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All Journal Journal of Food and Pharmaceutical Science Jurnal Tumbuhan Obat Indonesia Jurnal Penelitian Pascapanen Pertanian Majalah Obat Tradisional Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY Indonesian Journal of Chemical Science Jurnal Farmasi Sains dan Komunitas Majalah Farmaseutik Jurnal Ilmu Kefarmasian Indonesia Jurnal Insan Farmasi Indonesia Journal of Fundamental and Applied Pharmaceutical Science Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Food and Pharmaceutical Sciences Jurnal Tumbuhan Obat Indonesia Jurnal Kefarmasian Indonesia
Nanang Fakhrudin, Nanang
Department Of Pharmaceutical Biology, Faculty Of Pharmacy, Universitas Gadjah Mada, Jl. Sekip Utara, Sleman, Yogyakarta, Indonesia, 55281.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health

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POTENSI AKTIVITAS ANTIOKSIDAN DAN PENETAPAN KADAR FENOLIK TOTAL EKSTRAK DAUN KRATOM (Mitragyna speciosa Korth.) MENGGUNAKAN VARIASI PELARUT Akhmad Riski; Nanang Fakhrudin; Agung Endro Nugroho; Rakhmadhan Niah; Lalu Husnul Hidayat
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2802

Abstract

Kratom (Mitragyna speciosa) is a medicinal plant native to Southeast Asia that contains a wide range of secondary metabolites. The characteristics of medicinal plant extracts are strongly influenced by the type of solvent used during the extraction process, particularly with respect to phenolic compounds that play a key role in antioxidant activity. This study aimed to evaluate the antioxidant activity and total phenolic content of Mitragyna speciosa leaf extracts obtained using solvents with different degrees of polarity. Kratom leaves were extracted with water using the decoction method, as well as with 70% and 90% ethanol using the maceration method. Total phenolic content was determined by Spectrophotometer UV–Vis employing the Folin–Ciocalteu reagent with gallic acid as the standard, while antioxidant activity was assessed based on IC₅₀ values using the DPPH assay. The results showed that the total phenolic content of the water, 70% ethanol, and 90% ethanol extracts was 81.27 ± 0.13, 93.85 ± 0.07, and 99.21 ± 0.07 mg GAE/g extract, respectively. Antioxidant activity analysis revealed IC₅₀ values of 64.71 µg/mL for the water extract (strong antioxidant), 35.52 µg/mL for the 70% ethanol extract (very strong antioxidant), and 35.12 µg/mL for the 90% ethanol extract (very strong antioxidant). Based on these findings, the 90% ethanol extract exhibited the highest total phenolic content and the most potent antioxidant activity, indicating its potential for development as a natural antioxidant source derived from kratom leaves.
Evaluation of the Antithrombotic Activity of Acmella oleracea L. Flower Ethanol Extract Tiaravista, Amanda Gita; Putri, Laras Widawaty; Nurrochmad, Arief; Widyarini, Sitarina; Fakhrudin, Nanang
Journal of Fundamental and Applied Pharmaceutical Science Vol. 4 No. 1 (2023): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v4i1.19055

Abstract

Acmella oleracea L. (hereinafter abbreviated as AOE) is one of the plants with the potential for antithrombosis, one of the deadliest cardiovascular diseases in Indonesia. The antithrombotic activity test on AOE leaf extract revealed that it could lyse blood clots. However, no information regarding the AOE flower as an antithrombosis is provided. This study, thus, aims to determine the chromatography profile and the antithrombotic activity of the AOE flower ethanol extract. To identify the AOE chemical profile, thin-layer chromatography was carried out. Antithrombotic testing was performed on male rats of the Sprague-Dawley strain. Then, the antithrombotic activity was tested using the FeCl3-induced rat method, with the observed parameter being total occlusion time. The test animals were also divided into six groups: normal, solvent (CMC-Na 0.9%), comparator drug (clopidogrel 8.67 mg/kg), and AOE (doses 125, 250, and 375 mg/kg). The data obtained were then analyzed statistically using Kruskal-Wallis, followed by Tukey's. The TLC profile results confirmed the presence of the alkaloid compound in AOE. The authors also found that AOE at doses of 125, 250, and 375 mg/kg significantly prolonged the occlusion time comparable to that of clopidogrel at 8.67 mg/kg (p > 0.05). This finding indicates that AOE has antithrombotic activity in FeCl3-induced rats.
Co-Authors Abdul Rohman Agung Endro Nugroho Agung Endro Nugroho Agustinus Widodo Akhmad Khumaidi Akhmad Riski Anak Agung Gede Sugianthara Andayana Puspitasari Gani Andayana Puspitasari Gani Argandita Meiftasari Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arifah, Mitsalina Fildzah Ayu Ina Solichah Chelvin Ari Kusnanto Dirman, Arifin Djoko Santosa Djoko Santosa Ediati Sasmito Efendi Efendi Eka Kumalasari Endang Lukitaningsih Endang Lukitaningsih Endang Lukitaningsih Eny Dwi Astuti Febrianti, Dwi Rizki Gani, Andayana Puspitasari Gharsina Ghaisani Yumni Hifdzur Rashif Rija’i Ika Puspitasari Indah Hastuti Ipang Djunarko Jovanita Fara Addina Kahfi Nur Fatimah Khoerul Anwar Khoerul Anwar KRISNA KHARISMA PERTIWI Kusnanto, Chelvin Ari Lalu Husnul Hidayat Laras Widawaty Putri Muhammad Hafizh Ridho Muhammad Ma'ruf Ni'ma, Neli Syahida Niah, Rakhmadhan Nimas Ayu Kurniailla Nita Testikawati Nita Testikawati Normilawati Nurlely Nurlely Oktariani Pramiastuti Peni Susilowati Putri Peni Susilowati Putri, Peni Susilowati Puji Astuti Rahmawati, Adillah Rakhmadhan Niah Ratih Anggar Kusumaningtyas Retno Murwanti Rimala Sanipurnama Kindkasman Riris Istighfari Jenie Riski, Akhmad Rusydan, Azka M. Rusydan, Azka Muhammad Sari Rosiati Nur Khasanah Sigit Hartomo Siluh Astuti Siluh Astuti Siluh Putu Yuni Astuti Sitarina Widyarini Soda Farida Sofa Farida Sofa Farida Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sutomo Sutomo Sutomo Sutomo T. N. Syaifullah Sulaiman Tahoangako, Sarmadhan Saputra Tatang Irianti Teuku Nanda Saifullah Sulaiman Tiaravista, Amanda Gita Widhihastuti, Endah Wirasti, Wirasti Yuli Widiyastuti Yuvianti Dwi Franyoto