Micro, Small, and Medium Enterprises (MSMEs) are recognized as a critical driver of national economic growth, yet they continue to encounter persistent barriers such as limited digital literacy, restricted access to financing, and insufficient innovation capacity. These challenges highlight the urgent need for an entrepreneurial ecosystem that promotes not only economic advancement but also social empowerment and inclusiveness. This study introduces a community service initiative designed to build such an ecosystem using the Penta Helix framework, which integrates five key actors: academia, business, community, government, and media. The implementation approach was based on collaboration through training programs, mentoring sessions, and the strengthening of socio-economic networks aimed at enhancing MSME independence. The findings indicate that MSMEs demonstrated improved ability to leverage social networks for market expansion, stronger collaboration among stakeholders, and the establishment of an entrepreneurial ecosystem that is both inclusive and sustainable. Notably, the community emerged as a central element, serving as a foundation for ensuring equitable economic benefits at the grassroots level. The novelty of this study lies in integrating social dimensions into the Penta Helix model, shifting the orientation from purely economic growth to broader social sustainability. In conclusion, the synergy of business, community, and government provides a practical framework to strengthen MSME competitiveness while reinforcing social cohesion, aligning with Sustainable Development Goals (SDGs), particularly Goal 8 and Goal 10.