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Associations between lifestyle factors and acute respiratory infection incidence at Mayen Primary Health Clinic Meliala, Yose Marselius A.P.; Nasution, Sri Lestari Ramadhani; Suhartina, Suhartina; Nadapdap, Thomson Parluhutan; Sulistijanto, Eddy; Liena, Liena; Rezeki, Naomi Grace; Syahputra, Ari Denggan; Putri, Nadya Nazimuddin
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7812

Abstract

Background: Acute Respiratory Infections (ARI) remain a significant global health burden with high morbidity, particularly in developing nations. Modern lifestyle shifts—characterised by smoking habits, poor dietary patterns, physical inactivity, and compromised sleep quality—alongside environmental pollution, are hypothesised to contribute to susceptibility to these infections. Objective: This study aims to analyse the association between lifestyle factors (smoking, diet, physical activity, sleep quality) and environmental pollution exposure with the incidence of ARI among patients at the Mayen Primary Clinic in 2023–2024. Methods: This study employed an analytic observational design with a cross-sectional approach. The research was conducted at the Mayen Primary Clinic, Medan, involving 82 respondents selected via consecutive sampling. Data were collected using medical records and validated lifestyle questionnaires, followed by analysis using the Chi-Square test. Results: The findings revealed that the majority of respondents were suffering from ARI (85.4%). Bivariate analysis demonstrated significant correlations between ARI incidence and smoking habits (p<0.001), dietary patterns (p=0.001), sleep quality (p<0.001), and air pollution exposure (p<0.001). However, no significant association was observed between physical activity and ARI incidence (p=0.601). Conclusion: Unhealthy lifestyles and environmental pollution are primary determinants of ARI incidence in primary care settings, necessitating health interventions focused on behavioural modification and environmental control.
Aqueous and n-Hexane Fractions of Eruca sativa Differentially Target Glycemic Control and Pancreatic Islet Protection in Diabetic Rats Nasution, Sri Lestari Ramadhani; Tamarin, Tamarin; Purba, Amelia Salsabila; Suhartina, Suhartina; Sihotang, Widya Yanti
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3994

Abstract

BACKGROUND: The search for novel antidiabetic agents that simultaneously lower blood glucose and protect pancreatic β-cells is crucial. While Eruca sativa is known for its antidiabetic properties, the specific contribution of its solvent fractions to different therapeutic targets remains poorly understood. Therefore, this study was conducted to identify how different fractions selectively target glycemic control or pancreatic islet integrity.METHODS: Twenty-five male Wistar rats were rendered diabetic by a single intraperitoneal injection of 45 mg/kg streptozotocin. Diabetic animals were divided into five groups (n=5): diabetic control, positive control (0.45 mg/kg glibenclamide), and three treatment groups receiving n-hexane, ethyl acetate, or aqueous fractions of 400 mg/kgBW E. sativa for 14 days. Phytochemical screening was performed to identify bioactive profiles. Blood glucose was monitored periodically, and pancreatic tissues were assessed using a histopathological scoring system (0–4) and islet area measurement.RESULTS: Aqueous fraction showed the most potent antihyperglycemic activity, significantly reducing blood glucose (208.8±36.02 mg/dL) compared to the diabetic control (419.6± 117.11 mg/dL). Conversely, the n-hexane fraction provided superior pancreatic protection, maintaining the highest islet area (19,109.81±7,549.98 µm²) and the best histopathological score (2.8±0.8) among all treatment groups. Phytochemical screening revealed a distinct distribution of compounds, with flavonoids concentrated in the aqueous fraction and terpenoids in the n-hexane fraction.CONCLUSION: This study demonstrates that therapeutic efficacy of E. sativa is fraction-specific, driven by its distinct phytochemical profiles. The aqueous fraction is the most effective for rapid glycemic control, significantly reducing blood glucose levels. Conversely, the n-hexane fraction provides superior pancreatic protection, as evidenced by the highest islet area and improved histopathological scores. These findings suggest that E. sativa possesses a dual-target potential; while the aqueous fraction excels in antihyperglycemic action, the n-hexane fraction is more potent for pancreatic islet preservation. KEYWORDS: Eruca sativa, diabetes mellitus, histopathology, pancreatoprotective, solvent fractions, antihyperglycemic
Co-Authors A, Nita A. Sabambang, A. Sabambang Abd. Rahman Agustina Ali, Najmah Amansyah , Adek Ananda, Wahyu Anita Merry Cisca Arif, Maria Nisaul ARSYAD, Hasmita Dewi Eliyanti Astuti, Mia Puji Aswin Aswin Bahtiar Bahtiar Dahliana, Besse Dahniar Dahniar Dahniar, Daniar Dewi, Cindar DK, Taufik Eka Wati, Novi Elisabeth Elisabeth F. Najah, F. Najah Fahrodi, Deka U. Farida Juwita Faris Jumawan, Faris Girsang, Ermi Halifah, Syarifah Hamdanah Hamdanah Herman, Arfian Alinda Hutagalung, Caroline Febrina Ibrahim, Syahrianti Ikram, Zul Indrawan Indrawan Intan Andrella Nalrirati Irma S Irma Susanti S irza Haicha Pratama Ismar, Elza Fahliza Johar Amir Kangga, Elizabeth Khatifah Khlaiq, Taufiq Dunialam Liena, Liena Lister, Clarissa Luwandi Suhartono M. Masdi, M. Masdi M. Mustari, M. Mustari Manalu, Angelia Tesalonika Mawarni Meldawati Artayani Meliala, Yose Marselius A.P. Misbar, Nurul Fadilah Morgan, Julian Muammar Muammar, Muammar Muhammad Erik Kurniawan Muhammad Irfan Mukhtar, Zulfikri Mulyani, Yuli Wahyu Tri Mutia, Maya Sari Nasution, Chairul Radjab Natali, Oliviti Nurzhafirah, Nurzhafirah Oktavia, Silvin Pancarina Pardi Pardi, Pardi Purba, Amelia Salsabila Purba, Arna Fransisca Millyanti Putri, Nadya Nazimuddin Putri, Rizkiana Raisa, Daeva Mubarika Ratna Septiyanti Rauf, Eka Ubaya Taruna Renaldi, Muhammad Rizal Rezeki, Naomi Grace S, Irma Susanti Sabambang, Arif Said, Nur S. San, Kon Sari, Agustina Sari, Nini N. Sembiring , Intan Permata Sari br. Siti Nuraliah, Siti Sri Lestari Ramadhani Nasution Sri Rika Amriani. H Sujatmiko3, Cahya Sukoco, Hendro Sulistijanto, Eddy Susanti, Laila Syah, Setiawan Putra Syahputra, Ari Denggan Tamarin, Tamarin Taruna Rauf, Eka Ubaya Taufik Dunialam Khaliq Thomson Parluhutan Nadapdap, Thomson Parluhutan Todung Donald Aposan Silalahi Utami, Rahmawati Ning Widya Yanti Sihotang Wienaldi, Wienaldi Wisnaningsih, Wisnaningsih Yanti Sri Rejeki Yosep Primus Tafonao Yuli Evadianti, Yuli Zul Astri Zulkifli Zulkifli