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All Journal Jurnal Riset Kesehatan Indonesian Journal of Biotechnology Journal of Health (JoH) Titian Ilmu: Jurnal Ilmiah Multi Sciences JMM (Jurnal Masyarakat Mandiri) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Kesehatan Prima Jurnal Analis Medika Biosains (JAMBS) JPP Jurnal Kesehatan Poltekkes Palembang Jaringan Laboratorium Medis Hydrogen: Jurnal Kependidikan Kimia Bima Nursing Journal Jurnal Sains Natural Journal of Indonesia Laboratory Students (JILTS) Thrive Health Science Journal Jurnal Indonesia Mengabdi Jurnal Info Kesehatan
Fihiruddin, Fihiruddin
Politeknik Kesehatan Mataram
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Fluktuasi Aktivitas Enzim SGOT dan SGPT pada Pasien Kanker Payudara yang Menjalani Kemoterapi di RSUD Provinsi NTB Ananda, Fadila Rizki; Tatontos, Erlin Yustin; Fihiruddin, Fihiruddin
Jaringan Laboratorium Medis Vol. 7 No. 2 (2025): November 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jlm.v7i2.13322

Abstract

Chemotherapy is one of the primary treatment for breast cancer. Despite its effectiveness, chemotherapy has the potential to cause hepatotoxicity due to drug metabolism in the liver. This condition is generally indicated by elevated levels of SGOT and SGPT enzymes. Liver enzyme monitoring is essential to assess hepatocellular function throughout the course of therapy. This research aims to determine fluctuations in SGOT and SGPT enzyme activity in breast cancer patient undergoing chemotherapy at the NTB Provincial Hospital, and describe the pattern of changes in enzyme values based on the frequency of chemotherapy cycles. An analytical observational study with a cross-sectional approach was employed. Samples were selected purposively based on the medical records of breast cancer patients who underwent 1 to 6 cycles of chemotherapy between January and December 2024. Data were analyzed descriptively based on the distribution and the average of SGOT and SGPT enzyme levels. The results showed fluctuating SGOT and SGPT levels across different chemotherapy cycles. There was no consistent pattern of increase in enzyme activity based on chemotherapy frequency.  The average SGOT levels from cycle 1 to 6 were 24, 28, 27, 30, 33, and 24 IU/L, while the average SGPT levels were 35, 27, 29, 25, 29, and 29 IU/L, with a range of SGOT values of 13-404 IU/L and SGPT with a range of 5-304 IU/L. most enzyme values remained within normal range. It was concluded that chemotherapy frequency did not show a consistent association with increased SGOT and SGPT activity. These research emphasize the importance of routine monitoring of liver function during each chemotherapy cycle, so that potential hepatotoxicity can be adjusted according to the patient condition.  
Pengaruh Penambahan Glukosa terhadap Pertumbuhan Bakteri Escherichia coli pada Media Pemupuk Nutrient Broth (NB) Hidayati, Nurul; Sukmana, Dhika Juliana; Ariami, Pancawati; Urip, Urip; Fihiruddin, Fihiruddin
JSN : Jurnal Sains Natural Vol. 2 No. 2 (2024): Mei
Publisher : Puslitbang Sekawan Institute Nusa Tenggara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35746/jsn.v2i2.538

Abstract

Infectious diseases are caused by microorganisms, one of them is Escherichia coli. The process of isolation and identification of bacteria requires enrichment media to increase the number of bacteria. Media Brain Infusion Broth (BHIB) media, the growth of Escherichia coli bacteria is better than Nutrient Broth (NB). Demahui's glucose as a normal source of organic carbon for the growth of Escherichia coli bacteria, while in NB media there is no glucose. This study is quoted to obey the effect of the addition of glucose on the NB fertilizer media on the growth of Escherichia coli bacteria. This study is a pre-ecperimental study of the addition of 1 gram of glucose, 2 grams, 3 grams, 4 grams and 5 grams of media Nutrient Broth fertilizer media (NB). Termanhan is observed from the number of colonies that grow on the nutrient media so that the plate (NAP). The sample used was the suspension of the pure isolates of the Escherichia coli ATCC 35218. The calculation of the average number of colonies obtained from each treatment was 79, 90, 144, 126, and 103 colonies with a control of 63 colonies. Based on the statistical test one -way ANOVA P value (0,000) <? (0.05) which means there is an influence of the addition of glucose on the growth of Escherichia coli bacteria Nutrient Broth (NB). The optimal concentration of the addition of glucose is 3 grams in 1 L of NB media.
Comparison of Results of Atypical Lymphocyte Test, RT-PCR and ELISA Using Recombinant Multivalent Envelope Protein Domain III (ED-III) Dengue Virus in Dengue Fever Patients Inayati, Nurul; Fihiruddin, Fihiruddin; Ernawati, Sri; Unsunnidhal, Lalu; Jannah, Raudatul
JURNAL INFO KESEHATAN Vol 22 No 3 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss3.1644

Abstract

Prevention of the transmission of dengue hemorrhagic fever (DHF) is carried out by breaking the chain of dengue transmission and administering vaccines, but to date, this has not achieved the expected target. Dengue virus tests using RT-PCR require skills and relatively expensive equipment. Serological test of IgM and IgG often shows false negatives or false positives, especially in dengue-endemic areas. The antibody test against NS1 using the ELISA method has weaknesses because anti-dengue IgM is often not detected in secondary infections. The development of serodiagnostic tests for rapid, affordable, sensitive, and specific detection of dengue virus infection is very necessary. Recombinant multivalent envelope proteins domain III (ED-III) dengue virus is a biomarker that has the potential to be developed to detect all dengue virus serotypes. One of the proteins that has high antigenicity is glycoprotein E which is found in the envelope of the dengue virus and is the most antigenic part of the virus. This research aims to combine several parts of the antigenic protein found in all dengue virus serotypes as immunoserodiagnostic material. This research is an analytical survey research, that compares the results of the atypical lymphocyte test, RT-PCR, and ELISA using the multivalent ED-III antigen. The number of samples used was 26 samples obtained from patients who were diagnosed with dengue fever using an accidental sampling technique. The results of the atypical lymphocyte examination showed 14 positive samples, while the results of the RT-PCR and ELISA examinations were 23 and 24 positive respectively. The average Optical density (OD) of examination using the ELISA method was 1.902 with sensitivity and specificity levels of 92% and 96%. There is no difference result of the RT-PCR compared with the ELISA test. Therefore, recombinant multivalent envelope protein domain III (ED-III) dengue virus can be used as a diagnostic tool to detect dengue fever infection.
Relationship between Cholesterol Levels and Ca 15-3 Tumor Markers in Patients with Carcinoma Mammae Faylori, Adelia Yusnita; Pauzi, Iswari; Fihiruddin
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.17460

Abstract

Breast cancer is the most common malignancy among women worldwide and remains a major cause of cancer-related mortality in Indonesia. Various risk factors, including hormonal, genetic, lifestyle, and metabolic factors, such as elevated cholesterol levels, have been associated with the development and progression of breast cancer. Cholesterol plays a crucial role in cell membrane formation and hormone synthesis, and recent studies have suggested its potential role in tumor growth and metastasis, particularly through the modulation of estrogen receptors and inflammatory pathways. CA 15-3 is a tumor marker widely used for monitoring breast cancer progression and recurrence. However, the correlation between cholesterol levels and CA 15-3 remains underexplored. The research objective is to determine the correlation between total cholesterol levels and the breast cancer tumor marker CA 15-3 in patients diagnosed with breast carcinoma at the Regional General Hospital of West Nusa Tenggara Province (RSUDP NTB). A cross-sectional analytic observational study was conducted using secondary data from the medical records of 33 breast carcinoma patients collected between January to November 2024. Cholesterol and CA 15-3 levels were analyzed using standard laboratory procedures. Data distribution was tested using the Kolmogorov-Smirnov test, and Pearson correlation analysis was applied to evaluate the relationship between cholesterol levels and CA 15-3. Showed that the mean cholesterol level was 214.24 mg/dL, and the mean CA 15-3 level was 41.55 U/mL, both exceeding normal reference values. Pearson correlation analysis demonstrated a very strong and statistically significant positive correlation between total cholesterol and CA 15-3 levels (r = 0.940, p < 0.001), indicating that higher cholesterol levels are associated with increased CA 15-3 concentrations. The study found a significant correlation between cholesterol levels and CA 15-3 in breast carcinoma patients, suggesting that cholesterol may influence tumor activity. Routine monitoring of cholesterol levels may be valuable in the clinical management of breast cancer, especially in assessing disease progression.
Treatment Duration and Its Impact on the Number of Polymorphonuclear, Mononuclear and Neutrophil Lymphocyte Ratio as Indicators of Recovery Rate in Tuberculosis Patients Aini, Aini; Fihiruddin, Fihiruddin; Diarti, Maruni Wiwin; Tatontos, Erlin Yustin; Salleh, Mohd Nazil
JURNAL INFO KESEHATAN Vol 23 No 4 (2025): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol23.Iss4.1960

Abstract

The calculation of leukocyte types can be used to assess the level of infection or inflammation, particularly through the neutrophil-lymphocyte ratio (NLR). The NLR has been established as a useful biomarker for predicting bacteremia. Although differential leukocyte count and the neutrophil–lymphocyte ratio (NLR) have been widely proposed as indicators of infection and inflammation, their clinical interpretation remains unclear across disease states, particularly in tuberculosis. Current evidence is limited regarding how leukocyte profiles and NLR change during standard anti tuberculosis treatment (ATT), especially in the early and intermediate phases of therapy. Furthermore, it is not well established whether changes in leukocyte subtypes reflect treatment response or disease recovery in tuberculosis patients. Therefore, there is a need to quantify changes in leukocytes and NLR during TB treatment and to determine their potential role as readily accessible biomarkers for monitoring therapy outcomes. The goal of this study was to determine the effect of treatment duration on the number of polymorphonuclear cells, mononuclear cells, and the neutrophil-lymphocyte ratio as indicators of recovery in TB patients. This study employed a cross-sectional design with an analytical observational approach, involving 26 TB patients undergoing treatment for 1 to 6 months. The results showed the following average cell counts (per microliter) over the treatment period: basophils at 0.04, eosinophils at 0.30, neutrophils at 4.10, lymphocytes at 2.36, monocytes at 1.84, and a neutrophil-lymphocyte ratio of 0.53. One-way ANOVA analysis revealed a positive correlation between basophils, neutrophils, lymphocytes, monocytes, and the neutrophil-lymphocyte ratio with TB recovery. In conclusion, treatment of TB patients during the fourth to sixth month, or in the advanced phase of treatment showed differences in the number of  polymorphonuclear cells, mononuclear cells and  the NLR ratio compared to intensive phase treatment in TB patients at the Karang Taliwang and akranegara Health Centers.
Analysis Of Urine Nicotine In Electronic Cigarette Smokers and Regular Cigarette Smokers saadaty, nila uthari; Fihiruddin; Yunan Jiwintarum; Urip; Fachrudi Hanafi
Journal of Indonesia Laboratory Students (JILTS) Vol. 4 No. 2 (2025): Journal of Indonesia Laboratory Students
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jilts.v4i2.411

Abstract

Latar Belakang: Penggunaan rokok, baik konvensional maupun elektrik, merupakan masalah kesehatan masyarakat yang semakin meningkat di Indonesia.paparan nikotin yang terdapat pada rokok elektrik dan konvensional dapat berdampak buruk bagi kesehatan. Nikotin, sebagai zat adiktif utama dalam rokok, akan dimetabolisme menjadi cotinine yang dapat dideteksi dalam urine sebagai biomarker penting untuk menilai tingkat paparan dan risiko kesehatan.Tujuan: Menganalisis nikotin dalam urine pada pengguna rokok elektrik dan rokok konvensional.Metode: Penelitian ini menggunakan metode observasional deskriptif dengan racangan peneltian cross sectional. Sebanyak 30 subjek yang memenuhi kriteria inklusi dan eksklusi dengan teknik pengambilan sampel purposive sampling. Pengolahan sampel dilakukan dengan metode deskriptif.Hasil Penelitian: Hasil penelitian menunjukkan bahwa 15 sampel perokok elektrik dan 15 sampel dari perokok konvensional menunjukkan hasil positif nikotin dalam urine. Kesimpulan: Ditemukan positif nikotin urine pada perokok elektrik dan konvensional dengan pemeriksaan RDT.  
Penggunaan Nicotine Replecment Therapy (NRT) dan therapy community sebagai upaya menghentikan kebiasaan merokok Fihiruddin Fihiruddin; Fachrudi Hanafi; Nurul Inayati; Muhammad Hasbi
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 8, No 1 (2024): March
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v8i1.19414

Abstract

AbstrakRokok merupakan salah satu penyebab kematian terbesar di dunia. Perilaku merokok dapat memberikan dampak negatif bagi kesehatan. Penyakit-penyakit yang diakibatkan rokok antara lain kanker paru, penyakit paru obstruktif kronik, kanker mulut, hipertensi, penyakit jantung koroner, gangguan kehamilan dan gangguan pernapasan yang berakibat pada tingginya beban biaya pengobatan. Penduduk usia produktif dan remaja di Desa Karang bayan merupakan perokok aktif. Kebiasaan merokok mulai dilakukan sejak kecil atau dimasa remaja. Secara psikologis, upaya berhenti merokok menjadi sulit karena adanya pengaruh lingkungan sosial, kemudahan akses rokok, tidak adanya aturan yang membatasi usia perokok dan pengaruh teman sebaya. Tujuan Pengabdian kepada Masyarakat ini menurunkan kasus merokok pada remaja dengan melakukan intervensi menggunakan NTR dan melakukan therapy community, sehingga dapat menghentikan perilaku merokok secara efektif  pada remaja perokok aktif di Desa Karang Bayan. Metode yang digunakan pada kegiatan ini adalah sosialisasi dan observasi, penyuluhan, demonstrasi serta evaluasi. Pengisian quisioner dilakukan sebelum intervensi dan setelah intervensi dengan NRT dan therapy community. Kegiatan ini dilaksanakan dari bulan maret sampai juli 2021, yang melibatkan Kepala Desa, sekretaris Desa, kader Desa dan 50 orang remaja perokok aktif. Setelah pemberian intervensi NTR dan therapy community terjadi penurunan jumlah konsumsi rokok perhari, dimana jumlah remaja yang merokok <5 batang per hari dari 5 orang (20%) menjadi 15 orang (60%), sedangkan yang merokok 5-10 batang per hari dari  9 orang (36%)  menjadi 7 orang (28%) dan yang merokok  >10 batang per hari juga mengalami penurunan dari  11 orang (44%) menjadi 3 orang (12%). Pemberian intervensi NRT dan therapy community dapat menurunkan jumlah konsumsi rokok per hari dan dapat menghentikan remaja untuk berhenti merokok yang dibuktikan dengan adanya tiga orang remaja yang berhenti merokok. Kata kunci: merokok; NRT; remaja; therapy community. AbstractSmoking are one of the leading causes of mortality in the world. Smoking habits can have a negative im pact on health. Diseases caused by smoking include lung cancer, chronic obstructive pulmonary disease, oral cancer, hypertension, coronary heart disease, pregnancy disorders and respiratory problems. Productive age-populations and teenagars in karang bayan village are active smokers. The smoking habits starts from childhood or adolescence. Psychologically, trying to stop smoking become difficult due to the social environment, easy access to cigarettes, the absence of regulations that limit the age of smoker and the influence of peers. The aim of this community service is to reduce smoking cases in teenagers by intervening using nicotine replacement therapy (NRT) and carrying out community therapy, so that they can stop smoking behavior effectively in active smoking teenagers in Karang Bayan village. The methods used for this event is socialization and observation, counseling, demonstration as well as evaluation. The questionnaire was filled out before the intervention and after the intervention with NRT and community therapy. This activity was carried out from March to July 2021, involving the Village Head, Village Secretary, Village cadres and 50 teenagers who active smoking. After providing NTR and community therapy interventions, there was a decrease in the number of cigarettes consumed per day, where the number of teenagers who smoked <5 cigarettes per day from 5 people (20%) to 15 people (60%), while those who smoked 5-10 cigarettes per day from 9 people (36%) to 7 people (28%) and those who smoke >10 cigarettes per day also decreased from 11 people (44%) to 3 people (12%). Providing NRT and community therapy interventions can reduce the number of cigarettes consumed per day and can stop teenagers from quitting smoking as evidenced by the three teenagers who quit smoking. Keywords: smoking; NRT; teenager; community therapy.
Co-Authors Abdiah Zikrilah Agrijanti, Agrijanti Agus Supinganto Aini, Aini Ananda, Fadila Rizki Anisa Prisilia Prisilia Aolani, Almira Zaida Ari Khusuma Arjita, I Putu Dedy Astriani, Astriani Azharin, Intan Baiq Linda Rolian ocatari Barandi Sapta Widartono Danuarti, Maruni wiwin Dewi, Lale Budi Kusuma Drs. I Wayan Getas Dwi Kurnia Febrianti kurnia Dwi Melbaow Aisyiah Putri Erlin Yustin Tatontos Erna Kristinawati Erna Kristinawati Fachrudi Hanafi Fachrudi Hanafi Fachrudi Hanafi Fachrudi Hanafi Faylori, Adelia Yusnita Getas, I Wayan Hanifa Falahul Ilmi I Wayan Getas I Wayan Getas I wayan Getas Iswari Pauzi Juliantini, Ni Komang Lalu Srigede Lalu Unsunnidhal Maruni Wiwin Diarti Maruni Wiwin Diarti Muhammad Hasbi Ni Komang Juliantini Nurul Hidayati Nurul Inayati Nurul Inayati Nurul Inayati Nurul Inayati Nurul Inayati Nurul Inayati Nurul Inayati Nurul Qomariah Pancawati Ariami Pauzi, Iswari Putri, Ananda Kinanti RAI WIADNYA, IDA BAGUS raudatul jannah Raudatul Jannah Resnhaleksmana, Ersandhi Rizki Ananda Putri Rohmi saadaty, nila uthari Salleh, Mohd Nazil Septiani, Erna Shohifatul Wahyuni Siti zaetun Sri Ernawati Sukmana, Dhika Juliana Tasya, Rabaika Monica Thomas Tandi Manu Unsunnidhal, Lalu Urip Urip Urip, Urip Wahyuni, Shohifatul Wayan Tunas Artama Yudha Anggit Jiwantoro Yuliana Wardani Yunan Jiwintarum Yunan Jiwintarum