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All Journal VALENSI ASPIRATOR Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia E-Dimas: Jurnal Pengabdian kepada Masyarakat Jurnal Kesehatan Bakti Tunas Husada SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Journal of Pharmacopolium Pharmacology and Clinical Pharmacy Research Jurnal Kreativitas PKM Jurnal Ilmu Kefarmasian Indonesia Jurnal FARMAKU (Farmasi Muhammadiyah Kuningan) Health Sciences and Pharmacy Journal Jurnal Ilmiah Farmako Bahari Jurnal Farmasi Jurnal Farmasi Sains dan Praktis Jurnal Kesehatan Bakti Tunas Husada Jurnal Medika: Medika ASPIRATOR - Journal of Vector-Borne Diseases Studies
Nur Rahayuningsih, Nur
Universitas Bakti Tunas Husada Tasikmalaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Synthesis, Characterization and In Silico Study of Fe(III) Complex with N'-(4-Chlorobenzoyl)-Isonicotino-Hydrazide as Anti Tuberculosis Candidate Ruswanto Ruswanto; Fajar Setiawan; Nur Rahayuningsih; Richa Mardianingrum; Nur Laili Dwi Hidayati; Elsi Eryanti
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1586.366 KB) | DOI: 10.15408/jkv.v6i1.11788

Abstract

The synthesis of Fe(III) complexes with ligands N'-(4-Chlorobenzoyl)isonicotinohydrazide can be synthesized through mixing metal and ligand dissolved in ethanol by reflux at ± 75oC for 5 hours. The instruments for the characterization of the complex were used UV-Visible and Infrared Spectrophotometry. The aims of the study are: to determine the synthesis method, characterize of the complex, and to study the interaction of the complex with target receptors. The weight of the synthesized compound was obtained by 38.1 mg. The purity of the complex has been tested using the determination of melting point and got a melting point range was 196-198oC. The maximum wavelength of Fe(III)N'-(4-Chlorobenzoyl)isonicotinohydrazid) complex was  261.0 nm and provide absorption of Fe-O vibrations at wavenumbers 530.42 cm-1. The docking process was done using AutodockTools-1.5.6 software which shows that the Fe(III)N'-(4-Chlorobenzoyl) isonicotinohydrazide complex can interact with Enoyl-Acyl Carrier Protein Reductase from Mycobacterium Tuberculosis and it has better  interaction than isoniazid or N'-(4-Chlorobenzoyl)isonicotinohydrazide compound with the acquisition of free energy binding (ΔG) -9.80 kcal/mol and inhibition constant (Ki ) 0.06529 μM.
Co-Authors Agisna, Kiki Rizki Ajeng Diantini, Ajeng Anggraeni, Anggi Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anisa Pebiansyah Anna Yuliana, Anna Annissya, Widia Primi Aprillia, Ade Yeni Aulia Nurlatifah Awaliyah, Risma Citra Dewi Salasanti Desi Agni Mutia Dhiyannisa, Risella Shafa Diana S. Zustika Diana Sri Zustika, Diana Sri Elin Kharina Elsi Eryanti Enas, Ujang Fadilah, Dedeh Zahratul Fajar Setiawan FAJAR SETIAWAN Fakhri, Najah Najia Fathurrahman, Reza Firman Gustaman Fitri Nurafia Gatut Ari Wardani Gustaman, Firman Hernaeni Hernaeni Hernaeni, Hernaeni Idacahyati, Keni Ilham Alifiar Ilham Alifiar ilham alifiar Ilham Alifiar, Ilham Indra Indra Indra, Indra Ira Rahmiyani Juliani, Defanny Padiyah Julyanti, Ai Rian Kamila, Marda Keni Idacahyati Kharina, Elin Lidiasari, Alda Lilis Tuslinah Lusi Nurdianti, Lusi Maharani, Teti Maryam, Cantiya Mida Hamidah Mochamad Fathurohman Muharam Priatna Muharam Priatna, Muharam Muzaffar, Muhammad Nabiil Naim, Anna Jannatun Najma, Nabila Nur Ngguwa Ari, Stephania Caecar Nisa, Ainun Latifa Nur Aulia, Iva Fadia Nur Laili Dwi Hidayati Nurafia, Fitri Nuraulia, Rifa Nurjahan, Nurjahan Nuryadin, Dichy Oktavia, Dwi Fani Parhatussani, Alia Paujia, Eneng Sipa Pebiansyah, Anisa Piranti Piranti Pratidina, Reza Prisnawati, Epi Putri, Sherly Gautama Rachmadhiani, Ana Noviana Rahma, Gita Rahmawati Rahmawati Raihan, M. Rizky Ramadhanti, Febby Nuzuliyah Rianingsih, Restu Richa Mardianingrum Rinaldi, Rusdi Aris Robiyatul, Siti Rusdi Aris Rinaldi Ruswanto, Ruswanto Saeful Amin SALSABILA, ANNISA Sarah, Myra Sinuraya, Rano K. Siti Robiyatul Sulistiani, Dewi A. Sunja'va, Salwa Aurantiva Suwantika, Auliya A. Talistra, Muhammad Royhan Tisnawati, Eva Tita Nofianti Tita Nofianti Tita Nofianti, Tita Tresna Lestari Tresna Lestari, Tresna Utari, Tresna Ayu Vera Nurviana Wafaa Aliifah, Maitsa Wafaa Wildan, Muhammad Maulana Winda Trisna Wulandari, Winda Trisna Yadi Aditya Prawira Yedy Purwandi Sukmawan Zahara, Raisya Ataina