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All Journal Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT JURNAL FARMASIMED (JFM) PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Riset Kefarmasian Indonesia Community Development Journal: Jurnal Pengabdian Masyarakat Madaniya Indonesian Journal of Chemical Science and Technology Jurnal Farmasi dan Sains Indonesia (JFSI) International Journal of Community Service Jurnal Pengabdian Masyarakat (ABDIRA) International Journal of Health and Pharmaceutical (IJHP) Jurnal Farmasi Klinik dan Sains Jurnal Pengabdian West Science FARMASAINKES Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Masyarakat dan Riset Pendidikan E-Amal: Jurnal Pengabdian Kepada Masyarakat

Yayuk Putri Rahayu

Department Of Pharmacy, Universitas Muslim Nusantara Al Washliyah

Author-ID : 5483010

Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Formulasi dan uji aktivitas antibakteri sediaan salep daging daun lidah buaya (Aloe vera L.) terhadap bakteri Staphylococcus aureus pada penyembuhan luka bernanah Dena, Mutia; Dalimunthe, Gabena Indrayani; Lubis, Minda Sari; Rahayu, Yayuk Putri
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.388

Staphylococcus aureus is one of the bacteria that can cause infectious diseases of the skin, one of which is purulent wound disease. Aloe vera (Aloe vera L.) belongs to the family Asphodelaceae, which is a plant known to have antibacterial compounds. The study was conducted experimentally. The independent variable is the concentration of aloe vera leaf flesh, 20%, 30% and 40%. The concentration of aloe leaf meat ointment is 20%, 30%, and 40%. The dependent variables are the antibacterial activity of aloe vera leaf meat ointment preparations against staphylococcus aureus bacteria. The results of the antibacterial Zone of Inhibition (ZOI) value of aloe vera leaf meat against staphylococcus aureus of 8.1 mm (20% concentration); 8.5 mm (concentration 30%); and 10.5 mm (concentration 40%). Antibacterial ZOI value of aloe leaf meat ointment against staphylococcus aureus by 10.6 mm (F1 20%), 11.5 mm (F2 30%), and 12.5 mm (F3 40%). The test results on purulent wounds in rat test animals get moderate healing scores on F1, F2, F3 and K + (gentamicin sulfate 0.1%) strong, so it can be said that aloe vera leaf meat ointment preparations can inhibit antibacterial growth in purulent wound healing even with a moderate category compared to Gentamicin ointment 0.1% with a strong (sensitive) category.

Prevalensi dan identifikasi cemaran bakteri patogen staphylococcus aureus pada ayam krispy Daerah Amplas Kota Medan menggunakan rabbit coagulase plasma with EDTA Rahayu, Yayuk Putri; Nasution, Haris Munandar; Supiyani, Supiyani
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 3 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i3.435

Staphyococcus aureus bacteria is one of the bacteria that contaminates crispy chicken meat and can cause Extraordinary Events or Kejadian Luar Biasa (KLB) in Indonesia as a cause of diarrhea. This is due to lack of hygiene in processing, storing and serving crispy chicken. Poisoning can occur due to food contamination by S. aureus enterotoxin. The aim of the research was to analyze the prevalence and identify the presence of S. aureus bacteria found in crispy chicken meat in the Amplas area of Medan city using Rabbit Coagulase Plasma with EDTA. Method for identifying S. aureus using BPA (Baird Parker Agar Base) and Egg Yolk media. Specific identification testing using Gram staining, catalase test, and coagulase test using Rabbit Coagulase Plasma with EDTA. The value of S. aureus bacterial contamination using the TPC (Total Plate Count) method and analysis of the prevalence of S. aureus contamination. The results of research on roadside cart krispy chickens were found to be positive for S. aureus with characteristics of Gram positive, positive coagulase and positive catalase as well as contamination values above 1X102 CFU/ml exceeding the threshold so they do not meet SNI standards. Meanwhile, the local fast food crispy chicken value for the presence of S. aureus bacteria does not exceed the threshold of 1X102 CFU/ml so it meets SNI standards. The prevalence value of S. aureus contamination in roadside cart krispy chicken was 75.0% and local fast food was 8.3%.

Aktivitas antioksidan dan uji toksisitas ekstrak kulit batang kayu raru (Cotylelobium lanceolatum Craib) dengan menggunkan metode DPPH dan metode BSLT Rossa, Aliffa; Daulay, Anny Sartika; Ridwanto, Ridwanto; Rahayu, Yayuk Putri
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.436

Raru (Corylelobium lanceolatum Craib) is a group of endemic tropical forest plants from the Dipterocarpaceae family in Indonesia. Raru is a term for a group of types of bark added to palm sap, which aims to increase the taste and alcohol content of the drink. People in Sumatra believe that raru bark (Cotylelobium lanceolatum Craib) can be used as an antidiabetic drug. This study aims to determine the antioxidant activity of raru bark, the toxicity activity of raru bark extract, and the secondary metabolites in raru bark. This research was conducted in descriptive was born with a descriptive method. The sample used was raru bark. The research phase included sample preparation, plant identification, simplicial manufacture, antioxidant activity test, DPPH standard stock preparation, blank solution preparation, phytochemical screening, antioxidant activity test based on IC50, Toxicity test, and toxicity activity test based on LC50 value. The result obtained in testing the antioxidant activity of raru bark had an IC50 value of 94.25 µg/mL in the vary strong category. While the result of the probit analysis for the toxicity of raru bark extract using the BSLT method obtained an LC50 value of 350.9942 µg/mL. It is in the toxic category and has the potential to be an anticancer.

Penentuan konsentrasi hambat minimum dan konsentrasi bunuh minimum ekstrak dan nanopartikel ekstrak daun pepaya (Carica Papaya L.) terhadap Bakteri Cutibacterium acnes Khofifah , Nur; Rahayu, Yayuk Putri; Nasution , Haris Munandar; Miswanda, Dikki
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.720

One of the skin diseases that often occurs is acne (Acne vulgaris). Acne is caused by the activity of the Cutibacterium acnes bacteria. Current acne treatment still depends on the use of antibiotics, but long-term use of antibiotics can cause bacterial resistance. Therefore, it is necessary to develop alternative treatments for acne that are effective and safe, one of which is by using medicinal plants. One plant that has potential is papaya leaves (Carica papaya L.). This research aims to determine the minimum inhibitory concentration (MIC) and minimum killing concentration (KBM) of ethanol extract and papaya leaf extract nanoparticles as well as testing antibacterial activity against Cutibacterium acnes bacteria. The research was carried out experimentally. The independent variables are the concentration of papaya leaf extract (6.25% concentration, 12.5% concentration, 25% concentration and 50% concentration), and the concentration of papaya leaf extract nanoparticles (0.625% concentration, 1.25% concentration, 2.5% concentration % and Concentration 5%). The dependent variable is the antibacterial activity of papaya leaf ethanol extract and nanoparticles extract against Cutibacterium acnes. Characterization of the size of the extracted nanoparticles using a Particle Size Analyzer (PSA). The characteristic results for the extract size were 2,203.45 nm while the size of the extract nanoparticles was 330.27 nm. The minimum inhibitory concentration (MIC) value of 1.25% papaya leaf ethanol extract nanoparticles is better than 12.5% papaya leaf ethanol extract, and the minimum lethal concentration (KBM) value of 5% papaya leaf ethanol extract nanoparticles is better than papaya leaf ethanol extract 50% against Cutibacterium acnes bacteria. 5% papaya leaf ethanol extract nanoparticles have the same antibacterial ability as 50% papaya leaf ethanol extract and are sensitive to Cutibacterium acnes bacteria, so it can be said that 5% papaya leaf ethanol extract nanoparticles can reduce the dose concentration of antibacterial compounds up to one-tenth of the time compared to ethanol extract papaya leaves 50% (1:10)

Uji aktivitas antioksidan dan toksisitas dari ekstrak kayu kuning (Arcangelisia flava (L.Merr)) Shilvia, Fatin; Daulay, Anny Sartika; Ridwanto, Ridwanto; Rahayu, Yayuk Putri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.776

Currently, people are beginning to shift towards traditional medicine using natural ingredients. One of the medicinal plants is Yellow Wood (Arcangelisia flava (L.) Merr). Yellow wood has been proven to have antioxidant, antimalarial, antidepressant, antidiabetic, and anticancer activities. The purpose of this study is to determine the antioxidant activity of yellow wood by analyzing its IC50 value and to evaluate the toxicity of yellow wood extract by determining its LC50 value. In this study, the antioxidant activity of the extract was tested using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method, while the toxicity of yellow wood extract was assessed using the brine shrimp lethality test (BSLT) method with several concentration variants. The analysis of antioxidant activity in yellow wood using the 1,1-diphenyl-2-picrylhydrazyl method resulted in an IC50 value of 9.65 µg/ml, while vitamin C had an IC50 value of 3.96 µg/ml. Based on these results, both yellow wood and vitamin C fall into the category of very strong antioxidant activity. The probit analysis of the toxicity test of yellow wood extract using the brine shrimp lethality test method showed an LC50 value of 287.872 µg/ml, which is categorized as toxic.

Konsentrasi hambat minimum dan konsentrasi bunuh minimum ekstrak etanol dan nanopartikel ekstrak etanol daun matoa (Pometia pinnata) terhadap Cutibacterium acnes Safira , Liyuza; Rahayu, Yayuk Putri; Nasution , Haris Munandar; Miswanda, Dikki
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.786

Infectious diseases are caused by the entry and proliferation of microorganisms, including bacteria, fungi, parasites, and viruses. These diseases occur when microbial interactions lead to host tissue damage, resulting in various clinical symptoms and signs. This study aimed to formulate nanoparticles of ethanol extract from matoa leaves and compare the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values, as well as evaluate the antibacterial activity of both the extract and its nanoparticles against Cutibacterium acnes. This research was conducted experimentally. The independent variables were the concentrations of matoa leaf extract (6.25%, 12.5%, 25%, and 50%) and matoa leaf extract nanoparticles (0.625%, 1.25%, 2.5%, and 5%). The dependent variable was the antibacterial activity of both formulations against Escherichia coli and Cutibacterium acnes. Nanoparticle size characterization was performed using a Particle Size Analyzer (PSA), yielding an average size of 528.95 nm. The MIC values for C. acnes were 12.5% for the extract and 1.25% for the nanoparticles, while the MBC values were 50% and 5%, respectively. The highest antibacterial activity of matoa leaf ethanol extract against C. acnes was observed at a concentration of 50% (inhibition zone: 27.86 mm), whereas the nanoparticles exhibited a maximum inhibition zone of 26.53 mm at a 5% concentration. These findings indicate that matoa leaf extract nanoparticles exhibit strong antibacterial activity against C. acnes at lower concentrations compared to the crude extract, suggesting their potential as an effective antibacterial agent.

PENGABDIAN KEPADA MASYARAKAT MELALUI KULIAH KERJA NYATA (KKN) DI DESA BATU PENJEMURAN KECAMATAN NAMORAMBE Yayuk Putri Rahayu; Najwa Lailatulqodri; Burju Artha Marshalina Silitonga; Cynthia Syahni; Rahman Halim; Ahmad Gozali Siregar
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 6 (2024): Vol. 5 No. 6 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i6.40776

Pengabdian Kepada Masyarakat (PKM) melalui kegiatan Kuliah Kerja Nyata (KKN) dalam rangka memberikan kontribusi dengan sosialisasi, edukasi, dan memberikan solusi bagi permasalahan masyarakat di desa Batu Penjemuran kecamatan Namorambe, Sumatera Utara. Tujuan kegiatan PKM KKN ini adalah menjadikan peran mahasiswa untuk memberikan sosialisasi, edukasi, dan meningkatkan jiwa wirausaha dan kegiatan pembelajaran melalui kegiatan Kuliah Kerja Nyata (KKN) di desa Batu Penjemuran. Metode yang digunakan adalah: (1) Penyuluhan (sosialisasi), dan (2) Edukasi dan pelatihan tentang anti-bullying, keterampilan mencuci tangan standar World Health Organization (WHO), keterampilan membuat obat kumur, keterampilan membuat jamu instan, keterampilan membuat pestisida alami, dan pengetahuan gotong royong kebersihan lingkungan. Kegiatan PKM KKN dilakukan dengan beberapa tahap: (1) Tahap survey, melakukan kerjasama dengan kepala desa, dan menentukan tema kegiatan; (2) Tahap persiapan PKM KKN; (3) Tahap penyuluhan, sosialisasi, dan edukasi penyampaian materi. Hasil yang didapatkan dari kegiatan PKM KKN ini adalah pengetahuan dan keterampilan masyarakat di desa Batu Penjemuran Namorambe menjadi meningkat terkait pengetahuan anti-bullying, keterampilan mencuci tangan standar WHO, keterampilan membuat obat kumur, keterampilan membuat jamu instan, keterampilan membuat pestisida alami, dan pengetahuan gotong royong kebersihan lingkungan. Hasil yang diperoleh adalah pengetahuan mitra masyarakat di desa Batu Penjemuran meningkat dari rata-rata nilai pengetahuan 46,67 meningkat menjadi 81,67. Kesimpulan dari kegiatan pengabdian PKM KKN ini adalah mitra masyarakat di desa Batu Penjemuran, Kecamatan Namorambe menjadi mendapatkan pengetahuan yang meningkat sebesar 75%, sehingga dapat meningkatkan kualitas hidup di masyarakat

Edukasi Penyimpanan Sediaan Obat dan Kosmetik yang Baik dan Benar di Rumah: Penelitian Rahmadani Rahmadani; Supiyani Supiyani; Ainil Fithri Pulungan; Yayuk Putri Rahayu
Jurnal Pengabdian Masyarakat dan Riset Pendidikan Vol. 5 No. 1 (2026): Jurnal Pengabdian Masyarakat dan Riset Pendidikan Volume 5 Nomor 1 (Juli 2026 -
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jerkin.v5i1.7461

Tujuan penelitian ini adalah meningkatkan pengetahuan dan kesadaran masyarakat tentang penyimpanan obat dan kosmetik yang benar di rumah melalui edukasi di Puskesmas Teladan Medan. Penyimpanan yang tidak tepat dapat menurunkan kualitas, efektivitas, dan keamanan produk sehingga meningkatkan risiko kesehatan. Kegiatan dilakukan dengan pendekatan pendidikan kesehatan melalui diskusi interaktif dan tanya jawab yang melibatkan pasien serta masyarakat. Materi mencakup suhu, kelembapan, paparan sinar matahari, tanggal kedaluwarsa, keutuhan kemasan, dan penyimpanan yang aman dari jangkauan anak. Efektivitas program dievaluasi menggunakan kuesioner pretest dan posttest. Hasil menunjukkan peningkatan pengetahuan dan kesadaran peserta mengenai praktik penyimpanan yang benar, termasuk pentingnya menjaga kondisi lingkungan, memeriksa kedaluwarsa, mempertahankan kemasan asli, dan mencegah kontaminasi. Peserta juga lebih percaya diri menerapkan serta menyebarluaskan informasi kepada keluarga. Edukasi melalui fasilitas kesehatan primer terbukti mendukung penggunaan obat yang rasional, menjaga mutu produk, dan mencegah risiko kesehatan akibat penyimpanan yang tidak tepat. Oleh karena itu, program edukasi berkelanjutan perlu terus dilaksanakan untuk memperkuat promosi kesehatan dan mendorong perubahan perilaku masyarakat.

Application Of Dryer Machines In The Development Of Karo Traditional Herb Business In Tambar Malem Group In Batu Jong Jong Village, Langkat, North Sumatra Yayuk Yuliana; Yayuk Putri Rahayu; Harianto II; Cici Niken Ariyanti; Ghalih Anwar
International Journal Of Community Service Vol. 2 No. 3 (2022): August 2022 (Indonesia - Malaysia - Kamboja)
Publisher : CV. Inara in Colaboration with www.stie-sampit.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijcs.v2i3.120

The partner of the service activity is the Tambar Malem Group which is engaged in the business of Karo traditional herbs for traditional medicinal ingredients. The Tambar Malem group which consists of housewives to date still producing traditional Karo ingredients . Mitra is located in Bahorok District, Langkat Regency, North Sumatra Province. Partner problems in the field of production. In production still use simple tools and manuals so the amount of production is still small. The implementation method uses education and counseling,focus group discussions, ,accompaniment, evaluation. Solutions to partner priority problems from (1) Aspectproduction including Focus Group Discussion (2) procurement and use of equipment (3) preparation of materials; (3) Implementation of training (4) Evaluation. The results of the service activities Increasing knowledge and management skills of business development and implementation of drying machine technology

Bioautographic Analysis And Antibacterial Activity Test Of Mengkudu Leaf (Morinda Citrifolia L.) Ethanol Extract On The Bacteria Propionibacterium Acnes Rati Satri Situmorang; Haris Munandar Nasution; Minda Sari Lubis; Yayuk Putri Rahayu
International Journal of Health and Pharmaceutical (IJHP) Vol. 3 No. 1 (2022): February 2023
Publisher : CV. Inara

Noni contains alkaloids, flavonoids, tripertinoid, protein, lime, iron, carotene, glycosides antarkiron. The content of anthraquinin, scaloptin, flavonoid and adaptogen compounds are active compounds that have antifungal and antimicrobial effects. The antibiotics commonly used are antibiotics such as tetracycline, clindamycin and others. These chemical-based antibacterials have many negative side effects, therefore other alternatives are needed as antibacterials, one of which is by using noni. This study aims to analyze bioautography and determine the antibacterial activity of noni leaf ethanol extract against Propionibacterium acnes bacteria.This research was conducted experimentally using noni leaf ethanol extract with concentrations of 30%, 40%, 50% as independent variables and bioautographic analysis and antibacterial activity as dependent variables. The bioautography analysis was performed using TLC and the antibacterial activity test was performed using paper discs.The results of antibacterial testing of noni leaf ethanol extract with a concentration of 30% had an inhibition zone of 8.36 mm with a medium category, a concentration of 40% had an inhibition zone of 10.3 mm with a strong category and a concentration of 50% had an inhibition zone of 11.1 mm in a strong category. positive control tetracycline 30µg had an inhibition zone of 20.8 mm which was categorized as very strong. The results of the bioautography test using contact bioautography using the mobile phase of chloroform: n-hexane (7:3). The inhibition zone was obtained at an Rf value of 0.17, and the characteristics of the chromatogram spots were carried out by spraying 10% FeCl3 suspected that the spots were flavonoid compounds.

Co-Authors Adelia Ramadani Adelia Ramadani Adli Nuzula Rahmah Ahmad Gozali Siregar Alfi Wahyudi Nasution Amaliana, Amaliana Anny Sartika Daulay Ayu , Tri Indah Pagar Barutu, Liza Anisa Shevia Burju Artha Marshalina Silitonga Cici Niken Ariyanti Cindy Widya Rosa Br Simarmata Cynthia Syahni D Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang Delvi Amira Hutagaol Dena, Mutia Dikki Miswanda Elma Natasya Fatikasari, Cilki Fithri Pulungan, Ainil Fitri Mulyani, Fitri Gabena Indrayani Dalimunthe Ghalih Anwar Habibie, Dian Harahap, Azmi Kurniawan Harahap, Siti Salimah Harianto II Haris Munandar Nasution Haris Munandar Nasution Healthy Aldriany Prasetyo Hendri Gunawan Hutagaol, Delvi Amira Huzeila Nisa Siregar Ika Fitriani Ika Yeni Siahaan Khofifah , Nur Lastri Afni Leni Safriani Linda, Rosa Lisda Mayanti Lubis, Minda Sari Lubis, Nadya Frestika Lulu Ilma Khoirun Nissa M Pandapotan Nasution M Pandapotan Nasution M. Pandapotan Nasution M. Pandapotan Nasution M. Pandapotan Nasution Merani Phaustina Lumban Gaol Muhammad Amin Nasution Muhammad Arif Muhammad Hizbullah Muhammad Pandapotan Nasution Muhammad Wahyu Ikhsan Muhammad Wahyu Ikhsan Munaziatul Jannah Nadia Salsabilla Najwa Lailatulqodri Nanda Nadia Nasution , Muhammad Amin Nasution, M. Pandapotan Nelsa Fahira Nofa Lismandaria Nomi Noviani Novi Yuliandari Novika Utami Novriani Putri Santia Nurul Hasanah Oca Putri Nazuhra Oktavia, Sri Rahayu Rafita Yuniari Rafita Yuniart Rahmadani Rahmadani Rahman Halim Rati Satri Situmorang Ridwanto Ridwanto Rosalinda Mahdalena Sinaga Rosalinda Mahdalena Sinaga Rossa, Aliffa Safira , Liyuza Selfiani Selfiani Sepriani, Ananda Shilvia, Fatin Sinaga, Rosalinda Mahdalena Siti Aisyah Jamil Sony , Suyefri Sopha, Diana Sri Wahyuni Sri Wahyuni Supiyani, Supiyani Syarifah Elena Gultom Tahnia Maulidya Tawir Rina Rezeki Tusaddiah, Ria Winata, Ageng Tegar Yani, Farida Yayuk Yuliana Yayuk Yuniarti, Rafita Zulmai Rani

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