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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Inspiration JOIV : International Journal on Informatics Visualization Unnes Science Education Journal BIOEDUSCIENCE Journal of Education and Instruction (JOEAI) Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Ilmu Komputer Fakultas Ilmu Komputer Universitas Al Asyariah Mandar Cakrawala Indonesia Mazahibuna: Jurnal Perbandingan Mazhab Kognitif: Jurnal Riset HOTS Pendidikan Matematika Jurnal Minfo Polgan (JMP) Journal of Natural Science and Technology Adpertisi: Bidang Sains dan Teknologi JURNAL SIPISSANGNGI: Jurnal Pengabdian Kepada Masyarakat Journal of Technology Research in Information System and Engineering Samalewa: Jurnal Riset dan Kajian Manajemen Asian Journal of Applied Education Waluya The International Science of Health Journal Ilmu Manajemen Sosial Humaniora (JIMSH) Hayyan Journal
Muhammad Arafah
Program Teknik Informatika, STMIK AKBA, Makassar
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Potential of Quercetin Compound from Guava Leaves (Psidium guajava L.) as a Inhibitor COVID-19 Sengka, Rani; Rompegading, Andi Badli; Irfandi, Rizal; Nur, Muhammad; Arafah, Muhammad; Yani, Ahmad
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 3 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i3.49666

Abstract

This research is a computer-based experimental study using the molecular docking method of quercetin compounds in the leaves of the guava plant (Psidium guajava L.) against the target protein (receptor), namely Mpro SARS-CoV-2 (PDB ID: 6M2N) using various softwares. consists of Chem Draw Ultra version 7.0, Marvin Sketch, PLANTS, Yasara, Discovery Studio Visualizer 2021, and pkCSM online tool and, protox online tool. This study aims to find out how the potential  of the quercetin compound from the leaves of the guava plant (Psidium guajava L.) has on its ability to inhibit the spread of Covid-19 by molecular docking. Data analysis in this study was carried out based on data obtained from the analysis of pharmacokinetic profiles, physicochemical properties, molecular docking, and predictions of toxicity to compounds that have potential as drug ingredients. Based on the results of molecular docking, it was shown that the quercetin compound has the potential to act as an inhibitor of the Mpro receptor (PDB ID: 6M2N) as evidenced by the docking score obtained which is smaller than the docking score obtained by the original ligand of the target receptor.
Co-Authors Agung Gunawan Agus Halid, Agus ahmad yani Ambo Upe Amiruddin, Muh. Fauzan Andi Badli Rompegading Andi Sumardin, Andi Andis, Andis ANGRIAWAN, RANDY Asri, Andi Asriani, Besse Assidiq, Muhammad Asti, Mulham Jaki Awi Dassa, Awi Badli Rompegading, Andi Bahar, Erni Ekafitria Basri Basri Detti Uleng, Andi Dewanti, Lucky Fauziah Suhardi , Rifdah Tami Hair, Miftahul Hardianti Arafah, Eka Henny Sri Astuty Herlina, Besse ihya, Zahratul ILHAM Ilham Ilham Imran, Nadya Setyastuti Irfandi, Rizal Karim, Harli A Kawatu, Paul Johan M. Sabir, Fitriana Maslihatin, Tatik Maulidinnawati, Andi Muhajirin, M Muhajirin, Muhajirin Muhammad Nur Muhammad Sabri Muhammad Tahir Muhlis, Nur Fadhillah Nasser P, Muh Kemal Natsir, Khaidir Rahman Nur, Irsan Nurcaya Nurcaya NURZAENAB, NURZAENAB Parewe, Andi Maulidinnawati Abdul Kadir Pasnur Pasnur Pasnur Punjanan, Abraham Andromeda Putri, Nur Fisabilianti Rahmadani, Fitria Rahmatullah, Andi Muhammad Ridha Resha, Muhammad Rika, Rika Rony, Zahara Tussoleha Sabir, Fitriana M. Saputra, Febri Hidayat Sengka, Rani Sitti Aminah Sodikin Sodikin Sofyan Sri Hardianti Rosadi Sumardin, A Sunarsih Sunarsih Suryadi Syamsu, Suryadi Syafruddin, S Syamsiar, Syamsiar Syamsu Rijal Tamrin, Fadli Tanjung, Akbar Tantu, Zakiah Tatik Maslihatin Taufik Trywulan Syah, Uswah Yunus, Nur Hafsah Yusuf , Andi M