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All Journal Journal of Food and Pharmaceutical Science Jurnal Tumbuhan Obat Indonesia Jurnal Penelitian Pascapanen Pertanian Majalah Obat Tradisional Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY The Indonesian Biomedical Journal Indonesian Journal of Chemical Science Jurnal Farmasi Sains dan Komunitas Majalah Farmaseutik JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia Journal of Fundamental and Applied Pharmaceutical Science Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Food and Pharmaceutical Sciences Jurnal Tumbuhan Obat Indonesia Jurnal Kefarmasian Indonesia
Nanang Fakhrudin, Nanang
Department Of Pharmaceutical Biology, Faculty Of Pharmacy, Universitas Gadjah Mada, Jl. Sekip Utara, Sleman, Yogyakarta, Indonesia, 55281.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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KARAKTERISTIK PARAMETER SPESIFIK DAN NON SPESIFIK DAUN KRATOM (Mitragyna speciosa Korh.) ASAL KALIMANTAN SELATAN Febrianti, Dwi Rizki; Wahyuono, Subagus; Fakhrudin, Nanang; Riski, Akhmad; Kumalasari, Eka; Normilawati; Niah, Rakhmadhan; Mar'uf, Muhammad
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 2 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i2.2786

Abstract

Standardization is a process of fulfilling the requirements for raw materials of traditional medicine, aimed at ensuring and maintaining safety, consistent quality, and efficacy. Kratom leaves (Mitragyna speciosa) are a traditional medicinal plant found in the interior regions of Kalimantan. This plant functions as a source of energy due to its stimulant properties. This study aims to determine the standardization of kratom leaf extract simplicia, including both specific and non-specific parameters. The extraction method used in this study was maceration with ethanol. The results showed that the scientific name of kratom leaves is Mitragyna speciosa. The standardization of kratom leaf simplicia powder includes parameters such as loss on drying, total ash, water-insoluble ash, acid-insoluble ash, total microbial count (ALT), total yeast and mold count (AKK), and heavy metal contamination, with the following results: 9.5%; 5.51%; 3.58%; 0.39%; 6.9 × 10² cfu/g; >3.0 × 10³ cfu/g; <0.001 mg/kg. Meanwhile, the standardization of kratom leaf extract includes ash content and heavy metal contamination, with results of 6.06% and <0.001 mg/kg, respectively. The active compounds contained in the kratom leaf simplicia and extract are alkaloids, flavonoids, and tannins.
Co-Authors Abdul Rohman Agustinus Widodo Akhmad Khumaidi Anak Agung Gede Sugianthara Andayana Puspitasari Gani Andayana Puspitasari Gani Argandita Meiftasari Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arief Nurrochmad Arifah, Mitsalina Fildzah Ayu Ina Solichah Chelvin Ari Kusnanto Dirman, Arifin Djoko Santosa Ediati Sasmito Efendi Efendi Eka Kumalasari Endang Lukitaningsih Endang Lukitaningsih Endang Lukitaningsih Eny Dwi Astuti Febrianti, Dwi Rizki Gani, Andayana Puspitasari Gharsina Ghaisani Yumni Hifdzur Rashif Rija’i Ika Puspitaningrum Ika Puspitasari Indah Hastuti Ipang Djunarko Jovanita Fara Addina Kahfi Nur Fatimah Khoerul Anwar KRISNA KHARISMA PERTIWI Kusnanto, Chelvin Ari Laras Widawaty Putri Mar'uf, Muhammad Muhammad Hafizh Ridho Muthi Ikawati Ni'ma, Neli Syahida Niah, Rakhmadhan Nimas Ayu Kurniailla Nita Testikawati Nita Testikawati Normilawati Oktariani Pramiastuti Peni Susilowati Putri Peni Susilowati Putri, Peni Susilowati Puji Astuti Rahmawati, Adillah Ratih Anggar Kusumaningtyas Riris Istighfari Jenie Riski, Akhmad Rusydan, Azka M. Rusydan, Azka Muhammad Sari Rosiati Nur Khasanah Sigit Hartomo Siluh Astuti Siluh Astuti Siluh Putu Yuni Astuti Sitarina Widyarini Soda Farida Sofa Farida Sofa Farida Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sutomo Sutomo Sutomo Sutomo T. N. Syaifullah Sulaiman Tahoangako, Sarmadhan Saputra Tatang Irianti Teuku Nanda Saifullah Sulaiman Tiaravista, Amanda Gita Widhihastuti, Endah Wirasti, Wirasti Yuli Widiyastuti Yuvianti Dwi Franyoto