cos and so on. Keywords: dissolution; method; narrative review
Co-Authors Achmad Fachrodji Agenilia Permatasari Aghna Mafruha Zahrah, Aghna Mafruha Agus Santosa Agustina Setiawati Aji Winanta Akhmad Fauzy Akhmad Nabil Akhmad Nabil, Akhmad Ali Djamhuri Anggara Setyabawana Putra Aprianto . Aprianto Aprianto Arba Pramundita Ramadani Arifa Caryn Dea Utami Hasyono Arismunandar, Arif Asih Triastuti Baharuddin Yusuf Baharudin Yusuf Baruna, Renno Ramadhani Ika Cynthia Astiti Putri Dewi, Melynia Sintha Dimas Adhi Pradana Dzihni Meytasari Farah Deastasa Nabilah Ferdy Firmansyah Gandhi Barajana Vedha Gani, Michael Raharja Gelu, Maria Andriani Guanse, Yovi Hamzah, Hasyrul Hanida Destriana Fatmawati Hani’atul Kharimah Hannie Fitriani Hasnaeni hasnaeni, Hasnaeni Hastri Kholifah Hayati, Farida Herman Felani Hilda Ismail, Hilda Ipaenin, Jahiria Jenita Gandi, Brigita Tuelvin Kamarulzaman, Ezatul Ezleen Kholidah, Ziyyatul Kinanti, Valentina Putri Embun M. Pandoman febrian Maemonah, Maemonah Martien, Ronny Maulana Ardhi Mimiek Murrukmihadi Mufrod Mufrod Muh Iqbal Pangestu Muhammad Faisal Muhammad Ikhwan Rizki Muhammad Iqbal Pangestu Muhammad Safarullah Muhtadi, Wildan Khairi Muslim, M. Rifqi Fadillah Mutiara Herawati, Mutiara Muzakir, Mellisa Nurul Afifi Lobubun Oktavia Indrati, Oktavia Pramundita, Arba Putra, Prima Aulia Reihan Khairiati Renno Ramadhani Ika Baruna Ria Cahya Andriana Rini Dwiastuti Ririn Wulandari Rischi Dwi Irianti Rischi Dwi Irianti, Rischi Dwi Rizki Awaluddin Rizqi, Syifa Maulidia Rochmy Istikharah Ronny Martien Ronny Martien Samsul Hadi Siti Zahliyatul Munawiroh Suryani, Arman Syarif Hidayatullah Tamhid, Hady Anshory Taufikurrahmi Taufikurrahmi Trianloka, A. M. Bagas Tunny, Risman Uzulul Hikmah Wahyu, Imron Yandi Syukri Yosi Febrianti, Yosi Ziyyatul Kholidah