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Indri Safitri, Indri
Program Studi Pendidikan Fisika, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Pasir Pengaraian
Religion Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Ethanol Extract of Marigold Flower (Tagetes Erecta L.) Decreases The Total Cholesterol, Low Density Lypoprotein (LDL), Malondialdehyde (MDA), and Apoliprotein B (APOB) on Hyperlipidemia Rat Models Kresnapati, I Nyoman Bagus Aji; Khaerunnisa, Siti; Safitri, Indri
Folia Medica Indonesiana Vol. 57, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

This study aimed to determine the effect of ethanol extract of gemitir flower (Tagetes erecta L.) on total cholesterol levels, Low-Density Lipoprotein C (LDL), Malondialdehyde (MDA), Apolipoprotein B (ApoB). Forty-eight Rattus norvegicus were randomly divided into 6 groups, groups were given standard feed (K-) and 5 groups of hyperlipidemia models (K +, P1, P2, P3, P4) were given High Fat Diet (HFD) for 35 days. On the 36th day, the total cholesterol levels were checked through the tail of Rattus norvegicus, and from day 37 to day 50 were given a normal diet (K-), HFD (K +), simvastatin 10 mg/kgBW (P1), ethanol extract of gemitir flowers (Tagetes erecta L.) 200 (P2), 400 BW (P3), and 800 mg/kgBW (P4). On day 51, the total cholesterol, LDL-C, MDA, and ApoB blood serum levels were checked. The results showed total cholesterol, Low-Density Lipoprotein (LDL), Malondialdehyde (MDA), and Apolipoprotein B (ApoB) given ethanol extract of gemitir flowers 200 and 400 mg/kgBW (P2) had a significant reduction (P < 0.05). Giving ethanol extract of gemitir flower (Tagetes erecta L.) could reduce levels of total cholesterol, LDL, MDA, and Apo B.
Co-Authors Adi, Ginanjar Sasmito Agus Adhi Nugroho Agus Hermawan Amin, Indah Binti Mohd Anggraeni, Zuhrotul Eka Yulis Asep Muhamad Ramdan Azizah, Najwa Bakhtiar, Arief Bashkara, Oktavian Teguh Bayu Satria Wiratama Elvaretta, Clarissa Ely Rahmatika Nugrahani, Ely Rahmatika Ely Siswanto Erry Sunarya Ervan Prasetyo Faradila, Fian Arifiona Fauziani, Meilidya Gunawan Gunawan Halawa, Victorius Harianto Notopuro Hendri Susilo Hevitria Hevitria Humairah, Ira Ifkari Safitri, Heida Ika Daruwati, Ika Ilham, Ahmad Rowatul Irwani, Fransiska Mareta Kevin, Sebastian Khaerunnisa, Siti Kinasih, Dewangga Sakti Satria Kresnapati, I Nyoman Bagus Aji Kukarnia, Septio Kurnianti, Dinni Kurniasi, Eka Rachma Lea Kristi Agustina Lukitasari, Lina Lukitasari, Lina Mazmuloh, Hot Meilidya Meliana, Ahila Melisa, Nessa Naufaldi, Muhammad Iqbal Oktaviani Ari Wardhaningrum Palupi, Dian Eka Roro Prabowo, Gwenny Ichsan Prasetyaningrum, Dhea Prawitasari, Dita Sukmaya Putraloka, Arvico Qurnianingsih, Ema Rachma Kurniasi, Eka Retno Handajani Rizka Rizka, Rizka Sabilillah, Maria Sihombing, Andreas Pujian SOETJIPTO . Sohibun -, Sohibun Susi Wahyuning Asih, Susi Wahyuning Suwandito, Suwandito Syafa'ah, Irmi Ummah, Fithriyah Cholifatul Wardhani, Herlina Kusuma Waskito, Langgeng Agung Wijaya, Dody Ariyantho Kusma WULANDARI Wungu, Citrawati Dyah Kencono Wungu, Citrawati Dyah Kencono Zulka, Ayesie Natasha