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All Journal Journal of Food and Pharmaceutical Science Jurnal Ilmiah Farmasi Indonesian Journal of Pharmaceutical Science and Technology MEDISAINS AJIE (Asian Journal of Innovation and Entrepreneurship) JURNAL PHARMASCIENCE Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) CHEESA: Chemical Engineering Research Articles JSFK (Jurnal Sains Farmasi & Klinis) AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Abdimas Madani dan Lestari (JAMALI) Jurnal Ners Medfarm: Jurnal Farmasi dan Kesehatan Journal of Pharmaceutical and Health Research Jurnal Nuansa Akademik: Jurnal Pembangunan Masyarakat Hydrogen: Jurnal Kependidikan Kimia Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Khazanah: Jurnal Mahasiswa Eduvest - Journal of Universal Studies Journal of Food and Pharmaceutical Sciences Parapemikir Jurnal Ilmiah Farmasi Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Pharmascience
Lutfi Chabib, Lutfi
Department Of Pharmacy, Islamic University Of Indonesia
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Formulasi Granul Effervescent Ekstrak Aseton Rimpang Kencur (Kaempferia Galanga L.) dengan Variasi Konsentrasi Polivinilpirolidon Nurul Afifi Lobubun; Lutfi Chabib
Journal of Pharmaceutical and Health Research Vol 3 No 3 (2022): October 2022
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v3i3.2922

Abstract

Kencur is one of the plants that is useful as an anthelmintic drug. This study aims to formulate effervescent granules of acetone extract of Kencur rhizome (Kaempferia galanga L.) with various concentrations of polyvinylpyrrolidone. Kencur rhizome extraction was carried out by maceration method using acetone solvent for 3 days then filtered and concentrated with a rotary vacuum evaporator. The extract was granulated using the wet granulation method with a ratio of citric acid monohydrate and tartaric acid 1:2. Variations in PVP concentrations were 2%, 4%, and 6%. Physical evaluation of granules includes Density and Porosity, Compressibility Index (Carr Index), Flow Time, and Angle of Bed. The best porosity was in formula 3 with 30.47±1.471. The compressibility index (Carr Index) of the three formulas is in the range of 515%. The best dosage flow times were formulas 2 and 3 with 8.67±0.526 and 7.58±0.344. The Hausner Ratio of the three formulas is below 1.25. The angles of repose in formulas 1 and 2 are 24.94º and 29.74º with a recline angle <40. The foam stopping time is 23 seconds. From theresults abtained it can be concluded that the formula with good pharmaceutical properties is formula 3 with a variation of 6% pvp concentration.
KANDUNGAN SENYAWA SAMBILOTO DAN JAHE TERHADAP PROTEIN TARGET COVID-19 MENGGUNAKAN DOCKING MOLEKULER Renno Ramadhani Ika Baruna; Gandhi Barajana Vedha; Lutfi Chabib
Parapemikir : Jurnal Ilmiah Farmasi Vol 12, No 2 (2023): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v12i2.5056

Abstract

Virus corona yang mewabah pada 2020 atau yang lebih dikenal sebagai covid-19 bukanlah merupakan virus fari family baru melainkan masih 1 fanily dengan virus SARS (Zhu et al. 2020). Penggunaan tanaman merupakan alternatif untuk pengobatan seperti kandungan dari jahe mampu sebagai antivirus (Chang et al 2013), sementara ekstrak sambiloto mampu sebagai imunostimulan dan sebagai antivirus (Churiyah et al 2014). Sehingga pada penelitian ini bertujuan mencari potensi senyawa jahe dan sambiloto untuk berinteraksi dengan protein dari corona yaitu 3Clpro dan Plpro serta mengevaluasi parameter farmakokinetik senyawa terpilih. Menggunakan metode docking molekuler dengan software autodock dengan ligan uji dari 17 Senyawa dalam Jahe Asamenew et al. (2019) dan 16 senyawa sambiloto dalam penelitian Kumar et al. (2018). Hasil dipilih dengan memeprtimbangkan lowest binding energy dan num in clus. Hasil dilanjutkan dengna melihat interaksi ligan-protein menggunakan Discovery dan proteinplus selanjutnya senyawa dilakukan prediksi farmakokinetik dengan ADMETLab.Hasil dari proses docking didapati 16 senyawa dari jahe dan sambiloto berperan memiliki interaksi dengan protein target. Senyawa dari jahe maupun sambiloto untuk berinteraksi dengan protein 3Clpro memiliki interaksi yang sama dengan ligan asli sementara pada protein Plpro hanya 5,8,2’-Trihydroxy-7-Methoxyflavone dari sambiloto karena tipe interaksinya yang serupa dengan ligan asli. Senyawa untuk hasil prediksi farmakokinetik dari senyawa terpilih mendapati hasil beragam namun senyawa terbaik adalah 6-gingerol dari jahe dan Androgpraholide dari sambiloto karena potensinya
Acute Toxicity of Self-Nanoemulsifying Drug Delivery System of Ipomoea reptans Poir Leaves Extract on Female Wistar Rats Cynthia Astiti Putri; Farida Hayati; Lutfi Chabib; Muhammad Iqbal Pangestu
Borneo Journal of Pharmacy Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i1.2099

Abstract

Ipomoea reptans Poir has many health benefits, such as decreasing blood glucose and as an antioxidant. Self-nano emulsifying drug delivery systems (SNEDDS) are an innovation in pharmaceutical technology that minimizes drug molecules and maximizes surface area, thus increasing drug absorption. This study aimed to investigate SNEDDS of I. reptans acute toxicity in female Wistar rats. An acute toxicity test was done using a limit test of OECD 423. Female Wistar rats were divided into control and treatment groups, with three animals for each group being used per step. No animals died after they were given SNEDDS of I. reptans leaves extract at a dose of 2000 mg/kg. No toxic effect was detected at clinical examination and histopathology of the organ. SNEDDS of I. reptans leaves extract had an LD50 cut-off value of 5000 mg/kg.
FORMULASI TABLET EKSTRAK BUAH NAGA (Hylocereus polyrhizus) MENGUNAKAN AMILUM UBI JALAR PREGELATINASI SEBAGAI BAHAN PENGHANCUR Aji Winanta; Yandi Syukri; Lutfi Chabib
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 3 No 2 (2019)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v3i2.56

Abstract

Buah naga (Hylocereus polyrhizus) telah dikenal oleh masyarakat sebagai tanaman yang kaya akan kandungan antioksidan sehingga mempunyai manfaat sebagai antikanker. Sediaan dari buah naga belum banyak digunakan oleh masyarakat luas, oleh karena itu dibuat suatu formulasi sediaan tablet dari ekstrak buah naga yang dapat dikonsumsi oleh masyarakat sebagai suplemen kesehatan yang dapat dengan praktis dikonsumsi. Tablet ekstrak buah naga dibuat dengan menggunakan amilum pregelatinasi ubi jalar sebagai bahan penghancur. Penelitian ini bertujuan untuk mengetahui pengaruh variasi kadar amilum ubi jalar pregelatinasi (kadar 5%; 6,5%; 8%; dan 10%) terhadap sifat fisik tablet ekstrak buah naga. Ekstraksi buah naga dilakukan dengan metode maserasi dan proses penabletan menggunakan metode granulasi basah. Hasil yang diperoleh pada formula I mempunyai kekerasan 7,97 Kg, kerapuhan 0,29%,waktu hancurnya 41,69 menit. Formula II mempunyai kekerasan 6,23 Kg, kerapuhan 0,58%, waktu hancur 36,43 menit. Formula III memiliki kekerasan 7,65 Kg, kerapuhan 0,46%, waktu hancur 35,15 menit. Dan pada Formula IV mempunyai kekerasan 7,43 Kg, kerapuhan 1,18% dan waktu hancur 32,03 menit. Kesimpulannya semakin tinggi konsentrasinya akan membuat kekerasan tablet menurun, kerapuhan menjadi semakin besar dan waktu hancur tablet semakin cepat.
Nanoparticles and Nanoliposomes for Hair Growth Serum Arismunandar, Arif; Chabib, Lutfi; Ramadani, Arba Pramundita; Suryani, Arman; Kamarulzaman, Ezatul Ezleen
CHEESA: Chemical Engineering Research Articles Vol. 7 No. 1 (2024)
Publisher : Universitas PGRI Madiun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/cheesa.v7i1.19908.57-66

Abstract

Solubility in penetrating the follicles is the main obstacle in the formulation of hair growth serum preparation with chemicals derived from natural or synthetic materials. Therefore, a delivery system is needed to deliver more chemical compounds into the follicles. Nanoparticles and nanoliposomes are potential chemical compound delivery systems in hair growth serum. Specifically, nanoparticles with a particle size of less than 200 nm can increase the transport of serum chemical compounds into the scalp. The small particle size makes the interaction between atoms and molecules faster and prevents clumping with the repulsive force of dispersed particles. Meanwhile, nanoliposomes with lipids as encapsulation in the delivery of lipophilic or hydrophilic chemical compounds with nanosizes can significantly increase serum diffusion on the scalp.
KARAKTERISTIK GEL-NANOLIPOSOM MINYAK ROSEMARI (Rosmarinus officinalis) UNTUK FORMULASI SEDIAAN PENINGKATAN PERTUMBUHAN RAMBUT Baruna, Renno Ramadhani Ika; Ramadani, Arba Pramundita; Chabib, Lutfi
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 13 No 1 (2024): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v13i1.253

Abstract

Hair loss occurs in many people, both men and women. Rosemari (Rosemarinus officinalis) is one of the plants shown to significantly improve hair growth in alopecia patients. Nanoliposome gel can enhance the activity of bioactive agents by increasing solubility, bioavailability, stability and preventing unnecessary interactions with other molecules in cosmetic preparations. The purpose of this study was to determine the physical characteristics and stability of nanoliposome gel as a carrier of rosemary oil produced. The nanoliposome formulations were evaluated: organoleptical, particle size and zeta potential, and morphological tests. The results of the physical characteristics of nanoliposomes in the form of a slightly cloudy clear gel, semi-liquid texture and typical aromatic odor of rosemary, particle size of 210.5 nm, zeta potential of -23.2 nV, and spherical morphology. Rosemary oil nanoliposome gel preparation has good physical characteristics and stability, so it can be used as a preparation formulation for hair growth.
EFEKTIVITAS DAN EFEK SAMPING DARI IMPLAN LEVONORGESTREL DAN IMPLAN ETONOGESTREL: REVIEW ARTICLE Chabib, Lutfi; M. Pandoman febrian; Hannie Fitriani; Uzulul Hikmah
Majalah Farmasi dan Farmakologi Vol. 27 No. 3 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i3.24910

Abstract

Implan levonorgestrel (LVN) dan etonogestrel (ENG) merupakan contoh long-acting reversible contraception (LARC) yang memiliki efektifitas yang tinggi dalam pencegahan kehamilan pada jangka waktu yang panjang. Penulisan review ini bertujuan untuk membandingkan efektifitas dan efek samping terkait LVN 2 batang dan ENG 1 batang sebagai alat kontrasepsi implan subdermal. Studi mengenai perbandingan efikasi implan LVN dengan implan ENG menunjukkan bahwa keduanya memiliki efikasi sebagai kontrasepsi yang baik diamati dari tingkat kejadian kehamilan yang sangat rendah. Perbedaan antara keduanya dapat dilihat dari berapa lama durasi yang disetujui untuk perlindungan dalam pencegahan kehamilan yaitu 3 tahun untuk implan ENG dan 5 tahun untuk implan LVN. Selain itu, Efektivitas kedua implan tersebut dalam mencegah kehamilan menunjukkan efek yang sebanding dari berbagai pengujian. Terkait studi mengenai efek samping menunjukkan bahwa efek samping pendarahan pada penggunaan ENG lebih besar dibandingkan pada implan LVN, sehingga LVN lebih dipilih dibandingkan dengan ENG.
Innovative insight: ChatGPT's contribution to advanced health research articles Muslim, M. Rifqi Fadillah; Chabib, Lutfi; Hamzah, Hasyrul; Santosa, Agus
MEDISAINS Vol 21, No 3 (2023)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v21i3.20211

Abstract

The current technological advancement follows a pattern of both disruptive and gradual changes. The field of communication is currently the most extensively utilized technology. The rapid development of AI has enabled those without a background in computer coding or specialized health knowledge to utilize this technology, which gives rise to numerous issues. This phenomenon elicits curiosity and engenders debate among the general public, scholars, healthcare providers, and researchers in the health industry. Utilizing AI in the composition of scientific publications necessitates explicit norms and regulations, a robust validation procedure, and effective collaboration between AI systems and human expertise. Ensuring transparency and acknowledgment of AI usage is crucial to maintaining human researchers' accountability for the ultimate outcomes of their research.
Potential advancement utilizing nanotechnology-based delivery system to enhance the therapeutic properties of lavender essential oil: a review article Trianloka, A. M. Bagas; Chabib, Lutfi; Ramadani, Arba Pramundita
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art6

Abstract

Background: Essential oils (EO), such as lavender (Lavandula spp.), which are derived from its flower, have become a growing trend in recent years as an alternative medicine in therapy. However, the poor physicochemical properties of EOs have several disadvantages for their application. Integrating nanotechnology into the formulation of medicinal dosage forms may provide a viable way to mitigate these limitations and improve the effectiveness of EO utilization.Objective: This literature review aims to gather information on the medicinal benefits of lavender EO and the prospective applications of nanotechnology-based delivery systems for EOs.Method: Online databases such as PubMed, Science Direct, Research Gate, Google Scholar, and other reliable sources were used to find 65 publications between 1991 and 2021, which are assessed in this review.Results: It is revealed that the main constituents of lavender EO are linalool, linalyl acetate, and lavandulyl acetate. Its effectiveness as an antibacterial, antioxidant, anticancer, anti-anxiety, and having effects on the central nervous system, along with other qualities including pain relief, has been demonstrated via numerous studies. Additionally, it was demonstrated to have dermatological properties that helped treat dermatitis and encouraged both hair growth and wound healing. Furthermore, it was also found that the application of nanotechnology in EOs has improved the concentration of active compounds in the blood and produced a stable dosage form while also increasing its efficacy.Conclusion: It is feasible to create nanoparticle dosage forms from lavender EO that can improve the substance's solubility, stability, and pharmacological effects. More research is necessary to formulate lavender EO by applying nanotechnology.
PKM KELOMPOK PKK DESA BANDUNGREJO KABUPATEN MAGELANG JAWA TENGAH DALAM PEMBUATAN MINUMAN HERBAL INSTAN Chabib, Lutfi; Wahyu, Imron; Felani, Herman; Muzakir, Mellisa
Amaliah: Jurnal Pengabdian Kepada Masyarakat Vol 8 No 2 (2024): Amaliah Jurnal: Pengabdian kepada Masyarakat
Publisher : LPPI UMN AL WASHLIYAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/ajpkm.v8i2.3789

Abstract

Desa Bandungrejo merupakan salah satu desa yang terletak di Kecamatan Ngablak, Kabupaten Magelang, Provinsi Jawa Tengah. Desa Bandungrejo terletak sekitar 10 km dari Kota Magelang dengan waktu tempuh 30 menit. Desa Bandungrejo memiliki luas 375 ha, dengan pekarangan/bangunan seluas 52 ha dan ladang seluas 292 ha. Kelurahan Bandungrejo terdapat 9 dusun yaitu: Noyogaten, Bakalan, Bandungrejo, Pendem, Citrogaten, Brongkol, Kayuares, Kenanggan, Soromayan. Kondisi tanah yang berada di daerah pegunungan menjadikan desa Bandungrejo sangat cocok untuk tanaman sayuran dan tanaman herbal berupa jahe, kunyit, temulawak dan kencur yang masih terbatas dalam pengolahan dan pemanfaatannya. Berdasarkan permasalahan tersebut maka pemberdayaan Masyarakat ini akan di laksanakan oleh Kelompok PKK Barokah Desa Bandungrejo, faktor tersebut akibat dari keterbatasan mitra dalam mengolah dan menghasilkan produk herbal yang siap konsumsi dan layak jual, faktor tersebut akibat dari aspek produksi, aspek sumber daya manusia, dan aspek manajemen. Tujuan pelaksanaan program pengabdian masyarakat ini adalah mendorong terciptanya peningkatan ekonomi warga yang selama ini terjadi dikarenakan rendahnya pengetahuan dan pemahaman teknologi dalam pengolahan produk herbal menjadi produk siap konsumsi dan layak jual bernilai ekonomis lebih tinggi. Metode yang digunakan dalam mencapai tujuan tersebut dengan pendampingan pengenalan tanaman herbal, pengolahan, produksi dan pemasaran. Luaran yang di capai dalam kegiatan pengabdian ini adalah peningkatan kapasitas sumber daya manusia kelompok PKK Desa Bandungrejo dalam membuat produk minuman herbal instan serta peningkatan kapasitas dalam motivasi berwirausaha, manajemen dan pemasaran.
Co-Authors Achmad Fachrodji Agenilia Permatasari Aghna Mafruha Zahrah, Aghna Mafruha Agus Santosa Agustina Setiawati Aji Winanta Akhmad Fauzy Akhmad Nabil Akhmad Nabil, Akhmad Ali Djamhuri Alviansyah, Muhammad Rizal Anggara Setyabawana Putra Annisa, Viviane Aprianto . Aprianto Aprianto Arba Pramundita Arba Pramundita Ramadani Ardiyanto, Abdul Mu’is Arifa Caryn Dea Utami Hasyono Arismunandar, Arif Asih Triastuti Awaluddin Nurmiyanto, Awaluddin Awaluddin, Rizki Baharuddin Yusuf Baharudin Yusuf Baruna, Renno Ramadhani Ika Cermenda, Riska Cynthia Astiti Putri Dewi, Melynia Sintha Dimas Adhi Pradana Dzihni Meytasari Farah Deastasa Nabilah Ferdy Firmansyah Gandhi Barajana Vedha Gani, Michael Raharja Gelu, Maria Andriani Guanse, Yovi Hady Anshory Hamzah, Hasyrul Hani’atul Kharimah Hanida Destriana Fatmawati Hani’atul Kharimah Hannie Fitriani hartanto hartanto Hasnaeni hasnaeni, Hasnaeni Hastri Kholifah Hayati, Farida Herman Felani Hilda Ismail, Hilda Ipaenin, Jahiria Jenita Gandi, Brigita Tuelvin Kamarulzaman, Ezatul Ezleen Kholidah, Ziyyatul Kinanti, Valentina Putri Embun Lumakso, Fajar Aji M. Pandoman febrian Maemonah, Maemonah Martien, Ronny Maulana Ardhi Mimiek Murrukmihadi Mufrod Mufrod Muh Iqbal Pangestu Muhammad Faisal Muhammad Ikhwan Rizki Muhammad Iqbal Pangestu Muhammad Safarullah Muhtadi, Wildan Khairi Munawiroh, Siti Zahliyatul Muslim, M. Rifqi Fadillah Mutiara Herawati, Mutiara Muzakir, Mellisa Nurul Afifi Lobubun Oktavia Indrati, Oktavia Prabowo, Erlangga Prima Aulia Putra Pujimagfiroh, Isnaini Reihan Khairiati Renno Ramadhani Ika Baruna Ria Cahya Andriana Rifqi, Muhammad Nurur Rini Dwiastuti Ririn Wulandari Rischi Dwi Irianti Rischi Dwi Irianti, Rischi Dwi Rizqi, Syifa Maulidia Rochmy Istikharah Ronny Martien Ronny Martien Samsul Hadi Siti Zahliyatul Munawiroh Suryani, Arman Syarif Hidayatullah Taufikurrahmi Taufikurrahmi Trianloka, A. M. Bagas Tunny, Risman Uzulul Hikmah Wahyu, Imron Yandi Syukri Yosi Febrianti, Yosi Yulianto Yulianto Ziyyatul Kholidah