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All Journal MNJ (Malang Neurology Journal) Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kesehatan Prima Majalah Kedokteran Neurosains Journal of Pain, Vertigo and Headache Journal of Global Pharma Technology Journal of General Procedural Dermatology and Venereology Indonesia IJRETINA - International Journal of Retina Magna Neurologica
Shahdevi Nandar Kurniawan, Shahdevi Nandar
Neurology Department, Medical Faculty, Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia.
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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LIGHT EXPOSURE’S EFFECTS ON INACTIVE STATE DURATION AND SLEEP LATENCY IN ZEBRAFISH (DANIO RERIO) LARVAE INSOMNIA MODEL Zamroni Afif; Mochammad Istiadjid Eddy Santoso; Husnul Khotimah; Irawan Satriotomo; Edi Widjajanto; Masruroh Rahayu; Shahdevi Nandar Kurniawan; Dheka Sapti Iskandar; Annisatul Hakimah; Syafiatul Azizah; Nurvia Andriani; Kartika Agustina
MNJ (Malang Neurology Journal) Vol. 8 No. 2 (2022): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.02.11

Abstract

Background: Insomnia is defined as difficulty falling or staying asleep or a sleep state that cannot restore the body's condition. The zebrafish (Danio rerio) is a vertebrate model that has been extensively studied to study sleep and neurological disorders. One of the most widely used methods to examine the effect of the light-dark cycle on the circadian system is by exposing animals and humans to pulse wave light. Objective: To see the effect of light exposure on zebrafish larvae by looking at inactive state duration and sleep latency in zebrafish (Danio rerio) larvae insomnia model. Methods: This study used four groups of zebrafish larvae i.e : (1) normal group (2) minutes of light exposure and 2 minutes off (2/2)), (3) Four minutes of light exposure and 1 minute off (4/1), and (4)  24 hours on (24/0). Observation of larval movement was carried out on 5, 6, and 7 dpf (day post fertilization). Observation time was 30 minutes before and after turned off of light exposure. Results: There were significant differences on days 5, 6, and 7 between the normal group and the three light treatment groups on inactive state duration and sleep latency in dark and light conditions with p-values (p<0.05) and (p< 0.031), but there was no significant difference among groups of light exposure 2 minutes on 2 minutes off, 4 minutes on 1 minute off, and 24 hours on. The 24-hour on treatment showed the most inactive state duration among the light treatments, while the sleep latency was found in the 24-hour treatment. Conclusion: Light treatment of 2 minutes on 2 minutes off, 4 minutes on 1 minute off, and 24 hours on can cause insomnia, but the most substantial insomnia effect is obtained from the 24-hour treatment.
LEPROSY NEUROPATHY : CLINICAL PRESENTATION Rizki Rahamatullah Noer; Shahdevi Nandar Kurniawan
Journal of Pain, Headache and Vertigo Vol. 4 No. 2 (2023): September
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jphv.2023.004.02.1

Abstract

Leprosy is a chronic infection caused by the bacteria M. leprae and causes damage to the skin and peripheral nervous system outside the brain and spinal cord, including the skin, mucous membranes of the nose, testicles, and eyes. This disease develops slowly over a long period, ranging from 6 months to 40 years, and can cause skin lesions and secondary defects. Leprosy is a common and treatable cause of peripheral neuropathy in many tropical and subtropical countries. Neuropathy is a condition that causes damage to the function and structure of the sensory, autonomic, and motor nerves in the peripheral nervous system. Complications of neuropathy can include loss of sensory abilities and muscle weakness. Impaired sensory nerve function is often the first symptom that appears in leprosy neuropathy. Therefore, early detection and treatment of neuropathy in leprosy is very important to prevent disability.
PERONEAL NERVE PALSY Vely Eva Meria; Shahdevi Nandar Kurniawan
Journal of Pain, Headache and Vertigo Vol. 4 No. 2 (2023): September
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jphv.2023.004.02.2

Abstract

Peroneal nerve palsy is a disorder caused by interference with the peroneal nerve. Usually, a drop foot is seen in patients who have peroneal nerve palsy. Basically, the causes of peroneal nerve palsy are multifactorial. Trauma, compression of the nerve, systemic disease, ischemia, and idiopathy are factors that cause peroneal nerve palsy. Management of peroneal nerve palsy can be done non-operatively or operatively, depending on the cause and severity.
DRUG INDUCED NEUROPATHY Anisa Syahfitri Hanum; Shahdevi Nandar Kurniawan
Journal of Pain, Headache and Vertigo Vol. 4 No. 2 (2023): September
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jphv.2023.004.02.3

Abstract

Neuropathy is a painful condition and originates from a variety of etiologies. Many drugs can cause neuropathy, which is known as Drug-Induced Neuropathy (DIN), which is included in iatrogenic cases. These drugs are chemotherapy agents, antimicrobials, cardiovascular drugs, psychotropics, anticonvulsants, etc. Not all neuropathies require pharmacological therapy, but simply stop therapy, and the complaints will improve (reversible). However, there are quite a few DINs with a “coasting" response neuropathy when DIN is stopped. This review synthesizes current clinical concepts regarding mechanisms, drug-induced neuropathy, and treatment options for drug-induced peripheral neuropathy.
GUILLAIN-BARRÉ SYNDROME Gyang Hanandita Gusti Putri; Nectarine Natasya Regitta Yasmin; Shahdevi Nandar Kurniawan
Journal of Pain, Headache and Vertigo Vol. 4 No. 2 (2023): September
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jphv.2023.004.02.4

Abstract

Guillain-Barré Syndrome (GBS) is an infection-preceded autoimmune disease attacking myelin sheath of neurons through molecular mimicry, causing neuron demyelination and conduction disruption. GBS is classified into four subtypes: Acute Inflammatory Demyelinating (AIDP), Acute Motor Axonal Neuropathy (AMAN), Acute Motor Sensory Axonal Neuropathy (AMSAN), and Miller Fisher Syndrome. It affects spinal radix which resulted in polyneuropathy, showing mainly symptoms of ascending paresis of the extremity and areflexia. Cerebrospinal fluid evaluation is essential to distinguish GBS from its vast differential diagnosis, with main finding of albuminocytologic dissociation. GBS needs to be managed as fast as possible with intravenous immunoglobulin administration or fresh frozen plasma exchange due to its fast progression.
PATOFISIOLOGI MIASTENIA GRAVIS Devita Anggraeni Soeroso; Shahdevi Nandar Kurniawan
Journal of Pain, Headache and Vertigo Vol. 4 No. 2 (2023): September
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jphv.2023.004.02.5

Abstract

Myasthenia Gravis (MG) is an autoimmune disease that disrupts transmission at the neuromuscular junction (NMJ). In myasthenia gravis, the immune system will attack the acetylcholine receptor (AChR) or other proteins involved in neuromuscular transmission or due to abnormalities in the thymus, which plays a role in immunity. This causes characteristic manifestations in the form of muscle weakness, which will improve after rest. So, in its management, the use of immunosuppressive therapy and removal of the thymus can be a therapeutic option depending on the type and severity of the disease.
The effectivity of ultrasound-guided platelet-rich plasma perineural injection in improving leprosy sensory peripheral neuropathy Brahmanti, Herwinda; Widiatmoko, Arif; Widasmara, Dhelya; Sari, Diane Tantia; Kurniawan, Shahdevi Nandar; Santoso, Widodo Mardi; Laksono, Ristiawan Muji; Gofur, Abdul
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Sensory nerve damage is the earliest leprosy sign which can lead to disability. Previous studies showed that autologous platelet-rich plasma (PRP) perineural blind injection can stimulate leprosy sensory nerve regeneration. Our study provided a safer and more accurate PRP agent delivery method through ultrasound-guided injection and was the first to compare PRP versus standard neuropathy treatment, the neurotropic vitamin. This study aimed to determine the effectiveness of combination therapy of ultrasound-guided PRP perineural injection and oral vitamin B complex compared to single oral vitamin B complex in sensory peripheral neuropathy of posterior tibial nerve in leprosy patients.
SEVERE POSTURE AND GAIT DISTURBANCE IN LUMBAR SPINAL STENOSIS: A CASE REPORT Lestari, Dwi Indriani; Anggraini, Vivid Prety; Pringga, Gutama Arya; Kurniawan, Shahdevi Nandar; Misnasari, Putri Priela
Journal of Pain, Headache and Vertigo Vol. 5 No. 1 (2024): March
Publisher : PERDOSNI (Perhimpunan Dokter Spesialis Neurologi Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jphv.2024.005.01.4

Abstract

One of the causes of low back pain is lumbar spinal stenosis (LSS). LSS is defined as a disorder resulting from degenerative processes leading to narrowing of the spinal canal. The nature of pain in LSS—the neurogenic claudication—was aggravated by upright or extended trunk positions, such as during walking, descending stairs, or simply standing. Patient self-adjustments in response to pain can induce further muscle disturbance and worsen the condition. A 56-year-old male suffering from poor posture with antalgic and Trendelenburg gait. The MRI showed multiple spinal canal stenosis with compression of the L4-S1 nerve roots affected the gait and worsened posture. Physical medicine rehabilitation (PMR) program—including the use of ultrasound diathermy for severe muscle spasm followed by muscle stretching, Transcutaneous Electrical Stimulation (TENS) for pain relief, Neuromuscular Electrical Stimulation (NMES) for muscle strength improvement and several therapeutic exercises—has proven beneficial in reducing patient’s symptoms thus correcting the posture and gait. At this point spinal canal narrowing is not only causing pain with neurological deficit but may lead to posture and gait disturbance that increasing the patient's disability. The use of physical modalities combined with exercise has been shown to benefit patients similarly to surgery but without invasive approach.
PERINEURAL INJECTION THERAPY AS INTERVENTIONAL PAIN MANAGEMENT IN POST HERPETIC NEURALGIA : A CASE REPORT Pringga, Gutama Arya; R, Rahmad; Pudji, Rosalyna; Kurniawan, Shahdevi Nandar; Suratmono, Mia Fajarningtyas
Journal of Pain, Headache and Vertigo Vol. 5 No. 1 (2024): March
Publisher : PERDOSNI (Perhimpunan Dokter Spesialis Neurologi Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jphv.2024.005.01.5

Abstract

Introduction: Post Herpetic Neuralgia is a neurological complication of herpes zoster resulting in neuropathic pain syndrome that worsens as a direct result of peripheral nerve damage that occurs during an attack of herpes zoster. It manifests as significant dermatomal pain or abnormal sensations and impacting various aspects of quality of life. Physically, patients may experience fatigue, anorexia, weight loss, insomnia, reduced mobility, and physical inactivity. Psychologically, it can lead to depression, anxiety, emotional burden, difficulty in concentration, and fear. Perineural Injection Therapy (PIT), developed by John Lyftogt, offers a treatment option for chronic neuropathic pain. Case Report: A 65-year-old male, currently unemployed for the past two years and previously worked as a tire repairman, came to the Husada Asih Clinic, with sharp, not radiating, and continuous left facial pain (VAS 9-10). He received treatment comprising Transcutaneous Electrical Nerve Stimulation (TENS) and Low Laser Light Therapy (LLLT) on the left face, combined with PIT injections using 5% dextrose at the left side of the face, targeting dermatomes left N V.1, V.2, V.3, and C3 , with repetition after three weeks. After the third injection, the pain at his left head was reduced (VAS 6). Pain at his left jaw and left neck reduced and became intermittently (VAS 5). Barthel Index : 20/20 (Independent). Discussion: The immediate clinical improvement in PIT administration is attributed to the sensorineural effects of dextrose. Clinically, pain decreases immediately or within 1-2 days after therapy. In this case, three series PIT resulted in significant pain relief, reduced burning sensation, improved left muscle motor function, full mouth opening, eased in eating and speaking, and the ability to resume social activities and work. Conclusion: Perineural injection therapy (PIT), previously developed by John Lyftogt, involves a series of subcutaneous injections using 5% dextrose in sterile water (D5W) near the affected nerve. This regenerative therapy offers pain control for PHN patients by targeting skin nerves as potential pain generators. PIT proves to be a valuable rehabilitation tool for managing PHN.
NEURODEGENERATION AS AN EARLY SIGN OF DIABETIC RETINOPATHY Dewi, Nadia Artha; Arfan, Muhammad; Rahmasari, Herisa; Putri, Mutiara Kristiani; Rosandi, Rulli; Kurniawan, Shahdevi Nandar
MNJ (Malang Neurology Journal) Vol. 8 No. 1 (2022): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2022.008.01.12

Abstract

Diabetic retinopathy is major cause of visual impairment and blindness in diabetic patients worldwide. The concept of diabetic retinopathy as vascular disease has established into not only microvascular complication but also neurodegeneration problems. Neurodegeneration plays an important role in pathogenesis of diabetic retinopathy. In fact, neuroretinal changes in diabetes can take place even before vasculopathy can be clinically detected.  This condition is marked by accelerated loss of neurons due to apoptosis, particularly in the inner retinal layer. The characteristic of neurodegeneration can be detected through retinal imaging and electrodiagnostics. This review is very crucial, because identifying the pathophysiology of diabetic neurodegeneration better, we may be able to provide interventions using the appropriate therapy. We may also be able to utilize these diagnostic tools  for early detections of diabetic retinopathy, thus preventing blindness due to diabetes.
Co-Authors Abdul Gofur Afiyfah Kaysa Waafi Al-Rasyid, Harun Aldita Husna Violita Aldita Husna Violita Andaru Cahya S Anggraini, Vivi Laras Anggraini, Vivid Prety Anisa Syahfitri Hanum Annisatul Hakimah Asmiragani, Syaifullah Auliya Nur Muthmainnina Badrul Munir Badrul Munir, Badrul Basya Adnani Basyar Adnani Chomsin Sulistya Widodo Chozin, Iin Noor Dalhar, Mochamad Damayanti, Ria DAMAYANTI, ZUHRIA PUSPITA Dessika Rahmawati Devi Annisa Devita Anggraeni Soeroso Dewi Permata Sari Dheka Sapti Iskandar Dhelya Widasmara Didi Candradikusuma Dini Jatiya Anggraini, Dini Jatiya Dwi, Pratiwi Suryanti Dyah Kusuma Wardhani Edi Widjajanto Eko Arisetijono Ekowati Retnaningtyas F, Fahimma Fahrani Yossa Prachika Farida Widyastuti Fitria Nikmahtustsani, Mulika Ade Gerry Gunawan, Gerry Gonius, Andry Gyang Hanandita Gusti Putri Hanestya Oky Hermawan, Hanestya Oky Hani Susianti Harbiyanti, Novita Titis Hardi Adiyatma Harun Al Rasyid Helena Era Millennie Heri, Sutanto Herwinda Brahmanti Husnul Khotimah Husnul Khotimah I Ketut Suada Irawan Satriotomo Irsyah Dwi Rohmayanti Izza Ayudia Hakim Janet, Karensa Abby Jatmiko, Sarazata Indi Rozaany Kadek Putri Paramita Abyuda Kartika Agustina Kinesya, Billi Lestari, Dwi Indriani Machlusil Husna Machlusil Husna, Machlusil Made Ayu Hariningsih Sunaga Masruroh Rahayu Masruroh Rahayu Masruroh Rahayu Masruroh Rahayu Masruroh Rahayu Masruroh Rahayu, Masruroh Masykur, Umar Jundullah Maziya, Yulianda Mega Yulia Rusmayanti Michelle Anisa Misnasari, Putri Priela Mochammad Istiadjid Eddy Santoso Mokhamad Fahmi Rizki Syaban Mondiani, Yeni Quinta Muhammad Welly Dafif Nadia Artha Dewi Nadiya Elfira Bilqis, Nadiya Elfira Nasution, Ali Napiah Nata Sanjaya Nectarine Natasya Regitta Yasmin Nidia Suriani Nurvia Andriani Petrarizky, Alfred Julius Pramesti, Fathia Annis Pratiwi, Made Dinda Pringga, Gutama Arya Pudji, Rosalyna Purbasari, Bethasiwi Putri, Dwi Sandhi Aulia Pramesti Putri, Laily Ardhianti Putri, Mutiara Kristiani R, Rahmad Rahma, Annisa Rahmasari, Herisa Rahmawati, Dessika Raisa, Neila Reza Rachmantoko Rislan Faiz Muhammad Rislan Faiz Muhammad Ristiawan Muji Laksono Rizki Rahamatullah Noer Rodhiyan Rakhmatiar Rulli Rosandi Safira Dita Arviana Sari, Atika Windra Sari, Diane Tantia Sari, Diane Tantia Sela Pricilia Siti Nurlaela Sri Budhi Rianawati Sri Budhi Rianawati, Sri Budhi Sri Budi Rianawati Suratmono, Mia Fajarningtyas Syafiatul Azizah Titin Andri Wihastuti Tri Wahju Astuti, Tri Wahju Vely Eva Meria Wa Ode Intan Nur Octina Wahyuni Ramadhani Suaib Widiatmoko, Arif Widodo Mardi Santoso Widodo Mardi Santoso, Widodo Mardi Wirathmawati, Andina Yudiansyah, Anggi Gilang Yuyun Yueniwati Zahra, Farah Shabri Alifia Zamroni Afif